Abstract: A method of calculating a climb-dive marker (CDM) that is visibly present on a display even as the aircraft approaches a roll angle of +/?90° is provided. An exemplary CDM method comprises obtaining, an X-axis velocity, a Y-axis velocity, and a Z-axis velocity in aircraft body coordinates of an aircraft; calculating a CDM elevation; and displaying, by the controller, the calculated CDM elevation. The method can further comprise obtaining an angle of attack (AoA) of the aircraft and a roll angle of the aircraft, wherein the AoA is set as the value of the CDM elevation when the roll angle is within a preset range. The CDM elevation may also be calculated using a combination of the AOA and the CDM formula when roll angle is within a second preset range.

Abstract: A non-transitory computer-readable medium storing instructions readable and executable by a workstation (18) including at least one electronic processor (20) to perform a quality control (QC) method (100). The method includes: receiving a current QC data set acquired by a pixelated detector (14) and one or more prior QC data sets acquired by the pixelated detector; determining stability levels of detector pixels (16) of the pixelated detector over time from the current QC data set and the one or more prior QC data sets; labeling a detector pixel of the pixelated detector as dead when the stability level determined for the detector pixel is outside of a stability threshold range; and displaying, on a display device (24) operatively connected with the workstation, an identification (28) of the detector pixels labelled as dead.

Abstract: Systems and methods for determining the identity of a liquid within a liquid dispenser are provided. A device includes a holder having an opening that is configured to retain the liquid dispenser. A surface of the liquid dispenser is configured to affix a label identifying a liquid within the liquid dispenser. A plurality of lenses are mounted on the holder. Each lens has a respective field of view that includes a respective portion of the surface of the liquid dispenser. In addition, the device includes a plurality of fiber bundles. Each fiber bundle includes an input that is configured to receive a respective signal from a respective one of the plurality of lenses. Further, the device includes an imaging sensor that is configured to receive the respective signals from the plurality of fiber bundles and to form a plurality of images of the surface of the liquid dispenser.

Abstract: An optical sensor for a rotating blade stage of a turbomachine is disclosed. The optical sensor includes a housing to be mounted relative to a circumferential interior surface of a casing of the turbomachine. Optical fiber(s) are operatively coupled to the housing for communicating: an optical signal for sending toward the rotating blade stage and a return optical signal reflected by the rotating blade stage, through the casing. An optical signal redirecting element is configured to redirect the optical signal from optical fiber(s) inwardly toward the rotating blade stage relative to the casing, and redirect the return optical signal reflected by the rotating blade stage into the at least one optical fiber. Optical fiber(s) have a longitudinal shape configured to follow the circumferential interior surface of the casing.

Abstract: This invention pertains to modified compositions for use in CRISPR systems, and their methods of use. In particular, length-modified and chemically-modified forms of crRNA and tracrRNA are described for use as a reconstituted guide RNA for interaction with Cas9 of CRISPR systems. The resultant length-modified and chemically-modified forms of crRNA and tracrRNA are economical to produce and can be tailored to have unique properties relevant to their biochemical and biological activity in the context of the CRISPR Cas9 endonuclease system.

Abstract: A method for dynamically scheduling a data-processing workload includes recognizing minimum and maximum execution slice sizes and predicting an execution slice size for a current job of a collection of jobs. If the predicted execution slice size exceeds the maximum slice size or if the job involves date-dependent records in the future of the current date, the job is split into a working slice and a remainder slice, the remainder slice is added to the collection of jobs and the working slice is executed. Otherwise, if the predicted execution slice size is between the minimum and maximum execution slice sizes, the current job is executed.

Abstract: A virtualization system implemented within a cloud server enables the simulation of robot structure and behavior in a virtual environment. The simulated robots are controlled by clients remote from the cloud server, enabling human operators or autonomous robot control programs running on the clients to control the movement and behavior of the simulated robots within the virtual environment. Data describing interactions between robots, the virtual environment, and objects can be recorded for use in future robot design. The virtualization system can include robot templates, enabling users to quickly select and customize a robot to be simulated, and further enabling users to update and re-customize the robot in real-time during the simulation. The virtualization system can re-simulate a portion of the robot simulation when an intervention by a human operator is detected, positioning robots, people, and objects within the virtual environment based on the detected intervention.

Abstract: A virtualization system implemented within a cloud server enables the simulation of robot structure and behavior in a virtual environment. The simulated robots are controlled by clients remote from the cloud server, enabling human operators or autonomous robot control programs running on the clients to control the movement and behavior of the simulated robots within the virtual environment. Data describing interactions between robots, the virtual environment, and objects can be recorded for use in future robot design. The virtualization system can include robot templates, enabling users to quickly select and customize a robot to be simulated, and further enabling users to update and re-customize the robot in real-time during the simulation. The virtualization system can re-simulate a portion of the robot simulation when an intervention by a human operator is detected, positioning robots, people, and objects within the virtual environment based on the detected intervention.

