Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).

Abstract: This invention utilizes multiple charges of a transesterification catalyst in a transesterification process for the production of esters of alkyl (meth)acrylate monomers. The multiple catalyst charge addition strategy and reaction conditions provide for higher productivity and enhanced consistency.

Abstract: An air bag sensor module fastening device for a vehicle is provided includes a vehicle mounting structure having an internally threaded member. A sensor is secured to a base for sensing vibrations caused by a crash of the vehicle. The base has an aperture extending therethrough that is aligned with the internally threaded member. The aperture includes a retaining portion. A fastener for securing the base to the vehicle mounting structure has a shaft with a head and a threaded portion opposite the head. The threaded portion is temporarily retained within the retaining portion in a shipping position. The threaded portion has a minor diameter and the shaft portion has a shaft diameter less than the minor diameter. As a result, the shaft will not be in an interference fit relationship with the retaining portion so that the compressive load of the fastener alone secures the base to the vehicle mounting structure.

Abstract: 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile substantially free of 2,3,7-triamino-4,6-dimethyl-1,9-phenazinedicarbonitrile, and the anhydrous monoacetate salt thereof, are useful in the treatment of alpha-2 mediated disorders such as ocular hypertension.

Abstract: The present invention relates to a four hole offset alignment device that is adjustable in the lateral or medial direction and the anterior or posterior direction at a single interface between the two pieces of the present invention. A first piece is provided having a body with a central axis. A positioner is on the first side of the body. A dome with a pyramid is on the second side of the body. A second piece is provided having a central axis and a flange. Four walls upstand from the flange to define an opening. The positioner can be selectably received within the opening while the central axis of the first piece remains parallel to the central axis of the second piece. The pieces are lockable in place with respect to each other at the selected offset alignment.

Abstract: Compounds of formula (I) wherein R1 or R2 is an aromatic or non-aromatic ring directly joined or joined by a linker, as represented by L2 and L3, to a heteroaromatic core, and X, X?, Y, Y?, Z, Z?, R1, R2, R3, R3a, R3b, R4, R5, L, L2, and L3 are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).

Abstract: Compounds of formula (I) wherein R1 or R2 is a tricyclic or bicyclic ring, each of which contains at least two heteroatoms, and R1, R2, R3, R3a, R3b, R4, R5, L, X, X?, Y, Y?, Z, and Z? are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).

Abstract: The present invention comprises an angularly adjustable coupler. The first and second ends are in an angularly adjustable mating engagement. The first end has a longitudinal axis and a base with an optionally concave and serrated surface, and can comprise a collared clamp for connecting to a pylon. The second end has a longitudinal axis and a base with an optionally convex and serrated surface, and can comprise a receiver for connecting to a pyramidal adapter. The concave portion of the first end and the convex portion of the second end are complementary to each other. A connector is provided to connect the first and second ends in a selected angular alignment about a fixed axis of rotation. The range of angular alignment of the first and second components spans approximately 50 degrees about the fixed axis of rotation.

Abstract: Described herein are microcapsules and emulsions prepared from low Bloom gelatin and methods of making and using thereof.

Abstract: Compounds of formula (I) wherein R1 or R2 is an aromatic or non-aromatic ring directly joined or joined by a linker, as represented by L2 and L3, to a heteroaromatic core, and X, X?, Y, Y?, Z, Z?, R1, R2, R3, R3a, R3b, R4, R5, L, L2, and L3 are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).

Abstract: Compounds of formula (I) wherein R1 or R2 is a tricyclic or bicyclic ring, each of which contains at least two heteroatoms, and R1, R2, R3, R3a, R3b, R4, R5, L, X, X?, Y, Y?, Z, and Z? are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).

Abstract: An occupant restraint assembly and for a motor vehicle operates to sense the tension forces on a seat belt to detect the presence of a human occupant or a child restraint seat. A sensor attached to the seat belt measures tension forces. The sensor is mounted in line with the seat belt. A strain gauge senses tension on the seat belt. An additional embodiment of the sensor includes three prongs attached to a common beam that allow the sensor to be slipped onto the seat belt without modification to the seat belt. A middle prong includes the strain gauge to sense movement relative to outside prongs. The seat belt threads over the outside prongs and under the middle prong such that tension on the seat belt forces the middle prong transversely to tension exerted on the seat belt.

