Patents by Inventor Michael C. Murad

Michael C. Murad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200060821
    Abstract: A valve holder for delivering a prosthetic heart valve to an implant site is in various embodiments configured to reduce or eliminate the occurrence of suture looping or other damage to the prosthetic valve during implantation. The valve holder can be configured to deploy or actuate automatically when performing preparatory steps that are already familiar to practitioners, such as attaching a delivery handle to the valve holder, so that the valve holders will not require additional steps or training to use. Therefore, operation of the valve holders is kept simple, and occurrences of mistakes caused by user error can be minimized or reduced. Valve holders according to different embodiments can be designed to accommodate implantation of prosthetic heart valves from either the inflow end or the outflow end of the native valve annulus.
    Type: Application
    Filed: November 4, 2019
    Publication date: February 27, 2020
    Inventors: Brian S. Conklin, Michael C. Murad
  • Patent number: 10537430
    Abstract: A sizing tool for use in implanting a composite valved conduit having a prosthetic heart valve on a distal end attached to a conduit graft that extends to a proximal end. The tool includes a proximal handle and a distal shaft, a prosthetic heart valve sizer having an axis affixed to a distal end of the shaft, and a conduit graft replica having an axis mounted on the shaft proximal to the heart valve sizer. A method of securing a composite valved conduit includes introducing to an excised ascending aorta the sizing tool, measuring the aortic annulus with the prosthetic heart valve sizer, and determining whether the coronary arteries have sufficient length or whether an additional tubular coronary extension segment is required to add to one or both of the ends of the coronary arteries by extending the coronary arteries toward the conduit graft replica.
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: January 21, 2020
    Assignee: Edwards Lifesciences Corporation
    Inventors: Ruggero De Paulis, Michael C. Murad
  • Patent number: 10463485
    Abstract: A valve holder for delivering a prosthetic heart valve to an implant site is in various embodiments configured to reduce or eliminate the occurrence of suture looping or other damage to the prosthetic valve during implantation. The valve holder can be configured to deploy or actuate automatically when performing preparatory steps that are already familiar to practitioners, such as attaching a delivery handle to the valve holder, so that the valve holders will not require additional steps or training to use. Therefore, operation of the valve holders is kept simple, and occurrences of mistakes caused by user error can be minimized or reduced. Valve holders according to different embodiments can be designed to accommodate implantation of prosthetic heart valves from either the inflow end or the outflow end of the native valve annulus.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: November 5, 2019
    Assignee: Edwards Lifesciences Corporation
    Inventors: Brian S. Conklin, Michael C. Murad
  • Publication number: 20190321177
    Abstract: A holder for a prosthetic mitral heart valve that attaches to an inflow end of the valve and includes a simple tensioning mechanism that flexes the heart valve commissure posts inward to help prevent suture looping. The tensioning mechanism may include relatively movable rings of the holder or a generally unitary holder with a tensor, or rotatable knob. Connecting sutures thread through internal passages in the holder and travel in the outflow direction along valve commissure posts, emerging at the post tips and mutually crossing over the outflow side of the valve. A handle attaches off-center on the holder to increase visualization of and access to the heart valve through a central window for enhanced access to the commissure posts and leaflets. The holder is constructed of non-metallic materials so as to avoid interfering with imaging devices, and the handle is ergonomically curved and shaped to facilitate manipulation.
    Type: Application
    Filed: July 1, 2019
    Publication date: October 24, 2019
    Inventors: Alain F. Carpentier, Michael C. Murad
  • Publication number: 20190290261
    Abstract: Suture clip deployment devices for applying suture clips to sutures are described. Some embodiments can include a generally tubular main body and a vacuum port located at the distal end, a hollow inner body longitudinally slidable within the main body and extending from the main body at its distal end, and a suture recess located in the generally tubular main body. At least one suture clip configured to frictionally fit on an outer surface of the inner body is deployed during use. Clip deployment can occur after a vacuum source is applied to the device so as to draw the suture into the device. The suture lines can be retrieved through the suture recess, and the device can be actuated so as to deliver the suture clip off the delivery device and onto the suture, locking the suture in place.
    Type: Application
    Filed: June 10, 2019
    Publication date: September 26, 2019
    Inventors: Travis Zenyo Oba, Michael C. Murad, Manouchehr A. Miraki, Anthony P. Carcia, Fabian Daniel Schroeder, Raffaele Mazzei, Tyler Douglas Smith
  • Patent number: 10335274
    Abstract: A holder for a prosthetic mitral heart valve that attaches to an inflow end of the valve and includes a simple tensioning mechanism that flexes the heart valve commissure posts inward to help prevent suture looping. The tensioning mechanism may include relatively movable rings of the holder or a generally unitary holder with a tensor, or rotatable knob. Connecting sutures thread through internal passages in the holder and travel in the outflow direction along valve commissure posts, emerging at the post tips and mutually crossing over the outflow side of the valve. A handle attaches off-center on the holder to increase visualization of and access to the heart valve through a central window for enhanced access to the commissure posts and leaflets. The holder is constructed of non-metallic materials so as to avoid interfering with imaging devices, and the handle is ergonomically curved and shaped to facilitate manipulation.
