Patents by Inventor Michael A. Poss

Michael A. Poss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 7-oxabicycloheptane carboxylic acid prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-vasospastic compounds and method for preparing same
    Patent number: 5618946
    Abstract: The present invention relates to novel 7-oxabicycloheptane carboxylic acid prostaglandin analog intermediates which may be used to prepare a final anti-thrombotic, anti-vasospastic product, and to methods for preparing the same.
    Type: Grant
    Filed: February 29, 1996
    Date of Patent: April 8, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael A. Poss, Paul D. Pansegrau, Shaopeng Wang, John K. Thottathil, Janak Singh, Richard H. Mueller
  • Indole- and benzimidazole-substituted quinoline derivatives
    Patent number: 5616591
    Abstract: Compounds of the formula ##STR1## wherein X, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: March 27, 1992
    Date of Patent: April 1, 1997
    Assignee: E.R. Squibb & Sons, Inc.
    Inventor: Michael A. Poss
  • Process for preparing dioxolenone derivatives used for making prodrug esters and intermediates
    Patent number: 5610314
    Abstract: A process is provided for preparing dioxolenone derivatives of the structure ##STR1## wherein R is alkyl or aryl and R.sub.3 is CO.sub.2 R.sub.2 (where R.sub.2 is alkyl or arylalkyl such as benzyl, diphenylmethyl or para-methoxybenzyl). Intermediates produced in the above process are also provided as well as a method for preparing squalene synthetase inhibitors employing such intermediates.
    Type: Grant
    Filed: April 3, 1995
    Date of Patent: March 11, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Peter T. W. Cheng, Chong-Oing Sun, Michael A. Poss
  • Diol sulfonamide and sulfinyl renin inhibitors
    Patent number: 5545838
    Abstract: Compounds of the formula ##STR1## wherein Z is SO or SO.sub.2 possess renin inhibition activity and are useful in treating hypertension and other diseases where the reduction of the levels of circulating angiotensin II are beneficial.
    Type: Grant
    Filed: January 27, 1992
    Date of Patent: August 13, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Michael A. Poss
  • 7-Oxabicycloheotane carboxylic acid prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-vasospastic compounds and method for preparing same
    Patent number: 5539130
    Abstract: A method is provided for preparing carboxylic acid intermediates of the structure ##STR1##
    Type: Grant
    Filed: September 14, 1995
    Date of Patent: July 23, 1996
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael A. Poss, Paul D. Pansegrau, Shaopeng Wang, John K. Thottahil, Janak Singh, Richard H. Mueller
  • 7-oxabicycloheptane carboxylic acid prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-basopastic compounds and method for preparing same
    Patent number: 5512690
    Abstract: A method is provided for preparing carboxylic acid intermediates of the structure ##STR1##
    Type: Grant
    Filed: September 14, 1995
    Date of Patent: April 30, 1996
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael A. Poss, Paul D. Pansegrau, Shaopeng Wang, John K. Thottathil, Janak Singh, Richard H. Mueller
  • 7-oxabicycloheptane carboxylic acid protaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-vasospastic compounds and method for preparing same
    Patent number: 5508445
    Abstract: A method is provided for preparing carboxylic acid intermediates of the structure ##STR1##
    Type: Grant
    Filed: December 15, 1994
    Date of Patent: April 16, 1996
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael A. Poss, Paul D. Pansegrau, Shaopeng Wang, John K. Thottathil, Janak Singh, Richard H. Mueller
  • N-substituted imidazole and benzimidazole derivatives useful as angiotenson II antagonists
    Patent number: 5466704
    Abstract: Compounds are disclosed having the formula ##STR1## These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: June 22, 1994
    Date of Patent: November 14, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Michael A. Poss
  • 7-oxabicycloheptane carboxylic acid prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-vasospastic compounds and method for preparing same
    Patent number: 5399725
    Abstract: A method is provided for preparing carboxylic acid intermediates of the structure ##STR1## wherein an aldehyde of the structure ##STR2## is prepared and subjected to a Horner-Emmons reaction to form the ester of the structure ##STR3## and the ester is hydrogenated to the carboxylic acid which may be used in making the final anti-thrombotic--anti-vasospastic compounds.
