Abstract: Disclosed herein are deuterium-enriched N-Aryl pyridinone compounds, optionally in combination with one or more additional therapeutic agents, pharmaceutical compositions comprising the same, methods of preparation thereof, and methods of use thereof. Such compounds and compositions are useful, for example, in treating diseases, disorders, or conditions such as edema.

Abstract: Embodiments of the present disclosure provide a locking assembly for an attachment system of an electronic device. More specifically, embodiments of the present disclosure are directed to an attachment unit that is configured to be inserted and removed from a housing of a consumer product. The attachment unit and/or the housing includes a catch member or other such locking assembly configured to relaseably secure the attachment unit within the housing.

Abstract: This application provides a system for classifying a status of anhedonia, the system including an audio data collector adapted to collect a sample of speech, and a processing module including an audio feature extractor and a classification unit, wherein the audio feature extractor extracts a plurality of acoustic features from the sample of speech, and the classification unit classifies a status of anhedonia from the plurality of acoustic features.

Abstract: Embodiments presented herein describe techniques for tracking operators of a distributed computing environment (e.g., a streams processing environment) using metadata. During execution of a distributed application of the computing environment, a tracker tool monitors a plurality of operators of the distributed application. Each of the operators stores one or more specified metadata values associated with the operator. For each operator, the tracker tool retrieves the one or more specified metadata values associated with the operator. Upon determining that one of the one or more specified metadata values do not comply with a corresponding expected metadata value, the tracker tool generates an indicator for the operator. The indicator includes information describing the one or more specified metadata values.

Abstract: An all fiber wavelength selective coupler provides wavelength selective transfer of optical energy between two or more separated waveguides. The coupler includes signal cores that are separated enough that they can be fusion spliced to standard fibers as lead-in and lead-out pigtails. A bridge between the signal cores facilitates transfer of the optical energy through a process of evanescent coupling. In one example, the bridge is formed of a series of graded index cores.

Abstract: Some embodiments of the invention provide a GUI for a media editing application that provides visual cues (e.g., colors and/or lane sets) for media clips that are assigned different tags (or roles) in a media presentation. The GUI of the media application of some embodiments displays media clips of a composite media presentation, in which at least some of the media clips are associated with tags. The GUI also provides GUI controls for associating media clips associated with different tags with different colors and for displaying the media clips based on the clips' associated color. In some embodiments, the GUI includes a tool for arranging clips into groups based on assigned tags. The tool of some embodiments, upon selection, defines a set of lanes for each tag and displays any anchored clip that is associated with a tag in the set of lanes associated with the tag.

Abstract: System and method for generating notifications when a person is in a driving state, in a non-driving state, and optionally a destination arrival notification so that interested parties, such as family members, friends and/or co-workers, can make informed and proactive decisions to not call or text the person while driving is described. With push notifications, interested parties can thus make informed decisions and purposely delay making a phone call or texting a driver until after they have arrived at their destination and are no longer driving. As a result, drivers are not needlessly distracted, significantly improving road safety.

Abstract: Some embodiments of the invention provide a GUI for a media editing application that provides visual cues (e.g., colors and/or lane sets) for media clips that are assigned different tags (or roles) in a media presentation. The GUI of the media application of some embodiments displays media clips of a composite media presentation, in which at least some of the media clips are associated with tags. The GUI also provides GUI controls for associating media clips associated with different tags with different colors and for displaying the media clips based on the clips' associated color. In some embodiments, the GUI includes a tool for arranging clips into groups based on assigned tags. The tool of some embodiments, upon selection, defines a set of lanes for each tag and displays any anchored clip that is associated with a tag in the set of lanes associated with the tag.

Abstract: Some embodiments of the invention provide a GUI for a media editing application that provides visual cues (e.g., colors and/or lane sets) for media clips that are assigned different tags (or roles) in a media presentation. The GUI of the media application of some embodiments displays media clips of a composite media presentation, in which at least some of the media clips are associated with tags. The GUI also provides GUI controls for associating media clips associated with different tags with different colors and for displaying the media clips based on the clips' associated color. In some embodiments, the GUI includes a tool for arranging clips into groups based on assigned tags. The tool of some embodiments, upon selection, defines a set of lanes for each tag and displays any anchored clip that is associated with a tag in the set of lanes associated with the tag.

