Abstract: A laser detector includes a detection section, the detection section includes an array of photo-detectors configured to detect a vertical position of a beam. The laser detector also includes an indication section, the indication section includes an array of illumination elements configured to indicate the vertical position of the laser beam. The detection section has a height H1. The indication section has a height H2. H2 is in a range of from 0.75 to 1.25 H1.

Abstract: The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), compositions and reaction mixtures comprising the same, and methods of treatment using the same.

Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and administering to the patient a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.

Abstract: Embodiments are disclosed for channel-based audio (CBA) (e.g., 22.2-ch audio) to object-based audio (OBA) conversion. The conversion includes converting CBA metadata to object audio metadata (OAMD) and reordering the CBA channels based on channel shuffle information derived in accordance with channel ordering constraints of the OAMD. The OBA with reordered channels is rendered in a playback device using the OAMD or in a source device, such as a set-top box or audio/video recorder. In an embodiment, the CBA metadata includes signaling that indicates a specific OAMD representation to be used in the conversion of the metadata. In an embodiment, pre-computed OAMD is transmitted in a native audio bitstream (e.g., AAC) for transmission (e.g., over HDMI) or for rendering in a source device. In an embodiment, pre-computed OAMD is transmitted in a transport layer bitstream (e.g., ISO BMFF, MPEG4 audio bitstream) to a playback device or source device.

Abstract: A method of assessing the ability to remove powder from an additively manufacturable article includes performing the following for each of a plurality of discrete starting points distributed within a sampling volume: calculating the starting point directional trajectory lengths of a plurality of trajectories of a particle starting from the starting point and moving in an initial direction respectively along a plurality of combinations of a polar angle ? and an azimuthal angle ? of a spherical coordinate system about the starting point, and calculating an average of the starting point directional trajectory lengths to give a starting point average trajectory length for the starting point. The method also includes calculating an average of the starting point average trajectory lengths respectively of the plurality of starting points to give a global average trajectory length for the article.

Abstract: The present disclosure relates to compositions, kits, and methods of treating CNS diseases and disorders using a combination of a muscarinic receptor positive modulator and an NMDA receptor positive allosteric modulator.

Abstract: Systems and methods described herein are directed towards integrating a shield layer into a current sensor to shield a magnetic field sensing element and associated circuitry in the current sensor from electrical, voltage, or electrical transient noise. In an embodiment, a shield layer may be disposed along at least one surface of a die supporting a magnetic field sensing element. The shield layer may be disposed in various arrangements to shunt noise caused by a parasitic coupling between the magnetic field sensing element and the current carrying conductor away from the magnetic field sensing element.

Abstract: A virtual presence system and method integrates multiple virtual presence technologies, including the ability to enable a user to experience a remote location through a plurality of different types of virtual presence devices. The different types of virtual presence devices might include virtual presence robots, as well drones, land vehicles, devices arranged to be worn by a person, and other virtual presence devices, all of which are accessible through a single website hosted on a server that provides links to the different types of virtual presence devices at selectable locations through a hierarchical query database that stores geographic coordinates, types, and features of the virtual presence devices, GIS to analyze and display geographic information, and communication methods, together with IP addresses and/or aliases that enable the devices to be accessed and controlled.

Abstract: A single-use fluid container includes a flexible bag having a bottom surface and one or more side surfaces. A port or aperture is formed in the bottom surface of the flexible bag that serves as an inlet port to a multi-outlet pump that is fluidically coupled to the flexible bag. The flexible bag includes one or more return ports disposed in one or more side surfaces and/or bottom surface of the flexible bag, the one or more return ports having a valve therein. One or more of the outlets of the pump are connected to conduit or tubing that also connect to one or more of the return ports. Fluid contained in the flexible bag can then be recirculated back into the flexible bag for mixing and/or agitation. Optional sparger ports may be provided for the addition of a sparging gas.

Abstract: Magnetic coupling devices are disclosed having magnetic field sensors. The magnetic coupling device may include degaussing coils wrapped about pole extension shoes of the magnetic coupling device.

