Abstract: A group I intron-derived ribozyme which binds RNA in trans, excises an internal segment from within the RNA, and splices the remaining 5? and 3? ends of the RNA back together (the trans-excision-splicing reaction) is disclosed. The excised segment can be as long as 28 nucleotides, or more, and as little as one nucleotide. The ribozymes of the invention are easily modified to alter their sequence specificity. Such ribozymes represent a new and potentially powerful class of generally adaptable genetic therapeutics.

Abstract: Dye receptivity of fibers used in the dyeing and printing of cationic dyeable nylon as used as carpet fibers or similar polymers difficult to dye with anionic dyes are improved by a coating rendering these fibers more receptive to anionic dyes.

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient, and methods for treating physiological disorders, particularly congestive heart disease, comprising administering to a patient in thereof an effective amount of a compound of Formula I.

Abstract: A system for fixing a substrate with a heat transferring device in an assembled orientation; the system comprising: a substantially rod-shaped positioning member having a length generally symmetrically oriented about an axis and a generally constant lateral expanse substantially perpendicular with said axis substantially along said length; said positioning member interferingly fitting within at least one of a first aperture in said substrate and a second aperture in said heat transferring device to maintain a predetermined separation between said substrate and said heat transferring device in said assembled orientation.

Abstract: A system and method for sending device specific data in a bus transaction. A device configurable field is preallocated in a packet sent by the sending device to a receiving device. The sending device can configure the data to be stored in the device configurable field. Upon receipt of the packet, the receiving device generates a response packet in which the contents of the device configurable field is simply copied into a corresponding field in the response packet.

Abstract: An apparatus for transferring heat from an electrical module includes: (a) a thermally conductive base member having a plurality of edges establishing a polygonal perimeter and having a first side for presentation toward the electrical module; and (b) a heat transferring structure integrally formed with the base member and extending from a second side of the base member opposite from the first side. The heat transferring structure occupies less than all of the second side and establishes a margin substantially about the perimeter.

Abstract: Vinyl polymer adhesive using glass powder as a filler. The glass powder includes the use of recycled automotive and architectural glass as a filler material for several vinyl polymer adhesives, such as hot melt adhesives, polyvinyl chloride adhesives, and vinyl acetate-ethylene (VAE) emulsion adhesives. The glass powder may have an average particle size between 100 and 400 mesh.

Abstract: A laboratory apparatus that is readily adapted to execute a wide range of sample preparation protocols is a set forth. The laboratory apparatus comprises a plurality of tools that are adapted to execute one or more processes in preparing a sample for subsequent analysis and a hollow rotor that is mounted for rotation about a rotation axis. A septum divides the hollow rotor into first and second chambers. Both the first and second chambers are accessible to one or more of the plurality of tools. One or more valve mechanisms are disposed to control fluid communication between the first and second chambers based, at least in part, on the rotation rate imparted to the hollow rotor.

Abstract: A computer-implemented method of visualizing time-dependent data is disclosed. The method comprises loading at least a first set of time-dependent data into a computer. The method also comprises color coding the at least first set of time-dependent data with the computer. Further, the method comprises generating an output from the computer such that clinically significant excursions in the at least first set of time-dependent data are visually identified. The at least first set of time-dependent data may be sorted according to a plurality of configurable time periods. The color coding step may include selecting at least one of a color and a brightness as a function of numerical values of the time-dependent data. A computer-implemented method of visualizing time-dependent data of at least two time-dependent sets of data is also disclosed. The method comprises loading at least a first and second set of time-dependent data into the computer.

Abstract: Computer assisted systems, methods and mediums for filling one or more orders. One embodiment of the present invention is a system that includes an order consolidation station configured to receive at least one bottle containing pills individually counted and/or at least one package containing pharmaceutical products without having been designated for any of the orders when the package was created and/or at least one literature pack optionally including patient specific information. The order consolidation station is further configured to combine automatically the received bottle and/or package and/or literature pack into a container to be sent to a recipient including, for example, mail order pharmacies, wholesalers and/or central fill dealers for subsequent distribution or sale including retailer distribution or sale. The bottle is specifically designated for the order, and the order generally includes at least one prescription for the package.

Abstract: The present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation comprising administering to a patient in need thereof an effective amount of a compound of the formula (I): or a pharmaceutically acceptable salt thereof. In addition, the present invention provides novel pharmaceutical compounds of Formula (I), including the pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions which comprise as an active ingredient a compound of Formula (I).

Abstract: A synchronous bus system that enables the bus lengths between devices to be extended such that the timing budget is more than one clock cycle. A reset process resets the transmission and reception circuitry and both circuitry function according to prespecified parameters relative to the deassertion of the reset signal such that the amount of logic required to latch and sample the data is minimized. As the timing budget is not limited to one clock cycle, devices can be spaced further apart providing more physical space for devices. Furthermore, skew sensitivity is reduced as to the skew is distributed over multiple clock periods.

