Abstract: Hedgehog acyltransferase (Hhat), a membrane-bound O-acyl transferase (MBOAT) protein, is responsible for the palmitoylation of Shh and is crucial to proper Shh signaling. Hhat inhibitors that are capable of preventing Shh palmitoylation and mitigating Shh signaling, and therefore can be used in the treatment and/or prevention of diseases (e.g., proliferative diseases, such as cancer). Provided herein are Hhat inhibitors, such as compounds of Formula (I), (II), and (III), which are useful for the treatment and/or prevention of disease.

Abstract: Peripheral blood flow signals of a feature can be acquired and analyzed to determine blood flow characteristics for evaluating a physiological condition. Paradigmatic characteristics of blood flow of the feature can be used to associate a physiological condition with a subject. Upon determination that a blood flow characteristic is associated with a physiological condition, action can be taken. For example, the physiological condition can be monitored and given early treatment.

Abstract: By providing a substantially continuous, arcuately curved, helical-shaped, spring-like coil or ribbon as the cutting element and securely mounting and retaining the coil/ribbon in a holding member, a substantially improved, highly effective, and long-lasting cutting blade assembly is realized. Furthermore, the cutting blade assembly of this invention is substantially less expensive to manufacture, assemble, and employ in a shaver when compared to prior art constructions. In the preferred construction, an elongated coil holding bar is employed for securely holding and retaining the entire length of the helical-shaped, spring-like coil/ribbon, imparting the required rigidity for enabling the elongated coil/ribbon to function in the desired manner.

Abstract: A lithium battery for use in a vehicle includes a container, a plurality of positive terminals extending from a first end of the lithium battery, and a plurality of negative terminals extending from a second end of the lithium battery. The plurality of positive terminals are provided in a first configuration and the plurality of negative terminals are provided in a second configuration, the first configuration differing from the second configuration. A battery system for use in a vehicle may include a plurality of electrically connected lithium cells or batteries.

Abstract: A data processing system which includes memory, a processor connected to the memory, and logic for causing the processor to perform a method for executing computer code having a plurality of transactions within the computer code. The method includes steps for examining the computer code being executed for a change in observable state; for storing data for the executed computer code that are part of the plurality of transactions within the computer code; for maintaining a pointer to the logical beginning of the stored data and maintaining a pointer to the end of the stored data for the last transaction within the computer code to be fully executed; and responsive to detecting a change in observable state, for committing a portion of the stored data.