Abstract: A tire bead breaking tool for removing a tire from a tire wheel rim includes an elongated support, which is positionable across the diameter of the tire. First and second clamps are coupled to the elongated support for securing the tire bead breaking tool to the wheel rim. The elongated support is attached to a first and second bracket. A lever arm is removably coupled to the first bracket and provides force against a bead breaker foot, which contacts the tire. The bead breaker foot is positioned at a 10 degree angle and extends between the first and second clamps for facilitating breaking of the bead of the tire. The second clamp is threadedly attached to the tire bead breaking tool for adjustment of the second clamp with respect to the first clamp for using the bead breaking tool for various sized tires.

Abstract: The present invention relates to a system with modular components for forming a prosthetic limb, wherein the effective length of the limb is adjustable to accommodate changing needs of a particular person. Several modular components are provided, including sleeve and spacer modules. Each sleeve module has a body with a selected length and has two opposed ends that are internally threaded. Each spacer module has a body of a selected length and has two opposed ends that are externally threaded. The modules are usable with existing prosthetic components have respective mating ends. The modules are twistable with respect to each other, which enables the effective length of the prosthetic limb to be adjusted. Further, the modules can be interchanged with modules having a different length, which enables large adjustment capabilities. A fully custom fitted prosthetic limb is therefore achievable without the need to custom make a single component.

Abstract: A control circuit that provides a driving signal to a transducer coupled to a mechanical cutting element. The transducer is capable of operating in a resonant mode. The driving signal contains a plurality of pulses provided in a time interval that does not cause the transducer to operate in the resonant mode.

Abstract: An offset alignment device with a longitudinal axis is provided that can offset two prosthetic components a selected distance along an alignment axis that is selectably oriented in a plane that is generally perpendicular to the longitudinal axis, and can also adjust the distance between the two prosthetic components in a direction generally parallel to the longitudinal axis. The present invention comprises first and second members. The first member has a channel and the second member has a bar for being adjustably connected to the channel along the alignment axis. A set screw can be through a hole in the wall of the channel in a direction generally perpendicular to the alignment axis to contact the bar and hold it stationary within the channel. One or both of the first and second members can be rotatably connected to one or both of the first and second prosthetic components, respectively.

Abstract: A control circuit that provides a driving signal to a transducer coupled to a mechanical cutting element. The transducer is capable of operating in a resonant mode. The driving signal contains a plurality of pulses provided in a time interval that does not cause the transducer to operate in the resonant mode.

Abstract: A method of manufacture and assembly of multiwell plates employing targeted radiation at an interface in order to achieve bonding is disclosed. The method accommodates glass and polymer attachment as well as polymer to polymer attachment. Resultant plates have unique flatness and optical properties.

Abstract: The present invention comprises an angularly adjustable coupler. The first and second ends are in an angularly adjustable mating engagement. The first end has a longitudinal axis and a base with an optionally concave and serrated surface, and can comprise a collared clamp for connecting to a pylon. The second end has a longitudinal axis and a base with an optionally convex and serrated surface, and can comprise a receiver for connecting to a pyramidal adapter. The concave portion of the first end and the convex portion of the second end are complimentary to each other. A connector is provided to connect the first and second ends in a selected angular alignment about a fixed axis of rotation. The range of angular alignment of the first and second components spans approximately 50 degrees about the fixed axis of rotation.

Abstract: An air bag sensor module fastening device for a vehicle is provided includes a vehicle mounting structure having an internally threaded member. A sensor is secured to a base for sensing vibrations caused by a crash of the vehicle. The base has an aperture extending therethrough that is aligned with the internally threaded member. The aperture includes a retaining portion. A fastener for securing the base to the vehicle mounting structure has a shaft with a head and a threaded portion opposite the head. The threaded portion is temporarily retained within the retaining portion in a shipping position. The threaded portion has a minor diameter and the shaft portion has a shaft diameter less than the minor diameter. As a result, the shaft will not be in an interference fit relationship with the retaining portion so that the compressive load of the fastener alone secures the base to the vehicle mounting structure.