Abstract: The present invention provides improved methods for gene delivery to, or genetic modification of, target cells, wherein the gene delivery or other genetic modification of the target cells is performed in the presence of endothelial cells, or after co-culture of the target cells with endothelial cells, or wherein co-culture of the target cells with endothelial cells is employed immediately after gene delivery in order to “rescue” cells that may have been damaged during the gene delivery process. In some embodiments gene delivery is performed by transfection. In some embodiments gene delivery is performed by transduction. In some embodiments the endothelial cells are organ-specific endothelial cells. In some embodiments the endothelial cells are E4ORF1-expressing endothelial cells (E4ORF1+ ECs). In some embodiments the target cells are stem cells, such as hematopoietic stem cells.

Abstract: The present invention relates to compositions comprising a constituent, derivative or extract of cannabis in amorphous form. The invention also relates to products comprising such compositions and methods of manufacturing them.

Abstract: Predicting local layout effects using a variational autoencoder with integrated regression and classification network including identifying a vector of features and a vector of output metrics from a dataset; performing basic training of a neural network machine learning variational autoencoder (VAE) combined with a regression network using the vector of features and the vector of output targets constrained to a latent space of the VAE; performing interpolation training of the VAE and combined regression network; determining a set of influential features of an integrated circuit layout based on an input gradient using an output of the VAE and combined regression network with interpolation training; using the set of influential features as input into a parallel neural network to generate a function for each influential feature; and creating a compact model to calculate local layout effects based on the functions for each influential feature.

Abstract: The present disclosure provides an apparatus for facilitating a flow of a fluid. Further, the apparatus may include a housing which may be configured to be attached to a toilet bowl. Further, the housing may include of two or more openings. Further, the two or more openings may include an inlet opening which may be configured to be in fluid connection with a bowl interior region of the toilet bowl. Further, the two or more openings may include an outlet opening in fluid connection with the inlet opening. Further, the apparatus may include a flow generator comprising an intake and an exhaust. Further, the intake may be in fluid connection with the inlet opening. Further, the exhaust may be in fluid connection with the outlet opening. Further, an actuation of the flow generator facilitates a flow of a fluid from the inlet opening to the outlet opening.

Abstract: A multi-sensor smart patch is disclosed that can be worn by a user to monitor multiple physiological systems of the user. The multi-sensor smart patch can make use of two or more acoustic sensors, such as accelerometer contact microphones (ACMs), to collect acoustic data from multiple locations on the user's body. The multi-sensor smart patch can include electrodes for detecting the heart's electrical activity and/or assessing the user's bioimpedance. The multi-sensor smart patch can provide useful data associated with the user's cardiovascular system, respiratory system, and electrical characteristics. The multi-sensor smart patch can be in the form of a reusable electronics module couplable to a disposable patch adhesive.

Abstract: The present invention relates to compositions comprising constituents, derivatives or extracts of cannabis. The invention also relates to uses of such compositions and methods of manufacturing them.

Abstract: A portable emergency safety device that is configured to be deployed underneath an individual in a precarious situation having a high probability of falling. The invention includes a body wherein the body includes a plurality of inflation chambers defining the shape thereof. The inflation chambers have secured to the top thereof a catch member wherein the catch member completely covers the top area of the body and is configured to receive and retain a falling individual. The catch member is secured to the body utilizing a plurality of keepers. The body moves from a first state which is deflated and stored to a second state utilizing a compressed gas source. One embodiment of the present invention includes at least one terrain adapting inflation chamber that is disposed along a portion of the circumference of the body and is configured to maintain the body in a horizontal position on sloped terrain.

Abstract: A method of utilizing a distractor in a joint replacement procedure is provided. The method includes releasably engaging a datum to a datum securement of the distractor and gripping a handle of the distractor in an insertion position. The handle includes a first handle portion and a second handle portion. The method includes disposing a paddle of a tissue engaging portion of the distractor against a tissue surface and adjusting the handle from the insertion position to the distraction position to thereby independently move the paddle with respect to both the second handle portion and the first handle portion such that the paddle remains at a generally constant angle against the tissue surface as the tissue surface is distracted. The paddle is attached directly and exclusively to a distal tip of the second handle portion such that the paddle pivots about an axis transverse to a length of the handle.

