Abstract: A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR.

Abstract: The present invention relates to a training simulator designed to improve the accuracy and efficiency of strap application techniques, specifically in medical settings. The simulator features a user-friendly interface with a compressible apparatus and an integrated LCD display for real-time visual feedback. It incorporates advanced pressure sensing technology to accurately measure and monitor compression pressure applied during strap usage. Immediate feedback is provided through visual and auditory cues, ensuring users achieve the desired compression range. The system also includes data logging and analysis capabilities, enabling users to track their performance over time. Wireless connectivity and virtual reality integration allow for remote collaboration and real-time virtual training sessions, fostering global knowledge exchange. Additionally, the simulator offers customizable training modes for various skill levels and specific medical procedures.

Abstract: A single use heat exchanger device includes an outer bag formed from a flexible polymer film and defining an interior compartment, the outer bag having a first port and a second port disposed therein to provide fluid access to and from the interior compartment. An inner bag is formed from a flexible polymer film and defines an interior flow path between a third port and a fourth port, the third port and the fourth port extending through the outer bag and provide fluid access to and from the interior flow path. In other embodiments, a flexible bag or container incorporates heat exchanger flow path(s) into one or more surfaces. In another embodiment, a container or vessel incorporates heat exchange flow path around a cylindrical surface formed by an inner jacket and outer jacket.

Abstract: Authentication elements that can be physically associated with objects in order to authenticate the objects are provided. An authentication element encodes at least a portion of an authentication code. In some embodiments, an authentication element is readable using x-rays, radio waves (e.g., in combination with a magnetic field), sound waves, or a combination thereof. An authentication code may be known only to a certain individual or organization. An authentication code may be distinct in some manner, for example, may be unique or correspond to a certain individual or organization. In some embodiments, a composite authentication element is used, for example, for a set of objects where each object is physically associated with a distinct portion of the composite authentication element. An authentication element (or composite authentication element) may be a passive element, for example that does not contain any circuitry and/or antenna.

Abstract: An apparatus is provided to receive a three-dimensional (3D) map of at least a part of a body of a user. A tunable VCSEL laser has one or more active regions having quantum wells and barriers, the active regions surrounded by one or more p-n junctions, the one or more active regions can include a selected shape structure, as well as one or more tunnel junctions (TJ), one or more apertures are provided with the selected shape structure, one or more buried tunnel junctions (BTJ) or oxide confine apertured, additional TJ's, planar structures and or additional BTJ's created during a regrowth process that is independent of a first growth process with a VCSEL output.

Abstract: Robot includes a propulsion system configured to transport the robot and a controller in communication with the propulsion system. A material handler is carried by the robot and configured for depositing articles into one or more destination containers. The material handler has a tilt tray having sections that are configured for tilting in any number of directions relative to a vertical of the robot. Each section of the tilt tray may include a respective conveyor that moves articles at variable speed.

Abstract: Disclosed herein is a computer-implemented method of generating a three-dimensional structure for a thermal management component. The computer-implemented method of generating a three-dimensional structure for a thermal management component comprises selecting, by a processor, at least one three-dimensional element from a plurality of three-dimensional elements. The computer-implemented method of generating a three-dimensional structure for a thermal management component also comprises determining, by the processor, a surface area necessary to dissipate heat from a first fluid according to a desired temperature difference and a desired heat transfer coefficient.

Abstract: Systems and methods for adjusting the behavior of an endpoint security agent based on a network location are provided. According to an embodiment, an agent of an endpoint device detects whether the endpoint has moved to a new network by monitoring for changes to an IP address associated with the endpoint. When the detecting is affirmative, the agent further determines whether a trusted network determination service associated with a cloud-based security service is reachable. When the determining is affirmative, the agent further identifies whether the new network is among a set of trusted networks that have been previously registered with the cloud-based security service by querying the trusted network determination service. When the identifying is affirmative, a particular security feature on the endpoint is configured for operation within a trusted network and when the identifying is negative, the particular security feature is configured for operation outside of a trusted networks.

Abstract: Circuitry and measurement approaches are described herein that can be used to reduce or suppress sensitivity to variation of sensor properties or characteristics over time for a respective monolithically integrated resistive temperature sensor. Such measurement approaches can also help to suppress measurement variations between sensors, such as to provide stable temperature measurement characteristics across locations and over time for the respective different temperature measurement sites on or within the integrated circuit package. The approaches described herein can also reduce or suppress sensitivity to variation in excitation source characteristics, such as using a relative indication (e.g., a ratio) of measured signal values corresponding to a respective temperature sensor and a co-integrated reference device. Calibration or absolute temperature measurements can be performed, such as using an off-chip (e.g., off-die or off-package) calibration reference.

Abstract: A steering column jacket assembly for a steering system of motor vehicle includes a first steering jacket extending along a longitudinal axis and a second steering jacket arranged for telescoping movement relative to the first steering jacket along the longitudinal axis. A guide bracket is fixed to the second steering jacket. The guide bracket has a guide bushing disposed between the guide bracket and the first steering jacket, the guide bushing self-centering the first steering jacket and the second steering jacket relative to one another to inhibit relative rotation between the first steering jacket and the second steering jacket.

