Patents by Inventor Michael Brines

Michael Brines has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11434649
    Abstract: A support device with at least first and second support members movable with respect to each other in a direction parallel to their longitudinal axes. The support device having distal ends and the distal ends each including an anchor portion to engage directly or indirectly with a suitable surface in use, the support device including a biasing assembly for biasing one or more of the distal ends of the support device into engagement with a suitable surface in use, and the biasing assembly is located at or adjacent an end of at least one of said first and second support members and between said support member end and the anchor portion nearest to said support member end. The support device is particularly suited to a safety fence or assembly or a worker protection system.
    Type: Grant
    Filed: October 31, 2019
    Date of Patent: September 6, 2022
    Assignee: RAPID EPS LTD
    Inventor: David Michael Brine
  • Publication number: 20210107942
    Abstract: The present invention provides peptides an peptide analogs that have tissue protective activities while having little or no potentionally undesirable hematopoietic effects. The peptides and peptide analogs are useful in preventing and treating a variety of diseases and disorders associated with tissue damage.
    Type: Application
    Filed: May 19, 2020
    Publication date: April 15, 2021
    Inventors: Michael Brines, Anthony Cerami
  • Patent number: 10864253
    Abstract: Provided herein are peptides and peptide analogs that have tissue protective activities. The peptides and peptide analogs are useful in preventing and treating a variety of diseases and disorders associated with tissue damage.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: December 15, 2020
    Assignee: Araim Pharmaceuticals, Inc.
    Inventors: Michael Brines, Anthony Cerami
  • Publication number: 20200360476
    Abstract: The present invention provides peptides and peptide analogs that have tissue protective activities while having little or no potentially undesireable hematopoietic effects. The peptides and peptide analogs are useful in preventing and treating a variety of diseases and disorders associated with tissue damage.
    Type: Application
    Filed: December 20, 2019
    Publication date: November 19, 2020
    Inventors: Anthony Cerami, Michael Brines
  • Publication number: 20200141138
    Abstract: A support device with at least first and second support members movable with respect to each other in a direction parallel to their longitudinal axes. The support device having distal ends and the distal ends each including an anchor portion to engage directly or indirectly with a suitable surface in use, the support device including a biasing assembly for biasing one or more of the distal ends of the support device into engagement with a suitable surface in use, and the biasing assembly is located at or adjacent an end of at least one of said first and second support members and between said support member end and the anchor portion nearest to said support member end.
    Type: Application
    Filed: October 31, 2019
    Publication date: May 7, 2020
    Inventor: David Michael Brine
  • Publication number: 20190134156
    Abstract: Provided herein are peptides and peptide analogs that have tissue protective activities. The peptides and peptide analogs are useful in preventing and treating a variety of diseases and disorders associated with tissue damage.
    Type: Application
    Filed: April 28, 2017
    Publication date: May 9, 2019
    Inventors: Michael Brines, Anthony Cerami
  • Publication number: 20190016769
    Abstract: The present invention is directed to novel tissue protective peptides. The tissue protective peptides of the invention may bind to a tissue protective receptor complex. In particular, the present invention is drawn to tissue protective peptides derived from or sharing consensus sequences with portions of cytokine receptor ligands, including Erythropoietin (EPO), that are not involved in the binding of the ligand to the receptor complex, e.g., to the EPO receptor homodimer. Accordingly, the tissue protective peptides of the invention are derived from the amino acid sequences of regions of cytokine receptor ligands that are generally located on or within the region of the ligand protein that is opposite of the receptor complex, i.e., are generally derived from amino acid sequences of regions of the ligand protein that face away from the receptor complex while the ligand is bound to the receptor.
    Type: Application
    Filed: September 25, 2018
    Publication date: January 17, 2019
    Applicant: Araim Pharmaceuticals, Inc.
    Inventors: Anthony Cerami, Michael Brines, Thomas Coleman
  • Patent number: 10100096
    Abstract: The present invention is directed to novel tissue protective peptides. The tissue protective peptides of the invention may bind to a tissue protective receptor complex. In particular, the present invention is drawn to tissue protective peptides derived from or sharing consensus sequences with portions of cytokine receptor ligands, including Erythropoietin (EPO), that are not involved in the binding of the ligand to the receptor complex, e.g., to the EPO receptor homodimer. Accordingly, the tissue protective peptides of the invention are derived from the amino acid sequences of regions of cytokine receptor ligands that are generally located on or within the region of the ligand protein that is opposite of the receptor complex, i.e., are generally derived from amino acid sequences of regions of the ligand protein that face away from the receptor complex while the ligand is bound to the receptor.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: October 16, 2018
    Assignee: Araim Pharmaceuticals, Inc.
