Abstract: A vacuum aspiration system and methods of use are disclosed. The system and method can be configured to provide deep pulsatile suction to a catheter body to more efficiently aspirate a clot material from a patient. In some embodiments, a deep pulse can include a rapid increase in flow rate of the fluid through the catheter body to a sustained high flow rate range for a short period of time followed by a rapid decrease in the flow rate to a low or negligible flow rate level to minimize blood loss without any changes to the suction pressure being applied to the catheter.

Abstract: A hemostasis valve may be used with a catheter such as an aspiration catheter. The hemostasis valve comprises a support, and at least a first lever, pivotably carried with respect to the support. A collapsible tubular sidewall defining a valve lumen is carried by the support. A filament is formed into a loop around the tubular sidewall, the filament having at least a first tail portion extending away from the loop to the first lever. A first spring may be configured to move the first lever in a direction that pulls the first tail portion away from the tubular sidewall, reducing the diameter of the valve lumen in response to reducing the diameter of the loop. A second tail portion may extend away from the loop to a second lever. Each tail portion may be attached to its respective lever, or may be slidably advanceable around a fulcrum on the lever and attached with respect to the support.

Abstract: A vacuum aspiration system and methods of use are disclosed. The system and method can be configured to provide deep pulsatile suction to a catheter body to more efficiently aspirate a clot material from a patient. In some embodiments, a deep pulse can include a rapid increase in flow rate of the fluid through the catheter body to a sustained high flow rate range for a short period of time followed by a rapid decrease in the flow rate to a low or negligible flow rate level to minimize blood loss without any changes to the suction pressure being applied to the catheter.

Abstract: A hemostasis valve may be used with a catheter such as an aspiration catheter. The hemostasis valve comprises a support, and at least a first lever, pivotably carried with respect to the support. A collapsible tubular sidewall defining a valve lumen is carried by the support. A filament is formed into a loop around the tubular sidewall, the filament having at least a first tail portion extending away from the loop to the first lever. A first spring may be configured to move the first lever in a direction that pulls the first tail portion away from the tubular sidewall, reducing the diameter of the valve lumen in response to reducing the diameter of the loop. A second tail portion may extend away from the loop to a second lever. Each tail portion may be attached to its respective lever, or may be slidably advanceable around a fulcrum on the lever and attached with respect to the support.

Abstract: There is a housing preferably for accommodating electrical components. The housing has the following: (A) at least one first housing part and at least one second housing part, which form a closed housing when assembled, (B) at least the first housing part has a circumferential edge or circumferential contour in an edge area, (C) at least one compressible element, which is at least arranged on the circumferential edge or in or on the circumferential contour, and which is arranged between the first housing part and the second housing part in the assembled state, and (D) and at least one first electrically conductive layer. The first electrically conductive layer covers the inside of the first housing part in the assembled state of the housing.

Abstract: A blood reintroduction system may include a canister configured to collect blood. The system may include an inlet configured to be fluidly connected to a first tubing in fluid communication with an aspiration system configured to apply aspiration to a vasculature of a patient. The system may include a first outlet configured to be fluidly connected to a second tubing in fluid communication with an aspiration pump. The system may include a second outlet configured to interact with a blood reintroduction device, wherein the blood reintroduction device is configured to withdraw the blood collected inside the canister. The system may include a filter positioned inside a flow path leading to the second outlet.

Abstract: A blood reintroduction system may include a canister configured to collect blood. The system may include an inlet configured to be fluidly connected to a first tubing in fluid communication with an aspiration system configured to apply aspiration to a vasculature of a patient. The system may include a first outlet configured to be fluidly connected to a second tubing in fluid communication with an aspiration pump. The system may include a second outlet configured to interact with a blood reintroduction device, wherein the blood reintroduction device is configured to withdraw the blood collected inside the canister. The system may include a filter positioned inside a flow path leading to the second outlet.

Abstract: A blood reintroduction system can include a canister having a chamber configured to collect blood. A system may include an inlet configured to fluidically connect the chamber to a first tubing in fluid communication with an aspiration catheter. A system may include a first filter within the chamber, wherein the first filter is configured to separate blood from thrombus. A system may include a second filter downstream of the first filter, wherein the second filter is configured to separate blood from thrombus. A system may include a second tubing connected to an outlet of the chamber, wherein the second tubing is configured to reintroduce filtered blood from the chamber to a patient's vasculature.

Abstract: An insulator device for a battery housing, the battery housing comprising at least one housing wall for enclosing an interior for receiving a battery cell arrangement, the insulator device comprising at least one first insulating layer arranged between the battery cell arrangement and the housing wall in the interior, wherein the at least one first insulating layer is configured for electrical and thermal insulation of the battery cell arrangement.

Abstract: A thrombus engagement tool having a flexible shaft, a clot engagement tip, and a handle. The engagement tip may include one or more radially outwardly extending structures such as a helical thread. The helical thread can be advanced through a catheter to engage a clot. The handle may be configured to be rotated by hand. When the handle is rotated, the helical thread of the engagement tip can rotate in the same direction thereby allowing the helical threat to engage the clot. The helical thread can wrap around the flexible shaft at least about one, two, or four or more full revolutions, but in some cases no more than about ten or no more than about six revolutions.

