Patents by Inventor Michael C. Murad
Michael C. Murad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10058425Abstract: A valved conduit including a bioprosthetic aortic heart valve connected to a tubular conduit graft forming an ascending aorta. The conduit graft may attach to the heart valve in a manner that facilitates a redo operation in which the valve is replaced with another valve. A sewing ring may be pre-attached to the inflow end of the graft, and then the valve connected to a delivery holder advanced into the graft and secured to the sewing ring. Dry bioprosthetic valves coupled with conduit grafts sealed with a bioresorbable medium can be stored with the delivery holder.Type: GrantFiled: September 10, 2015Date of Patent: August 28, 2018Assignee: Edwards Lifesciences CorporationInventors: Michael C. Murad, Hilda Z. Fann, Mark Van Nest, John X. Wang
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Publication number: 20180125653Abstract: An improved holder and storage system for a tissue-type prosthetic mitral heart valve that constricts the commissure posts of the valve and prevents suture looping. A rod axially movable relative to the holder tensions lengths of attachment sutures that extend between the commissure post tips to create a tent and flex the tips inward, thus helping to prevent looping of any of an array of pre-implanted sutures around the leading tips during delivery of the valve. The holder has a safety mechanism that prevents valve delivery before the rod is deployed. One embodiment automatically deploys the rod upon opening a storage jar. One embodiment permits a delivery handle to directly deploy the rod, while another uses a separate worm screw and coupling. A holder clip that attaches to a packaging sleeve may be formed of flexible members meshed together from which the heart valve and holder are easily pulled free to eliminate a step of decoupling the clip from the sleeve.Type: ApplicationFiled: January 8, 2018Publication date: May 10, 2018Inventors: Michael C. Murad, Emil Karapetian, Wesley V. Adzich
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Publication number: 20180104058Abstract: A sizing tool for use in implanting a composite valved conduit having a prosthetic heart valve on a distal end attached to a conduit graft that extends to a proximal end. The tool includes a proximal handle and a distal shaft, a prosthetic heart valve sizer having an axis affixed to a distal end of the shaft, and a conduit graft replica having an axis mounted on the shaft proximal to the heart valve sizer. A method of securing a composite valved conduit includes introducing to an excised ascending aorta the sizing tool, measuring the aortic annulus with the prosthetic heart valve sizer, and determining whether the coronary arteries have sufficient length or whether an additional tubular coronary extension segment is required to add to one or both of the ends of the coronary arteries by extending the coronary arteries toward the conduit graft replica.Type: ApplicationFiled: December 18, 2017Publication date: April 19, 2018Inventors: Ruggero De Paulis, Michael C. Murad
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Patent number: 9861478Abstract: An improved holder and storage system for a tissue-type prosthetic mitral heart valve that constricts the commissure posts of the valve and prevents suture looping. A rod axially movable relative to the holder tensions lengths of attachment sutures that extend between the commissure post tips to create a tent and flex the tips inward, thus helping to prevent looping of any of an array of pre-implanted sutures around the leading tips during delivery of the valve. The holder has a safety mechanism that prevents valve delivery before the rod is deployed. One embodiment automatically deploys the rod upon opening a storage jar. One embodiment permits a delivery handle to directly deploy the rod, while another uses a separate worm screw and coupling. A holder clip that attaches to a packaging sleeve may be formed of flexible members meshed together from which the heart valve and holder are easily pulled free to eliminate a step of decoupling the clip from the sleeve.Type: GrantFiled: March 21, 2016Date of Patent: January 9, 2018Assignee: Edwards Lifesciences CorporationInventors: Michael C. Murad, Emil Karapetian, Wesley V. Adzich
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Patent number: 9844436Abstract: A sizing tool for use in implanting a composite valved conduit having a prosthetic heart valve on a distal end attached to a conduit graft that extends to a proximal end. The tool includes a proximal handle and a distal shaft, a prosthetic heart valve sizer having an axis affixed to a distal end of the shaft, and a conduit graft replica having an axis mounted on the shaft proximal to the heart valve sizer. A method of securing a composite valved conduit includes introducing to an excised ascending aorta the sizing tool, measuring the aortic annulus with the prosthetic heart valve sizer, and determining whether the coronary arteries have sufficient length or whether an additional tubular coronary extension segment is required to add to one or both of the ends of the coronary arteries by extending the coronary arteries toward the conduit graft replica.Type: GrantFiled: October 24, 2013Date of Patent: December 19, 2017Assignee: Edwards Lifesciences CorporationInventors: Ruggero De Paulis, Michael C. Murad
