Abstract: A mobile construction equipment for operation on a surface having at least one longitudinal slope grade includes: a blade that is movable with respect to the mobile construction equipment, the blade having a first blade side and a second blade side opposite the first blade side, the blade imparting at least one cross slope grade on the surface; and a controller for receiving the at least one longitudinal slope grade, a first blade side position of the first blade side, and at least one target cross slope grade, and, based on the at least one longitudinal slope grade and the first blade side position, adjusting a second blade side position of the second blade side so as to impart the at least one target cross slope grade on the surface.

Abstract: Apparatus, systems, and methods are used for activating a downhole tool, powered by an exothermic reaction, for operation, while deploying a tubing string from a wellbore surface. The tubing string comprises a coupling for enabling pressurized activation of the downhole tool, which comprises a fuel (e.g., thermite) for producing the exothermic reaction. The coupling enables fluid to flow into an interior of the coupling through a first flow passage, during descent of the downhole tool. A stopper is dropped and/or seated to cause the coupling interior to pressurize to an activation pressure, which causes an activator to activate a burn within the downhole tool. Once the downhole tool completes its operation, the coupling interior is further pressurized to burst a burst disc, which opens a second flow passage for fluid to flow from the interior to exterior of the coupling, while downhole tool and coupling are raised to the surface.

Abstract: An encapsulated valve system includes a first housing portion having a first facing surface, the first facing surface comprising a plurality of branch pathways formed as a recess within the first facing surface. The valve system further includes a second housing portion having a second facing surface, the second facing surface comprising a plurality of branch pathways formed as a recess within the second facing surface. A disposable conduit is configured to be interposed between the first and second housing portions and disposed within the recess of the first facing surface and the recess of the second facing surface. The disposable conduit is thus sandwiched between the first and second facing surfaces. A plurality of pinch valve actuators are mounted on one or both of the first housing portion and the second housing portion, the plurality of pinch valve actuators configured to pinch the disposable conduit at selective branch pathways.

Abstract: Various embodiments provide a fastener including a head, a shank connected to the head and having a tip, one or more helical thread formations extending outwardly from the shank, and wherein a bottom portion of the head includes a plurality of ribs that extend towards the tip of the shank and that are shaped to abruptly frictionally engage a surface of a first object being attached to a second object to create an immediate frictional torsional resistance of a desired force level to the tightening of the fastener. This frictional resistance is provided back to the tightening tool to inform the operator of the tightening tool that the head of the fastener has sufficiently engaged the first object and that further tightening or clockwise rotation of the fastener is unnecessary.

Abstract: Some embodiments provided herein relate to methods and compositions for making genetically modified T cells. In some such embodiments, CD4+ and CD8+ T cells are cultured in a single serum-free volume. In some embodiments, co-cultured CD4+ and CD8+ T cells can be transduced with a lentiviral vector, and a population of transduced T cells can be harvested within a shorter period of time than other conventional methods.

Abstract: Audio content coded for a reference speaker configuration is downmixed to downmix audio content coded for a specific speaker configuration. One or more gain adjustments are performed on individual portions of the downmix audio content coded for the specific speaker configuration. Loudness measurements are then performed on the individual portions of the downmix audio content. An audio signal that comprises the audio content coded for the reference speaker configuration and downmix loudness metadata is generated. The downmix loudness metadata is created based at least in part on the loudness measurements on the individual portions of the downmix audio content.

Abstract: Systems to control movement of a motor grader include a sensor for providing a bounce signal indicative of a bouncing movement of the motor grader, and a controller programmed with instructions that, when executed: receive the bounce signal from the sensor; analyze the bounce signal from the sensor; determine whether the maximum amplitude of the bouncing movement exceeds a threshold; in response to determining whether the maximum amplitude exceeds the threshold, generate an articulation angle command signal to change an articulation angle of the motor grader; and transmit the articulation angle command signal to change the articulation angle.

Abstract: An apparatus is provided to receive a three dimensional (3D) map of at least a part of a body of a user. A light emitting device is included with tunable VCSEL laser with one or more active regions having quantum wells and barriers. The active regions are surrounded by one or more p-n junctions. The one or more active regions can include a selected shape structure. One or more tunnel junctions (TJ) 2 are provided. One or more apertures are provided with the selected shape structure. One or more buried tunnel junctions (BTJ) or oxide confine the apertures, additional TJ's, planar structures and or additional BTJ's created during a regrowth process that is independent of a first growth process. A VCSEL output is determined in response to an application of the VCSEL laser. The VCSEL laser includes an HCG grating and a bottom DBR. A user monitoring device includes the VCSEL laser.

Abstract: A non-shedding hybrid nonwoven web comprised of 99% by mass of functional material(s) co-mingled with the filaments. High level of particle retention within the fabric is provided without the aid of adhesives, binders, adhesive polymers, or post processes. This composite web has a multi-layered structure with a uniform distribution of sorptive particles and desired opposed color contrast on each side. The process includes providing two converging streams of blown polymeric filaments, passive feed of functional material(s) in between the filament streams, and collecting the hybrid webs.

Abstract: Provided are methods for preventing or ameliorating toxicity caused by or due to a therapy, such as an immunotherapy or a cell therapy, by pre-emptive or early administration toxicity-targeting agent(s). In some embodiments, the therapy is a cell therapy in which the cells generally express recombinant receptors such as chimeric receptors, e.g., chimeric antigen receptors (CARs) or other transgenic receptors such as T cell receptors (TCRs). Features of the methods, including the timing of the administration of the agents or treatments for toxicity, provide various advantages, such as lower toxicity while maintaining persistence and efficacy of the administered cells.

