Abstract: A computing system includes a processor; an electronic network; and a memory having stored thereon computer-executable instructions that, when executed, cause the computing system to: process segmented tile images by: (i) predicting a respective biomarker classification, and (ii) predicting a respective tissue classification; determine, based on (i) and (ii), a predicted presence of biomarkers; and transmit the predicted presence. A non-transitory computer-readable medium includes computer-executable instructions that, when executed by a processor, cause a computer to: process segmented tile images by: (i) predicting a respective biomarker classification, and (ii) predicting a respective tissue classification; determine, based on (i) and (ii), a predicted presence of biomarkers; and transmit the predicted presence.

Abstract: A generalizable and interpretable deep learning model for predicting biomarker status and biomarker metrics from histopathology slide images is provided.

Abstract: The disclosed technology provides for an improved approach to AI code generation. In various embodiments, the disclosed technology provides for an AI agent architecture platform for generating, revising, testing, and debugging code using a customizable team of agents with specific tasks.

Abstract: An indoor, stationary, bicycle training device that provides advantages over conventional designs of exercise bicycles is provided. The stationary bicycle may include a tilting/pivoting mechanism to orient the indoor bicycle to simulate descending or climbing. The indoor bicycle may include flexible and resilient frame elements to support the indoor training device to move side-to-side under some riding situations thereby simulating the side-to-side swaying motion of an outdoor bicycle under the same riding situations. The indoor bicycle may include several combinations of frame adjustments to provide configurable dimensions of the indoor bicycle to adjust the frame to properly fit the rider, which may be adjusted based on corresponding dimensions of a user's outdoor bicycle. Still other aspects of the stationary bicycle device may aid in creating an “outdoor” feeling while using the device.

Abstract: The present invention generally relates to an image guided variable spot stimulation-based electrophysiology assessment device for different biomedical applications. Specifically, the invention relates to application of the device to perform image-guided functional assessment upon variable spot optical stimulation of light-activatable biological specimens to determine changes in the functional health during disease progression and therapy. More specifically, the invention relates to the application of the device in the diagnosis of visual and neurological disorders.

Abstract: A method for qualifying a specimen prepared on one or more hematoxylin and eosin (H&E) slides by assessing an expected yield of nucleic acids for tumor cells and providing associated unstained slides for subsequent nucleic acid analysis is provided.

Abstract: The present invention generally relates to an image guided variable spot stimulation-based electrophysiology assessment device for different biomedical applications. Specifically, the invention relates to application of the device to perform image-guided functional assessment upon variable spot optical stimulation of light-activatable biological specimens to determine changes in the functional health during disease progression and therapy. More specifically, the invention relates to the application of the device in the diagnosis of visual and neurological disorders.

Abstract: Provided are nanonets comprising a) a surfactant aggregate having an average aggregate diameter; and b) a polymer having an average particle diameter which average particle diameter is the same or smaller than the average aggregate diameter, wherein the nanonet has a diameter larger than the average particle diameter. Also provided are kits therefor and methods for sequestering non-water moieties from aqueous solutions using nanonets.

Abstract: Provided are nanonets comprising a) a surfactant aggregate having an average aggregate diameter; and b) a polymer having an average particle diameter which average particle diameter is the same or smaller than the average aggregate diameter, wherein the nanonet has a diameter larger than the average particle diameter. Also provided are kits therefor and methods for sequestering non-water moieties from aqueous solutions using nanonets.

Abstract: Provided are sequestering agents for sequestering non-water moieties from an aqueous solution. The sequestering agents may comprise a detergent; and a polymer operable to stabilize formation of a detergent micelle thereby causing the detergent and polymer to self-assemble into a nanonet upon exposure to the aqueous solution. Also provided are kits therefore and methods for use of the sequestering agents and kits.

Abstract: A method for qualifying a specimen prepared on one or more hematoxylin and eosin (H&E) slides by assessing an expected yield of nucleic acids for tumor cells and providing associated unstained slides for subsequent nucleic acid analysis is provided.

Abstract: Provided are compositions comprising: (a) compound of formula (I): and (b) a compound of formula II: These compositions are NanoNets™ and generally comprise a surfactant of formula (I) and a polymer of formula (II). These NanoNets™ may be used in the treatment of aqueous solutions and more particularly may be used for the removal of boron from aqueous solutions.

Abstract: A computing system includes a processor; an electronic network; and a memory having stored thereon computer-executable instructions that, when executed, cause the computing system to: process segmented tile images by: (i) predicting a respective biomarker classification, and (ii) predicting a respective tissue classification; determine, based on (i) and (ii), a predicted presence of biomarkers; and transmit the predicted presence. A non-transitory computer-readable medium includes computer-executable instructions that, when executed by a processor, cause a computer to: process segmented tile images by: (i) predicting a respective biomarker classification, and (ii) predicting a respective tissue classification; determine, based on (i) and (ii), a predicted presence of biomarkers; and transmit the predicted presence.

Abstract: There is disclosed vision quantification systems and methods designed to evaluate functional vision. Specifically, the systems are designed with the intent to track a subject's vision using mobility and dexterity assessments. More specifically, at least one aspect of the invention relates to the design and application of the systems in the functional vision assessments in patients with low vision.

Abstract: The present invention generally relates to an image guided variable spot stimulation-based electrophysiology assessment device for different biomedical applications. Specifically, the invention relates to application of the device to perform image-guided functional assessment upon variable spot optical stimulation of light-activatable biological specimens to determine changes in the functional health during disease progression and therapy. More specifically, the invention relates to the application of the device in the diagnosis of visual and neurological disorders.

Abstract: A system for identifying biomarkers in a digital image of a Hematoxylin and Eosin-stained slide of a target tissue includes a processor and an electronic network; and a memory having stored thereon computer-executable instructions that, when executed by the one or more processors, cause the computing system to: process segmented tile images determine a predicted biomarker presence; and transmit the predicted presence. A non-transitory computer-readable medium includes a set of computer-executable instructions that, when executed by one or more processors, cause a computer to: process segmented tile images; determine a predicted biomarker presence; and transmit the predicted presence. A computer-implemented method includes processing segmented tile images; determining a predicted biomarker presence; and transmitting the predicted presence.

Abstract: An indoor, stationary, bicycle training device that provides advantages over conventional designs of exercise bicycles is provided. The stationary bicycle may include a tilting/pivoting mechanism to orient the indoor bicycle to simulate descending or climbing. The indoor bicycle may include flexible and resilient frame elements to support the indoor training device to move side-to-side under some riding situations thereby simulating the side-to-side swaying motion of an outdoor bicycle under the same riding situations. The indoor bicycle may include several combinations of frame adjustments to provide configurable dimensions of the indoor bicycle to adjust the frame to properly fit the rider, which may be adjusted based on corresponding dimensions of a user's outdoor bicycle. Still other aspects of the stationary bicycle device may aid in creating an “outdoor” feeling while using the device.