    Type: Grant
    Filed: July 11, 2015
    Date of Patent: July 2, 2019
    Assignee: Edwards Lifesciences Corporation
    Inventors: Alain F. Carpentier, Michael C. Murad
  • Patent number: 10314573
    Abstract: Suture clip deployment devices for applying suture clips to sutures are described. Some embodiments can include a generally tubular main body and a vacuum port located at the distal end, a hollow inner body longitudinally slidable within the main body and extending from the main body at its distal end, and a suture recess located in the generally tubular main body. At least one suture clip configured to frictionally fit on an outer surface of the inner body is deployed during use. Clip deployment can occur after a vacuum source is applied to the device so as to draw the suture into the device. The suture lines can be retrieved through the suture recess, and the device can be actuated so as to deliver the suture clip off the delivery device and onto the suture, locking the suture in place.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: June 11, 2019
    Assignee: Edwards Lifesciences Corporation
    Inventors: Travis Zenyo Oba, Michael C. Murad, Manouchehr A. Miraki, Anthony P. Carcia, Fabian Daniel Schroeder, Raffaele Mazzei, Tyler Douglas Smith
  • Publication number: 20190046317
    Abstract: A valved conduit including a bioprosthetic aortic heart valve connected to a tubular conduit graft forming an ascending aorta. The conduit graft may attach to the heart valve in a manner that facilitates a redo operation in which the valve is replaced with another valve. A sewing ring may be pre-attached to the inflow end of the graft, and then the valve connected to a delivery holder advanced into the graft and secured to the sewing ring. Dry bioprosthetic valves coupled with conduit grafts sealed with a bioresorbable medium can be stored with the delivery holder.
    Type: Application
    Filed: August 2, 2018
    Publication date: February 14, 2019
    Inventors: Michael C. Murad, Hilda Z. Fann, Mark Van Nest, John X. Wang, Derrick Johnson
  • Publication number: 20180289477
    Abstract: A valve holder for delivering a prosthetic heart valve to an implant site is in various embodiments configured to reduce or eliminate the occurrence of suture looping or other damage to the prosthetic valve during implantation. The valve holder can be configured to deploy or actuate automatically when performing preparatory steps that are already familiar to practitioners, such as attaching a delivery handle to the valve holder, so that the valve holders will not require additional steps or training to use. Therefore, operation of the valve holders is kept simple, and occurrences of mistakes caused by user error can be minimized or reduced. Valve holders according to different embodiments can be designed to accommodate implantation of prosthetic heart valves from either the inflow end or the outflow end of the native valve annulus.
    Type: Application
    Filed: April 6, 2017
    Publication date: October 11, 2018
    Inventors: Brian S. Conklin, Michael C. Murad
  • Patent number: 10058425
    Abstract: A valved conduit including a bioprosthetic aortic heart valve connected to a tubular conduit graft forming an ascending aorta. The conduit graft may attach to the heart valve in a manner that facilitates a redo operation in which the valve is replaced with another valve. A sewing ring may be pre-attached to the inflow end of the graft, and then the valve connected to a delivery holder advanced into the graft and secured to the sewing ring. Dry bioprosthetic valves coupled with conduit grafts sealed with a bioresorbable medium can be stored with the delivery holder.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: August 28, 2018
    Assignee: Edwards Lifesciences Corporation
    Inventors: Michael C. Murad, Hilda Z. Fann, Mark Van Nest, John X. Wang
  • Publication number: 20180125653
    Abstract: An improved holder and storage system for a tissue-type prosthetic mitral heart valve that constricts the commissure posts of the valve and prevents suture looping. A rod axially movable relative to the holder tensions lengths of attachment sutures that extend between the commissure post tips to create a tent and flex the tips inward, thus helping to prevent looping of any of an array of pre-implanted sutures around the leading tips during delivery of the valve. The holder has a safety mechanism that prevents valve delivery before the rod is deployed. One embodiment automatically deploys the rod upon opening a storage jar. One embodiment permits a delivery handle to directly deploy the rod, while another uses a separate worm screw and coupling. A holder clip that attaches to a packaging sleeve may be formed of flexible members meshed together from which the heart valve and holder are easily pulled free to eliminate a step of decoupling the clip from the sleeve.
