Abstract: A test system is provided for a component of an engine. This test system includes a combustor test section and an air system. The combustor test section includes a fuel injector, an ignitor and a combustion chamber. The fuel injector is configured to direct fuel into the combustion chamber for mixing with cooled air. The ignitor is configured to ignite a mixture of the fuel and the cooled air within the combustion chamber. The air system is configured to deliver the cooled air to the combustor test section. The air system includes a compressed air source, a cryogenic cooling system and an air circuit. The cryogenic cooling system includes a cryogenic heat exchanger. The air circuit extends through the cryogenic heat exchanger and fluidly couples the compressed air source to the combustor test section.

Abstract: An incident clustering system for detecting clusters among incident reports can include a data intake module configured to receive incident text strings associated with respective incident reports input by a user, a pre-processing module operatively connected to the data intake module to receive the incident text strings from the data intake module and to pre-process the incident text strings to output pre-processed text strings associated with the respective incident reports, and a token module operatively connected to the pre-processing module to receive the pre-processed text strings. The token module can be configured to identify one or more phrases-of-interest having a plurality of words in the pre-processed text strings and concatenate the plurality of words of each of one or more phrases-of-interest to output concatenated tokens associated with the respective incident reports.

Abstract: In one embodiment, a system includes a multistage dielectrophoretic filter system for purification of extracellular vesicles from a complex sample comprising an array of fluidic cells having electrodes that receive and process the sample, fluid transfer devices, actuated valves, storage containers, an electronic control board and power supply. In another embodiment, an extracellular vesicle analysis system for analyzing biomarkers in the purified extracellular vesicles is described. In yet another embodiment are described methods for purifying extracellular vesicles, and analyzing extracellular vesicle biomarker profiles for identifying subjects for treatment or for diagnosis.

Abstract: The present invention provides improved methods for gene delivery to, or genetic modification of, target cells, wherein the gene delivery or other genetic modification of the target cells is performed in the presence of endothelial cells, or after co-culture of the target cells with endothelial cells, or wherein co-culture of the target cells with endothelial cells is employed immediately after gene delivery in order to “rescue” cells that may have been damaged during the gene delivery process. In some embodiments gene delivery is performed by transfection. In some embodiments gene delivery is performed by transduction. In some embodiments the endothelial cells are organ-specific endothelial cells. In some embodiments the endothelial cells are E4ORF1-expressing endothelial cells (E4ORF1+ ECs). In some embodiments the target cells are stem cells, such as hematopoietic stem cells.

Abstract: The invention generally relates to an improved processes for the preparation of a cyclic dinucleotide which is useful as a STING agonist of the following formula (I), involving the use of compounds A and B.

Abstract: A method of manufacturing ceramic tape includes a step of directing a tape of partially-sintered ceramic into a furnace. The tape is partially-sintered such that grains of the ceramic are fused to one another yet the tape still includes at least 10% porosity by volume, where the porosity refers to volume of the tape unoccupied by the ceramic. The method further includes steps of conveying the tape through the furnace and further sintering the tape as the tape is conveyed through the furnace. The porosity of the tape decreases during the further sintering step.

Abstract: A person support apparatus, such as a bed, cot, stretcher, or the like, includes an exit detection system that has, in some embodiments, multiple user-selectable modes. A first mode issues an alert in response to a static condition being met and the second mode issues an alert in response to a dynamic condition being met. The static condition may be defined by an unchanging boundary that triggers an alert if the occupant's center of gravity crosses the boundary. The dynamic condition may be defined by a changing boundary that triggers an alert if the occupant's center of gravity crosses it. The changing boundary may change based upon the occupant's height, weight, BMI, vital sign, or other characteristic. The changing boundary may also change based upon a position of one or more components of the person support apparatus, such as a siderail or Fowler section.

Abstract: Interesting features of an object within a physical environment are identified from a video of the physical environment. A model of the object is obtained, the model includes dimensions of the object. A first array is maintained with the pixel coordinates of the identified features within the video. A second array is maintained with the dimensions of the features obtained from the model. A processing framework is provided for using the first and second arrays and estimating, updating, and tracking the anchor pose in the physical environment within the video along with any AR generated objects placed in the video. The framework provided to an Augmented Reality (AR) app to initiate an AR session and to maintain the session.

Abstract: A dilation device is provided for modeling mitral regurgitation in a mitral valve that includes an annular housing surrounding an aperture; a first anterior blade mounted to the housing and defining a substantially straight inner edge adjacent the aperture; and a plurality of posterior blades mounted to the housing and defining a curved inner edge adjacent the aperture, the posterior blades movable to dilate a valve mounted to the blades. An annulus of a valve may be sutured to the blades such that valve is disposed adjacent the aperture, and the dilation device may be actuated to cause the posterior blades to dilate a posterior region of the valve.

