Abstract: Methods and materials for treating propionic acidemia are provided herein. For example, methods and materials for using AAVs to express a PCCA polypeptide and/or a PCCB polypeptide within a mammal to treat propionic acidemia are provided.

Abstract: Methods of tattooing and tattoo inking systems comprising a housing, an ink reservoir, a pump and a tattoo cartridge. According to a further embodiment the tattoo inking system comprises a system of channels and valves that allow the artist to provide ink to the tattoo cartridge while working and without dipping.

Abstract: Various embodiments are provided for configuring optimization problems from one or more sources in a computing environment by a processor. A knowledge graph may be generated from a knowledge domain and one or more data sources. One or more graph pattens may be applied to match one or more entities in the knowledge graph with one or more atomic optimization templates. An optimization problem configured from the one or more atomic optimization templates and a plurality of data may be executed.

Abstract: This invention relates to methods and materials for nucleic acid delivery, vaccination, and/or treating cancer. More specifically, methods and materials for nucleic acid delivery, vaccination, and/or treating cancer using one or more recombinant adenoviruses (Ads) as an oncolytic agent are provided.

Abstract: This document relates to adenovirus vectors and methods and materials related to using adenovirus vectors. For example, viruses, nucleic acid molecules encoding viruses, cell lines containing viral vectors, and methods for using viruses to deliver nucleic acid to cells in vitro or in vivo are provided. Methods and materials for using adenovirus vectors to induce immune responses and to treat cancer also are provided.

Abstract: This invention relates to methods and materials for nucleic acid delivery, vaccination, and/or treating cancer. More specifically, methods and materials for nucleic acid delivery, vaccination, and/or treating cancer using one or more recombinant adenoviruses (Ads) as an oncolytic agent are provided.

Abstract: This document relates to adenovirus vectors and methods and materials related to using adenovirus vectors. For example, viruses, nucleic acid molecules encoding viruses, cell lines containing viral vectors, and methods for using viruses to deliver nucleic acid to cells in vitro or in vivo are provided. Methods and materials for using adenovirus vectors to induce immune responses and to treat cancer also are provided.

Abstract: An apparatus for sensing acoustic energy in a borehole penetrating the earth includes an optical interrogator and a sensing optical fiber having a length Ls optically coupled to the optical interrogator and configured to sense the acoustic energy to provide sensed acoustic data. The apparatus also includes a reference optical fiber having a length Lr optically coupled to the optical interrogator to provide reference data, wherein the optical interrogator corrects the sensed acoustic data using the reference data to provide corrected sensed acoustic data.

Abstract: This document provides adenovirus vectors and methods and materials related to using adenovirus vectors. For example, adenoviruses for delivering nucleic acid encoding one or more immunogens (e.g., one or more immunogens associated with a pathogen causing an infection) to cells within a mammal such that the mammal produces an effective immune response against the immunogen(s) are provided.

Abstract: This invention relates to methods and materials for nucleic acid delivery, vaccination, and/or treating cancer. More specifically, methods and materials for nucleic acid delivery, vaccination, and/or treating cancer using one or more recombinant adenoviruses (Ads) as an oncolytic agent are provided.

Abstract: A method may be provided. One or more packets from a client may be received, in a block based modulation environment, at one or more switchable antennas of an access point. The access point may have a plurality of switchable antennas. Each switchable antenna may have an antenna state. The plurality of switchable antennas may be switched among such that at least five of the antenna states are sampled. Angle of arrival of the client may be calculated based on the at least five of the antenna states.

Abstract: This invention provides methods and materials for treating cancer. The invention encompasses methods and materials for delivering programmed death-ligand 1 (PD-L1) binding compounds and/or compositions containing one or more monovalent or multivalent programmed death-ligand 1 (PD-L1) binding compounds which are administered to a mammal having cancer to treat the mammal. In some cases, a multivalent PD-L1 binding compound can include two or more programmed cell death protein 1 (PD-1) polypeptides (and/or fragments thereof having the ability to bind PD-L1). This invention also provides methods and materials for making multivalent PD-L1 binding compounds and methods and materials for making nucleic acid molecules that encode PD-L1 binding compounds.

Abstract: A method may be provided. One or more packets from a client may be received, in a block based modulation environment, at one or more switchable antennas of an access point. The access point may have a plurality of switchable antennas. Each switchable antenna may have an antenna state. The plurality of switchable antennas may be switched among such that at least five of the antenna states are sampled. Angle of arrival of the client may be calculated based on the at least five of the antenna states.

Abstract: This document relates to adenovirus vectors and methods and materials related to using adenovirus vectors. For example, viruses, nucleic acid molecules encoding viruses, cell lines containing viral vectors, and methods for using viruses to deliver nucleic acid to cells in vitro or in vivo are provided. Methods and materials for using adenovirus vectors to induce immune responses and to treat cancer also are provided.

Abstract: This document relates to adenovirus vectors and methods and materials related to using adenovirus vectors. For example, viruses, nucleic acid molecules encoding viruses, cell lines containing viral vectors, and methods for using viruses to deliver nucleic acid to cells in vitro or in vivo are provided. Methods and materials for using adenovirus vectors to induce immune responses and to treat cancer also are provided.

Abstract: This document provides adenovirus vectors and methods and materials related to using adenovirus vectors. For example, adenoviruses for delivering nucleic acid encoding one or more immunogens (e.g., one or more immunogens associated with a pathogen causing an infection) to cells within a mammal such that the mammal produces an effective immune response against the immunogen(s) are provided.

Abstract: This invention relates to methods and materials for nucleic acid delivery, vaccination, and/or treating cancer. More specifically, methods and materials for nucleic acid delivery, vaccination, and/or treating cancer using one or more recombinant adenoviruses (Ads) as an oncolytic agent are provided.

Abstract: This document provides adenovirus vectors and methods and materials related to using adenovirus vectors. For example, adenoviruses for delivering nucleic acid encoding one or more immunogens (e.g., one or more immunogens associated with a pathogen causing an infection) to cells within a mammal such that the mammal produces an effective immune response against the immunogen(s) are provided.

Abstract: Various embodiments are provided for managing and interacting with a conversational agent in an internet of things (IoT) environment by a processor. One or more graph patterns may be extracted from a knowledge graph generated from a sensor list containing one or more IoT sensors. One or more conversation patterns and conversation dialogs may be learned from the sensor list and graph patterns. The conversational agent may be automatically configured with the one or more graph patterns, the one or more conversational patterns and conversation dialogs, sensor data and analytics from the one or more IoT sensors according to one or more queries to engage in a conversation dialog with a user.