    Type: Application
    Filed: January 8, 2018
    Publication date: May 10, 2018
    Inventors: Michael C. Murad, Emil Karapetian, Wesley V. Adzich
  • Publication number: 20180104058
    Abstract: A sizing tool for use in implanting a composite valved conduit having a prosthetic heart valve on a distal end attached to a conduit graft that extends to a proximal end. The tool includes a proximal handle and a distal shaft, a prosthetic heart valve sizer having an axis affixed to a distal end of the shaft, and a conduit graft replica having an axis mounted on the shaft proximal to the heart valve sizer. A method of securing a composite valved conduit includes introducing to an excised ascending aorta the sizing tool, measuring the aortic annulus with the prosthetic heart valve sizer, and determining whether the coronary arteries have sufficient length or whether an additional tubular coronary extension segment is required to add to one or both of the ends of the coronary arteries by extending the coronary arteries toward the conduit graft replica.
    Type: Application
    Filed: December 18, 2017
    Publication date: April 19, 2018
    Inventors: Ruggero De Paulis, Michael C. Murad
  • Patent number: 9861478
    Abstract: An improved holder and storage system for a tissue-type prosthetic mitral heart valve that constricts the commissure posts of the valve and prevents suture looping. A rod axially movable relative to the holder tensions lengths of attachment sutures that extend between the commissure post tips to create a tent and flex the tips inward, thus helping to prevent looping of any of an array of pre-implanted sutures around the leading tips during delivery of the valve. The holder has a safety mechanism that prevents valve delivery before the rod is deployed. One embodiment automatically deploys the rod upon opening a storage jar. One embodiment permits a delivery handle to directly deploy the rod, while another uses a separate worm screw and coupling. A holder clip that attaches to a packaging sleeve may be formed of flexible members meshed together from which the heart valve and holder are easily pulled free to eliminate a step of decoupling the clip from the sleeve.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: January 9, 2018
    Assignee: Edwards Lifesciences Corporation
    Inventors: Michael C. Murad, Emil Karapetian, Wesley V. Adzich
  • Patent number: 9844436
    Abstract: A sizing tool for use in implanting a composite valved conduit having a prosthetic heart valve on a distal end attached to a conduit graft that extends to a proximal end. The tool includes a proximal handle and a distal shaft, a prosthetic heart valve sizer having an axis affixed to a distal end of the shaft, and a conduit graft replica having an axis mounted on the shaft proximal to the heart valve sizer. A method of securing a composite valved conduit includes introducing to an excised ascending aorta the sizing tool, measuring the aortic annulus with the prosthetic heart valve sizer, and determining whether the coronary arteries have sufficient length or whether an additional tubular coronary extension segment is required to add to one or both of the ends of the coronary arteries by extending the coronary arteries toward the conduit graft replica.
    Type: Grant
    Filed: October 24, 2013
    Date of Patent: December 19, 2017
    Assignee: Edwards Lifesciences Corporation
    Inventors: Ruggero De Paulis, Michael C. Murad
  • Publication number: 20170119375
    Abstract: Suture clip deployment devices for applying suture clips to sutures are described. Some embodiments can include a generally tubular main body and a vacuum port located at the distal end, a hollow inner body longitudinally slidable within the main body and extending from the main body at its distal end, and a suture recess located in the generally tubular main body. At least one suture clip configured to frictionally fit on an outer surface of the inner body is deployed during use. Clip deployment can occur after a vacuum source is applied to the device so as to draw the suture into the device. The suture lines can be retrieved through the suture recess, and the device can be actuated so as to deliver the suture clip off the delivery device and onto the suture, locking the suture in place.
    Type: Application
    Filed: December 20, 2016
    Publication date: May 4, 2017
    Applicant: Edwards Lifesciences Corporation
    Inventors: Travis Zenyo Oba, Michael C. Murad, Manouchehr A. Miraki, Anthony P. Carcia, Fabian Daniel Schroeder, Raffaele Mazzei, Tyler Douglas Smith
  • Patent number: 9549730
    Abstract: Suture clip deployment devices for applying suture clips to sutures are described. Some embodiments can include a generally tubular main body and a vacuum port located at the distal end, a hollow inner body longitudinally slidable within the main body and extending from the main body at its distal end, and a suture recess located in the generally tubular main body. At least one suture clip configured to frictionally fit on an outer surface of the inner body is deployed during use. Clip deployment can occur after a vacuum source is applied to the device so as to draw the suture into the device. The suture lines can be retrieved through the suture recess, and the device can be actuated so as to deliver the suture clip off the delivery device and onto the suture, locking the suture in place.
