Abstract: The present application discloses a method, system, and computer system for managing data using keys. The method includes receiving a request to access data stored within a tenant database associated with a tenant, wherein the data is encrypted based at least in part on a tenant service encryption key (TSEK) corresponding to the tenant database, determining a wrapper key used in connection with encrypting the TSEK based at least in part on a TSEK metadata stored in association with the TSEK, determining a top-level key used in connection with encrypting the wrapper key based at least in part on wrapper key metadata stored in association with the encrypted version of the wrapper key, obtaining the data stored within the tenant database, comprising decrypting at least part of the data based at least in part on (i) the TSEK, (ii) the wrapper key, and (iii) the top-level key, and providing the data in response to the request. The TSEK metadata is stored in the tenant database.

Abstract: Provided herein are compositions and methods for the treatment of a cancer. Said compositions comprise a KDM4 inhibitor.

Abstract: The present application discloses a method, system, and computer system for managing data using keys. The method includes receiving a request to access data, wherein the data is encrypted based on a tenant service encryption key (TSEK) corresponding to the tenant database, determining a wrapper key used in connection with encrypting the TSEK based on a TSEK metadata, determining a top-level key used in connection with encrypting the wrapper key based on wrapper key metadata stored in association with the encrypted version of the wrapper key, obtaining the data stored within the tenant database, comprising decrypting at least part of the data based on (i) the TSEK, (ii) the wrapper key, and (iii) the top-level key, and providing the data in response to the request. The TSEK metadata is stored in the tenant database. An encrypted version of the wrapper key is stored in a key management service.

Abstract: A medical implant assembly includes a body and at least one support removably coupled to the body. The body has an outer surface, a cavity defined by an inner surface, a rim surrounding a cavity opening with a plurality of bores extending from the rim to the outer surface and one or more openings extending between the inner surface and the outer surface. The at least one support includes a first end structured to frictionally fit within one of the plurality of bores and an opposing second end positioned away from the body and structured to be secured to a host bone tissue. At least one of: (i) the at least one support; and (ii) the body, are structured to allow or promote at least one of: (i) bone ingrowth; and (ii) bone ongrowth.

Abstract: A computer system for generating code for use in processing patient test data from point of care devices. The computer system comprises object definition storage storing a plurality of definition objects, each definition object defining a generic function to be performed in response to an output of a point of care device; instantiation data storage storing instantiation data for use in instantiating definition objects as processing objects for specific functions to be performed in response to outputs from specific point of care devices; and a code generating processor for generating code for at least one processing object to perform at least one specific processing function to process an output from a point of care device by accessing at least one definition object in the object definition storage and the instantiation data in the instantiation data storage to instantiate the at least one definition object using instantiation data for the point of care device.

Abstract: The present application discloses a method, system, and computer system for managing data using keys. The method includes receiving a request to access data stored within a tenant database associated with a tenant, wherein the data is encrypted based at least in part on a tenant service encryption key (TSEK) corresponding to the tenant database, determining a wrapper key used in connection with encrypting the TSEK based at least in part on a TSEK metadata stored in association with the TSEK, determining a top-level key used in connection with encrypting the wrapper key based at least in part on wrapper key metadata stored in association with the encrypted version of the wrapper key, obtaining the data stored within the tenant database, comprising decrypting at least part of the data based at least in part on (i) the TSEK, (ii) the wrapper key, and (iii) the top-level key, and providing the data in response to the request. The TSEK metadata is stored in the tenant database.

Abstract: The present application discloses a method, system, and computer system for managing data using keys. The method includes receiving a request to access data stored within a tenant database associated with a tenant, wherein the data is encrypted based at least in part on a tenant service encryption key (TSEK) corresponding to the tenant database, determining a wrapper key used in connection with encrypting the TSEK based at least in part on a TSEK metadata stored in association with the TSEK, determining a top-level key used in connection with encrypting the wrapper key based at least in part on wrapper key metadata stored in association with the encrypted version of the wrapper key, obtaining the data stored within the tenant database, comprising decrypting at least part of the data based at least in part on (i) the TSEK, (ii) the wrapper key, and (iii) the top-level key, and providing the data in response to the request. The TSEK metadata is stored in the tenant database.