Abstract: An apparatus and method for delivering fluid from a syringe to a subject using a pumping device of a flow control apparatus. The method includes locating the flow control apparatus on a horizontal support surface. Providing the syringe with a volume of fluid including a total amount of preferred nutrient and an amount of non-preferred nutrient liquid. Mounting the syringe relative to the flow control apparatus whereby the syringe is oriented in a generally vertical orientation such that an outlet of the syringe faces upward. Initiating operation of the pumping device to draw the fluid from the syringe for a duration of time to preferentially deliver at least a portion of the total amount of preferred nutrient in the fluid to the subject.

Abstract: The invention includes a chimeric autoantibody receptor (CAAR) specific for anti-muscle-specific kinase (MuSK) B cell receptor (BCR), compositions comprising the CAAR, polynucleotides encoding the CAAR, vectors comprising a polynucleotide encoding the CAAR, and recombinant cells comprising the CAAR.

Abstract: Balloon covers for a delivery apparatus for a prosthetic valve are disclosed. As one embodiment, a balloon cover includes first and second shell members that are configured to matingly engage with each other, each of the first and second shell members including a first portion and a second portion, the second portion having a larger width than the first portion. The first portions of the first and second shell members define a first cavity configured to receive a distal end portion of the delivery apparatus and at least a portion of an inflatable balloon mounted on the distal end portion of the delivery apparatus. The second portions of the first and second shell members define a second cavity configured to receive a positioning device mounted on the distal end portion of the delivery apparatus, proximal to a valve mounting portion of the distal end portion of the delivery apparatus.

Abstract: Apparatus are provided that comprise a tie down assembly. The assembly includes a flexible elongated line, at least one terminal connector, and a rotating line adjustment mechanism. In one embodiment, the rotating line adjustment mechanism includes a spiral return spring supported by and fixed to the housing and having a retraction portion fixed to the line whereby the retraction portion pulls and thereby shortens the line.

Abstract: A multi-level induction station is disclosed. The multi-level induction station includes multiple sorting levels arranged in a vertical stacked configuration; a vertically traveling automated lift that carries articles vertically between the sorting levels along a frame positioned proximate to the multiple sorting levels; an information acquisition device positioned to read information from an article on the lift; multiple transport devices positioned on the sorting levels to receive the articles; and a control system that directs the multi-level induction station to determine a destination for an article and direct the lift to a platform where a transport device is at an article-receiving position at the sorting level to receive the article.

Abstract: Embodiments of the methods and compositions provided herein relate to chimeric antigen receptors (CARs) that specifically bind to B7H3. Some embodiments relate to cell-based immunotherapy targeting tumors, such as tumors comprising B7H3+ cells.

Abstract: A microfabricated thermal platform can be formed over a substrate, such as a silicon wafer, that may form part of the platform. The substrate is coated in a thermally-insulating material, which may be an organic polymer such, as polyimide or SUS. The surface of the thermally-insulating material may include an arrangement of one or more thermal sites, with each site having a reaction plate (or thermal plate) over which chemical reactions may occur. A heating element may be positioned beneath each reaction plate. A fluidic medium, such as a liquid or a gas, may be disposed over the thermal sites. One application is in chemical and biological reactions. In such reactions, the fluidic medium may be an aqueous solution which comprises reagents for those reactions. The fluidic medium may be an ionically conducting fluid, organic solution or a gas. Precise temperature control enables the correct reactions.

Abstract: Methods and systems for rotationally aligning a commissure of a prosthetic heart valve with a commissure of a native valve are disclosed. In some examples, a delivery apparatus can include a first shaft configured to rotate around a central longitudinal axis of the delivery apparatus to rotationally align a prosthetic valve mounted on the delivery apparatus with native anatomy, a second shaft extending through the first shaft and having a distal end portion extending distally beyond a distal end portion of the first shaft, an inflatable balloon coupled to the distal end portion of the first shaft, and a distal shoulder mounted on the distal end portion of the second shaft and arranged within a distal end portion of the balloon. The distal shoulder comprises a base portion and a flared portion that extends radially outward from the base portion, and a radiopaque marker is disposed on the flared portion.

Abstract: The Automata Processor Workbench (AP Workbench) is an application for creating and editing designs of AP networks (e.g., one or more portions of the state machine engine, one or more portions of the FSM lattice, or the like) based on, for example, an Automata Network Markup Language (ANML). For instance, the application may include a tangible, non-transitory computer-readable medium configured to store instructions executable by a processor of an electronic device, wherein the instructions include instructions to represent an automata network as a graph.

Abstract: This application is directed to diffusing light using a light modulator. The light modulator has an integral piece of material and a cavity. The integral piece of material includes a first wall and a second wall that is separate from the first wall. The cavity is located between the first wall and the second wall. The light modulator is configured to diffuse light emitted by a light source that is (i) disposed in proximity to the light modulator and (ii) faces the first wall, by scattering the light at surfaces of the first wall, the cavity, and the second wall, and diffracting the light within at least the first wall and the second wall. In some embodiments, an edge structure extends from one or more edges of the first wall to one or more corresponding edges of the second wall.