Abstract: The subject technology provides for an architecture that isolates two interfaces of a circuit with an isolating communication element while also protecting against overstress transients such as electro-static discharge (ESD) and other electrical overstress (EOS) transients across the isolating communication element that can be significantly larger than the ESD rating of the isolating communication element, and/or that may be repeated in succession. The subject technology provides isolation using a two die implementation with an isolation interface including an isolation tub in each die, or a single die containing both isolation tubs in the die. The two dice include respective substrates that are connected together and float with respect to any signal or ground. The isolation enables a large offset voltage on the order of hundreds of volts to exist between the sides. Being relatively large, each isolation tub can handle a significant amount of energy.