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Publication number: 20170119375Abstract: Suture clip deployment devices for applying suture clips to sutures are described. Some embodiments can include a generally tubular main body and a vacuum port located at the distal end, a hollow inner body longitudinally slidable within the main body and extending from the main body at its distal end, and a suture recess located in the generally tubular main body. At least one suture clip configured to frictionally fit on an outer surface of the inner body is deployed during use. Clip deployment can occur after a vacuum source is applied to the device so as to draw the suture into the device. The suture lines can be retrieved through the suture recess, and the device can be actuated so as to deliver the suture clip off the delivery device and onto the suture, locking the suture in place.Type: ApplicationFiled: December 20, 2016Publication date: May 4, 2017Applicant: Edwards Lifesciences CorporationInventors: Travis Zenyo Oba, Michael C. Murad, Manouchehr A. Miraki, Anthony P. Carcia, Fabian Daniel Schroeder, Raffaele Mazzei, Tyler Douglas Smith
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Patent number: 9549730Abstract: Suture clip deployment devices for applying suture clips to sutures are described. Some embodiments can include a generally tubular main body and a vacuum port located at the distal end, a hollow inner body longitudinally slidable within the main body and extending from the main body at its distal end, and a suture recess located in the generally tubular main body. At least one suture clip configured to frictionally fit on an outer surface of the inner body is deployed during use. Clip deployment can occur after a vacuum source is applied to the device so as to draw the suture into the device. The suture lines can be retrieved through the suture recess, and the device can be actuated so as to deliver the suture clip off the delivery device and onto the suture, locking the suture in place.Type: GrantFiled: March 16, 2015Date of Patent: January 24, 2017Assignee: Edwards Lifesciences CorporationInventors: Travis Zenyo Oba, Michael C. Murad, Manouchehr A. Miraki, Anthony Peter Carcia, Fabian Daniel Schroeder, Raffaele Mazzei, Tyler Douglas Smith
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Patent number: 9414837Abstract: Suture clip deployment devices for applying suture clips to sutures are described. Some embodiments can include a generally tubular main body and a vacuum port located at the distal end, a hollow inner body longitudinally slidable within the main body and extending from the main body at its distal end, and a suture recess located in the generally tubular main body. At least one suture clip configured to frictionally fit on an outer surface of the inner body is deployed during use. Clip deployment can occur after a vacuum source is applied to the device so as to draw the suture into the device. The suture lines can be retrieved through the suture recess, and the device can be actuated so as to deliver the suture clip off the delivery device and onto the suture, locking the suture in place.Type: GrantFiled: June 18, 2014Date of Patent: August 16, 2016Inventors: Travis Zenyo Oba, Michael C. Murad, Manouchehr A. Miraki, Anthony Peter Carcia, Fabian Daniel Schroeder, Raffaele Mazzei, Tyler Douglas Smith
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Publication number: 20160199185Abstract: An improved holder and storage system for a tissue-type prosthetic mitral heart valve that constricts the commissure posts of the valve and prevents suture looping. A rod axially movable relative to the holder tensions lengths of attachment sutures that extend between the commissure post tips to create a tent and flex the tips inward, thus helping to prevent looping of any of an array of pre-implanted sutures around the leading tips during delivery of the valve. The holder has a safety mechanism that prevents valve delivery before the rod is deployed. One embodiment automatically deploys the rod upon opening a storage jar. One embodiment permits a delivery handle to directly deploy the rod, while another uses a separate worm screw and coupling. A holder clip that attaches to a packaging sleeve may be formed of flexible members meshed together from which the heart valve and holder are easily pulled free to eliminate a step of decoupling the clip from the sleeve.Type: ApplicationFiled: March 21, 2016Publication date: July 14, 2016Inventors: Michael C. Murad, Emil Karapetian, Wesley V. Adzich
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Publication number: 20160166248Abstract: A multiple-fire securing device includes a hollow outer shaft, a reloader, a reloader movement assembly, a rail, and securing structures each defining an inner securing orifice. The reloader longitudinally moves within the outer shaft and has a distal end shaped to temporarily contact one of the securing structures. The rail is disposed within the reloader and has an installing location. The securing structures are disposed on the rail. The reloader movement assembly moves the reloader longitudinally in a distal direction to deliver a first securing structure to the installing location from a first proximal position and moves the reloader proximally away from the installing location without the first securing structure to a position in which the distal end of the reloader temporarily contacts a second one of the securing structures. The second and successive securing structures are moved one at a time to the installing location.Type: ApplicationFiled: December 10, 2015Publication date: June 16, 2016Inventors: Derek Dee Deville, Kevin W. Smith, Michael Walter Kirk, Carlos Rivera, George Nunez, Thomas O. Bales, JR., Korey Kline, Matthew A. Palmer, M. Sean McBrayer, Richard Cartledge, Max Pierre Mendez, Hengchu Cao, Anthony Peter Carcia, Kevin Dang, Carey Hendsbee, Brent K. Hoffman, Brian R. Jacobs, Mohammad Jafari, Brian Janish, Jeffrey L. Mahoney, Raffaele Mazzei, Manouchehr A. Miraki, Ryan Moehle, Jeremiah Morgan, Michael C. Murad, Travis Zenyo Oba, Ralph Schneider, Fabian Daniel Schroeder, Tyler Douglas Smith, Ming H. Wu