    Inventors: Anthony Cerami, Michael Brines, Thomas Coleman
  • Publication number: 20170232066
    Abstract: The present invention provides peptides and peptide analogs that have tissue protective activities while having little or no potentially undesirable hematopoietic effects. The peptides and peptide analogs are useful in preventing and treating a variety of diseases and disorders associated with tissue damage.
    Type: Application
    Filed: January 30, 2017
    Publication date: August 17, 2017
    Inventors: Anthony CERAMI, Michael BRINES
  • Patent number: 9580465
    Abstract: The present invention provides peptides and peptide analogs that have tissue protective activities while having little or no potentially undesirable hematopoetic effects. The peptides and peptide analogs are useful in preventing and treating a variety of diseases and disorders associated with tissue damage.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: February 28, 2017
    Assignee: Araim Pharmaceuticals, Inc.
    Inventors: Anthony Cerami, Michael Brines
  • Publication number: 20160244498
    Abstract: The present invention is directed to novel tissue protective peptides. The tissue protective peptides of the invention may bind to a tissue protective receptor complex. In particular, the present invention is drawn to tissue protective peptides derived from or sharing consensus sequences with portions of cytokine receptor ligands, including Erythropoietin (EPO), that are not involved in the binding of the ligand to the receptor complex, e.g., to the EPO receptor homodimer. Accordingly, the tissue protective peptides of the invention are derived from the amino acid sequences of regions of cytokine receptor ligands that are generally located on or within the region of the ligand protein that is opposite of the receptor complex, i.e., are generally derived from amino acid sequences of regions of the ligand protein that face away from the receptor complex while the ligand is bound to the receptor.
    Type: Application
    Filed: May 5, 2016
    Publication date: August 25, 2016
    Applicant: Araim Pharmaceuticals, Inc.
    Inventors: Anthony Cerami, Michael Brines, Thomas Coleman
  • Publication number: 20160168199
    Abstract: The present invention provides peptides and peptide analogs that have tissue protective activities while having little or no potentially undesirable hematopoietic effects. The peptides and peptide analogs are useful in preventing and treating a variety of diseases and disorders associated with tissue damage.
    Type: Application
    Filed: July 16, 2014
    Publication date: June 16, 2016
    Inventors: Michael Brines, Anthony Cerami
  • Patent number: 9340598
    Abstract: The present invention is directed to novel tissue protective peptides. The tissue protective peptides of the invention may bind to a tissue protective receptor complex. In particular, the present invention is drawn to tissue protective peptides derived from or sharing consensus sequences with portions of cytokine receptor ligands, including Erythropoietin (EPO), that are not involved in the binding of the ligand to the receptor complex, e.g., to the EPO receptor homodimer. Accordingly, the tissue protective peptides of the invention are derived from the amino acid sequences of regions of cytokine receptor ligands that are generally located on or within the region of the ligand protein that is opposite of the receptor complex, i.e., are generally derived from amino acid sequences of regions of the ligand protein that face away from the receptor complex while the ligand is bound to the receptor.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: May 17, 2016
    Assignee: Araim Pharmaceuticals, Inc.
    Inventors: Anthony Cerami, Michael Brines, Thomas Coleman
  • Publication number: 20150239932
    Abstract: The present invention provides peptides and peptide analogs that have tissue protective activities while having little or no potentially undesirable hematopoetic effects. The peptides and peptide analogs are useful in preventing and treating a variety of diseases and disorders associated with tissue damage.