    Type: Grant
    Filed: April 20, 1994
    Date of Patent: March 21, 1995
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Michael A. Poss, Paul D. Pansegrau, Shaopeng Wang, John K. Thottathil, Janak Singh, Richard H. Mueller
  • Indole- and benzimidazole-substituted imidazole and benzimidazole derivatives
    Patent number: 5374615
    Abstract: Novel compounds are disclosed having the formula ##STR1## wherein X, R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are substituents. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: February 7, 1992
    Date of Patent: December 20, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Michael A. Poss
  • Dihydropyrimidine derivatives
    Patent number: 5350752
    Abstract: Novel A-II receptor antagonists have the formula ##STR1## or its isomer ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6, are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: December 16, 1991
    Date of Patent: September 27, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Michael A. Poss, John Lloyd, Karnail S. Atwal
  • Acyl amidine and acyl guanidine substituted biphenyl derivatives
    Patent number: 5256695
    Abstract: Novel compounds are disclosed having the formula ##STR1## where A is ##STR2## and wherein R.sub.1, R.sub.2 and R.sub.3 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: September 16, 1992
    Date of Patent: October 26, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Michael A. Poss
  • Oxadiazinone substituted indole and benzimidazole derivatives
    Patent number: 5236916
    Abstract: Novel compounds having the formula ##STR1## wherein X, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: May 26, 1992
    Date of Patent: August 17, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harold N. Weller, III, Michael A. Poss
  • Substitute indole and benzimidazole derivatives
    Patent number: 5234923
    Abstract: Novel compounds are disclosed having the formula ##STR1## or its isomer ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and X are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: December 16, 1991
    Date of Patent: August 10, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Michael A. Poss, Karnail S. Atwal
  • Indole and benzimidazole-substituted dihydropyrimidine derivatives
    Patent number: 5212177
    Abstract: Novel compounds having the formula ##STR1## and its isomer ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and X are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, an antihypertensive agents.
    Type: Grant
    Filed: December 16, 1991
    Date of Patent: May 18, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Michael A. Poss, Karnail S. Atwal
  • Indole- and benzimidazole-substituted imidazole derivatives
    Patent number: 5208235
    Abstract: Novel compounds having the formula ##STR1## where X R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore for example, as antihypertensive agents.
    Type: Grant
    Filed: March 10, 1992
    Date of Patent: May 4, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Michael A. Poss
  • Substituted imidazole phosphonic and phosphinic acid derivatives
    Patent number: 5208234
    Abstract: Novel compounds having the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: March 10, 1992
    Date of Patent: May 4, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Michael A. Poss
  • Imidazole and benzimidazole derivatives
    Patent number: 5191086
    Abstract: Novel angiotensin-II receptor antagonists are disclosed having the general formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, W and X are as defined herein.
    Type: Grant
    Filed: March 19, 1991
    Date of Patent: March 2, 1993
    Assignee: E.R. Squibb & Sons, Inc.
    Inventor: Michael A. Poss
  • Benzoxazole and related heterocyclic substituted imidazole and benzimidazole derivatives
    Patent number: 5190942
    Abstract: Novel compounds are disclosed having the formula ##STR1## wherein X, Y, R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: April 22, 1991
    Date of Patent: March 2, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Michael A. Poss
  • Acyl amidine and acyl, guanidine substituted biphenyl derivatives
    Patent number: 5177097
    Abstract: Novel compounds are disclosed having the formula ##STR1## and wherein R.sub.1, R.sub.2 and R.sub.3 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: July 24, 1991
    Date of Patent: January 5, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Michael A. Poss