Abstract: A computer system for generating code for use in processing patient test data from point of care devices. The computer system comprises object definition storage storing a plurality of definition objects, each definition object defining a generic function to be performed in response to an output of a point of care device; instantiation data storage storing instantiation data for use in instantiating definition objects as processing objects for specific functions to be performed in response to outputs from specific point of care devices; and a code generating processor for generating code for at least one processing object to perform at least one specific processing function to process an output from a point of care device by accessing at least one definition object in the object definition storage and the instantiation data in the instantiation data storage to instantiate the at least one definition object using instantiation data for the point of care device.

Abstract: A computer system for generating code for use in processing patient test data from point of care devices, the computer system comprises object definition storage storing a plurality of definition objects, each definition object defining a generic function to be performed in response to an output of a point of care device; instantiation data storage storing instantiation data for use in instantiating definition objects as processing objects for specific functions to be performed in response to outputs from specific point of care devices; and a code generating processor for generating code for at least one processing object to perform at least one specific processing function to process an output from a point of care device by accessing at least one definition object in the object definition storage and the instantiation data in the instantiation data storage to instantiate the at least one definition object using instantiation data for the point of care device.

Abstract: A computer system for generating code for use in processing patient test data from point of care devices, the computer system comprises object definition storage storing a plurality of definition objects, each definition object defining a generic function to be performed in response to an output of a point of care device; instantiation data storage storing instantiation data for use in instantiating definition objects as processing objects for specific functions to be performed in response to outputs from specific point of care devices; and a code generating processor for generating code for at least one processing object to perform at least one specific processing function to process an output from a point of care device by accessing at least one definition object in the object definition storage and the instantiation data in the instantiation data storage to instantiate the at least one definition object using instantiation data for the point of care device.

Abstract: Squamous carcinoma stem cells (SCSC) are identified. The cells can be prospectively isolated or identified from primary tumor samples, and are shown to possess the unique properties of cancer stem cells in functional assays for cancer stem cell self-renewal and differentiation, and to form unique histological microdomains useful in cancer diagnosis.

Abstract: The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract: The invention is related to a method of treating disorders associated with hepatitis C by administering to an individual a pharmaceutical composition which comprises a therapeutically effective amount of an anti-viral phosphinate compound.

Abstract: A fastener comprising two parts (502,514) separable along a separation axis, at least one part (502) comprising a magnet (510) establishing magnetic force along the separation axis; and a mechanical coupling having complementary elements (508,522) formed respectively on the two parts (502,514) of the fastener, the mechanical coupling being configured such that movement together of the two parts (502,514) under magnetic force causes automatic relative rotation of the parts (502,514) about the axis.

Abstract: Cancer stem cells (CSCs) have been prospectively isolated or identified from primary tumor samples, and shown to possess the unique properties of self-renewal and differentiation, and can form unique histological microdomains useful in cancer diagnosis. Such cancer stem cells are shown herein to have the phenotype of containing decreased levels of reactive oxygen species (ROS) relative to non-tumorigenic (non-stem cell) cancer cells, as well as expression of other protective pathways. The CSCs are further shown to be more resistant to ionizing radiation (IR) and certain chemotherapies and to express high levels of ROS genes.

Abstract: The invention is related to a method of treating disorders associated with hepatitis C by administering to an individual a pharmaceutical composition which comprises a therapeutically effective amount of an anti-viral phosphinate compound.

Abstract: The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract: The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract: MicroRNA markers of breast cancer stem cells (BCSC) are provided herein. The markers are polynucleotides that are differentially expressed in BCSC as compared to normal counterpart cells. Uses of the markers include use as targets for therapeutic intervention; as targets for drug development, and for diagnostic or prognostic methods relating to breast cancer and BCSC cell populations. BCSCs have the phenotype of having lower expression of certain miRNAs compared to normal breast epithelial cells, or to cancer cells that are not cancer stem cells.