Abstract: A virtualization system implemented within a cloud server enables the simulation of robot structure and behavior in a virtual environment. The simulated robots are controlled by clients remote from the cloud server, enabling human operators or autonomous robot control programs running on the clients to control the movement and behavior of the simulated robots within the virtual environment. Data describing interactions between robots, the virtual environment, and objects can be recorded for use in future robot design. The virtualization system can include robot templates, enabling users to quickly select and customize a robot to be simulated, and further enabling users to update and re-customize the robot in real-time during the simulation. The virtualization system can re-simulate a portion of the robot simulation when an intervention by a human operator is detected, positioning robots, people, and objects within the virtual environment based on the detected intervention.

Abstract: The disclosure provides compositions and methods for the treatment of ocular conditions associated with angiogenesis comprising administering an antibody that targets a tyrosine phosphatase inhibitor in a subject.

Abstract: A cover for a camera body having a hot shoe and an attached lens has a flexible sleeve that has an opening for the end of the lens and an opening through which the camera body and lens can be inserted and through which the camera body can be manipulated. The sleeve is provided with a clear panel or window for viewing the camera body. The cover has a connector attached to the sleeve and protruding inwardly for detachable connection to the hot shoe of the camera body.

Abstract: A GMP adapted to provide the PAL gene for the treatment of PKU when administered orally. The GMP of the present invention may include a probiotic, a PAL gene to be expressed using the probiotic, wherein the PAL gene is functionally attached to a promoter and a ribosome binding site, and may be codon-optimized for expression in a certain host organism. A method of treating the metabolic disease of PKU by oral administration and ingestion of a GMP is also provided.

Abstract: Methods, apparatus, systems and articles of manufacture (e.g., physical storage media) to credit commercial broadcasts are disclosed. Example commercial crediting apparatus disclosed herein compare first identification information and first timing information obtained from a first monitored data feed with second identification information and second timing information in a second monitored data feed to identify a first final distributor code represented in the second monitoring data feed, the first identification information and the first timing information corresponding to a first commercial represented in the first monitored data feed. Disclosed example apparatus also access data that maps a first original distributor code to the first final distributor code, identify the first commercial in lineup data based on the first original distributor code, and adjust, based on a duration of the first commercial, a duration obtained for a first media program listed in the lineup data.

Abstract: The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.

Abstract: A combined altitude display apparatus for generating a combined altitude value is provided. The apparatus comprises a first altitude input interface, wherein the first altitude input interface receives a first altitude value; a second altitude input interface, wherein the second altitude input interface receives a second altitude value, wherein the second altitude value indicated by the second altitude input interface has a cyclical range; an altitude output interface, wherein the altitude output interface outputs a third altitude value; and a data fusion component coupled to the first altitude input interface and the second altitude input interface and configured to calculate the third altitude value based on the first altitude value and the second altitude value.

Abstract: The disclosure provides compositions and methods for the treatment of ocular conditions associated with angiogenesis comprising administering an antibody that targets a tyrosine phosphatase inhibitor in a subject.

Abstract: Certain aspects of the present disclosure relate to methods and apparatus for improving inter-Radio Access Technology (RAT) measurements. A user equipment (UE) determines, while in a connected state Discontinuous Reception (CDRX) mode in a first cell of a first Radio Access Technology Network (RAT), that a second cell of a second RAT is to be measured. The UE schedules at least two operational periods related to transitioning between ON and OFF states of the CDRX mode to overlap, to increase a period available for measuring signals in the second cell.

Abstract: Low sulphur marine fuel compositions are provided. Embodiments comprise 10 to 50 wt % of a residual hydrocarbon component, with the remaining 50 to 90 wt % selected from a non-hydroprocessed hydrocarbon component, a hydroprocessed hydrocarbon component, and a combination thereof. Embodiments of the marine fuel composition can have a sulphur content of about 0.1 wt % or less.

Abstract: This invention pertains to mutant Cas9 nucleic acids and proteins for use in CRISPR/Cas endonuclease systems, and their methods of use. In particular, the invention pertains to an isolated mutant Cas9 protein, wherein the isolated mutant Cas9 protein is active in a CRISPR/Cas endonuclease system, wherein the CRISPR/Cas endonuclease system displays reduced off-target editing activity and maintained on-target editing activity relative to a wild-type CRISPR/Cas endonuclease system. The invention also includes isolated nucleic acids encoding mutant Cas9 proteins, ribonucleoprotein complexes and CRSPR/Cas endonuclease systems having mutant Cas9 proteins that display reduced off-target editing activity and maintained on-target editing activity relative to a wild-type CRISPR/Cas endonuclease system.