Abstract: The invention relates to means and methods for assessing clonal immunoglobulin (IG)/T cell receptor (TR) gene rearrangements in a clinical, diagnostic and/or research setting. Provided is a quality control composition comprising a mixture of genomic DNA isolated from a set of nine cultured cell lines, said set comprising the B cell lines ALL/MIK (ALL), Raji (Burkitt lymphoma), REH (B cell precursor ALL), TMM (CML-BC/EBV+B-LCL), TOM-1 (B cell precursor ALL), WSU-NHL (B cell lymphoma) and the T cell lines JB6 (ALCL), Karpas299 (ALCL) and MOLT-13 (ALL), or wherein one or more cell lines of said set is replaced with one or more other cell line(s) comprising the same IG/TR gene rearrangements. Also provided is a quality control composition consisting of essentially equimolar amounts of genomic DNA isolated from healthy human thymus, healthy human tonsil and healthy human peripheral blood mononuclear cells.

Abstract: Methods of selectively excising polynucleotide segments including segments comprising non-essential DNA and/or selectable marker genes from transgenic loci from transgenic plants as well as making targeted genetic changes with genome editing techniques are provided. Also provided are transgenic plants comprising the transgenic loci lacking the non-essential DNA and/or selectable markers and use of such methods and plants to facilitate plant breeding are disclosed.

Abstract: Transgenic plants comprising synthetic protospacer adjacent motifs (sPAMs) or synthetic guide RNA recognition sites introduced at or near the junctions the transgene insert with non-transgenic genomic DNA, methods of making such plants, and use of such plants to facilitate breeding are disclosed.

Abstract: The disclosure relates to precise modifications in wheat plant genomes including the heterologous integration of nucleic acid sequences that include a regulatory element at a predetermined locus. Also provided are wheat cells, wheat plants, wheat seeds, and processed wheat products comprising the modified wheat genomes.

Abstract: Transgenic INIR6 maize plants comprising modifications of the DP-4114 maize locus which provide for facile excision of the modified DP-4114 transgenic locus or portions thereof, methods of making such plants, and use of such plants to facilitate breeding are disclosed.

Abstract: Transgenic INHT31 soybean plants comprising modifications of the MON89788 soybean locus which provide for facile excision of the modified MON89788 transgenic locus or portions thereof, methods of making such plants, and use of such plants to facilitate breeding are disclosed.

Abstract: Embodiments are disclosed for a method. The method includes determining a granularity of hypervectors. The method also includes receiving an input hypervector representing a data structure. Additionally, the method includes performing an iterative process to factorize the input hypervector into individual hypervectors representing the cognitive concepts. The iterative process includes, for each concept: determining an unbound version of a hypervector representing the concept by a blockwise unbinding operation between the input hypervector and estimate hypervectors of other concepts. The iterative process further includes determining a similarity vector indicating a similarity of the unbound version of the hypervector with each candidate code hypervector of the concept. Additionally, the iterative process includes generating an estimate of a hypervector representing the concept by a linear combination of the candidate code hypervectors, and weights of the similarity vector.

Abstract: Embodiments are disclosed for a method. The method includes bundling a set of M code hypervectors, each of dimension D, where M>1. The bundling includes receiving an M-dimensional vector comprising weights for weighting the set of code hypervectors. The bundling further includes mapping the M-dimensional vector to an S-dimensional vector, sk, such that each element of the S-dimensional vector, sk, indicates one of the set of code hypervectors, where S=D/L and L?1. Additionally, the bundling includes building a hypervector such that an ith element of the built hypervector is an ith element of the code hypervector indicated in an ith element of the S-dimensional vector, sk.

Abstract: Provided are novel human-derived monoclonal neutralizing Nogo-A specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Polynucleotides, vectors, host cells and kits related to the Nogo-A specific antibodies are also provided. The antibodies, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for Nogo-A targeted immunotherapy and diagnosis, respectively.

Abstract: Provided herein are machine learning-based methods for assessing the combined impact of multiple genetic variants, as well as the uses of such methods for various applications, such as in synthetic biology, personalized medicine, agricultural breeding, and genetic engineering. Also provided herein are exemplar computer-readable storage media and electronic devices for performing such methods.

Abstract: Transgenic INIR11 maize plants comprising modifications of the MON89034 maize locus which provide for facile excision of the modified MON89034 transgenic locus or portions thereof, methods of making such plants, and use of such plants to facilitate breeding are disclosed.

Abstract: The invention relates to a holder (10) for detachably fastening a flat, approximately rectangular device—such as a tablet computer or a smartphone—to a motor vehicle seat (20), wherein the holder has a fastening device (12) for the detachable plug-in fastening of the holder to a plug-in receptacle (18) allocated to the motor vehicle seat, and wherein the holder has a holding device (24) for detachably holding the device to the holder, wherein the fastening device and the holding device are connected to one another via a coupling element (36), wherein the coupling element is connected to the fastening device via a first joint and to the holding device via a second joint, wherein the joints are designed as swivel joints with a first swivel joint (42) and a first swivel axis (38) and with a second swivel joint (44) and a second swivel axis (40), wherein the first swivel axis and the second swivel axis are oriented parallel to one another.

Abstract: Transgenic INIR19 soybean plants comprising modifications of the DAS81419 soybean locus which provide for facile excision of the modified DAS81419 transgenic locus or portions thereof, methods of making such plants, and use of such plants to facilitate breeding are disclosed.

Abstract: Transgenic INIR20 soybean plants comprising modifications of the MON87701 soybean locus which provide for facile excision of the modified MON87701 transgenic locus or portions thereof, methods of making such plants, and use of such plants to facilitate breeding are disclosed.

Abstract: The disclosure relates to improvements in methods for efficient editing of two or more endogenous soybean genes by insertion of one or more single stranded DNA donor molecules that are not homologous to the insertion sites in the soybean genome.

Abstract: Aspects of the present disclosure are directed to radar signal processing apparatuses and methods. As may be implemented in accordance with one or more embodiments, digital signals representative of received reflections of radar signals transmitted towards a target are mathematically processed to provide or construct a matrix pencil based on or as a function of a forward-backward matrix. Eigenvalues of the matrix pencil are computed and an estimation of the direction of arrival (DoA) of the target is output based on the computed eigenvalues.

Abstract: The disclosure relates to gene edited wheat plants, seeds, and compositions, as well as improvements to wheat plant breeding and methods for creating modifications in wheat plant genomes.

Abstract: Transgenic INHT31 soybean plants comprising modifications of the MON89788 soybean locus which provide for facile excision of the modified MON89788 transgenic locus or portions thereof, methods of making such plants, and use of such plants to facilitate breeding are disclosed.

Abstract: Transgenic INHT26 soybean plants comprising modifications of the DAS44406-6 soybean locus which provide for facile excision of the modified DAS44406-6 transgenic locus or portions thereof, methods of making such plants, and use of such plants to facilitate breeding are disclosed.

Abstract: Methods of selectively excising transgenic loci from transgenic plants and use of such methods to facilitate plant breeding are disclosed.