Abstract: This document relates to adenovirus vectors and methods and materials related to using adenovirus vectors. For example, viruses, nucleic acid molecules encoding viruses, cell lines containing viral vectors, and methods for using viruses to deliver nucleic acid to cells in vitro or in vivo are provided. Methods and materials for using adenovirus vectors to induce immune responses and to treat cancer also are provided.

Abstract: This document provides adenovirus vectors and methods and materials related to using adenovirus vectors. For example, adenoviruses for delivering nucleic acid encoding one or more immunogens (e.g., one or more immunogens associated with a pathogen causing an infection) to cells within a mammal such that the mammal produces an effective immune response against the immunogen(s) are provided.

Abstract: This invention relates to methods and materials for nucleic acid delivery, vaccination, and/or treating cancer. More specifically, methods and materials for nucleic acid delivery, vaccination, and/or treating cancer using one or more recombinant adenoviruses (Ads) as an oncolytic agent are provided.

Abstract: This document provides adenovirus vectors and methods and materials related to using adenovirus vectors. For example, adenoviruses for delivering nucleic acid encoding one or more immunogens (e.g., one or more immunogens associated with a pathogen causing an infection) to cells within a mammal such that the mammal produces an effective immune response against the immunogen(s) are provided.

Abstract: Various embodiments are provided for managing and interacting with a conversational agent in an internet of things (IoT) environment by a processor. One or more graph patterns may be extracted from a knowledge graph generated from a sensor list containing one or more IoT sensors. One or more conversation patterns and conversation dialogs may be learned from the sensor list and graph patterns. The conversational agent may be automatically configured with the one or more graph patterns, the one or more conversational patterns and conversation dialogs, sensor data and analytics from the one or more IoT sensors according to one or more queries to engage in a conversation dialog with a user.

Abstract: A method and apparatus for measuring a pressure. A pressure gauge includes a first plate having a resonant frequency related to a pressure at the pressure gauge. The first plate is thermally-excited at a selected frequency, and a sensor measures a first power level of a first light having a first wavelength reflected from the first plate and a second power level of a second light having a second wavelength reflected from the first plate. A processor determines a thermal drift in the resonant frequency of the first plate due to the thermal excitation of the first plate from the first power level and the second power level, corrects a pressure measurement determined from the resonant frequency of the first plate for the thermal drift of the resonant frequency, and operates a device based on the pressure measurement.

Abstract: An apparatus for sensing acoustic energy in a borehole penetrating the earth includes an optical interrogator and a sensing optical fiber having a length Ls optically coupled to the optical interrogator and configured to sense the acoustic energy to provide sensed acoustic data. The apparatus also includes a reference optical fiber having a length Lr optically coupled to the optical interrogator to provide reference data, wherein the optical interrogator corrects the sensed acoustic data using the reference data to provide corrected sensed acoustic data.

Abstract: This invention provides methods and materials for treating cancer. The invention encompasses methods and materials for delivering programmed death-ligand 1 (PD-L1) binding compounds and/or compositions containing one or more monovalent or multivalent programmed death-ligand 1 (PD-L1) binding compounds which are administered to a mammal having cancer to treat the mammal. In some cases, a multivalent PD-L1 binding compound can include two or more programmed cell death protein 1 (PD-1) polypeptides (and/or fragments thereof having the ability to bind PD-L1). This invention also provides methods and materials for making multivalent PD-L1 binding compounds and methods and materials for making nucleic acid molecules that encode PD-L1 binding compounds.

Abstract: Downhole fiber optic interrogation systems are described. The systems include a fiber optic control system, a first sensing system, a second sensing system, an optical fiber disposed within a well, and an optical switch arranged between the optical fiber and the first and second sensing systems, wherein the fiber optic control system performs time division multiplex control of the optical switch wherein the first sensing system is operably connected to the optical fiber and the second sensing system is not connected to the optical fiber, and further controls the optical switch such that the second sensing system is operably connected to the optical fiber and the first sensing system is not connected to the optical fiber.