Abstract: Embodiments of the present disclosure provide enhanced systems and methods for predicting optimal design flow parameters for optimized output targets for physical design synthesis of a given IC design. A Variational Autoencoder (VAE) along with a regression network are trained using a dataset comprising synthesis design construction flows from historical IC designs to provide a training data representation of the dataset constrained to a latent space of the VAE. The system generates feature vectors based on the training data representation of the dataset and updates the feature vectors with initial design characteristics of the given IC design. The system iteratively performs an input gradient search of the updated feature vectors to optimize an objective function of the design targets to identify locally optimal design parameters. The system identifies globally optimal design flow parameters for optimized design targets based on locally optimal design parameters.

Abstract: Systems, apparatus, articles of manufacture, and methods to facilitate user interaction across multiple computing systems are disclosed. An example apparatus includes interface circuitry, machine readable instructions, and programmable circuitry to at least one of instantiate or execute the machine readable instructions to, cause content to be provided to a host computing system to present the content via a display, access an edit instruction from a user of the apparatus, the edit instruction to cause a change of the content, and cause the edit instruction to be provided to the host computing system to apply the change to the content presented on the display.

Abstract: The present invention is directed to methods of producing algal biomass and algal cell cultures, and lipid compounds and compositions thereof, including fatty acids, carotenoids and fat soluble vitamins. The present invention is further directed to methods of preparing related food products and industrial and pharmaceutical compositions. In various exemplary embodiments, the methods comprise growing algae in a juice based medium, including a medium that contains natural nitrogen or a medium that is free of chemical additives and preservatives, to produce algal cell cultures, algal biomass, algae derived lipid compounds and compositions, and related products, all that can be certified organic.

Abstract: The present invention relates to compositions comprising constituents, derivatives or extracts of cannabis. The invention also relates to uses of such compositions and methods of manufacturing them.

Abstract: Methods, apparatus, systems, and articles of manufacture for user-to-avatar mapping and adjustment are disclosed. An example apparatus includes processor circuitry to at least one of instantiate or execute the machine readable instructions to: determine a dissonance between a first orientation of a user in a real-world environment and a second orientation of an avatar in a virtual environment, the avatar corresponding to the user; determine an avatar adjustment value based on the dissonance; and apply the avatar adjustment value to the avatar model to change the second orientation.

Abstract: The present invention relates to methods for preparing compositions comprising a constituent, derivative or extract of cannabis. The invention also relates to the compositions and products incorporating them.

Abstract: The present invention relates to compositions comprising a constituent, derivative or extract of Cannabis in a water soluble matrix. The invention also relates to uses of such compositions and methods of manufacturing them.

Abstract: The present invention relates to compositions comprising a constituent, derivative or extract of cannabis in solution or in a solubilised form. The invention also relates to products including such compositions and methods of manufacturing them.

Abstract: Systems, apparatus, articles of manufacture, and methods to implement predictive video decoding and rendering based on artificial intelligence are disclosed. Example apparatus disclosed herein are to predict that rendering of a video frame of a media stream will be unsynchronized with rendering of corresponding audio data of the media stream. Disclosed example apparatus are also to generate a synthetic frame based on a machine learning model to replace the video frame. Disclosed example apparatus are further to cause the synthetic frame to be rendered with the corresponding audio data.

Abstract: The present disclosure provides an electric power transmission system. The system includes an electric power generator configured to generate an output electric power. The system includes a first inverter electrically coupled between the electric power generator and one or more load elements. The first inverter includes a first inverter controller. The system includes a second inverter configured to be electrically coupled to the first inverter and with an electric power grid. The second inverter includes a second inverter controller configured to receive at least a first portion of a total generated output electric power from the first inverter to the second inverter when the total generated output electric power is greater than a total required electric power. The second inverter controller is further configured to transmit, through the plug-in inverter, the received first portion of the total generated output electric power to the electric power grid.

Abstract: An example apparatus disclosed herein is to receive network data communicated via a first channel associated with the online collaboration session, the network data including received media data packets. The disclosed example apparatus is also to analyze the network data to determine first loopback data, the first loopback data including at least one of a first quality score based on a first analysis of the received media data packets or a second quality score based on a second analysis of media decoded from the received media data packets. The disclosed example apparatus is also to analyze local data obtained by a local client during the online collaboration session to determine second loopback data. The disclosed example apparatus is further to cause transmission of a loopback message to a moderator client via the second channel, the loopback message based on the first loopback data and the second loopback data.

Abstract: This disclosure provides techniques for executing a software program by separating a dynamic link editor from a process executing the software program. For example, the dynamic link editor can reside outside of the process being dynamically linked and would perform dynamic linking operations for the process before the process executes its first instruction. Such techniques optionally complement or replace other methods for executing a software program.