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Patent number: 9289293Abstract: An improved holder and storage system for a tissue-type prosthetic mitral heart valve that constricts the commissure posts of the valve and prevents suture looping. A rod axially movable relative to the holder tensions lengths of attachment sutures that extend between the commissure post tips to create a tent and flex the tips inward, thus helping to prevent looping of any of an array of pre-implanted sutures around the leading tips during delivery of the valve. The holder has a safety mechanism that prevents valve delivery before the rod is deployed. One embodiment automatically deploys the rod upon opening a storage jar. One embodiment permits a delivery handle to directly deploy the rod, while another uses a separate worm screw and coupling. A holder clip that attaches to a packaging sleeve may be formed of flexible members meshed together from which the heart valve and holder are easily pulled free to eliminate a step of decoupling the clip from the sleeve.Type: GrantFiled: March 3, 2015Date of Patent: March 22, 2016Assignee: Edwards Lifesciences CorporationInventors: Michael C. Murad, Emil Karapetian, Wesley V. Adzich
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Publication number: 20160067042Abstract: A valved conduit including a bioprosthetic aortic heart valve connected to a tubular conduit graft forming an ascending aorta. The conduit graft may attach to the heart valve in a manner that facilitates a redo operation in which the valve is replaced with another valve. A sewing ring may be pre-attached to the inflow end of the graft, and then the valve connected to a delivery holder advanced into the graft and secured to the sewing ring. Dry bioprosthetic valves coupled with conduit grafts sealed with a bioresorbable medium can be stored with the delivery holder.Type: ApplicationFiled: September 10, 2015Publication date: March 10, 2016Applicant: Edwards Lifesciences CorporationInventors: Michael C. Murad, Hilda Z. Fann, Mark Van Nest, John X. Wang
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Publication number: 20150313712Abstract: A holder for a prosthetic mitral heart valve that attaches to an inflow end of the valve and includes a simple tensioning mechanism that flexes the heart valve commissure posts inward to help prevent suture looping. The tensioning mechanism may include relatively movable rings of the holder or a generally unitary holder with a tensor, or rotatable knob. Connecting sutures thread through internal passages in the holder and travel in the outflow direction along valve commissure posts, emerging at the post tips and mutually crossing over the outflow side of the valve. A handle attaches off-center on the holder to increase visualization of and access to the heart valve through a central window for enhanced access to the commissure posts and leaflets. The holder is constructed of non-metallic materials so as to avoid interfering with imaging devices, and the handle is ergonomically curved and shaped to facilitate manipulation.Type: ApplicationFiled: July 11, 2015Publication date: November 5, 2015Inventors: Alain F. Carpentier, Michael C. Murad
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Publication number: 20150196394Abstract: An improved holder and storage system for a tissue-type prosthetic mitral heart valve that constricts the commissure posts of the valve and prevents suture looping. A rod axially movable relative to the holder tensions lengths of attachment sutures that extend between the commissure post tips to create a tent and flex the tips inward, thus helping to prevent looping of any of an array of pre-implanted sutures around the leading tips during delivery of the valve. The holder has a safety mechanism that prevents valve delivery before the rod is deployed. One embodiment automatically deploys the rod upon opening a storage jar. One embodiment permits a delivery handle to directly deploy the rod, while another uses a separate worm screw and coupling. A holder clip that attaches to a packaging sleeve may be formed of flexible members meshed together from which the heart valve and holder are easily pulled free to eliminate a step of decoupling the clip from the sleeve.Type: ApplicationFiled: March 3, 2015Publication date: July 16, 2015Inventors: Michael C. Murad, Emil Karapetian, Wesley V. Adzich
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Patent number: 9078750Abstract: A holder for a prosthetic mitral heart valve that attaches to an inflow end of the valve and includes a simple tensioning mechanism that flexes the heart valve commissure posts inward to help prevent suture looping. The tensioning mechanism may include relatively movable rings of the holder or a generally unitary holder with a tensor, or rotatable knob. Connecting sutures thread through internal passages in the holder and travel in the outflow direction along valve commissure posts, emerging at the post tips and mutually crossing over the outflow side of the valve. A handle attaches off-center on the holder to increase visualization of and access to the heart valve through a central window. The holder is constructed of non-metallic materials so as to avoid interfering with imaging devices, and the handle is ergonomically curved and shaped to facilitate manipulation. The holder may be shaped as a ring with an open inner diameter for enhanced access to the commissure posts and leaflets.Type: GrantFiled: November 29, 2011Date of Patent: July 14, 2015Assignee: Edwards Lifesciences CorporationInventors: Alain F. Carpentier, Michael C. Murad
