Abstract: The invention is directed to indoline amide derivatives as EP4 receptor ligands, antagonists or agonists, useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis, rheumatoid arthritis, cancer and glaucoma. Pharmaceutical compositions and methods of use are also included.

Abstract: Embodiments of the present invention relate to multi-functional carriers for carrying items and methods for constructing carriers. According to some embodiments the carrier includes a holder and a strap molded of foam material. The strap and holder may be coupled together in various configurations to create loop through which one or more objects may be inserted or removed from within a cavity in the holder.

Abstract: The present invention provides variants of cyanovirin-N and water-soluble polymer conjugates thereof, and methods of preparing such conjugates. The cyanovirin-N of the invention are particularly suited for site-selective covalent attachment of one or more water soluble polymers, to provide polymer conjugates of cyanovirin-N variants exhibiting antiviral activity.

Abstract: This invention relates to class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

Abstract: A composition comprising a substantially purified compound of the formula: in combination with at least one additional therapeutic agent, and methods of preventing or treating cancer and a condition treatable by the inhibition of vacuolar-type (H+)-ATPase.

Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

Abstract: The present invention provides a compound of the formula: wherein R1 is H, alkyl, alkenyl or aryl, wherein R1 is unsubstituted or substituted, R2 is H, alkyl, alkenyl or aryl, wherein R2 is unsubstituted or substituted, R3 is H, a alkyl, alkenyl or aryl, R4-R8 are the same or different and each is R10, C(O)R10 or SO2R10, wherein R10 is H, alkyl, alkenyl or aryl, wherein R10 is unsubstituted or substituted, and R9 is R9a, C(O)R9a or S02R9a, wherein R9a is H alkyl, alkenyl or aryl. R9a can be unsubstituted or substituted with one or more groups such as oxo (?O), OR9b, OC(O)R9b, OSO2R9b, NHR9b, NHC(O)R9b and NHSO2R9b, wherein R9b is H, alkyl alkenyl or aryl. R9b can be unsubstituted or substituted with one or more groups such as oxo (?O), OR9c, CO2R9c and OC(O)R9c, wherein R9c is H, or a unsubstituted or substituted alkyl, alkenyl or aryl.

Abstract: This invention relates to class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis. They have the following structure: Formula (I).

Abstract: A system and method for interfacing video devices over a link where electronic digital video data having a quantity (n) of bits of parallel data transmitted electronically at a first clock rate (R1) is converted to a stream of electronic serial data that is transmitted a second clock rate (R2=R1×n). The stream of electronic serial data is transmitted over a link that can be a fiber optic link or include one or more conductors. A receiver is employed to convert the data transmitted over the link into an output data stream having (n) bits of parallel data transmitted electronically at the first clock rate (R1). If the link is a fiber optic link, the receiver can convert the data transmitted over the link into to a second stream electronic serial data that is transmitted at the second clock rate (R2) and then to the output data stream.

Abstract: A reversing automatic feed assembly for a stump grinder includes at least one sensor adapted to sense excessive load placed on the stump grinder and output a signal thereof. The reversing automatic feed assembly also includes a control system operatively connected to the least one sensor to automatically reverse feed movement of the cutting assembly in response to the signal from the at least one sensor.