Patents by Inventor Michael A. Rogawski

Michael A. Rogawski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FOSPROPOFOL METHODS AND COMPOSITIONS
    Publication number: 20230277567
    Abstract: The present disclosure pertains to the use of fospropofol, pharmaceutically acceptable salts of fospropofol, or mixtures thereof. Pharmaceutical compositions comprising fospropofol, pharmaceutically acceptable salts of fospropofol, or mixtures thereof, and methods of treating diseases or disorders, including migraine are also disclosed.
    Type: Application
    Filed: February 15, 2023
    Publication date: September 7, 2023
    Inventors: Steven L. Krill, Feng-Jing Chen, Michael A. Rogawski, Edward Brendan Magrab, Allen H. Heller
  • Fospropofol methods and compositions
    Patent number: 11628178
    Abstract: The present disclosure pertains to the use of fospropofol, pharmaceutically acceptable salts of fospropofol, or mixtures thereof. Pharmaceutical compositions comprising fospropofol, pharmaceutically acceptable salts of fospropofol, or mixtures thereof, and methods of treating diseases or disorders, including migraine are also disclosed.
    Type: Grant
    Filed: March 4, 2022
    Date of Patent: April 18, 2023
    Assignee: Epalex Corporation
    Inventors: Steven L. Krill, Feng-Jing Chen, Michael A. Rogawski, Edward Brendan Magrab, Allen H. Heller
  • MITIGATION OF EPILEPTIC SEIZURES BY COMBINATION THERAPY USING BENZODIAZEPINES AND NEUROSTEROIDS
    Publication number: 20230111081
    Abstract: Provided are compositions comprising a benzodiazepine and a neurosteroid, containing one or both of the benzodiazepine and the neurosteroid in a subtherapeutic dose, and administration of such compositions for mitigation of an epileptic seizure. Further provided are compositions comprising a benzodiazepine, a neurosteroid, and an NMDA blocker, and administration of such compositions for mitigation of an epileptic seizure.
    Type: Application
    Filed: November 19, 2022
    Publication date: April 13, 2023
    Inventors: Michael A. Rogawski, Isaac N. Pessah, Zhengyu Cao, Pamela J. Lein
  • PROPOFOL PRODRUG METHODS AND COMPOSITIONS
    Publication number: 20230084521
    Abstract: The present disclosure pertains to the use of propofol prodrugs, pharmaceutically acceptable salts of propofol prodrugs, or mixtures thereof, to treat migraine.
    Type: Application
    Filed: September 9, 2022
    Publication date: March 16, 2023
    Inventors: Michael A. Rogawski, Enrique Carrazana, Edward Brendan Magrab, Steven L. Krill, Allen H. Heller
  • Mitigation of epileptic seizures by combination therapy using benzodiazepines and neurosteroids
    Patent number: 11510929
    Abstract: Provided are compositions comprising a benzodiazepine and a neurosteroid, containing one or both of the benzodiazepine and the neurosteroid in a subtherapeutic dose, and administration of such compositions for mitigation of an epileptic seizure. Further provided are compositions comprising a benzodiazepine, a neurosteroid, and an NMDA blocker, and administration of such compositions for mitigation of an epileptic seizure.
    Type: Grant
    Filed: August 19, 2019
    Date of Patent: November 29, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Michael A. Rogawski, Isaac N. Pessah, Zhengyu Cao, Pamela J. Lein
  • FOSPROPOFOL METHODS AND COMPOSITIONS
    Publication number: 20220265686
    Abstract: The present disclosure pertains to the use of fospropofol, pharmaceutically acceptable salts of fospropofol, or mixtures thereof. Pharmaceutical compositions comprising fospropofol, pharmaceutically acceptable salts of fospropofol, or mixtures thereof, and methods of treating diseases or disorders, including migraine are also disclosed.
    Type: Application
    Filed: March 4, 2022
    Publication date: August 25, 2022
    Inventors: Steven L. Krill, Feng-Jing Chen, Michael A. Rogawski, Edward Brendan Magrab, Allen Heller
  • ALLOPREGNANOLONE COMPOSITIONS AND USES THEREOF
    Publication number: 20220202832
    Abstract: This disclosure is related to non-invasive methods of treating, preventing, inhibiting, delaying, and/or mitigating conditions that are modulated by physiological levels of allopregnanolone and are susceptible to allopregnanolone therapy.
    Type: Application
    Filed: April 6, 2020
    Publication date: June 30, 2022
    Inventors: Michael A. ROGAWSKI, Dorota ZOLKOWSKA
  • PROPOFOL PRODRUG METHODS AND COMPOSITIONS
    Publication number: 20220105050
    Abstract: The present disclosure pertains to the use of propofol prodrugs, pharmaceutically acceptable salts of propofol prodrugs, or mixtures thereof, to treat migraine.
    Type: Application
    Filed: October 9, 2020
    Publication date: April 7, 2022
    Inventors: Michael A. Rogawski, Enrique Carrazana, Edward Brendan Magrab, Steven L. Krill, Allen Heller
  • FOSPROPOFOL METHODS AND COMPOSITIONS
    Publication number: 20220105111
    Abstract: The present disclosure pertains to the use of fospropofol, pharmaceutically acceptable salts of fospropofol, or mixtures thereof, to treat migraine.
    Type: Application
    Filed: March 26, 2020
    Publication date: April 7, 2022
    Inventors: Michael A. Rogawski, Enrique Carrazana, Edward Brendan Magrab, Steven L. Krill, Allen H. Heller
  • ANTICONVULSANT ACTIVITY OF STEROIDS
    Publication number: 20210100817
    Abstract: The present invention relates to methods of preventing, inhibiting, delaying, and/or mitigating seizures by administration of a steroid, e.g., a neurosteroid, e.g., allopregnanolone.