Abstract: Disclosed herein are improved cross-linked resilin compositions and methods of making these improved compositions. These include new methods of cross-linking resilin compositions, use of polar nonaqueous solvents for adjusting material properties of cross-linked resilin solid compositions, and resilin foam compositions and methods of making the same.

Abstract: One aspect of the disclosure includes a fluid moving system. The fluid moving system includes a fluid moving apparatus configured to convey a fluid through a housing from an inlet to an outlet. The fluid moving system includes an active cleaning device configured to neutralize or remove at least a portion of an undesired matter from the fluid conveyed through the housing. The fluid moving system includes an electric motor including a rotor coupled to the fluid moving apparatus and configured to turn the fluid moving apparatus upon application of electric power to a stator of the electric motor. The fluid moving system includes a motor controller communicatively coupled to the electric motor and configured to control at least one of a speed output or a torque output thereof.

Abstract: Fiber optic terminals comprising an input connection port in optical communication with an input multi-fiber ferrule of the input connection port and a plurality of output ports for making optical connections are disclosed. The terminals are configured with an input multi-fiber connection port and one or more single-fiber output ports along with a first multifiber output connection port suitable for linking the output of the first terminal with an input connection port of a second terminal. The multi-fiber connection port may include an alignment block supports a length of the adapter sleeve for stabilizing the optical mating of the multi-fiber ferrule associated with respective multi-fiber connection port(s) of the terminal. Terminals may also include other features for securing respective the external plug connector(s) that may be received in the connection port of the fiber optic terminal.

Abstract: The present application is directed to compounds of Formula I: compounds comprising these compounds and their uses, for example as medicaments for the treatment of diseases, disorders or conditions mediated or treatable by inhibition of binding between WDR5 protein and its binding partners.

Abstract: The present disclosure relates to systems, devices, and methods for analyzing health of vehicle batteries. Vehicle batteries tend to degrade over time. The described systems, devices, and methods quantify this degradation (or quantify remaining health of the battery) by comparing average energy used to charge or discharge the battery by a charge level unit to a nominal quantity of energy used to charge or discharge a battery in optimal health by a charge level unit. Charge data for previous charge events of the vehicle battery can be used in the calculation, and can be filtered by identifying qualified charge events based on at least one of a number of metrics. Usage data for previous usage events of the vehicle battery can be used in the calculation, and can be filtered by identifying qualified usage events or subgroups of usage event based on at least one of a number of metrics.

Abstract: Described herein are compositions, and more particularly to alloy compositions, methods of using the alloy compositions, and articles formed from with the alloy compositions. The alloy compositions are broadly applicable in applications requiring superalloys, including welding processes, additive manufacturing processes, metal casting processes, coating processes, repairing processes, powder metallurgy, and/or combinations thereof.

Abstract: An intelligent marking paint applicator system and method of use. The applicator, such as a marking stick or gun for example, can include a composition marking applicator and associated electrical and electronic components mounted in or in association with the device to identify and record composition (such as spray paint for example) marking activity. The device may optionally include GPS locating sensing capability to identify the location of the composition marking activity. The device may optionally provide marking activity to one or more separate devices, including in order to identify the location of the composition marking activity. Some embodiments of the applicator can also be lightweight, compact, and economical—in some embodiments, relying on use of the device with one or more other separate smart devices to provide geolocation of device for example.

Abstract: A system provides interoperation between Fifth Generation (5G) Non-Terrestrial Networks (NTN) and 3rd Generation Partnership Project (3GPP) 5G network with a satellite-based communications network. The system includes a Satellite Access Network (SAN) configured to process Satellite Digital Video Broadcast (DBB) waveforms, a Satellite Access Node (sAN) configured with functionality of a ground station modem and portions of an existing network management system (NMS), and a Fixed Network-Residential Gateway (FN-RG) that comprises a logical representation of the remote modem.

Abstract: Embodiments of the inventive subject matter are directed to retirement plan optimization. By collecting client information, systems and methods of the inventive subject matter are configured to develop scenarios for a user. From those scenarios, multiple simulations can be run. Each scenario features scenario parameters, and each simulation features simulation parameters. Scenario parameters can include ranges of values or a set of different possible values. For a given scenario, many simulations can be run, where each simulation has a corresponding set of simulation parameters, and where each set of simulation parameters features set values for each of the scenario parameters for that scenario. After running multiple simulations for each scenario, high performing simulations can be identified based on a base case performance and based on one or more optimization goals. Once high performing simulations are identified, actionable retirement plans can be developed therefrom.