Abstract: The present invention is directed to carbazole compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

Abstract: The present invention is directed to carbazole compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

Abstract: The present disclosure provides compounds which are immunomodulators and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.

Abstract: The present invention is directed to carbazole compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

Abstract: The present invention is directed to carbazole compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

Abstract: A multi-arm fishing rig with flexible arms has been developed. The fishing rig includes a head that connects to a fishing line and multiple arms that connect to the head. The arms are suitable for attaching bait to each individual arm. The arms are also made of a flexible material that allows each arm to be adjusted in a position relative to the other arms and to retain the position while in use.

Abstract: The present invention provides novel amino-benzazoles and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.

Abstract: The present invention provides novel amino-benzazoles and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.

Abstract: The present invention provides novel amino-benzazoles and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.

Abstract: The invention contemplates a body structure for a vehicle. The body structure includes a roof panel and a side frame. The attachment flange of an outer body side panel includes a roof mounting portion with a dual angle, a glass mounting portion at an angle that matches one of the dual angles, and a transition area where the dual angle of the roof mounting portion tapers to the glass mounting portion with the single angle.

Abstract: In general, the instant invention comprises compounds of Formulas I and II including pharmaceutically acceptable salts thereof. The compounds of the invention are useful as protein kinase inhibitors and therefore are useful for treating cancer and other protein kinase mediated diseases.

Abstract: An improved brazing system having a plurality of heat sources is adapted for brazing in tandem a plurality of adjacent workpieces and for reducing porosity in the braze joint. The system preferably includes a first laser beam that engages the workpieces to vaporize surface contaminants thereupon, a second laser beam configured to melt the brazing material, and a third laser beam configured to further heat the material, so as to extend the thermal cycle thereof or re-melt the material.

Abstract: In general, the instant invention comprises compounds of Formulas I and II including pharmaceutically acceptable salts thereof. The compounds of the invention are useful as protein kinase inhibitors and therefore are useful for treating cancer and other protein kinase mediated diseases.

Abstract: The present invention provides novel amino-benzazoles and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.

Abstract: A method of forming a vehicle body side structure assembly includes the steps of providing a plurality of tubular members to form a frame structure and assembling the tubular members together to pre-form the frame structure. The method also includes the step of positioning the pre-formed frame structure between open die halves mating with one another to define a tubular cavity portion. The method includes the step of closing the die halves to capture the pre-formed frame structure within the tubular cavity portion. The method further includes the step of pressurizing an interior of the pre-formed frame structure to expand and conform the pre-formed frame structure to the tubular cavity portion to form a final frame structure.

Abstract: A pet bed that is modeled after the anatomy of the canine shape. It uses a specially designed comfort area in the top pad that aligns with the hip and shoulder areas to provide a supportive and conforming area to help improve blood flow to the hips and legs. It also has a honeycomb support system molded into the base that aids in adjusting the overall pressure across the entire surface of the bed, making the bed truly form fitting. A back and head/neck rest support are also included. These areas are designed to allow the pet to choose a multiple of head/neck and paw placements to allow complete comfort with all of the therapeutic support benefits that the pet requires.

Abstract: Amino-pyrimidine and amino-triazine derivatives having 5-HT7 antagonist activity for the treatment of sleeping disorders, depression, schizophrenia, anxiety, obsessive compulsive disorders, circadian rhythm disorders, ocular disorders and/or centrally and peripherally mediated hypertension are provided.

Abstract: Benzoic acid derivatives of the formula where X is oxygen, sulfur, —NH, —NR1, —N—CN, —N—OR1 or —N—NO2; Y is a single bond, —C═C—, or —NH; R1 is alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocyclo, or (heterocyclo)alkyl; and R2 is aryl or heterocyclo. The compounds of formula I are useful in the treatment of arrhythmia.

Abstract: The present invention describes compounds of formula I: and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, m and n are as defined in the specification. The compounds of formula I are protein kinase inhibitors and are useful in the treatment of proliferative diseases, for example, cancer, inflammation and arthritis. They may also be useful in the treatment of Alzheimer's disease, chemotherapy-induced alopecia, and cardiovascular disease.