Abstract: In alternative embodiments, provided are methods for treating and ameliorating a cancer, or recurrence of a cancer such as acute myeloid leukemia (AML) comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 (or rebecsinib) and second drug such as an ATP-competitive protein tyrosine kinase inhibitor such as dasatinib. In alternative embodiments, provided are methods for the in vivo inhibition of myeloproliferative neoplasm (MPN) or AML stem cell propagation comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 and second drug. In alternative embodiments, provided are methods for the in vivo inhibition pre-leukemia stem cell (pre-LSC) transformation into leukemia stem cells (LSCs) comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 and second drug.

Abstract: A tool is provided that includes unitary plate that includes a blade portion and a tang portion. The blade portion can include an edge. The tang portion can include a positioning hole, a first hole, a slot, a second hole, a rivet hole, and one or more teeth (also referred to as one or more barbs) on a side of the tang portion. The tool can further include a hilt member which includes a through passage, a tab, and a notch. The tool includes an overlay on a body to create a handle for gripping the tool. The tool further includes a hammerhead cap on an end of the body, the hammerhead cap is coupled to the handle with a rivet through the rivet hole.

Abstract: A severing apparatus is used for severing a conduit. The apparatus includes a main body section having an upper portion, a lower portion, and an intermediate portion. A combustible charge is located in the intermediate portion, and an ignition mechanism is coupled to the upper portion for igniting the combustible charge. A nozzle head is located in the lower portion and includes an internal cavity and a nozzle portion having apertures at spaced apart positions for providing passages from the internal cavity to outside of the nozzle head. The ignition mechanism is configured to ignite the combustible charge to create a flame and combustion products and pressure in the internal cavity for moving the nozzle head relative to the lower portion so that the nozzle portion protrudes out of the lower portion for passage of the flame and hot combustion products out of the apertures to sever the conduit.

Abstract: An apparatus for severing a conduit in the borehole includes a combustible fuel; a nozzle section comprising a cavity with apertures providing passages from the cavity to outside the apparatus; a movable swirl generator located between the combustible fuel and the nozzle section, the swirl generator comprising a piston and a plurality of helical vanes, the piston located initially above the apertures; and an activation device for igniting the combustible fuel for creating a matrix of combustion products that pass between and/or along the helical vanes and move the swirl generator in the cavity so that the piston is moved below the apertures for passage of the matrix of combustion products into the cavity and out of the apertures. The helical vanes rotate the matrix of combustion products and direct the rotating matrix of combustion products radially through of the apertures for cutting the conduit.

Abstract: An apparatus for cutting a conduit in a borehole includes combustible material within a body; a nozzle comprising apertures; a support element between the nozzle and the combustible material, the support element comprising a mixing cavity within the support element; an activation device for igniting the combustible material to form a matrix of combustion products for passage toward the nozzle via the mixing cavity; and a swirl diverter comprising an outer surface having a plurality of helical vanes which extend from one end of the swirl diverter toward an opposite end of the swirl diverter. The apertures of the nozzle are configured to direct the matrix of combustion products from the mixing cavity to the helical vanes, and the helical vanes are shaped to rotate the matrix of combustion products and direct the matrix of combustion products radially outward of the body for cutting the conduit.

Abstract: A downhole torch system and method of use includes a cylindrical housing, a protective material provided on at least one of the cylindrical housing and the fuel load, and a fuel load located within the cylindrical housing. The protective material is provided between the fuel load and the cylindrical housing to protect the cylindrical housing from adverse effects caused by the reaction of the burning fuel and/or the subsequent production of combustion products for cutting and/or perforating processes during operation of the torch system. The protective material significantly improves the cutting and/or perforating performance of the torch system.

Abstract: A tubular perforating apparatus includes a nozzle section comprising a nozzle head located therein and adjacent a combustible fuel material. The nozzle head includes an internal cavity and a nozzle portion including an opening on one side of the nozzle portion that directs the cutting fluids out the internal cavity in a first radial direction to produce a reaction force on the apparatus in an opposite second radial direction. The reaction force moves the apparatus in the second radial direction to be against an inner wall of the tubular and temporarily anchors the apparatus against the inner wall. The nozzle head is movable via the pressure and the cutting fluids from a closed position within the nozzle section to an open position in which the nozzle portion protrudes out of the nozzle section so that the opening is exposed to the tubular for directing the cutting fluids onto the tubular.

Abstract: A degradable plug device for a pipe prevents fluid flow through the pipe until the plug device has been removed from the pipe. The plug device includes a body which is at least partially of a degradable material. The exposed surfaces of the degradable plug include a protective layer thereon. The body includes a chamber therein. The body is disposable in the pipe to prevent fluid flow through the pipe. The plug is adapted to undergo a degradation initiation operation such that well fluid is able to enter the chamber to initiate corrosion or dissolution of the body from inside the chamber. The plug is useful for temporarily blocking a pipe within a well to control the flow of fluids or to actuate tools within the well.

Abstract: A location connector connects a first tubular to a second tubular, and includes a cylindrical main body extending in a longitudinal direction. An outer surface extends around a circumference of the main body, and an inner surface faces the central bore of the main body. A first connector, on a first end of the main body, is configured to attach to the first tubular. A second connector, on an opposite second end of the main body, is configured to attach to the second tubular. A female profile is provided on the inner surface, and includes a plurality of grooves for selective engagement with a discrete complementary profile comprising one or more protruding members of a downhole tool. Each of the grooves comprises a no-go shoulder that prevents movement of the tool in one direction, and each of the grooves permits clocking movement of the tool in an azimuthal direction.