    Type: Grant
    Filed: March 16, 2015
    Date of Patent: January 24, 2017
    Assignee: Edwards Lifesciences Corporation
    Inventors: Travis Zenyo Oba, Michael C. Murad, Manouchehr A. Miraki, Anthony Peter Carcia, Fabian Daniel Schroeder, Raffaele Mazzei, Tyler Douglas Smith
  • Patent number: 9414837
    Abstract: Suture clip deployment devices for applying suture clips to sutures are described. Some embodiments can include a generally tubular main body and a vacuum port located at the distal end, a hollow inner body longitudinally slidable within the main body and extending from the main body at its distal end, and a suture recess located in the generally tubular main body. At least one suture clip configured to frictionally fit on an outer surface of the inner body is deployed during use. Clip deployment can occur after a vacuum source is applied to the device so as to draw the suture into the device. The suture lines can be retrieved through the suture recess, and the device can be actuated so as to deliver the suture clip off the delivery device and onto the suture, locking the suture in place.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: August 16, 2016
    Inventors: Travis Zenyo Oba, Michael C. Murad, Manouchehr A. Miraki, Anthony Peter Carcia, Fabian Daniel Schroeder, Raffaele Mazzei, Tyler Douglas Smith
  • Publication number: 20160199185
    Abstract: An improved holder and storage system for a tissue-type prosthetic mitral heart valve that constricts the commissure posts of the valve and prevents suture looping. A rod axially movable relative to the holder tensions lengths of attachment sutures that extend between the commissure post tips to create a tent and flex the tips inward, thus helping to prevent looping of any of an array of pre-implanted sutures around the leading tips during delivery of the valve. The holder has a safety mechanism that prevents valve delivery before the rod is deployed. One embodiment automatically deploys the rod upon opening a storage jar. One embodiment permits a delivery handle to directly deploy the rod, while another uses a separate worm screw and coupling. A holder clip that attaches to a packaging sleeve may be formed of flexible members meshed together from which the heart valve and holder are easily pulled free to eliminate a step of decoupling the clip from the sleeve.
    Type: Application
    Filed: March 21, 2016
    Publication date: July 14, 2016
    Inventors: Michael C. Murad, Emil Karapetian, Wesley V. Adzich
  • Publication number: 20160166248
    Abstract: A multiple-fire securing device includes a hollow outer shaft, a reloader, a reloader movement assembly, a rail, and securing structures each defining an inner securing orifice. The reloader longitudinally moves within the outer shaft and has a distal end shaped to temporarily contact one of the securing structures. The rail is disposed within the reloader and has an installing location. The securing structures are disposed on the rail. The reloader movement assembly moves the reloader longitudinally in a distal direction to deliver a first securing structure to the installing location from a first proximal position and moves the reloader proximally away from the installing location without the first securing structure to a position in which the distal end of the reloader temporarily contacts a second one of the securing structures. The second and successive securing structures are moved one at a time to the installing location.
    Type: Application
    Filed: December 10, 2015
    Publication date: June 16, 2016
    Inventors: Derek Dee Deville, Kevin W. Smith, Michael Walter Kirk, Carlos Rivera, George Nunez, Thomas O. Bales, JR., Korey Kline, Matthew A. Palmer, M. Sean McBrayer, Richard Cartledge, Max Pierre Mendez, Hengchu Cao, Anthony Peter Carcia, Kevin Dang, Carey Hendsbee, Brent K. Hoffman, Brian R. Jacobs, Mohammad Jafari, Brian Janish, Jeffrey L. Mahoney, Raffaele Mazzei, Manouchehr A. Miraki, Ryan Moehle, Jeremiah Morgan, Michael C. Murad, Travis Zenyo Oba, Ralph Schneider, Fabian Daniel Schroeder, Tyler Douglas Smith, Ming H. Wu
  • Patent number: 9289293
    Abstract: An improved holder and storage system for a tissue-type prosthetic mitral heart valve that constricts the commissure posts of the valve and prevents suture looping. A rod axially movable relative to the holder tensions lengths of attachment sutures that extend between the commissure post tips to create a tent and flex the tips inward, thus helping to prevent looping of any of an array of pre-implanted sutures around the leading tips during delivery of the valve. The holder has a safety mechanism that prevents valve delivery before the rod is deployed. One embodiment automatically deploys the rod upon opening a storage jar. One embodiment permits a delivery handle to directly deploy the rod, while another uses a separate worm screw and coupling. A holder clip that attaches to a packaging sleeve may be formed of flexible members meshed together from which the heart valve and holder are easily pulled free to eliminate a step of decoupling the clip from the sleeve.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: March 22, 2016
    Assignee: Edwards Lifesciences Corporation
    Inventors: Michael C. Murad, Emil Karapetian, Wesley V. Adzich