Abstract: A CD20-OR-CD19 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD20-OR-CD19 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD20-OR-CD19 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR.

Abstract: A retainer has a base having a first side having an engagement member extending therefrom and a second side. The base comprising a base opening therethrough. A plunger has a body and a flange extending from the body. A lever member has a lever opening therethrough. The lever opening is sized to receive the body. The lever opening is smaller than the flange. A cover is coupled to the base. The cover comprises a first cover opening. The lever member comprises a first end rotatably coupled to the base or the cover or both. The lever has a second end extending through the first cover opening. A spring is disposed between the cover and the plunger. The spring is retractably urging the plunger into the first cover opening and the base opening.

Abstract: A computer-implemented method of generating an addendum surface for use in forming a sheet metal part by using an Incremental Sheet Forming (ISF) manufacturing process, wherein the method includes: providing a Computer Aided Design (CAD) geometry of the sheet metal part to be formed; and generating an addendum surface that surrounds and extends the CAD geometry; wherein the addendum surface has a constant slope everywhere and has no regions of self-intersection. The addendum surface can be used to manufacture a male and/or a female underform tool for use in the ISF process, such as Two-Point Incremental Forming (TPIF). The addendum surface has a user-specified constant design wall angle, ?c, which can be selected to prevent tearing of sheet metal parts during ISF due to excessive thinning at large wall angles (i.e., wall angles greater than 60°).

Abstract: An applicator for wrapping about an individual weed and applying a liquid herbicide to said individual weed. The applicator is comprised of an outer metal layer and an inner fabric layer soaked with a liquid herbicide. The two layers may be joined together by adhesive means, mechanical means or both. A method of use is also disclosed.

Abstract: A gas turbine engine includes a bypass duct, a rotating detonation augmentor, and a flow valve. The bypass duct is configured to conduct air through a flow path arranged around an engine core of the gas turbine engine. The rotating detonation augmentor is located in the bypass duct and configured to be selectively operated to detonate fuel and a portion of the air to increase thrust for propelling the gas turbine engine. The flow valve is configured to vary selectively the portion of the air flowing into the rotating detonation augmentor to control a magnitude of the thrust increase provided by the rotating detonation augmentor during operation of the rotating detonation augmentor.

Abstract: A CD20-OR-CD19 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD20-OR-CD19 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD20-OR-CD19 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR.

Abstract: A method of controlling autonomous vehicles is described. The method comprises receiving a text string regarding operation of an autonomous aircraft, analyzing the text string via a decoder module to identify one or more linguistic aircraft control components in the text string, and accessing an aircraft-related knowledge base associated with the decoder module to validate one or more identified linguistic aircraft control components. The method further comprises, based at least on the identified linguistic aircraft control components, determining a command for controlling the autonomous aircraft, and outputting the command for execution by the autonomous aircraft.

Abstract: Methods, systems, and apparatus for a conveyor assembly. The conveyor assembly includes a conveyor, at least one stationary track positioned parallel to the conveyor, a process dolly configured to operatively couple to the at least one stationary track, and a syncing apparatus configured to couple to the process dolly and operatively couple to the conveyor. The syncing apparatus is configured to lock the process dolly in place along the conveyor such that the process dolly moves together with the conveyor with respect to the at least one stationary track.

Abstract: A monitoring device system has a tunable VCSEL laser having one or more active regions including quantum wells and barriers. The active regions are surrounded by one or more p-n junctions. The one or more active regions can include a selected shape structure, as well as one or more tunnel junctions (TJ). One or more apertures are provided with the selected shape structure. One or more buried tunnel junctions (BTJ) or oxide confine the apertures, additional TJ's, planar structures and or additional BTJ's created during a regrowth process that is independent of a first growth process. A VCSEL output is determined in response to an application of the VCSEL laser. The VCSEL laser includes an HCG grating and a bottom DBR. A receiver receives the optical radiation that is reflected from a target scene and is indicative of respective times of flight of the pulses to and from a target scene.