Abstract: Disclosed are anti-CD45 antibodies and antibody drug conjugates (ADCs) useful in therapeutic methods, including targeting CD45 expressing hematopoietic stem cells (HSCs) or immune cells prior to transplantation.

Abstract: A device for connecting a lure to a fishing line, the device includes a main shaft having a line attachment end and a lure holding end. A line holding element is provided at the line attachment end and a lure holding loop is provided at the lure holding end. The device further includes various other components to improve lure retention without impairing lure movement. These other components include one or more from the group of a retaining loop, three or more resistance points, a zigzag structure and a reverse direction terminating segment.

Abstract: A turf applicator including a main body, a primary spray tank, an auxiliary spray tank, and a removable fertilizer hopper, where only one of the auxiliary spray tank or the removable fertilizer hopper is used at a time, a controller; and a removable frame. The removeable frame includes: a plurality of connection points to secure the removable fertilizer hopper or the auxiliary spray tank to the main body, a plurality of mounting flanges to support the removable fertilizer hopper or the auxiliary spray tank, and at least one vertical slot where at least one wing nut and at least one carriage bolt secure the removable frame with the removable fertilizer hopper or the auxiliary spray tank to the main frame. When the auxiliary spray tank is used the controller enables fluid transfer from the auxiliary spray tank to the primary spray tank to balance weight distribution.

Abstract: A manifold for use in a turf applicator spray system, the manifold includes: an inlet to receive fluid flow; a first and second outlet for directing the fluid flow; a valve plunger; a solenoid valve to raise and lower the valve plunger; a compression spring moveable between a compressed state and an uncompressed state; where when in the compressed state the valve plunger is compressed to send the fluid flow from the inlet to the first outlet and when in the uncompressed state the fluid flow is from the inlet to the second outlet.

Abstract: The invention provides anti-CD5 antibodies, antigen-binding fragments thereof, and antibody drug conjugates thereof, for use in treating, for example, a stem cell disorder, cancer, or autoimmune disease, among other hematological and proliferative diseases. Compositions and methods for depleting populations of CD5+ cells, such as CD5+ cancer cells and CD5+ immune cells are described, and can be used to treat cancers and autoimmune diseases directly as stand-alone therapies by eradicating cancerous cells and autoreactive immune cells that express CD5 and/or to prepare a patient for hematopoietic stem cell transplantation, for instance, by depleting populations of CD5+ immune cells that cross-react with, and mount an immune response against, non-self hematopoietic stem cells.

Abstract: The invention provides anti-CD5 antibodies, antigen-binding fragments thereof, and antibody drug conjugates thereof, for use in treating, for example, a stem cell disorder, cancer, or autoimmune disease, among other hematological and proliferative diseases. Compositions and methods for depleting populations of CD5+ cells, such as CD5+ cancer cells and CD5+ immune cells are described, and can be used to treat cancers and autoimmune diseases directly as stand-alone therapies by eradicating cancerous cells and autoreactive immune cells that express CD5 and/or to prepare a patient for hematopoietic stem cell transplantation, for instance, by depleting populations of CD5+ immune cells that cross-react with, and mount an immune response against, non-self hematopoietic stem cells.

Abstract: The electronic device may invoke a host application. The device may display a first host user interface on the display, the first host user interface including a first host user interface component associated with a child application. In response, the device may invoke, using the host application, the child application executed at the electronic device. The device may transmit, using the host application, a request for data associated with a child user interface component to the child application. The device may transmit, using the child application, the request for data associated with the child user interface component to a child application server, wherein the data associated with the child user interface component is inaccessible by the host application. The device may receive, using the child application, the data associated with the child user interface component from the child application server. The device may display the child user interface component.

Abstract: Various embodiments provide systems and methods for locating and aiding in the recovery of discarded tracking devices.

Abstract: A system may include an interface configured to couple to a network, and includes a processor and a memory accessible to the processor. The memory may be configured to store instructions that, when executed, cause the processor to process search results corresponding to multiple data owners to selectively filter personally identifiable information (PII) associated with one or more consumers from the set of search results according to data sharing permissions for each of the data owners to produce filtered results. The instructions may further cause the processor to provide the filtered results to a user device through the network.

Abstract: The present invention relates to epoxy curing agent compositions comprising naphthol and naphthol derivatives in combination with at least one polyamine having three or more active amine hydrogens, and use of these curing agents as hardener for epoxy resins. These curing agent compositions may be used to cure, harden and/or crosslink an epoxy resin.

