Abstract: An apparatus and method to control and exert a predetermined force back on the wellbore thereby controlling the hydrostatic force on the formation surrounding the well-bore, the inflow of fluids from the surrounding formation and the drilling circulating medium. The apparatus comprises and the method utilizes a pump having at least one pair of intermeshing and opposite-handed helical screws disposed within a chamber for restricting the flow of well bore returns. The speed of the pump may be varied to selectively restrict the flow of well bore returns from the well bore.

Abstract: A method and apparatus to regulate the down-hole hydrostatic pressure in a wellbore are provided which depend on regulating the resistance to the flow of wellbore returns produced by the wellbore. The resistance may be provided by the internal gas pressure in a gas/liquid separator receiving the flow of wellbore returns, where the internal gas pressure is regulated by an adjustable back pressure valve and a gas source. Alternatively or in addition, the resistance may be provided by a pump receiving the flow of wellbore returns, where the resistance of the pump is regulated by adjusting the speed of the pump.

Abstract: A rotating flow control device, and more particularly a rotating control flow device for use inside a riser assembly during offshore drilling activities. The rotating flow control device has a stationary housing adapted to mount between the interconnected ends of riser pipe. The bearing assembly of the rotating flow control device is entirely contained within the riser pipe and maybe remotely detached and removed from the stationary housing. The rotating flow control device may be positioned in the riser such that it effectively isolates the riser slip joint from pressurized well bore returns.

Abstract: The invention is directed to ?-carboline sulphonylurea derivatives as EP4 receptor antagonists useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, inflammation, osteoarthritis, and rheumatoid arthritis. Pharmaceutical compositions and methods of use are also included.

Abstract: Compound of formula I are antagonists of the PGD2 receptor, CRTH2, and as such are useful in the treatment and/or prevention of CRTH2-mediated diseases such as asthma.

Abstract: A power supply apparatus has at least one modular reserve battery magazine with a plurality of compartments. A plurality of reserve battery modules may be respectively replaceably provided in corresponding ones of the plurality of compartments, each of the plurality of reserve battery modules being configured to provide power when a reserve battery provided therein is activated. Each reserve battery module of the plurality of reserve battery modules includes a sleeve and a reserve battery provided within the sleeve, the sleeve being configured to fit within one of the plurality of compartments in a predetermined orientation. Each sleeve may be detachably connectable within any compartment of the plurality of compartments and includes electrical connections so that each reserve battery module of the plurality of reserve battery modules is separately replaceable while the power supply apparatus remains remotely located.

Abstract: A wood chipper comprises a frame, an infeed system, a rotatable cutting system, and at least one feed wheel disposed between the infeed system and the cutting system to feed wood material to the cutting system. The wood chipper also includes a winch comprising a winch line having a first end, and a collar disposed adjacent the first end of the winch line. The wood chipper further includes a detector adapted to detect a first and a second position of the winch line, wherein the detector is adapted to allow operation of the at least one feed wheel and prohibit operation of the winch when the first position of the winch line is detected, and to allow operation of the winch and allow operation of the at least one feed wheel in a predefined manner when the second position is detected. The wood chipper further comprises a bypass for operation of the at least one feed wheel.

Abstract: A computer-implemented process and apparatus for storing, accessing, and comparing genetic profiles in a form suitable for amateur human analysis is provided. The process includes imputing and storing data that represent individual genetic profiles which have been created using conventional genetic analysis processes. The process and apparatus allow remote consumer access via the internet to genetic profiles owned by consumer which can then be compared against other genetic profiles according to a genetic profile comparison process selected from several available processes. The resulting output of the process is a summary of the genetic profile comparison which answers the question posed by the consumer.

Abstract: Medical devices, methods and kits are described. An exemplary medical device comprises a catheter that has a catheter wall and defines a catheter lumen, a bend, and a coil disposed distal to the bend. The catheter defines one or more apertures that extend through the catheter wall and are in communication with the catheter lumen.

