Abstract: Presented herein are methods for making, isolating, and purifying N-acetylcysteine amide, (2R,2R?)-3,3?-disulfanediyl bis(2-acetamidopropanamide, diNACA), intermediates and derivatives thereof comprising: alternatively contacting cystine with methanol and a chlorinating reagent to form an organic solution containing L-cystine dimethylester dihydrochloride; combining dried or undried L-cystine dimethylester dihydrochloride with a triethylamine, an acetic anhydride, and an acetonitrile to form a di-N-acetylcystine dimethylester; mixing dried di-N-acetylcystine dimethylester with ammonium hydroxide to form a di-N-acetylcystine amide (diNACA); and separating dried di-N-acetylcystine dimethylester into N-acetylcysteine amide with dithiothreitol, triethylamine, and an alcohol.

Abstract: Systems and methods for localization of a subject vehicle may include: a plurality of sensors to gather data regarding features in an environment of the subject vehicle; a feature map module to generate a feature map using data gathered from one or more of the plurality of sensors; a feature raster module to generate a feature raster image from the feature map; a score computation module to register a plurality of transformations of the feature raster image with a map feature raster image, to generate a cost function for the registrations of the plurality of transformations, and to determine the transformation with the lowest cost function; and the score computation module using the transformation with the lowest cost function to determine localization of the subject vehicle.

Abstract: The present invention provides compounds of the formula: for use in the treatment of systemic sclerosis, fibrosis (e.g. pulmonary fibrosis), achondroplasia, thanatophoric dysplasia (e.g. type I), severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN), muenke syndrome or cancer.

Abstract: A mask assembly can include a mask seal. In some configurations, the mask assembly can be configured to be fully positioned lower than a bridge of a nose of a face of a user and to provide an exposed bridge of the nose of the user. The mask seal can comprise a nasal region comprising at least one nasal opening, a first paddle on a first side of the nasal region and a second paddle on a second side of the nasal region. The first paddle is configured to contact one side of the nose of the user and the second paddle is configured to contact the other side of the nose of the user.

Abstract: A robotic cleaner may include a body having a top surface, a navigation sensor extending from the top surface of the body, a protective cover defining a sensor cavity, the navigation sensor being at least partially received within the sensor cavity, and a cover liquid diverter extending from an upper portion of the protective cover, the cover liquid diverter being flared in a direction of the body.

Abstract: The present invention includes methods for making and isolating N-acetylcysteine amide, (2R,2R?)-3,3?-disulfanediyl bis(2-acetamidopropanamide, diNACA), intermediates and derivatives thereof comprising: contacting cystine with an alcohol and a chlorinating reagent to form an organic solution containing L-cystine dimethylester dihydrochloride; combining dried or undried L-cystine dimethylester dihydrochloride with a triethylamine, an acetic anhydride, and an acetonitrile to form a di-N-acetylcystine dimethylester; mixing dried di-N-acetylcystine dimethylester with ammonium hydroxide to form a di-N-acetylcystine amide (diNACA); and separating dried di-N-acetylcystine dimethylester into N-acetylcysteine amide with dithiothreitol, triethylamine and an alcohol.

Abstract: A dust extraction device for a hand-held power tool includes a housing, a mechanical interface for releasably connecting the dust extraction device to the hand-held power tool, a dust-collecting chamber which is connected to a filter unit, and a filter-cleaning unit. The filter-cleaning unit has an impact element which is mounted moveably in and/or on the housing of the dust extraction device. The impact element is designed to act upon the filter unit directly with an impact-like force.

Abstract: The present invention relates to an apparatus for providing respiratory assistance to a user via a user conduit. The apparatus being operable in a humidifying mode and a non-humidifying mode, and includes a humidification chamber for containing an amount of water that can be located in an operating position in the humidifying mode and, optionally separate from the apparatus in the non-humidifying mode. The apparatus may also have an auxiliary flow path that can be activated in the non-humidifying mode and a powered device that heats water in the humidification chamber when the apparatus is in the humidifying mode.

Abstract: A cushion for a respiratory mask is provided. The cushion includes a face contacting portion, a non-face contacting portion and an intermediate region. The face contacting portion is formed from an open cell foam material and includes an opening to provide, in use, a source of breathing gas to a user's airways. The non-face contacting portion is formed from an elastomeric material. The intermediate region is formed between the face contacting portion and the non-face contacting portion. Open cells of the open cell foam material in the intermediate region are filled with the elastomeric material.

Abstract: The present invention relates in general to the field of compositions and methods for using N-acetylcysteine amide (NACA) or (2R,2R?)-3,3?-disulfanediyl bis(2-acetamidopropanamide) (diNACA) for treating or alleviating a disorder or condition associated with ferroptosis, which can cause or contribute to diseases, disorders and conditions including aging associated with declining cognition, cognitive impairment, declining physical function, physical decline, elevated inflammation, endothelial dysfunction, insulin resistance, central obesity, loss of muscle mass (sarcopenia), neurological diseases and disorders, including neurodegeneration, stroke, including ischemic stroke and post-hemorrhagic stroke damage, and neurotrauma, including traumatic brain injury, Alzheimers disease, Huntington's disease, Niemann-Pick disease, Parkinson's disease, motor neuron disease, Amyotrophic Lateral Sclerosis, Sedaghatian-type spondylo-metaphyseal dysplasia, cancer, including breast cancer, kidney injuries including ischemia-re

Abstract: A mask assembly can include a mask seal. In some configurations, the mask assembly can be configured to be fully positioned lower than a bridge of a nose of a face of a user and to provide an exposed bridge of the nose of the user. The mask seal can comprise a nasal region comprising at least one nasal opening, a first paddle on a first side of the nasal region and a second paddle on a second side of the nasal region. The first paddle is configured to contact one side of the nose of the user and the second paddle is configured to contact the other side of the nose of the user.

Abstract: A cutting length display device for a hand-held machine tool includes at least one display unit that has at least one light source. The display unit is configured to display at least one position of a cutting edge of a machine tool on a workpiece to be machined depending on a set cutting depth of the machine tool by way of a light beam. The display unit has a mirror unit that is configured to deflect the light beam depending on the set cutting depth of the machining tool.

Abstract: Methods and systems are provided for providing a secure connection to a medical device for remote servicing of the medical device. In one embodiment, a computing device is in communication with a medical device, the computing device comprising non-transitory memory including executable instructions for: communicating with the medical device via a first protocol; and communicating with a remote computing device via an encrypted, second protocol. The computing device also includes a processor for executing said executable instructions.

Abstract: The present invention relates to a humidification apparatus having a compartment that receives a removable humidification chamber. The apparatus has an actuator that can be operated by a user to move the humidification chamber from an operating position to a releasing position. In the operating position the humidification chamber is received by the humidification compartment and forms a portion of the flow path through the humidification apparatus. In the releasing position the humidification chamber is displaced outwardly from the operating position so that a user can more easily remove the humidification chamber from the apparatus.

Abstract: A cushion for a respiratory mask is provided. The cushion includes a face contacting portion, a non-face contacting portion and an intermediate region. The face contacting portion is formed from an open cell foam material and includes an opening to provide, in use, a source of breathing gas to a user's airways. The non-face contacting portion is formed from an elastomeric material. The intermediate region is formed between the face contacting portion and the non-face contacting portion. Open cells of the open cell foam material in the intermediate region are filled with the elastomeric material.