Abstract: A pump comprises a stator and at lest one rotor mounted within a housing. The housing comprises a first fluid channel extending about the rotor, the rotor comprising at least one second fluid channel. A first sensor is configured to output a signal indicative of the temperature of the stator, and a second sensor is configured to output a signal indicative of the temperature of the rotor. The temperature of fluid in the channel is controlled depending on the magnitude of signals output from the sensors.

Abstract: A method and system for transferring data between a host and a Serial Attached Small Computer Interface (“SAS”) device using a storage controller is provided. The storage controller includes, a World Wide Name (“WWN”) module that includes a table having plural entries, wherein each row includes a WWN address, an initiator tag value field, an input/output counter value that tracks plural commands for a connection. A WWN index value represents the address of a row having plural entries. The method includes, comparing frame elements of incoming frames, including a unique WWN address with the WWN module entries; and if there is a match, updating a counter value for a connection between the storage controller and a device sending frames. The counter value is increased when a command frame is received and decreased when a command is executed and a response is sent to the device.

Abstract: This invention relates to a method, apparatus, and means for simulating interdependent infrastructures. This may involve selecting a subset of an interdependent infrastructure system, equivalencing the subset, creating a plurality of agents to model with the subset, and simulating multi-scale agent interactions.

Abstract: A process for cyanating an aldehyde is provided. The process comprises reacting the aldehyde with: i) a cyanide source which does not comprise a Si—CN bond or a C—(C?O)—CN moiety; and ii) a substrate susceptible to nucleophilic attack not comprising a halogen leaving group; in the presence of a chiral catalyst. Preferably, the chiral catalyst is a chiral vanadium or titanium catalyst. The cyanide source is preferably an alkali metal cyanide and the substrate susceptible to nucleophilic attack not comprising a halogen leaving group is a carboxylic anhydride.

Abstract: A process for cyanating an aldehyde is provided. The process comprises reacting the aldehyde with: i) a cyanide source which does not comprise a Si—CN bond or a C—(C?O)—CN moiety; and ii) a substrate susceptible to nucleophilic attack not comprising a halogen leaving group; in the presence of a chiral catalyst. Preferably, the chiral catalyst is a chiral vanadium or titanium catalyst. The cyanide source is preferably an alkali metal cyanide and the substrate susceptible to nucleophilic attack not comprising a halogen leaving group is a carboxylic anhydride.

Abstract: A tracking stage has an optical filter with a free spectral range greater than the maximum mode hop of a tunable laser. The free spectral range is sufficient to determine the wavelength of the laser output after the mode hop. The output is dithered or a quadrature signal is used to determine whether the mode hop is forwards or backwards. In a further embodiment, a second tracking stage with a shorter free spectral range is coupled to the tunable laser to provide enhanced wavelength resolution. Alternatively, the second tracking stage is omitted and the signal of the tracking stage is amplified to enhance wavelength resolution.

Abstract: The invention relates to a method for identifying a therapeutic having analogous activity to a thiazolidinedione by contacting a cell containing a PPAR&ggr; receptor with a candidate therapeutic; and determining the level of a selected gene expression; to indicate that the candidate therapeutic is a therapeutic for treating a disease associated with a PPAR&ggr; receptor. The invention also relates to a composition comprising a plurality of selected genes or gene fragments, or a plurality of proteins or proteins fragments selected from proteins encoded by the selected genes thereof. The invention further relates to a method for determining whether a subject is responsive to treatment with a therapeutic having analogous activity to a thiazolidinedione.

Abstract: The present invention discloses an air-entrainment mechanism for carbureted engine. The mechanism includes a plunger valve controlled by a solenoid. The solenoid is powered by a battery with a switch electrically coupled thereto. The plunger valve is interconnected to the carburetor to allow additional air entrainment. The solenoid is coupled to the valve for opening and closing the valve. The switch electrically couples the solenoid to the battery to activate the solenoid for movement of the valve. The switch disclosed herein includes a temperature sensor and an engine-running sensor. The switch is then closeable when the temperature sensor detects an engine temperature within a predetermined range as long as the engine is not already running.

Abstract: A process for cyanating an aldehyde is provided.

Abstract: Nucleic acid compositions are provided that encode a family of mammalian proteins expressed in the retina and brain. Members of the gene family are genetically linked to various neurosensory defects, including cochlear degeneration, peripheral retinal degeneration and cone-rod retinal dystrophy. The nucleic acid compositions find use in identifying DNA sequences encoding homologous or related proteins; for production of the encoded protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of neurosensory defects, identification of retinal cells based on expression, and the like. The DNA is further used as a diagnostic for genetic predisposition to the linked neurosensory defect.

Abstract: A genetic locus associated with asthma is identified. The genes within the locus, ASTH1I and ASTH1J, and the regulatory sequences of the locus are characterized. The genes are used to produce the encoded proteins; in screening for compositions that modulate the expression or function of ASTH1 proteins; and in studying associated physiological pathways. The DNA is further used as a diagnostic for genetic predisposition to asthma.

Abstract: The gene responsible for the autosomal recessive mouse obesity mutation tub was identified by positional cloning. The homologous human gene is also provided. The genes are used to produce tubby protein; in screening for compositions that modulate the expression or function of the tubby protein; and in studying associated physiological pathways. The DNA is further used as a diagnostic for genetic predisposition to obesity, retinal degeneration or cochlear degeneration. The mutation responsible for the tub phenotype is a G to T transversion that abolishes a donor splice site in the 3' coding region and results in a larger transcript containing the unspliced intron. A second, prematurely truncated transcript arises from the introduction of a premature polyadenylation site in the unspliced intron.

Abstract: The gene responsible for the autosomal recessive mouse obesity mutation tub was identified by positional cloning. The homologous human gene is also provided. The genes are used to produce tubby protein; in screening for compositions that modulate the expression or function of the tubby protein; and in studying associated physiological pathways. The DNA is further used as a diagnostic for genetic predisposition to obesity, retinal degeneration or cochlear degeneration. The mutation responsible for the tub phenotype is a G to T transversion that abolishes a donor splice site in the 3' coding region and results in a larger transcript containing the unspliced intron. A second, prematurely truncated transcript arises from the introduction of a premature polyadenylation site in the unspliced intron.

Abstract: The gene responsible for an autosomal dominant con-rod retinal dystrophy is identified, TULP2. The genes are used to produce the encoded protein; in screening for compositions that modulate the expression or function of TULP2 protein; and in studying associated physiological pathways.

Abstract: The gene responsible for the autosomal recessive retinal degenerative disease RP 14 is identified, TULP1. The genes are used to produce the encoded protein; in screening for compositions that modulate the expression or function of TULP1 protein; and in studying associated physiological pathways. The DNA is further used as a diagnostic for genetic predisposition to retinal degeneration.