Abstract: This document relates to adenovirus vectors and methods and materials related to using adenovirus vectors. For example, viruses, nucleic acid molecules encoding viruses, cell lines containing viral vectors, and methods for using viruses to deliver nucleic acid to cells in vitro or in vivo are provided. Methods and materials for using adenovirus vectors to induce immune responses and to treat cancer also are provided.

Abstract: Various embodiments are provided for managing and interacting with a conversational agent in an internet of things (IoT) environment by a processor. One or more graph patterns may be extracted from a knowledge graph generated from a sensor list containing one or more IoT sensors. One or more conversation patterns and conversation dialogs may be learned from the sensor list and graph patterns. The conversational agent may be automatically configured with the one or more graph patterns, the one or more conversational patterns and conversation dialogs, sensor data and analytics from the one or more IoT sensors according to one or more queries to engage in a conversation dialog with a user.

Abstract: A system and method to determine temperature include an optical fiber and at least two pulse laser sources to transmit light pulses with at least two wavelengths into the optical fiber. The system also includes an optical path length modulator to modulate the optical path length of the optical fiber as the light pulses are transmitted into the optical fiber. At least two photodetectors detect backscatter reflected in the optical fiber, and a processor determines the temperature based on the backscatter.

Abstract: This invention relates to methods and materials for nucleic acid delivery, vaccination, and/or treating cancer. More specifically, methods and materials for nucleic acid delivery, vaccination, and/or treating cancer using one or more recombinant adenoviruses (Ads) as an oncolytic agent are provided.

Abstract: This document relates to adenovirus vectors and methods and materials related to using adenovirus vectors. For example, viruses, nucleic acid molecules encoding viruses, cell lines containing viral vectors, and methods for using viruses to deliver nucleic acid to cells in vitro or in vivo are provided. Methods and materials for using adenovirus vectors to induce immune responses and to treat cancer also are provided.

Abstract: Downhole fiber optic interrogation systems are described. The systems include a fiber optic control system, a first sensing system, a second sensing system, an optical fiber disposed within a well, and an optical switch arranged between the optical fiber and the first and second sensing systems, wherein the fiber optic control system performs time division multiplex control of the optical switch wherein the first sensing system is operably connected to the optical fiber and the second sensing system is not connected to the optical fiber, and further controls the optical switch such that the second sensing system is operably connected to the optical fiber and the first sensing system is not connected to the optical fiber.

Abstract: A computing device can obtain a session key for encrypting data that is communicated between a client device and the computing device. The computing device can receive, from the client device, an encrypted request for data. The encrypted request can be encrypted by the client device using the session key. The data requested can be stored on a second computing device. The computing device can send, to the second computing device, a copy of the session key and the encrypted request for data. The second computing device can decrypt the data using the session key and can also encrypt data responsive to the request using the session key.

Abstract: This document relates to adenovirus vectors and methods and materials related to using adenovirus vectors. For example, viruses, nucleic acid molecules encoding viruses, cell lines containing viral vectors, and methods for using viruses to deliver nucleic acid to cells in vitro or in vivo are provided. Methods and materials for using adenovirus vectors to induce immune responses and to treat cancer also are provided.

Abstract: A method and apparatus for measuring a pressure. A pressure gauge includes a first plate having a resonant frequency related to a pressure at the pressure gauge. The first plate is thermally-excited at a selected frequency, and a sensor measures a first power level of a first light having a first wavelength reflected from the first plate and a second power level of a second light having a second wavelength reflected from the first plate. A processor determines a thermal drift in the resonant frequency of the first plate due to the thermal excitation of the first plate from the first power level and the second power level, corrects a pressure measurement determined from the resonant frequency of the first plate for the thermal drift of the resonant frequency, and operates a device based on the pressure measurement.