Abstract: Systems and methods include an extreme range anchor, having extending assemblies configured to engage a wellbore, for providing a self-centering, reusable anchor location within a wellbore. The extending assemblies include a first set of arms connected to a first brace, a second set of arms connected to a second brace, and a set of footplates. Each footplate in the set of footplates is connected to the first set of arms and the second set of arms. Each footplate includes a fixator coupled to a radially external face and configured to securely engage the wellbore. The system also includes a pull rod rigidly coupled to the first brace and slidably connected to the second brace. Forcing the pull rod in an axial direction shortens a distance between the first brace and the second brace and forces the set of footplates to move in a radial direction toward the wellbore.

Abstract: A degradable plug device for a pipe has an outer plug body and an inner plug for preventing fluid flow through the pipe until the inner plug has been removed from the outer plug body. The outer plug body and the inner plug are of a degradable material. The inner plug has a chamber with at least one port to the exterior of the inner plug. The exposed surfaces of the degradable plug have a protective layer thereon. The inner plug is disposable in at least a first position, in which the inner plug prevents the fluid flow through the pipe. The inner plug is adapted to undergo, in use, a degradation initiation operation such that fluid is able to enter the chamber via the at least one port to initiate corrosion or dissolution of the inner plug from inside the chamber.

Abstract: A setting tool having a tool body, a chamber configured to contain a non-explosive fuel configured to generate gas and plasma, a cavity, a bleed sub located between the chamber and the cavity. The bleed sub is configured to bleed pressure from the chamber to the cavity after the non-explosive fuel has been initiated. The setting tool also includes a piston disposed within the cavity oriented to stroke in a first direction after the non-explosive fuel has been initiated. The piston may divide the cavity into an upper volume that may receive the pressure increase from the bleed sub and a lower volume. The setting tool may also include a shaft mechanically connected to the piston within the lower volume of the cavity. The shaft may include a dampening conduit configured to drain a fluid from the lower volume after the non-explosive fuel has been initiated.

Abstract: Systems and methods include an extreme range anchor, having extending assemblies configured to engage a wellbore, for providing a self-centering, reusable anchor location within a wellbore. The extending assemblies include a first set of arms connected to a first brace, a second set of arms connected to a second brace, and a set of footplates. Each footplate in the set of footplates is connected to the first set of arms and the second set of arms. Each footplate includes a fixator coupled to a radially external face and configured to securely engage the wellbore. The system also includes a pull rod rigidly coupled to the first brace and slidably connected to the second brace. Forcing the pull rod in an axial direction shortens a distance between the first brace and the second brace and forces the set of footplates to move in a radial direction toward the wellbore.

Abstract: A tubular perforating apparatus includes a nozzle section comprising a nozzle head located therein and adjacent a combustible fuel material. The nozzle head includes an internal cavity and a nozzle portion including an opening on one side of the nozzle portion that directs the cutting fluids out the internal cavity in a first radial direction to produce a reaction force on the apparatus in an opposite second radial direction. The reaction force moves the apparatus in the second radial direction to be against an inner wall of the tubular and temporarily anchors the apparatus against the inner wall. The nozzle head is movable via the pressure and the cutting fluids from a closed position within the nozzle section to an open position in which the nozzle portion protrudes out of the nozzle section so that the opening is exposed to the tubular for directing the cutting fluids onto the tubular.

Abstract: Apparatus, systems, and methods are used for activating a downhole tool, powered by an exothermic reaction, for operation, while deploying a tubing string from a wellbore surface. The tubing string comprises a coupling for enabling pressurized activation of the downhole tool, which comprises a fuel (e.g., thermite) for producing the exothermic reaction. The coupling enables fluid to flow into an interior of the coupling through a first flow passage, during descent of the downhole tool. A stopper is dropped and/or seated to cause the coupling interior to pressurize to an activation pressure, which causes an activator to activate a burn within the downhole tool. Once the downhole tool completes its operation, the coupling interior is further pressurized to burst a burst disc, which opens a second flow passage for fluid to flow from the interior to exterior of the coupling, while downhole tool and coupling are raised to the surface.

Abstract: A severing apparatus is used for severing a conduit. The apparatus includes a main body section having an upper portion, a lower portion, and an intermediate portion. A combustible charge is located in the intermediate portion, and an ignition mechanism is coupled to the upper portion for igniting the combustible charge. A nozzle head is located in the lower portion and includes an internal cavity and a nozzle portion having apertures at spaced apart positions for providing passages from the internal cavity to outside of the nozzle head. The ignition mechanism is configured to ignite the combustible charge to create a flame and combustion products and pressure in the internal cavity for moving the nozzle head relative to the lower portion so that the nozzle portion protrudes out of the lower portion for passage of the flame and hot combustion products out of the apertures to sever the conduit.

Abstract: Systems and methods include an extreme range anchor, having extending assemblies configured to engage a wellbore, for providing a self-centering, reusable anchor location within a wellbore. The extending assemblies include a first set of arms connected to a first brace, a second set of arms connected to a second brace, and a set of footplates. Each footplate in the set of footplates is connected to the first set of arms and the second set of arms. Each footplate includes a fixator coupled to a radially external face and configured to securely engage the wellbore. The system also includes a pull rod rigidly coupled to the first brace and slidably connected to the second brace. Forcing the pull rod in an axial direction shortens a distance between the first brace and the second brace and forces the set of footplates to move in a radial direction toward the wellbore.