Abstract: A reaction vessel and a reaction system having an annular tube with an inlet, an outlet, and at least one expandable section between the inlet and the outlet. The expandable section of the annular tube has a first shape and a second expanded shape. The expandable section of the annular tube expands to from the first shape to the second expanded shape in response to a change in the physical environment of the annular tube. When the expandable section of the annular tube is in the second expanded shape, the portions of the annular tube adjoining the expandable section of the annular tube are substantially less expanded.

Abstract: Methods and systems automating medical device data management are provided. The subject methods and systems are implemented by or include a software program loadable on a host system. The software program is configured for polling medical devices located within a detectable range of the host system; detecting a medical device; downloading data from the detected medical device to the host system; and generating one or more reports comprising at least some of the downloaded data; wherein the aforementioned steps are performed without user intervention.

Abstract: By utilizing specially processed waste carpeting as a filler in the production of carpet backcoating, roofing materials, or other similar products, the amount of waste carpeting that is landfilled or otherwise disposed of is significantly reduced as is the need for mining the mineral fillers. Waste carpeting (post-consumer and/or waste from new carpet manufacture) containing calcium carbonate and a thermoplastic resin is collected and size-reduced to a size corresponding to the size of calcium carbonate typically used as a filler. The size-reduced waste carpeting is added as filler to at least one other material, such as polymers in standard latex, EVA, or PVC carpet backcoatings, to provide a composite used in the manufacture of a useful product (like carpet backcoating), and then the composite material is used to make the useful product (such as carpet backcoating, which is used as a primary or secondary backcoating in the manufacture of new carpeting).

Abstract: An analyte detection system utilizing a combination of fluorescent labels for labeling particles and an analyte specific fluorescent analyte detection dye. The particles contain a combination of fluorescent labels for coding the particles and an analyte specific fluorescent dye. The particles can be used to identify and quantify analytes in an analytical sample by reaction of the analytical sample with the particles. An analytical device can identify the particles according to the combination of fluorescent labels. The device can then correlate the identified particle with the analyte specific fluorescent analyte detection dye. Multiple subpopulations of particles can be used to identify and quantify multi-analytes in a single analytical sample. Near infrared (NIR) fluorescent labels useful in the detection system are also provided.

Abstract: A printing member such as a printing cylinder includes an at least partly metal cylinder, or a sleeve to be mounted on a mandrel rotating about its axis. The printing member comprises a body having a thickness. With the printing member there is associated an activatable signaling device that is connectable to a recording device that is arranged to store data related to at least one characteristic of the printing member or to the use of the printing member. The activatable signaling device can include a transponder such as an RFID.

Abstract: A system for analyzing samples having a portable analysis unit and a base unit. The portable analysis unit has a sample inlet, an analyzer, a reagent supply reservoir, a collection reservoir for waste, a reagent inlet for providing reagent to the supply reservoir, a waste outlet for removing waste from the collection reservoir, a supply conduit from the reagent supply reservoir to the analyzer, a waste conduit from the analyzer to the collection reservoir, a power source, a data output element, and a pressure source for moving reagent and waste. The base unit is connectable to the analyzer unit for providing reagent and receiving waste. The base unit has a reagent storage reservoir, a waste storage reservoir, a waste inlet for connection to the waste outlet; and an outlet for providing reagent from the reagent storage reservoir to the reagent inlet.

Abstract: The amount of waste carpeting that is landfilled or otherwise disposed of is significantly reduced, as is the need for the mining mineral fillers, by utilizing specially processed waste carpeting as a filler in the production of new hot melt carpet backcoating, roofing materials, or other similar products. Waste carpeting (post consumer and/or waste from new carpet manufacture) is collected and size reduced, typically in a first coarse size reduction, and then after densification to a finer size reduction. The size reduced waste carpeting is added as filler to at least one other material, such as polymers in standard latex, EVA, or PVC carpet backcoatings, to provide a hot melt composite used in the manufacture of a useful product (like carpet backcoating), and then the composite material is used to make the useful product (such as carpet backcoating, which is used as a primary or secondary backcoating in the manufacture of new carpeting).

Abstract: By utilizing specially processed waste carpeting as a filler in the production of carpet backcoating, roofing materials, or other similar products, the amount of waste carpeting that is landfilled or otherwise disposed of is significantly reduced as is the need for mining the mineral fillers. Waste carpeting (post-consumer and/or waste from new carpet manufacture) containing calcium carbonate and a thermoplastic resin is collected and size-reduced to a size corresponding to the size of calcium carbonate typically used as a filler. The size-reduced waste carpeting is added as filler to at least one other material, such as polymers in standard latex, EVA, or PVC carpet backcoatings, to provide a composite used in the manufacture of a useful product (like carpet backcoating), and then the composite material is used to make the useful product (such as carpet backcoating, which is used as a primary or secondary backcoating in the manufacture of new carpeting).