Abstract: Disclosed are anti-CD45 antibodies, antigen binding fragments thereof, and antibody drug conjugates (ADCs) that specifically bind to human CD45. Such antibodies and ADCs are useful in therapeutic methods, including methods of depleting CD45+ cells from a patient. The compositions and methods described herein can be used to treat a disorder directly, for instance, by depleting a population of CD45+ cancer cells or autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy, and to improve the engraftment of hematopoietic stem cell transplants, by selectively depleting endogenous CD45+ cells prior to the transplant procedure.

Abstract: The invention provides compositions and methods useful for the depletion of CD117+ cells and for the treatment of various hematopoietic diseases, metabolic disorders, cancers, e.g., acute myeloid leukemia (AML) and autoimmune diseases, among others. Described herein are antibodies, antigen-binding fragments, and conjugates thereof that can be applied to effect the treatment of these conditions, for instance, by depleting a population of CD117+ cells in a patient, such as a human. The compositions and methods described herein can be used to treat a disorder directly, for instance, by depleting a population of CD117+ cancer cells or autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy and to improve the engraftment of hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure.

Abstract: The present invention discloses a waterborne amine curing agent, process of making such curing agent, and curable amine-epoxy compositions.

Abstract: An applicator including: a frame with hopper mounted thereon to hold and dispense a granule product, the hopper including an electronically controlled gate(s); a tank to hold a liquid product; a electronically controlled spray tip(s) to dispense the liquid product; a spray pump located between the tank and spray tip(s); an operator control interface for receiving input from an operator; a control coupled to the operator control interface, the electronically controlled gate(s), and the spray tip(s), where the control receives input, dispenses the liquid or granule product based on the input received from the operator control; where when the liquid product is dispensed, the control provides a signal to the spray tip(s) to regulate a flow of the liquid product, and when the granule product is dispensed, the control provides a signal to the electronically controlled gate(s) to regulate a flow of the granule product.

Abstract: This application generally relates to defining, displaying and interacting with tags in a 3D model. In an embodiment, a method includes generating, by a system including a processor, a three-dimensional model of an environment based on sets of aligned three-dimensional data captured from the environment, and associating tags with defined locations of the three-dimensional model, wherein the tags are respectively represented by tag icons that are spatially aligned with the defined locations of the three-dimensional model as included in different representations of the three-dimensional model rendered via an interface of a device, wherein the different representations correspond to different perspectives of the three-dimensional model, and wherein selection of the tag icons causes the tags respectively associated therewith to be rendered at the device.

Abstract: A riding hydraulically driven aerator is disclosed herein. The aerator includes a frame, an engine, one or more hydraulic pumps, one or more drive wheels, one or more tine assemblies, and one or more hydraulic motors. The hydraulic motors are coupled to the drive wheels and to the tine assemblies. The hydraulic pumps provide power to the hydraulic motors and are coupled to the engine with a toothed timing belt.

Abstract: Disclosed are anti-CD45 antibodies, antigen binding fragments thereof, and antibody drug conjugates (ADCs) that specifically bind to human CD45. Such antibodies and ADCs are useful in therapeutic methods, including methods of depleting CD45+ cells from a patient. The compositions and methods described herein can be used to treat a disorder directly, for instance, by depleting a population of CD45+ cancer cells or autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy, and to improve the engraftment of hematopoietic stem cell transplants, by selectively depleting endogenous CD45+ cells prior to the transplant procedure.

Abstract: Pharmaceutical compositions comprising poorly water-soluble drugs (PSDs) and sucrose acetate isobutyrate (SAIB). The compositions are amorphous solid solutions or amorphous solid dispersions where the PSDs are present in the molecular or the amorphous state in the SAIB. The PSDs in amorphous form in the amorphous solid solutions can be stable against crystallization on exposure to elevated temperature and humidity conditions. Oral dosage forms containing the compositions are characterized by a higher dissolution rate in water, a higher serum maximum concentration (Cmax), and/or a greater area under the curve (AUG) than an equivalent oral dosage form without the SAIB.

Abstract: An illumination system for illuminating a lumen within a body of a patient comprising a tube having a proximal end and an opposed distal end and an internal chamber, the tube being configured for placement within a lumen of the body. The system also includes an illumination subsystem including an optical fiber that is sized and configured to seat within the internal chamber of the tube and a light source for generating light that is emitted by the fiber optic cable. The optical fiber, when mounted within the tube and when the light source generates light, emits light at the distal end of the tube so as to transilluminate the lumen and surrounding tissue so as to be able to locate the distal end of the tube within the lumen of the patient.