Abstract: A blood reintroduction system may include a canister configured to collect blood. The system may include an inlet configured to be fluidly connected to a first tubing in fluid communication with an aspiration system configured to apply aspiration to a vasculature of a patient. The system may include a first outlet configured to be fluidly connected to a second tubing in fluid communication with an aspiration pump. The system may include a second outlet configured to interact with a blood reintroduction device, wherein the blood reintroduction device is configured to withdraw the blood collected inside the canister. The system may include a filter positioned inside a flow path leading to the second outlet.

Abstract: Disclosed is an object identification code attachable to a physical object as well as a corresponding method for identifying a physical object using the object identification code. The object identification code may comprise a plurality of machine-readable optical codes, wherein each of the plurality of optical codes may be configured to encode a unique identifier of the physical object, to be independently scannable by a camera of an electronic device, to cause upon being scanned an object identification procedure to be performed by an object identification application of the electronic device and to be dynamically linkable to each other to form a predetermined scan pattern for at least one of verifying authenticity of the physical object and/or reaching a target address associated with the physical object.

Abstract: A counterflow temperature control device for the temperature control of at least one object, comprising at least one first temperature control section including at least one first flow channel for a temperature control medium to flow through in a first flow direction from a first channel inflow to a first channel outflow along a first flow path, and at least one second temperature control section including at least one second flow channel for a second temperature control medium to flow therethrough in a second flow direction from a second channel inflow to an opposite second channel outflow along a second flow path, wherein the first flow direction is designed to extend substantially opposite to the second flow direction, and wherein the at least one first and second flow channels are in thermally conductive connection with the at least one object to be temperature-controlled.

Abstract: A multi-channel temperature control device with at least one temperature control body comprising at least two flow channels, each with a channel cross-section for the flow of a temperature control medium along a flow path from a channel inlet to a channel outlet, at least one distribution channel for supplying the temperature control medium to at least two channel inlets, and at least one return collection channel for discharging the temperature control medium from at least two channel outlets, wherein at least two flow channels are connected in a materially bonded or adhesive manner to at least one distribution channel and/or to at least one return collection channel, and/or wherein at least two flow channels are integrally formed with at least one distribution channel and/or with at least one return collection channel across at least a part of the circumference of the channel cross-section.

Abstract: A large bore catheter has a guiding rail extending therethrough and an advance segment of the rail extends at least about 10 cm beyond the distal end of the catheter. The advance segment is advanced from the vena cava through the tricuspid and pulmonary valves of the heart into the central pulmonary artery while the distal end of the large bore catheter remains in the vena cava. The large bore catheter is thereafter distally advanced over the rail until the large bore catheter distal end is at least as far as the central pulmonary artery. The rail is thereafter proximally removed from the large bore catheter, and at least a portion of a clot is drawn from a pulmonary artery into the large bore catheter.

Abstract: A clot capture module can include a housing, a chamber inside the housing, a window, and a filter. The window permits visual inspection of a clot inside the chamber. The clot can access the chamber via an incoming flow path configured to direct blood from an aspiration catheter to an upstream surface of the filter. An aspiration control valve can block the flow of incoming aspirated blood until actuated to permit inflow of aspirated blood. An outgoing flow path can direct blood from a downstream surface of the filter to a remote vacuum canister.

Abstract: A clot capture module can include a housing, a chamber inside the housing, a window, and a filter. The window permits visual inspection of a clot inside the chamber. The clot can access the chamber via an incoming flow path configured to direct blood from an aspiration catheter to an upstream surface of the filter. An aspiration control valve can block the flow of incoming aspirated blood until actuated to permit inflow of aspirated blood. An outgoing flow path can direct blood from a downstream surface of the filter to a remote vacuum canister.

Abstract: A clot capture module can include a housing, a chamber inside the housing, a window, and a filter. The window permits visual inspection of a clot inside the chamber. The clot can access the chamber via an incoming flow path configured to direct blood from an aspiration catheter to an upstream surface of the filter. An aspiration control valve can block the flow of incoming aspirated blood until actuated to permit inflow of aspirated blood. An outgoing flow path can direct blood from a downstream surface of the filter to a remote vacuum canister.

Abstract: A clot capture module can include a housing, a chamber inside the housing, a window, and a filter. The window permits visual inspection of a clot inside the chamber. The clot can access the chamber via an incoming flow path configured to direct blood from an aspiration catheter to an upstream surface of the filter. An aspiration control valve can block the flow of incoming aspirated blood until actuated to permit inflow of aspirated blood. An outgoing flow path can direct blood from a downstream surface of the filter to a remote vacuum canister.

Abstract: A thrombus engagement tool having a flexible shaft, a clot engagement tip, and a handle. The engagement tip may include one or more radially outwardly extending structures such as a helical thread. The helical thread can be advanced through a catheter to engage a clot. The handle may be configured to be rotated by hand. When the handle is rotated, the helical thread of the engagement tip can rotate in the same direction thereby allowing the helical threat to engage the clot. The helical thread can wrap around the flexible shaft at least about one, two, or four or more full revolutions, but in some cases no more than about ten or no more than about six revolutions.