    Type: Application
    Filed: September 30, 2014
    Publication date: August 27, 2015
    Inventors: Anthony CERAMI, Michael BRINES
  • Publication number: 20150152156
    Abstract: The present invention is directed to novel tissue protective peptides. The tissue protective peptides of the invention may bind to a tissue protective receptor complex. In particular, the present invention is drawn to tissue protective peptides derived from or sharing consensus sequences with portions of cytokine receptor ligands, including Erythropoietin (EPO), that are not involved in the binding of the ligand to the receptor complex, e.g., to the EPO receptor homodimer. Accordingly, the tissue protective peptides of the invention are derived from the amino acid sequences of regions of cytokine receptor ligands that are generally located on or within the region of the ligand protein that is opposite of the receptor complex, i.e., are generally derived from amino acid sequences of regions of the ligand protein that face away from the receptor complex while the ligand is bound to the receptor.
    Type: Application
    Filed: February 10, 2015
    Publication date: June 4, 2015
    Inventors: Anthony Cerami, Michael Brines, Thomas Coleman
  • Publication number: 20140323401
    Abstract: The present invention is directed to novel tissue protective peptides. The tissue protective peptides of the invention may bind to a tissue protective receptor complex. In particular, the present invention is drawn to tissue protective peptides derived from or sharing consensus sequences with portions of cytokine receptor ligands, including Erythropoietin (EPO), that are not involved in the binding of the ligand to the receptor complex, e.g., to the EPO receptor homodimer. Accordingly, the tissue protective peptides of the invention are derived from the amino acid sequences of regions of cytokine receptor ligands that are generally located on or within the region of the ligand protein that is opposite of the receptor complex, i.e., are generally derived from amino acid sequences of regions of the ligand protein that face away from the receptor complex while the ligand is bound to the receptor.
    Type: Application
    Filed: April 8, 2014
    Publication date: October 30, 2014
    Applicant: Araim Pharmaceuticals, Inc.
    Inventors: Anthony CERAMI, Michael BRINES, Thomas COLEMAN
  • Patent number: 8853358
    Abstract: The present invention provides peptides and peptide analogs that have tissue protective activities while having little or no potentially undesirable hematopoietic effects. The peptides and peptide analogs are useful in preventing and treating a variety of diseases and disorders associated with tissue damage.
    Type: Grant
    Filed: January 22, 2009
    Date of Patent: October 7, 2014
    Assignee: Araim Pharmaceuticals, Inc.
    Inventors: Anthony Cerami, Michael Brines
  • Patent number: 8716245
    Abstract: Provided herein are tissue protective peptides derived from or sharing consensus sequences with portions of cytokine receptor ligands, including Erythropoietin (EPO), that are generally located on or within the region of the cytokine receptor ligand that faces away from a receptor complex while the ligand is bound to the receptor. Also provide herein are fragments, chimeras, as well as peptides designed to mimic the spatial localization of key amino acid residues within the tissue protective receptor ligands, e.g., EPO; methods for treating or preventing a disease or disorder using tissue protective peptides; and methods for enhancing excitable tissue function using tissue protective peptides.
    Type: Grant
    Filed: October 20, 2011
    Date of Patent: May 6, 2014
    Assignee: Araim Pharmaceuticals, Inc.
    Inventors: Anthony Cerami, Michael Brines, Thomas Coleman
  • Patent number: 8673861
    Abstract: Provided herein are tissue protective peptides derived from or sharing consensus sequences with portions of cytokine receptor ligands, including Erythropoietin (EPO), that are generally located on or within the region of the cytokine receptor ligand that faces away from a receptor complex while the ligand is bound to the receptor. Also provide herein are fragments, chimeras, as well as peptides designed to mimic the spatial localization of key amino acid residues within the tissue protective receptor ligands, e.g., EPO; methods for treating or preventing a disease or disorder using tissue protective peptides; and methods for enhancing excitable tissue function using tissue protective peptides.
    Type: Grant
    Filed: April 16, 2012
    Date of Patent: March 18, 2014
    Assignee: Araim Pharmaceuticals, Inc.
    Inventors: Anthony Cerami, Michael Brines, Thomas Coleman
  • Publication number: 20130102530
    Abstract: Methods and compositions are provided for protecting or enhancing an erythropoietin-responsive cell, tissue, organ or body part function or viability in vivo, in situ or ex vivo in mammals, including human beings, by systemic or local administration of an erythropoietin receptor activity modulator, such as an erythropoietin or a modified erythropoietin.
    Type: Application
    Filed: June 13, 2012
    Publication date: April 25, 2013
    Applicant: The Kenneth S. Warren Institute, Inc.
    Inventors: Michael Brines, Anthony Cerami, Carla Cerami