Patents by Inventor Michael C. Brown

Michael C. Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6227961
    Abstract: A fan control system suitable for use in air moving applications has a pressure sensor responsive to an air pressure in an air duct for supplying a static pressure signal representative of the air pressure. A supply air flow sensor is responsive to an air flow in a supply air duct and supplies a supply air flow signal representative of the air flow in the supply air duct. A return air flow sensor is responsive to an air flow in a return air duct and supplies a return air flow signal representative of the air flow in the return air duct. A supply fan moves air in the supply air duct. The supply fan is driven by a supply fan motor. A return fan moves air in the return air duct. The return fan is driven by a return fan motor. A unitary volumetric air flow controller is connected to the supply fan motor and to the return fan motor.
    Type: Grant
    Filed: January 14, 1999
    Date of Patent: May 8, 2001
    Assignee: General Electric Company
    Inventors: Scott W. Moore, Terry L. Webb, Michael C. Brown
  • Patent number: 5476190
    Abstract: A vending machine for dispensing relatively flat, thin articles, and particularly for dispensing valuable articles such as debit cards and tickets. The articles to be dispensed are stored in removable chutes. Lockable covers are provided for the chutes so as to provide safe transportation containers for the valuable articles. Automatic device is provided for displacing the covers upon insertion of the chutes into the dispensing mechanism so as to prepare the mechanism for immediately dispensing the articles and eliminating the need to totally remove the covers during usage.
    Type: Grant
    Filed: September 22, 1994
    Date of Patent: December 19, 1995
    Assignee: Lottery Enterprises Inc.
    Inventors: Herbert L. Herrmann, Jeffrey A. Belka, Michael C. Brown
  • Patent number: 5436319
    Abstract: Cell-free or released T cell antigen receptors, immunoassays which allow the detection of the released T cell antigen receptor in cell culture supernatants, cell lysates, and biological fluids, as well as diagnostic and therapeutic compositions and methods for monitoring and treating certain diseases or disorders which elicit or involve a T cell response are described. The released T cell antigen receptors described herein differ from the cell membrane bound antigen receptors and appear to exist in a variety of forms, some of which may be complexed with other T cell determinants such as the T3 antigen. Despite the size heterogeneity of the released T cell antigen receptors or receptor/complexes, these may be reliably identified using anti-receptor antibodies, including, but not limited to, anti-major framework, anti-minor frarmework and anti-clonotypic antibodies which define particular epitopes of the released T cell receptor or receptor/complex.
    Type: Grant
    Filed: September 26, 1994
    Date of Patent: July 25, 1995
    Assignee: T Cell Sciences, Inc.
    Inventors: Patrick C. Kung, Stephen H. Ip, Michael C. Brown
  • Patent number: 5292636
    Abstract: The present invention is directed to the measurement of soluble T cell growth factor receptors, soluble T cell differentiation antigens, or related soluble molecules or fragments thereof, and the use of such measurements in the diagnosis, staging, and therapy of diseases and disorders. Specific embodiments involve the diagnosis and monitoring of therapy using absolute values of such soluble molecules. Further embodiments involve detecting a change in the levels of such soluble molecules, in the diagnosis and therapy of diseases and disorders. In specific embodiments, measurements of interleukin-2 receptor levels can be made to detect lung cancer, or to stage squamous cell lung carcinoma. In other embodiments, detection of increases in both soluble IL2R and creatinine in the body fluid of a transplant patient can be used to differentially diagnose renal allograft rejection from infection.
    Type: Grant
    Filed: November 9, 1989
    Date of Patent: March 8, 1994
    Assignee: T Cell Diagnostics, Inc.
    Inventors: Patrick C. Kung, Stephen H. Ip, Michael C. Brown, Linda A. MacKeen
  • Patent number: 4845026
    Abstract: Methods are provided for detecting and determining the amount in a sample of an antigenic determinant from an antigen receptor derived and released from a T cell or NK cell. Methods are also provided for detecting and determining the amount in a sample of an antigenic determinant from a complex of at least a portion of an antigen receptor derived from and released from a T cell or NK cell and a protein complex. These methods form the bases for methods of diagnosing and monitoring in a subject a disease characterized by the presence or an amount different from a normal subject of one of these antigenic determinants in a body fluid. A soluble antigen receptor or complex thereof derived from a T cell or a NK cell but free of such T cell or NK cell is also provided.
    Type: Grant
    Filed: December 3, 1985
    Date of Patent: July 4, 1989
    Assignee: T Cell Sciences, Inc.
    Inventors: Patrick C. Kung, Michael C. Brown, Stephen H. Ip
  • Patent number: 4637986
    Abstract: Lysing reagents for use in flow cytometry instruments. Lysing reagents suitable for lysing red blood cells are provided thereby permitting 3-part differential counting of white blood cells. The reagents comprise a leukoprotective agent for preserving the lymphocyte cellular integrity during analysis, and buffers adjusted to provide the correct pH environment for optimal lysis and activity. Preferred embodiments will additionally incorporate non-ionic preservatives in very low concentrations.
    Type: Grant
    Filed: August 22, 1983
    Date of Patent: January 20, 1987
    Assignee: Ortho Diagnostic Systems, Inc.
    Inventors: Michael C. Brown, Stefan J. Kirchanski
  • Patent number: 4434150
    Abstract: An immunological substance detecting reagent is provided which, in the preferred embodiment, employs an immunological homolog specific for the immunological substance to be detected coupled to a water-soluble polymer having a net charge not greater than zero. The water-soluble polymer further has associated a plurality of marker substances such as fluorophore molecules thereby providing a reagent of increased sensitivity for the detection of an antigen-antibody immunological reaction.
    Type: Grant
    Filed: October 19, 1981
    Date of Patent: February 28, 1984
    Assignee: Ortho Diagnostic Systems, Inc.
    Inventors: A. R. M. Azad, Stefan J. Kirchanski, Michael C. Brown