Abstract: Compounds of formula (I) as defined herein, or a pharmaceutically acceptable salt, or an in-vivo-hydrolysable ester thereof, are useful as antibacterial agents. Processes for their manufacture and pharmaceutical compositions containing them are described.

Abstract: The invention concerns a compound of formula (I), wherein, for example: R1 is of the formula —NHC(═O)(1-4C)alkyl; R2 and R3 are hydrogen or fluoro; R4 and R5 are hydrogen or methyl; >A-B- is of the formula >C═CH—, >CHCH2, or >C(OH)CH2—(> represents two single bonds); D is O, S, SO, SO2 or —NR7; wherein R7 is hydrogen, R10CO—, R10SO2—, RaOC(Rb)═CH(C═O)—, RcC(═O)C(═O)—, RdN═C(Re)C(═O)—, RfNHC(Rg)═CHC(═O)— or R14CH(R13)(CH2)m—; wherein R10 is (1-6C)alkyl [optionally substituted by, for example, hydroxy or (1-6C)alkanoyl], R11C(O)O(1-6C)alkyl or R12O—; wherein R11 is optionally substituted (1-6C)alkyl; R12 is optionally substituted (1-6C)alkyl; Ra, Rb, Rc, Rd, Re, Rf, Rg are (1-6)alkyl; m is 0 or 1; R13 is cyano; R14 is hydrogen or (1-4C)alkyl; >X—Y— is of the formula >C═CH— or >CHCH2—; and pharmaceutically acceptable salts thereof

Abstract: The invention concerns a compound of the formula (I): wherein, for example: T is of the formula (IA), (IB), or (IC); R1 is of the formula —NHC(═O)Rb wherein Rb is (1-4C)alkyl; R2 and R3 are hydrogen or fluoro; >A—B— is >C═CH— (but not when T is (IA)) or >CH—CH2—; wherein when T is of the formula (IA) or (IB); R6 is, for example, (1-4C)alkyl; R5 is hydrogen, R10CO—, R10SO2— or R10CS— wherein R10 is, for example, optionally substituted phenyl, or (1-10C)alkyl, or when T is of the formula (IA), (IB); or (IC): R5 and R6 are linked to give a 5- or 6-membered ring which is fused to the ring shown in (IA), (IB), or (IC) so as to give an optionally substituted bicyclic ring; and pharmaceutically acceptable salts thereof, processes for their preparation, pharmaceutical compositions containing them, and their use as antibacterial agents.

Abstract: Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, 1

Abstract: An improved fastener for attaching metal to wood is described. The fastener is particularly suited for use as a railroad spike for attaching a metal rail to a wooden tie. The improved spike is adapted for installation by either driving or screwing the spike into the tie. A plurality of flutes are adapted to engage with the tie, thereby preventing loosening of the spike. The spike may be used with or without a metal boss or fishplate to secure a metal rail to a wooden tie.

Abstract: Apparatus and methods for the individual controlled preparation of a beverage from one or more beverage bags within a variety of containers and the quick and sanitary storage of the bag or bags once the beverage preparation has been completed. Preferably, the beverage preparation and bag storage apparatus is sized and shaped to be seated on the lip of a container to cover the mouth of the container. The apparatus includes a raised container lid bag retention structure that is openable or open such that at least a portion of the beverage bag may be drawn within and thereby retained in a position elevated above the beverage so that the beverage can be sampled and consumed even with the apparatus in place on the container and the bag or bags retained within the apparatus.

Abstract: A method for converting multi-bit digital video data signals to analogue form wherein the video data signals are in three formats, namely, standard definition, progressive scan and high definition formats, which permits a relatively low order analogue reconstruction filter to be used for filtering the analogue form of the signal. The three formats of the digital video data signals are over-sampled at relatively low over-sampling rates, the standard definition video signals being over-sampled at eight times the nyquist sampling frequency, the progressive scan format signals being over-sampled at four times the nyquist sampling frequency, while the high definition format signals are over-sampled at twice the nyquist sampling frequency.

Abstract: A method for selectively and sequentially converting digital video data signals in three formats, namely, standard definition, progressive scan and high definition formats to analogue form such that the same analogue reconstruction filter can be used for filtering the analogue forms of the signals after conversion. The digital signals prior to being converted are over-sampled at respective over-sampling frequencies for displacing image frequencies to frequencies sufficiently spaced apart from the widest band width signal so that the analogue reconstruction filter can be provided for filtering the widest band width signal as well as the other band width signals and also can be provided with a relatively low roll-off rate of attenuation.

Abstract: A transducer assembly for use with an apparatus comprising a sound transmitting earpiece comprises a sound transmitting element (1) adapted to be worn between such an earpiece and the ear, a sound transducer (3), to be located remote from the earpiece and a hollow tube (2) for acoustically coupling the sound transmitting element (1) to the transducer (3).

Abstract: Apparatus and methods for the individual controlled preparation of a beverage from one or more beverage bags within a variety of containers and the quick and sanitary storage of the bag or bags once the beverage preparation has been completed. Preferably, the beverage preparation and bag storage apparatus is sized and shaped to be seated on the lip of a container to cover the mouth of the container. The apparatus includes a raised container lid bag retention structure that is openable or open such that at least a portion of the beverage bag may be drawn within and thereby retained in a position elevated above the beverage so that the beverage can be sampled and consumed even with the apparatus in place on the container and the bag or bags retained within the apparatus.

Abstract: The present invention is directed to methods that can used for biotin labeling polypeptides in mammalian cells. The methods can be effectively used for cytoplasmic proteins, secreted proteins, and for proteins found on viral surfaces.

