Patents by Inventor Michael A. Rogawski

Michael A. Rogawski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTICONVULSANT ACTIVITY OF STEROIDS
    Publication number: 20180133229
    Abstract: The present invention relates to methods of preventing, inhibiting, delaying, and/or mitigating seizures by administration of a steroid, e.g., a neurosteroid, e.g., allopregnanolone.
    Type: Application
    Filed: June 25, 2017
    Publication date: May 17, 2018
    Applicant: The Regents of the University of California
    Inventors: Michael A. ROGAWSKI, Dorota ZOLKOWSKA
  • ANDROSTANE AND PREGNANE STEROIDS WITH POTENT ALLOSTERIC GABA RECEPTOR CHLORIDE IONOPHORE MODULATING PROPERTIES
    Publication number: 20170051008
    Abstract: This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.
    Type: Application
    Filed: November 2, 2016
    Publication date: February 23, 2017
    Applicants: RESEARCH TRIANGLE INSTITUTE, The United States of America, as represented by the Secretary, Department of Health and Human Serv
    Inventors: Scott P. RUNYON, Michael ROGAWSKI, Edgar COOK, John KEPLER, Herman NAVARRO, Rafal KAMINSKI, Matthew ORR
  • Androstane and pregnane steroids with potent allosteric GABA receptor chloride ionophore modulating properties
    Patent number: 9518080
    Abstract: This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: December 13, 2016
    Assignees: RESEARCH TRIANGLE INSTITUTE, The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Scott P Runyon, Michael Rogawski, Edgar Cook, John Kepler, Hernan Navarro, Rafal Kaminski, Matthew Orr
  • ANTICONVULSANT ACTIVITY OF STEROIDS
    Publication number: 20150313915
    Abstract: The present invention relates to methods of preventing, inhibiting, delaying, and/or mitigating seizures by administration of a steroid, e.g., a neurosteroid, e.g., allopregnanolone.
    Type: Application
    Filed: November 27, 2013
    Publication date: November 5, 2015
    Applicant: The Regents of the University of California
    Inventors: Michael A. ROGAWSKI, Dorota ZOLKOWSKA
  • EDIBLE OILS TO ENHANCE DELIVERY OF ORALLY ADMINISTERED STEROIDS
    Publication number: 20140343027
    Abstract: The present invention relates to the formulation of steroids, including neurosteroids (e.g., allopregnanolone (ALP)) in edible oils to enhance their absorption when administered, e.g., orally or transmucosally to a patient.
    Type: Application
    Filed: September 21, 2012
    Publication date: November 20, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Michael A. Rogawski
  • ANDROSTANE AND PREGNANE STEROIDS WITH POTENT ALLOSTERIC GABA RECEPTOR CHLORIDE IONOPHORE MODULATING PROPERTIES
    Publication number: 20140094619
    Abstract: This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.
    Type: Application
    Filed: August 23, 2013
    Publication date: April 3, 2014
    Applicants: US GOV BY THE SEC. OF DEPT. OF HEALTH & HUMAN SERV, RESEARCH TRIANGLE INSTITUTE
    Inventors: Scott P. RUNYON, Michael ROGAWSKI, Edgar COOK, John KEPLER, Hernan NAVARRO, Rafal KAMINSKI, Matthew ORR
  • MITIGATION OF EPILEPTIC SEIZURES BY COMBINATION THERAPY USING BENZODIAZEPINES AND NEUROSTEROIDS
    Publication number: 20140050789
    Abstract: Provided are compositions comprising a benzodiazepine and a neurosteroid, containing one or both of the benzodiazepine and the neurosteroid in a subtherapeutic dose, and administration of such compositions for mitigation of an epileptic seizure. Further provided are compositions comprising a benzodiazepine, a neurosteroid, and an NMDA blocker, and administration of such compositions for mitigation of an epileptic seizure.
    Type: Application
    Filed: August 12, 2013
    Publication date: February 20, 2014
    Applicant: The Regents of the University of California
    Inventors: Michael A. ROGAWSKI, Isaac N. PESSAH, Zhengyu CAO, Pamela J. LEIN
  • INTRAPULMONARY BENZODIAZEPINE FOR THE TREATMENT AND PREVENTION OF SEIZURES
    Publication number: 20130309306
    Abstract: This invention provides methods for the amelioration, termination and/or abortion of a seizure by the intrapulmonary administration of a benzodiazepine, for example, midazolam.
    Type: Application
    Filed: December 1, 2011
    Publication date: November 21, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Michael A. Rogawski, Ashish Dhir
  • Androstane and pregnane steroids with potent allosteric GABA receptor chloride ionophore modulating properties
    Patent number: 8575375
    Abstract: This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.
    Type: Grant
    Filed: June 16, 2008
    Date of Patent: November 5, 2013
    Assignees: Research Triangle Institute, The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Scott P. Runyon, Michael A. Rogawski, John Kepler, Hernan Navarro, Rafal Kaminski, Matthew Orr, Kevin M. Cook
  • ANDROSTANE AND PREGNANE STEROIDS WITH POTENT ALLOSTERIC GABA RECEPTOR CHLORIDE IONOPHORE MODULATING PROPERTIES
    Publication number: 20110092473
    Abstract: This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.
    Type: Application
    Filed: June 16, 2008
    Publication date: April 21, 2011
    Applicants: Research Triangle Institute, US GOV BY THE SEC. OF DEPT. OF HEALTH & HUMAN SERV.
    Inventors: Scott P. Runyon, Michael Rogawski, Edgar Cook, Kevin M. Cook, John Kepler, Hernan Navarro, Rafal Kaminski, Matthew Orr
  • 5-aminocarbonyl-5H-dibenzo[a.d]cyclohepten-5,10-imines for treatment of epilepsy and cocaine addiction
    Patent number: 5196415
    Abstract: This invention is in the field of clinical neurology and relates specifically to compounds, compositions and methods for treatment of patients with generalized epilepsy or partial (symptomatic) epilepsy using compounds of the formula: ##STR1## This invention also relates to compounds, compositions and methods of treatment for drug craving in patients addicted to cocaine.
    Type: Grant
    Filed: January 29, 1992
    Date of Patent: March 23, 1993
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: James A. Monn, Andrew Thurkauf, Shunichi Yamaguchi, Michael A. Rogawski, Kenner C. Rice, Mariena V. Mattson, Arthur E. Jacobson