Abstract: The disclosure relates to compounds of Formula (I), which are RXFP1 receptor agonists, compositions containing them, and methods of using them, for example, in the treatment of heart failure, fibrotic diseases, and related diseases such as lung disease (e.g., idiopathic pulmonary fibrosis), kidney disease (e.g., chronic kidney disease), or hepatic disease (e.g., non-alcoholic steatohepatitis and portal hypertension).

Abstract: An apparatus is provided to receive a three dimensional (3D) map of at least a part of a body of a user. A light emitting device is included with tunable VCSEL laser with one or more active regions having quantum wells and barriers. The active regions are surrounded by one or more p-n junctions. The one or more active regions can include a selected shape structure one or more tunnel junction (TJ) 20s provided. One or more apertures are provided with the selected shape structure. One or more buried tunnel junctions (BTJ) or oxide confine the apertures, additional TJ's, planar structures and or additional BTJ's created during a regrowth process that is independent of a first growth process. A VCSEL output is determined in response to an application of the VCSEL laser. The VCSEL laser includes an HCG grating and a bottom DBR. A user monitoring device 100 includes the VCSEL laser. A user monitoring device that includes the VCSEL laser 10.

Abstract: Provided herein are recombinases and compositions, methods of identification and methods of using thereof.

Abstract: The present invention relates to methods and systems for performing intravascular procedures. More particularly the present invention relates to a vascular treatment system that includes an elongate catheter having a configurable segment with a coaxial expandable member, an expandable ring implant mounted on the expandable member and a handle assembly connected to the catheter that actuates the configurable segment to change shape and maintain that shape during deployment of the expandable ring implant to secure a previously placed endovascular graft.

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

Abstract: One aspect of the disclosure relates to altering a probability of fulfilling a game objective in a game space. The game objective may be associated with a set of potential reward items, the set of potential reward items including a first item. Probabilities of the first item from the set of potential reward items being provided to individual users as a reward for completing the game objective may be determined based on the rates of usage of the game space by the user. The probability of the first user being provided with the first item as a reward for completing the game objective may be determined based on the rate of usage of the game space by the first user.

Abstract: System includes an article supply location that includes a plurality of articles to be sorted, first and second transport vehicles, each having a first position in which an article is stowed about the vehicle and a second position in which the article is deposited into a proximal container, and one or more removal devices that transport the container to a location of further processing. System further includes a control system configured to receive an order for a plurality of disparate articles, determine one destination container of a plurality of destination containers to direct the transport vehicle to deposit a selected article, direct the first transport vehicle to transport a selected article to the destination container, deposit the article in the destination container, and transport the destination container to a location for further processing by manipulation of the removal device.

Abstract: A processing system of a storage network operates by: sending, to at least one storage unit of the storage network, at least one read request corresponding to at least a read threshold number of a set of encoded data slices to be retrieved, wherein the set of encoded data slices correspond to data, wherein the data is coded in accordance with dispersed error coding parameters that include a write threshold number and the read threshold number, wherein the write threshold number is a number of encoded data slices in the set of encoded data slices and wherein the read threshold number is a number of the set of encoded data slices that is required to decode the data; receiving, at the at least one processing circuit and from the at least one storage unit, a first subset of the set of encoded data slices, wherein at least one missing encoded data slice was not included in the first subset and wherein a number of encoded data slices in the first subset is less than the read threshold number; generating, via the at

Abstract: Methods, systems, and apparatus for a conveyor assembly. The conveyor assembly includes a conveyor, at least one stationary track positioned parallel to the conveyor, a process dolly configured to operatively couple to the at least one stationary track, and a syncing apparatus configured to couple to the process dolly and operatively couple to the conveyor. The syncing apparatus is configured to lock the process dolly in place along the conveyor such that the process dolly moves together with the conveyor with respect to the at least one stationary track.

Abstract: A device for treating disease along a main vessel and at least one branch vessel extending from the main vessel includes a branch member for deployment in the branch vessel, the branch member having a branch lumen; and a main body for deployment in the main vessel. The main body has a generally tubular wall extending generally longitudinally between opposite first and second ends. The wall has an internal surface defining a main lumen and an opposite outer surface. The wall has a recessed portion that is recessed relative to the outer surface of the wall and positioned between the first and second ends of the main body. The main body has an opening formed in the recessed portion of the wall for receiving the branch member therethrough such that the branch lumen is in fluid communication with the main lumen.