Abstract: The present invention is directed to rotating flow control diverter having sealed bearing assembly that does not require external hydraulic pumping to circulate and cool the lubricating fluid used to lubricated the bearings of the sealed bearing assembly.

Abstract: Compound of formula I are antagonists of the PGD2 receptor, CRTH2, and as such are useful in the treatment and/or prevention of CRTH2-mediated diseases such as asthma.

Abstract: Methods and systems are provided for creating a configuration file template. One method for creating a configuration file template includes presenting 568 a base configuration file stored in memory in a window of a first pane 220, selecting 572 a portion of the base configuration file that indicates a syntax element 236, and defining 576 one 244 or more parameters 230/232/234 of the selected syntax element. The method also includes defining the one or more parameters upon receiving a value 244 or choosing from an already defined list of values 242, at least one of the parameters including a defined descriptor 240 for the selected syntax element, and presenting 576 the user defined descriptors 246/248 associated with the selected syntax element 236 or group of elements 227/228 in a second pane 222.

Abstract: Systems, components, and methods are described for obstacle detection by visually impaired users. A system can include a support element, such as a mobility cane, and one or more object sensors such as sonar, lidar, RF, or radar sensors. A system can also include a control system. A user interface may be included. The user interface may be attached or connected to the control system and/or support element. The object sensors may be oriented in multiple, separate directions.

Abstract: Compound of formula I are antagonists of the PGD2 receptor, CRTH2, and as such are useful in the treatment and/or prevention of CRTH2-mediated diseases such as asthma.

Abstract: A wood chipper comprises a frame, an infeed system, a rotatable cutting system, and at least one feed wheel disposed between the infeed system and the cutting system to feed wood material to the cutting system. The wood chipper also includes a winch comprising a winch line having a first end, and a collar disposed adjacent the first end of the winch line. The wood chipper further includes a detector adapted to detect a first and a second position of the winch line, wherein the detector is adapted to allow operation of the at least one feed wheel and prohibit operation of the winch when the first position of the winch line is detected, and to allow operation of the winch and allow operation of the at least one feed wheel in a predefined manner when the second position is detected.

Abstract: A wood chipper comprises a frame, an infeed system, a rotatable cutting system, and at least one feed wheel disposed between the infeed system and the cutting system to feed wood material to the cutting system. The wood chipper also includes a winch comprising a winch line having a first end, and a collar disposed adjacent the first end of the winch line. The wood chipper further includes a detector adapted to detect a first and a second position of the winch line, wherein the detector is adapted to allow operation of the at least one feed wheel and prohibit operation of the winch when the first position of the winch line is detected, and to allow operation of the winch and allow operation of the at least one feed wheel in a predefined manner when the second position is detected.

Abstract: Rotating flow control diverters and rotating blow our preventers having stabilized bearings. The bearing elements are stabilized in a neutral operational position using coil springs disposed in passages in a shoulder defined on the outer surface of the rotating tubular shaft of the rotating flow control device.

Abstract: A knife assembly for a waste processing system comprises a plurality of cutters disposed on a drum. The cutters further comprise a cutter body, a knife assembly including a first clamp, a second clamp, and a knife. The knife is removably affixed between the first and second clamp and has at least one cutting surface which extends beyond respective ends of the first and second clamps, whereby the cutter body and knife assembly are operably disposed on a drum for a waste processing system.

Abstract: a waste processing machine for reducing wood waste comprises an accumulator operatively connected to the cutting system so as to power the cutting system upon discharge thereof. The accumulator is adapted to receive, store, and release a charge developed from a charging device operatively connected to the accumulator and one or more systems of the waste processing machine.

Abstract: The invention is directed to indole and indoline cyclopropyl amide derivatives as EP4 receptor antagonists useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis, rheumatoid arthritis and cancer. Pharmaceutical compositions and methods of use are also included.