Abstract: The present disclosure relates to aerosol delivery devices and cartridges for aerosol delivery devices. The cartridge comprises a mouthpiece having a proximal end and a distal end, the proximal end of the mouthpiece having an exit portal defined therethrough, a tank defining a proximal end and a closed distal end, the tank being configured to contain a liquid composition that includes a distinctive characteristic, and a heater configured to heat the liquid composition. The distal end of the mouthpiece is configured to engage the proximal end of the tank, and when the cartridge is coupled with the aerosol delivery device at least one feature of the cartridge, or at least one feature of the control device, or at least one feature of both the cartridge and the control device, provides a visual indication of a color associated with the distinctive characteristic.

Abstract: Array microphone systems and methods that can automatically focus and/or place beamformed lobes in response to detected sound activity are provided. The automatic focus and/or placement of the beamformed lobes can be inhibited based on a remote far end audio signal. The quality of the coverage of audio sources in an environment may be improved by ensuring that beamformed lobes are optimally picking up the audio sources even if they have moved and changed locations.

Abstract: Systems and methods are provided for a computer-implemented method of implementing an on-demand computing network environment. A network specification is received from a user. Resources from one or more resource providers are provisioned including an audio server resource. The on-demand computing network is configured, where configuring includes assigning a first provisioned resource as a hub device. One or more second provisioned resources are assigned as rim devices, where rim devices are configured to communicate with one another only via the hub device. One rim device is a proxy server to which the user connects using a device having an address, where the audio server transmits audio data to the user via the proxy server without knowledge of the address of the user device.

Abstract: The disclosure provides processes for synthesizing compounds for use as CFTR modulators.

Abstract: Various embodiments of catheters are disclosed. In one aspect, a catheter includes a catheter shaft actuator (e.g., a catheter handle) and a catheter shaft, where the working length of the catheter shaft is adjustable, and where this working length is defined between distal ends of the catheter shaft actuator and catheter shaft, respectively. In another aspect, a catheter includes a catheter handle and a shuttle to which a catheter shaft may be secured, with the shuttle being movable relative to at least a distal end of the catheter handle. In another aspect, a catheter includes a catheter shaft, a catheter shaft actuator that is movably mounted on the catheter shaft, and a housing, where the catheter shaft extends proximally to the housing, where a generator cable extends proximally from the housing, and where the catheter shaft actuator is disposable distally of the housing along the catheter shaft.

Abstract: The present disclosure provides an aerosol delivery device and a cartridge for an aerosol delivery device. In various implementations, the aerosol delivery device comprises a control device that includes an outer housing defining a cartridge receiving chamber, and further includes a power source and a control component, and a cartridge that includes a mouthpiece, a tank, a heating assembly, and a bottom cap. The mouthpiece defines an exit portal in an end thereof, and the tank is configured to contain a liquid composition therein. The cartridge is configured to be removably coupled with the receiving chamber of the control device, and the heating assembly defines a vaporization chamber and is configured to heat the liquid composition to generate an aerosol. The heating assembly comprises a substantially planar heating member and a liquid transport element, wherein the heating member is installed in a bowed orientation.

Abstract: Array microphone systems and methods that can automatically focus and/or place beamformed lobes in response to detected sound activity are provided. The automatic focus and/or placement of the beamformed lobes can be inhibited based on a remote far end audio signal. The quality of the coverage of audio sources in an environment may be improved by ensuring that beamformed lobes are optimally picking up the audio sources even if they have moved and changed locations.

Abstract: A database management engine provides a user interface that allows users to access and modify employee information in a database. The database includes entries for employees, and each database entry includes identifying information about the associated employee. A user can request to modify data within database entries, for instance in order to update information associated with an employee. Responsive to the request, the database management engine identifies liabilities associated with the database modification stemming from associated tax laws. Based on the identified tax liabilities, the engine computes the aggregate tax liability owed by the employer and/or employee. Before modifying a database entry, the engine modifies the user interface to include interface elements detailing the computed aggregate tax liability. The user explicitly can be required to confirm the database modification in view of the aggregate tax liability.

Abstract: This application is directed to managing data. A computer system constructs a digital model of a user including a plurality of features representing demographic, medical, and activity data of the user. The computer system applies a classifier model to the digital model to identify a first set of actionable insights and identifies one or more clustering models generated from user data for a plurality of users in a vector space having dimensions correspond to the plurality of features. The computer system assigns the digital model to a respective cluster within each of the one or more clustering models, and identifies a second set of actionable insights according to respective clusters assigned to the digital model within the one or more clustering models. A subset of the first and second sets of actionable insights is presented to the user on a user interface.

Abstract: Apparatus uses engineered collection media to recover mineral particles in a mineral extraction process, e.g., for processing a tailings stream at the end of a flotation separation process. The engineered collection media are added to slurry/tailings containing the mineral particles. The engineered collection media have collection surfaces coated with a chemical selected for attracting the mineral particles to the collection surfaces so the engineered collection media becomes mineral laden media in the slurry/tailings in a loading stage. The apparatus include three stages: removing unwanted material from mineral laden media; using a stripping agent to strip the mineral particles from the mineral laden media; and separating the engineered collection media from the mineral particles and the stripping agent. The stripping agent is reused for stripping, and the engineered collection media are returned to the loading stage. The engineered collection media can have a smooth or foam-like surface.