Abstract: A laser level assembly includes a mounting bracket and a laser level on the mounting bracket. The mounting bracket includes a base part and a back cap. The laser level includes a laser generator, the laser level projects at least one of a horizontal line, a vertical line or a laser spot. The laser level also includes a battery pack receptacle configured to selectively receive a removable battery pack, a wireless transmitter, a circuit board in the mounting bracket, and a secondary power device on the circuit board. The removable battery pack is configured to power the at least one laser generator. The secondary power device is configured to selectively power the wireless transmitter.

Abstract: A biopsy system for harvesting larger volumes of tissue as compared to standard core biopsy needles. The system has a needle with a lumen, an aperture disposed at the distal end of the needle and connected to the lumen, and a cutting mechanism adapted to cut tissue. When the needle is rotated after it is inserted into a target tissue, the cutting mechanism cuts from the tissue and directs the cut tissue portions into the lumen. Multi-bioimpedance measurements are used to guide a needle and direct the application of electricity for cauterizing tissue.

Abstract: An ablation system comprises: an ablation catheter and a console. The ablation catheter comprises: a shaft including a proximal end, a distal portion and a distal end; an ablation element configured to deliver energy to tissue; and a force maintenance assembly comprising a force maintenance element and configured to control and/or assess contact force between the ablation element and cardiac tissue. The console is configured to operably attach to the ablation catheter and comprises: an energy delivery assembly configured to provide energy to the ablation element. Methods of ablating tissue are also provided.

Abstract: A retainer has a base having a first side having an engagement member extending therefrom and a second side. The base comprising a base opening therethrough. A plunger has a body and a flange extending from the body. A lever member has a lever opening therethrough. The lever opening is sized to receive the body. The lever opening is smaller than the flange. A cover is coupled to the base. The cover comprises a first cover opening. The lever member comprises a first end rotatably coupled to the base or the cover or both. The lever has a second end extending through the first cover opening. A spring is disposed between the cover and the plunger. The spring is retractably urging the plunger into the first cover opening and the base opening.

Abstract: A concrete trowel includes a frame, a drive assembly including a motor mounted on the frame and a drive hub configured to receive torque from the motor, a handle assembly extending from the frame for controlling the concrete trowel, a rotor including a plurality of blades, the rotor rotatably coupled to the drive assembly for rotating about a rotational axis, and a steering control system mounted on the handle assembly to selectively adjust an orientation of the drive hub relative to a work surface in a plurality of different directions to adjust a pressure applied by the blades against the work surface.

Abstract: A gas turbine engine (10) for an aircraft comprises an engine core (11) comprising a turbine (19), a compressor (14), a core shaft (26), and a core exhaust nozzle (20), the core exhaust nozzle (20) having a core exhaust nozzle pressure ratio calculated using total pressure at the core nozzle exit (56); a fan (23) comprising a plurality of fan blades; and a nacelle (21) surrounding the fan (23) and the engine core (11) and defining a bypass duct (22), the bypass duct (22) comprising a bypass exhaust nozzle (18), the bypass exhaust nozzle (18) having a bypass exhaust nozzle pressure ratio calculated using total pressure at the bypass nozzle exit; wherein a bypass to core ratio of: bypass ? exhaust ? nozzle ? pressure ? ratio core ? exhaust ? nozzle ? pressure ? ratio is configured to be in the range from 1.1 to 1.4 under aircraft cruise conditions.

Abstract: Provided herein are compositions, systems, and methods for the generation, identification, and characterization of effector domains for activating and silencing gene expression. In particular, high throughput systems are provided to discover and characterize effector domains.

Abstract: The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), compositions and reaction mixtures comprising the same, and methods of treatment using the same.

Abstract: A method for service location optimization may include methods for deriving service location utilization data from video, predicting an operational characteristic of a service location, optimizing an operational characteristic of a service location, and presenting a user interface for user-directed optimization of an operational characteristic of a service location.

Abstract: A multimodal method of three-dimensionally (3D) printing a light-emitting diode (LED) display includes extrusion printing a first conductive layer utilizing a first extrusion printing nozzle set, spray printing an active layer onto the first conductive layer utilizing a spray printing nozzle, and extrusion printing a second conductive layer utilizing a second extrusion printing nozzle set.