    Type: Application
    Filed: October 6, 2020
    Publication date: April 8, 2021
    Applicant: The Regents of the University of California
    Inventors: Michael A. ROGAWSKI, Dorota ZOLKOWSKA
  • MITIGATION OF EPILEPTIC SEIZURES BY COMBINATION THERAPY USING BENZODIAZEPINES AND NEUROSTEROIDS
    Publication number: 20200215078
    Abstract: Provided are compositions comprising a benzodiazepine and a neurosteroid, containing one or both of the benzodiazepine and the neurosteroid in a subtherapeutic dose, and administration of such compositions for mitigation of an epileptic seizure. Further provided are compositions comprising a benzodiazepine, a neurosteroid, and an NMDA blocker, and administration of such compositions for mitigation of an epileptic seizure.
    Type: Application
    Filed: August 19, 2019
    Publication date: July 9, 2020
    Inventors: Michael A. ROGAWSKI, Isaac N. PESSAH, Zhengyu CAO, Pamela J. LEIN
  • MITIGATION OF CNS DISORDERS BY COMBINATION THERAPY USING NEUROSTEROIDS, AND AMPA BLOCKERS
    Publication number: 20200030304
    Abstract: Provided are compositions and methods for treating epilepsy, including epilepsy caused by exposure to organophosphate nerve agents, that entail co-formulation and/or co-administration of a benzodiazepine, a neurosteroid and an AMPA receptor antagonist.
    Type: Application
    Filed: September 10, 2019
    Publication date: January 30, 2020
    Inventors: Michael A. ROGAWSKI, Ashish DHIR
  • Edible oils to enhance delivery of orally administered steroids
    Patent number: 10478505
    Abstract: The present invention relates to the formulation of steroids, including neurosteroids (e.g., allopregnanolone (ALP)) in edible oils to enhance their absorption when administered, e.g., orally or transmucosally to a patient.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: November 19, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Michael A. Rogawski
  • Mitigation of epileptic seizures by combination therapy using benzodiazepines and neurosteroids
    Patent number: 10426786
    Abstract: Provided are compositions comprising a benzodiazepine and a neurosteroid, containing one or both of the benzodiazepine and the neurosteroid in a subtherapeutic dose, and administration of such compositions for mitigation of an epileptic seizure. Further provided are compositions comprising a benzodiazepine, a neurosteroid, and an NMDA blocker, and administration of such compositions for mitigation of an epileptic seizure.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: October 1, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Michael A. Rogawski, Isaac N. Pessah, Zhengyu Cao, Pamela J. Lein
  • ANTICONVULSANT ACTIVITY OF STEROIDS
    Publication number: 20190142845
    Abstract: The present invention relates to methods of preventing, inhibiting, delaying, and/or mitigating seizures by administration of a steroid, e.g., a neurosteroid, e.g., allopregnanolone.
    Type: Application
    Filed: January 7, 2019
    Publication date: May 16, 2019
    Applicant: The Regents of the University of California
    Inventors: Michael A. ROGAWSKI, Dorota ZOLKOWSKA
  • Anticonvulsant activity of steroids
    Patent number: 10251894
    Abstract: The present invention relates to methods of preventing, inhibiting, delaying, and/or mitigating seizures by administration of a steroid, e.g., a neurosteroid, e.g., allopregnanolone.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: April 9, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Michael A. Rogawski, Dorota Zolkowska
  • Androstane and pregnane steroids with potent allosteric gaba receptor chloride ionophore modulating properties
    Patent number: 10087211
    Abstract: This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: October 2, 2018
    Assignees: RESEARCH TRIANGLE INSTITUTE, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Scott P. Runyon, Michael Rogawski, Edgar Cook, John Kepler, Hernan Navarro, Rafal Kaminski, Matthew Orr
  • EDIBLE OILS TO ENHANCE DELIVERY OF ORALLY ADMINISTERED STEROIDS
    Publication number: 20180256726
    Abstract: The present invention relates to the formulation of steroids, including neurosteroids (e.g., allopregnanolone (ALP)) in edible oils to enhance their absorption when administered, e.g., orally or transmucosally to a patient.
    Type: Application
    Filed: January 4, 2018
    Publication date: September 13, 2018
    Applicant: The Regents of the University of California
    Inventor: Michael A. ROGAWSKI
  • ANTICONVULSANT ACTIVITY OF STEROIDS
    Publication number: 20180193357
    Abstract: The present invention relates to methods of preventing, inhibiting, delaying, and/or mitigating seizures by administration of a steroid, e.g., a neurosteroid, e.g., allopregnanolone.
    Type: Application
    Filed: March 9, 2018
    Publication date: July 12, 2018
    Applicant: The Regents of the University of California
    Inventors: Michael A. ROGAWSKI, Dorota ZOLKOWSKA
  • MITIGATION OF EPILEPTIC SEIZURES BY COMBINATION THERAPY USING BENZODIAZEPINES AND NEUROSTEROIDS
    Publication number: 20180153906
    Abstract: Provided are compositions comprising a benzodiazepine and a neurosteroid, containing one or both of the benzodiazepine and the neurosteroid in a subtherapeutic dose, and administration of such compositions for mitigation of an epileptic seizure. Further provided are compositions comprising a benzodiazepine, a neurosteroid, and an NMDA blocker, and administration of such compositions for mitigation of an epileptic seizure.
    Type: Application
    Filed: July 13, 2017
    Publication date: June 7, 2018
    Applicant: The Regents of the University of California
    Inventors: Michael A. ROGAWSKI, Isaac N. PESSAH, Zhengyu CAO, Pamela J. LEIN