Abstract: In an approach to X-ray inspection image display systems, a colorized X-ray inspection image is received comprising a monochrome X-ray inspection image that is colorized in accordance with an X-ray inspection system false colorization scheme. The colorized X-ray inspection image is filtered by performing pixel shading on the colorized X-ray inspection image to generate a custom colorized X-ray inspection image having a custom false colorization scheme that is different from the X-ray inspection system false colorization scheme.

Abstract: A surface-mounted keylessly operated lock (10) comprises a chassis (11) mountable on one of two parts, especially a door and a door surround, to be locked and unlocked relative to one another and carrying locking means (17 to 23) transferrable between a locking state and an unlocking state respectively for the locking and unlocking, the locking means being electrically operable to cause or allow transfer from the locking state to the unlocking state. In addition, the lock includes a control module (16) mounted on the chassis (11) and carrying control means (30) for controlling supply of electrical operating power to the locking means. The chassis has a receptacle (25) for reception of an electrical energy source, especially batteries, for providing the operating power and the module (16) inclusive of the control means (20) is movable relative to the chassis (11) to permit access to the receptacle (25) to enable battery exchange without demounting of the installed lock.

Abstract: An expansion joint is provided. The expansion joint is formed from a plurality of layers comprising a ring tie-in ply, a pair of arch rings at opposing transition points, two body plies, with inverted bias cut angles between about 48° to 60°, where about is typically plus or minus 1 degree. The arch geometry is such that the arch has an axial length C between the transition points and an inner surface arch circumference length of A between the transition points in a neutral state, such that the maximum compression distance for the expansion joint is the length C, the maximum elongation distance for the expansion joint is a length (A-C), and a maximum lateral deflection length for the expansion joint is a length Y.

Abstract: A clock data recovery circuit includes a deglitch filter circuit and a timer circuit. The deglitch filter circuit is configured to remove pulses of less than a particular duration from a data signal to produce a deglitched data signal. The timer circuit is coupled to the deglitch filter, and is configured to compare a duration of a pulse of the deglitched data signal to a threshold duration, and identify the pulse as representing a logic one based on the duration of the pulse exceeding the threshold duration.

Abstract: The disclosure provides processes for synthesizing compounds for use as CFTR modulators.

Abstract: This disclosure provides peptides which can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer; treating infectious diseases; enhancing a response to vaccination; treating sepsis; and promoting hair re-pigmentation or lightening of pigmented skin lesions.

Abstract: Disclosed are methods and devices for interfacing to or interacting with the flow of liquid passing into or through lateral-flow assays and related paper- or membrane-based in-vitro diagnostic testing platforms. This is done for the purpose of improving their performance, sensitivity, accuracy, repeatability, degree of multiplexing, and/or level of quantitation, and/or reducing their inherent limitations while maintaining, in large part, their simplicity, cost effectiveness, and ease of use. New methods are disclosed for pre-sample purification, aliquoting, sequential liquid delivery, flow control and other functions that are largely automatic and require no action on the part of the user.

Abstract: A flow cytometer of a blood analyzer including a transverse-electric (TE) laser diode, a flow cell, a quarter wave plate (QWP), a plurality of lenses, and a side scatter detector. The TE laser diode is configured to output a laser beam along an optical axis and has a fast axis full width at half maximum (FWHM) divergence of from about 16 degrees to about 25 degrees. The QWP is disposed along the optical axis between the TE laser diode and the flow cell and configured to circularly polarize the laser beam. The plurality of lenses is disposed between the TE laser diode and the flow cell and configured to focus the laser beam at the flow cell.

Abstract: The present disclosure relates to aerosol delivery devices and cartridges for aerosol delivery devices. The cartridge comprises a mouthpiece having a proximal end and a distal end, the proximal end of the mouthpiece having an exit portal defined therethrough, a tank defining a proximal end and a closed distal end, the tank being configured to contain a liquid composition that includes a distinctive characteristic, and a heater configured to heat the liquid composition. The distal end of the mouthpiece is configured to engage the proximal end of the tank, and when the cartridge is coupled with the aerosol delivery device at least one feature of the cartridge, or at least one feature of the control device, or at least one feature of both the cartridge and the control device, provides a visual indication of a color associated with the distinctive characteristic.

Abstract: A method of applying a dielectric coating on a structure array of a component of an electrical device includes applying a first layer of a first dielectric material on a structure array with an atomic layer deposition (ALD) process or a spin-on cladding process. The structure array has a plurality of features. The method may include applying a second layer of a second dielectric material on the first layer with an evaporation deposition process, a physical vapor deposition process (PVD), or a flux-controlled chemical vapor deposition (CVD) process. The first layer has a first thickness and the second layer has a second thickness that is greater than the first thickness.