Abstract: The present application discloses a class of antibiotic compounds containing an oxazolidinone ring. These compounds have useful activity against Gram-positive pathogens including MRSA and MRCNS and, in particular, against various strains exhibiting resistance to vancomycin and against E. faecium strains resistant to both aminoglycosides and clinically used &bgr;-lactams. The compounds also possess a favourable toxicological profile. This invention further relates to processes for their preparation, to intermediates useful in their preparation, to their use as therapeutic agents and to pharmaceutical compositions containing them.

Abstract: A process of making paper or paper board comprising forming a cellulosic suspension, flocculating the suspension, mechanically shearing the suspension and optionally reflocculating the suspension, draining the suspension on a screen to form a sheet and then drying the sheet, wherein the suspension is flocculated or reflocculated by introducing a water-soluble polymer of intrinsic viscosity above 3 dl/g into the suspension, characterized in that the water soluble polymer exhibits a rheological oscillation value of tan delta at 0.005 Hz of above 1.1. The process has the advantage of improving retention.

Abstract: In an arcuate roof section including a series of rafters which each define an exposed end of the prescribed height, a device positionable along the exposed ends of the series of rafters to define an arcuate facia. The device comprises at least one facia member having an arcuate inner surface, an arcuate outer surface, a top edge and a bottom edge. The inner surface of the facia member is configured to abut the exposed ends of the rafters such that the outer surface defines the arcuate facia. Additionally, the width between the top edge and the bottom edge of the facia member exceeds the height of the exposed ends. The facia member may be formed from a plurality of laminated wood members or formed from bonded particulate matter. Additionally, the facia member may be formed from a plastic material.

Abstract: The invention concerns a compound of the formula (I): wherein, for example: R1 is of the formula —NHC(═O)Rb wherein Rb is, for example, (1-4C)alkyl; R2 and R3 are hydrogen or fluoro; R2 and R3 are hydrogen or fluoro; D is O; R4 and R5 are hydrogen, (1-4C)alkyl or AR-oxymethyl; AR is phenyl or phenyl(1-4C)alkyl; R6 is hydrogen; >A—B— is of the formula >C═C(Ra)—, >CHCHRa—, or >C(OH)CHRa— (> represents two single bonds) wherein Ra is hydrogen or (1-4C)alkyl; and pharmaceutically-acceptable salts thereof; processes for their preparation; pharmaceutical compositions containing them and their use as antibacterial agents.

Abstract: A seat support for use with a vehicle seat and adapted to engage a floor-mounted track, the track having two inwardly directed lips on opposed sides of a slot. The seat support has a framework to support the seat, and which is provided with a clamping mechanism to engage the lips of the track. The clamping mechanism has two spaced apart plates, with the spaced apart plates having inwardly inclined lower regions. The lower edge of each plate carries an outwardly directed flange. A mechanism is provided to move the lower regions outwardly against an inherent resistance bias provided by the plates from an initial position in which the flanges may be inserted between the lips of the track to an outer clamping position in which the flanges engage the lips of the track. A knife element is mounted between the plates and is adapted to be moved between an upper position and a lower clamping position.

Abstract: A compound of formula (I): wherein R1 is hydroxy or of the formula —NHC(═O)(1-4C)alkyl or —NHS(O)n(1-4C)alkyl wherein n is 0, 1 or 2; R2 and R3 are independently hydrogen or fluoro; R4 and R5 are independently hydrogen or methyl; >A—B— is of the formula >C═CH—, or >C(OH)CH2—; >X—Y— is of the formula >C=CH—, or >CHCH2—; and D is S, SO, or SO2; or a pharmaceutically-acceptable salt thereof.

Abstract: An anode structure for a magnetron includes T-shape anode vanes having a radially extensive component and a circumferentially extensive portion, the cylindrical faces of the circumferential portion facing a cathode in the complete magnetron. The use of T-shape vanes increases inductance and hence permits low frequency radiation to be generated without increasing the dimensions of the magnetron compared to those of a conventional magnetron. Also, capacitance is increased to give a further reduction in frequency by using more than two anode straps, and preferably four anode straps at each end of the anode structure. Preferably, the anode structure is incorporated in a magnetron in which a high magnetic field of the order of 500 Gauss for a magnetron operating at 100 MHZ is used. The anode shell itself may form part of the magnetic return path. Other anode vane configuration, for example L-shaped, may be used.

Abstract: A magnetron has an output comprising a coaxial line 15 which transmits energy from a wanted oscillator mode as a first coaxial waveguide mode and energy from an unwanted oscillator mode as a second cylindrical waveguide mode. Energy in the cylindrical waveguide mode is intercepted by slots 17, 18 in the coaxial line 15 and absorbed by material 19. This enables the modes to be separated. Preferably, the output is taken from the axis of the magnetron and the wanted oscillator mode in the &pgr;-1 mode.

Abstract: In an arcuate roof section including a series of rafters which each define an exposed end of the prescribed height, a device positionable along the exposed ends of the series of rafters to define an arcuate facia. The device comprises at least one facia member having an arcuate inner surface, an arcuate outer surface, a top edge and a bottom edge. The inner surface of the facia member is configured to abut the exposed ends of the rafters such that the outer surface defines the arcuate facia. Additionally, the width between the top edge and the bottom edge of the facia member exceeds the height of the exposed ends. The facia member may be formed from a plurality of laminated wood members or formed from bonded particulate matter. Additionally, the facia member may be formed from a plastic material.