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Publication number: 20150182217Abstract: Suture clip deployment devices for applying suture clips to sutures are described. Some embodiments can include a generally tubular main body and a vacuum port located at the distal end, a hollow inner body longitudinally slidable within the main body and extending from the main body at its distal end, and a suture recess located in the generally tubular main body. At least one suture clip configured to frictionally fit on an outer surface of the inner body is deployed during use. Clip deployment can occur after a vacuum source is applied to the device so as to draw the suture into the device. The suture lines can be retrieved through the suture recess, and the device can be actuated so as to deliver the suture clip off the delivery device and onto the suture, locking the suture in place.Type: ApplicationFiled: March 16, 2015Publication date: July 2, 2015Applicant: EDWARDS LIFESCIENCES CORPORATIONInventors: Travis Zenyo Oba, Michael C. Murad, Manouchehr A. Miraki, Anthony Peter Carcia, Fabian Daniel Schroeder, Raffaele Mazzei, Tyler Douglas Smith
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Patent number: 9017347Abstract: Suture clip deployment devices for applying suture clips to sutures are described. Some embodiments can include a generally tubular main body and a vacuum port located at the distal end, a hollow inner body longitudinally slidable within the main body and extending from the main body at its distal end, and a suture recess located in the generally tubular main body. At least one suture clip configured to frictionally fit on an outer surface of the inner body is deployed during use. Clip deployment can occur after a vacuum source is applied to the device so as to draw the suture into the device. The suture lines can be retrieved through the suture recess, and the device can be actuated so as to deliver the suture clip off the delivery device and onto the suture, locking the suture in place.Type: GrantFiled: December 14, 2012Date of Patent: April 28, 2015Assignee: Edwards Lifesciences CorporationInventors: Travis Zenyo Oba, Michael C. Murad, Manouchehr A. Miraki, Anthony Peter Carcia, Fabian Daniel Schroeder, Raffaele Mazzei, Tyler Douglas Smith
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Patent number: 8968394Abstract: An improved holder and storage system for a tissue-type prosthetic mitral heart valve that constricts the commissure posts of the valve and prevents suture looping. A rod axially movable relative to the holder tensions lengths of attachment sutures that extend between the commissure post tips to create a tent and flex the tips inward, thus helping to prevent looping of any of an array of pre-implanted sutures around the leading tips during delivery of the valve. The holder has a safety mechanism that prevents valve delivery before the rod is deployed. One embodiment automatically deploys the rod upon opening a storage jar. One embodiment permits a delivery handle to directly deploy the rod, while another uses a separate worm screw and coupling. A holder clip that attaches to a packaging sleeve may be formed of flexible members meshed together from which the heart valve and holder are easily pulled free to eliminate a step of decoupling the clip from the sleeve.Type: GrantFiled: May 11, 2012Date of Patent: March 3, 2015Assignee: Edwards Lifesciences CorporationInventors: Michael C. Murad, Emil Karapetian, W. Vaso Adzich
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Publication number: 20140303652Abstract: Suture clip deployment devices for applying suture clips to sutures are described. Some embodiments can include a generally tubular main body and a vacuum port located at the distal end, a hollow inner body longitudinally slidable within the main body and extending from the main body at its distal end, and a suture recess located in the generally tubular main body. At least one suture clip configured to frictionally fit on an outer surface of the inner body is deployed during use. Clip deployment can occur after a vacuum source is applied to the device so as to draw the suture into the device. The suture lines can be retrieved through the suture recess, and the device can be actuated so as to deliver the suture clip off the delivery device and onto the suture, locking the suture in place.Type: ApplicationFiled: June 18, 2014Publication date: October 9, 2014Applicant: Edwards Lifesciences CorporationInventors: Travis Zenyo Oba, Michael C. Murad, Manouchehr A. Miraki, Anthony Peter Carcia, Fabian Daniel Schroeder, Raffaele Mazzei, Tyler Douglas Smith
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Patent number: 8839957Abstract: Packaging for prosthetic heart valves including an assembly for securely retaining a heart valve within a sterile jar and facilitating retrieval therefrom. The assembly includes a packaging sleeve that fits closely within the jar and has a clip structure for securing a valve holder. A delivery handle on the end of a shaft couples with the valve holder while the packaging sleeve engages the jar to prevent rotation. The assembly of the packaging sleeve, valve, and holder can then easily be removed from the jar.Type: GrantFiled: February 14, 2011Date of Patent: September 23, 2014Inventors: Michael C. Murad, Mark Van Nest, Jackie Lau