Abstract: Embodiments of the methods and compositions provided herein relate to chimeric antigen receptors (CARs) that specifically bind to B7H3. Some embodiments relate to cell-based immunotherapy targeting tumors, such as tumors comprising B7H3+ cells.

Abstract: A method of generating a recursively mapped infill geometry for an additively manufacturable part. The method includes receiving a base unit cell mesh including a plurality of base quadrilateral elements. In each of a plurality of iterations, the method further includes receiving a target unit cell mesh including target quadrilateral elements. In each iteration, the method further includes generating a target hexahedral unit cell mesh including target hexahedral elements by extruding the target quadrilateral elements. In each of the iterations, the method further includes generating a recursive supercell mesh by mapping each of the base quadrilateral elements onto a target hexahedral element. If the current iteration is not a final iteration, the method further includes setting the recursive supercell mesh as the base unit cell mesh used in a subsequent iteration. The method further includes outputting a recursively mapped unit cell mesh including a final recursive supercell mesh.

Abstract: Improved security checkpoint includes a security scanning system having multiple personal item intake locations, a security scanner, multiple personal item retrieval locations, and a plurality of computer-controlled vehicles for transporting personal items between the personal item intake locations, the security scanner, and the personal item retrieval locations. Personal items are placed into a tote by an individual, and the computer-controlled vehicles collect the totes containing the personal items, transport the tote to an available security scanner, deposit the tote at the security scanner, and then transport the tote either to a retrieval location or secondary screening location after the personal item has been screened.

Abstract: A system and method is presented for sending a message between devices in a communication network. The system includes a first processor and a first memory in communication with the first processor. The first processor executes instructions stored in the first memory to divide the message into a plurality of segments according to a first procedure and assign a respective sequence number to each segment, and to construct a plurality of packets. Each packet comprises a payload and a header. The payload comprises at least one segment. The first processor further establishes a plurality of parallel socket connections, each to a second processor, and passes respective packets to respective parallel socket connections. The parallel socket connections are selected according to a second procedure, for transmission to the second processor until a determined number of segments has been successfully received and processed by the second processor.

Abstract: A steering column jacket assembly for a steering system of motor vehicle includes a first steering jacket extending along a longitudinal axis and a second steering jacket arranged for telescoping movement relative to the first steering jacket along the longitudinal axis. A guide bracket is fixed to the second steering jacket. The guide bracket has a guide bushing disposed between the guide bracket and the first steering jacket, the guide bushing self-centering the first steering jacket and the second steering jacket relative to one another to inhibit relative rotation between the first steering jacket and the second steering jacket.

Abstract: A glucose detection or monitoring system that includes a VCSEL laser with one or more active regions having quantum wells and barrier. The active regions are surrounded by one or more p-n junctions. The one or more active regions can include a selected shape structure, and one or more tunnel junctions (TJ). One or more apertures are provided with the selected shape structure, one or more buried tunnel junctions (BTJ) or oxide confine apertured, additional TJ's, planar structures and or additional BTJ's created during a regrowth process that is independent of a first growth process with a VCSEL output determined in response to a monitoring application of the VCSEL, the VCSEL having an HCG grating and a bottom DBR. A housing of a wearable device interior houses the VCSEL laser.

Abstract: Methods and compositions for modifying T-cells in which PD1 and/or CTLA-4 is repressed and/or inactivated using fusion proteins such as artificial transcription factors and nucleases.

Abstract: The present disclosure includes assays that involve measurement of expression levels of prognostic biomarkers, or co-expressed biomarkers, from a biological sample obtained from a prostate cancer patient, and analysis of the measured expression levels to provide information concerning the likely prognosis for the patient, and likelihood that the patient will have a recurrence of prostate cancer, or to classify the tumor by likelihood of clinical outcome or TMPRSS2 fusion status.

Abstract: Apparatus, systems, and methods are used for activating a downhole tool, powered by an exothermic reaction, for operation, while deploying a tubing string from a wellbore surface. The tubing string comprises a coupling for enabling pressurized activation of the downhole tool, which comprises a fuel (e.g., thermite) for producing the exothermic reaction. The coupling enables fluid to flow into an interior of the coupling through a first flow passage, during descent of the downhole tool. A stopper is dropped and/or seated to cause the coupling interior to pressurize to an activation pressure, which causes an activator to activate a burn within the downhole tool. Once the downhole tool completes its operation, the coupling interior is further pressurized to burst a burst disc, which opens a second flow passage for fluid to flow from the interior to exterior of the coupling, while downhole tool and coupling are raised to the surface.

Abstract: Method of sorting articles to a plurality of delivery routes includes sequencing a plurality of delivery stops within each of a plurality of routes based on a predefined criterion, and, depositing articles associated with a first delivery stop of each route in a first sequence container. The method also includes transferring articles from the first sequence container to a respective route container of a plurality of route containers, each route container associated with a route, depositing articles associated with a second delivery stop of each route in a second sequence container, and, transferring articles from the second sequence container to the respective route container of the plurality of route containers. Transferring articles from the second sequence container commences after completion of transferring articles from the first sequence container.