Abstract: System and method for generating notifications when a person is in a driving state, in a non-driving state, and optionally a destination arrival notification so that interested parties, such as family members, friends and/or co-workers, can make informed and proactive decisions to not call or text the person while driving is described. With push notifications, interested parties can thus make informed decisions and purposely delay making a phone call or texting a driver until after they have arrived at their destination and are no longer driving. As a result, drivers are not needlessly distracted, significantly improving road safety.

Abstract: A knitted structure is configured for heat generation and distribution. In some embodiments, the knitted structure includes a knitted fabric including a first knitted layer and a second knitted layer opposite the first knitted layer. The first knitted layer has a first thermal conductivity. The second knitted layer has a second thermal conductivity. The second thermal conductivity is greater than the first thermal conductivity to faciliate heat transfer toward the first knitted layer. The knitted structure may further include a plurality of electrodes at least partially disposed inside the knitted fabric. Each of the plurality of electrodes is configured to generate heat within the knitted fabric upon receipt of electrical energy in order to distribute heat along the knitted structure and toward the first knitted layer.

Abstract: The invention relates to the use of an amine masked moiety in a method of enzymatic nucleic acid synthesis. The invention also relates to said amine masked moieties per se and a process for preparing nucleotide triphosphates comprising said amine masked moieties.

Abstract: This application provides a system for classifying a status of anhedonia, the system including an audio data collector adapted to collect a sample of speech, and a processing module including an audio feature extractor and a classification unit, wherein the audio feature extractor extracts a plurality of acoustic features from the sample of speech, and the classification unit classifies a status of anhedonia from the plurality of acoustic features.

Abstract: The invention relates to a method of converting an azidomethyl ether substituent to a free hydroxyl group. The invention also relates to methods of nucleic acid synthesis and sequencing comprising the use of nucleotide triphosphates having a 3?-O-azidomethyl substituent, to kits comprising nucleotide triphosphates having a 3?-O-azidomethyl substituent and photoactivatable transition metal complex and to the use of said kits in methods of nucleic acid synthesis and sequencing.

Abstract: The invention relates to the use of specific terminal deoxynucleotidyl transferase (TdT) enzymes in a method of nucleic acid synthesis, to methods of synthesizing nucleic acids, and to the use of kits comprising said enzymes in a method of nucleic acid synthesis. The invention also relates to the use of terminal deoxynucleotidyl transferases and 3?-blocked nucleotide triphosphates in a method of template independent nucleic acid synthesis.

Abstract: The invention relates to a method of nucleic acid synthesis comprising the use of 3?-O-azidomethyl blocked nucleotide triphosphates which comprises the step of adding a capping group to any uncleaved 3?-O-azidomethyl groups and to the use of kits comprising said capping groups in a method of nucleic acid synthesis. The invention also relates to capped nucleotide triphosphates and 3?-O-azidomethyl capping groups.

Abstract: The invention relates to a device for attaching fixation elements to bone, having a longitudinal member with a channel extending therein adapted for receiving at least one fixation element. A shaft extends within the channel and is positioned coaxially within at least a portion of the longitudinal member and at least a portion of the shaft is retained within the longitudinal member and a distal end of the shaft is configured and adapted to contact at least a portion of the fixation element received within the longitudinal member. A spring is positioned adjacent the shaft for resiliently biasing the shaft in an axial direction and the shaft is moveable with respect to the longitudinal member to drive the fixation element into bone.

Abstract: In one embodiments, a method includes determining a current connection status of a first wireless device with respect to one or more second wireless devices configured to communicate wirelessly by a particular wireless communication protocol. The current connection status of the first wireless device potentially being that the first wireless device has scanned for and found one or more available ones of the second wireless devices to connect wirelessly to but has not yet having established a wireless connection to any one of them or potentially being that the first wireless device is currently attempting to establish a wireless connection to one of the available ones of the second wireless devices.

Abstract: A system and method are disclosed in which an initiating caller using a station connected to a data network receives advertisement information while waiting for a call to complete between the station and the receiving party. The station connects with a server that can access a database storing a plurality of advertisement information. The station includes a user interface, which allows the caller to interact with the station, and a flow controller, which monitors the bandwidth available to receive information from the server system.

Abstract: The invention provides polypeptides, polysaccharide-polypeptide conjugates, and expression vectors for treating or preventing pneumococcal infection. The compositions induce an anti-pneumococcal immune response when administered to a mammal. The compositions can be used prophylactically to vaccinate an individual and/or therapeutically to induce a therapeutic immune response in an infected individual.