Abstract: A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6, 7-dihydro-7, 14-methanobenzimidazo[1, 2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.

Abstract: A novel gRNA-ligand binding complex is provided. This complex may be used to bring Type V Cas proteins and additional effectors to DNA for base editing. The design of the systems allows for the production of efficient modular components that provide flexibility when editing DNA.

Abstract: A dieless crimp head is provided that includes a frame, an indentor, and a first positioning device. The frame has a first frame shell and a second frame shell, which define a frame opening. The indentor converges on a crimp center within the frame opening. The first positioning device has a connector slot defining a connector receipt area. The first positioning device is removably secured in the frame opening of the first frame shell at a use position in which the connector receipt area and the crimp center are aligned with, but offset along, a longitudinal axis of the crimp head.

Abstract: The present invention provides compositions comprising high densities of endothelial cells (such as human umbilical vein endothelial cells) in freezing media, methods of producing such compositions, and methods of using such compositions in the preparation of therapeutic endothelial cell compositions. Such compositions and methods provide numerous advantages including eliminating the requirement to remove cryopreservatives before administration of therapeutic endothelial cell compositions to human subjects and requiring minimal manipulations and human interventions before use in therapeutic methods.

Abstract: The present disclosure relates to the field of hematopoietic stem or progenitor cell transplantation. More specifically, methods, compositions and kits for improving expansion and engraftment of hematopoietic stem or progenitor cells by co-culturing and co-administering with endothelial cells are provided. The methods, compositions and kits are useful for treating various disorders relating to deficiencies in hematopoiesis caused by disease or myeloablative treatments.

Abstract: A dual action hydraulic piston assembly including a cylinder having first and second inlet ports on a first end and an outlet port on a second end, a conduit connected to the first inlet port and extending into the cylinder, an inner ram slidable along an outer surface of the conduit, and an outer ram slidable between the inner ram and the cylinder. The inner and outer rams are configured to move together toward the second end of the cylinder in response to a fluid being displaced via the first inlet port into the conduit, which displaces a second fluid through the outlet port at a first flow rate. The outer ram is configured to move toward the second end of the cylinder in response to a fluid being displaced via the second inlet port, which displaces the second fluid through the outlet port at a second flow rate.

Abstract: The present invention relates, in part, to blood-brain barrier-like tissues that comprise engineered E40RF1+ endothelial cells, and to various compositions and methods useful for making and using such blood-brain barrier-like tissues—both in vitro and in vivo.

Abstract: A ISOFIX guide element, having a base section, a rear side section, and two side sections connected to the base, an insertion opening, which is delimited by respective inner sides of the base section and the two side sections, a bracket opening formed between the base section and the rear side section which has notches formed in the side sections in such a way that a bracket-like fixing element can be accommodated in the notches, and that the fixing element is accessible through the insertion opening. It is provided here that at least one fastening element protruding from the base section is arranged on an outer side of the base section, wherein the fastening element has at least one oblong-hole-type fastening opening, which is connectable to a tab of a seat cushion or a seat cover of a vehicle seat.

Abstract: Provided herein are pharmaceutically acceptable compositions containing a selective cyclooxygenase-2 (COX-2) inhibitor (coxib) and optionally buprenorphine. In particular, compositions containing a coxib formulated for oral, topical or subcutaneous administration to treat pain or inflammation are described.

Abstract: Described is a system and apparatus that provides redundant flight control for an aerial vehicle without the use of independent and dedicated redundant flight control boards and processors. Additional compute resources available on processors of other device boards of an aerial vehicle may be used to execute redundant flight control programs. The device boards and/or those redundant flight control programs monitor the operability of the various flight controllers. If any of the flight controllers is determined to be inoperable, one of the redundant flight control programs assumes the role of the inoperable controller.

Abstract: The present invention provides compositions and methods for the mitigation of side effects of chemotherapy, for example in human subjects with hematologic malignancies (such as lymphoma, leukemia and myelodysplastic syndrome) as well as subjects with other malignancies or other conditions that may be treated with chemotherapy, such as high dose therapy (HOT) or a combination of high dose HDT and a hematopoietic stem cell transplant. The methods comprise administration of endothelial cells, such as engineered human umbilical vein endothelial cells engineered to express the adenoviral E40RF1 protein (E40RF1+HUVECs), to human subjects. The side effects mitigated by the compositions and methods of the invention include, but are not limited to, oral/gastrointestinal side effects and febrile neutropenia.

Abstract: A long reach cable cutting tool includes a handle, a motor electrically connectable to a battery, a trigger electrically connected to the motor to provide power from the battery to the motor when the trigger is activated, a pump connected to the motor, the pump is activated to displace a first fluid, a hydraulic actuating system connected to the hydraulic pump, the hydraulic actuating system is movable by the displacement of the first fluid to displace a second fluid, a pole having a first end and a second end, the pole connected to the handle at the first end, and a tool head connected to the pole at the second end, the tool head including a tool head hydraulic actuator hydraulically connected to the hydraulic actuating system, the tool head hydraulic actuator is movable by the displacement of the second fluid to cause relative movement of the actuator with respect to the tool head.

Abstract: A bonding material is described that is well suited to bonding polymer films, such as polyester films, to other substrates. In one embodiment, for instance, the bonding material can be used to bond a polyester film to a polypropylene article. The bonding material generally comprises an adhesive agent combined with a cross-linking agent. The adhesive agent may comprise a carboxylic acid modified polypropylene homopolymer, copolymer or ionomer. In one embodiment, the adhesive agent comprises a polypropylene modified by an unsaturated dicarboxylic acid anhydride. The cross-linking agent, on the other hand, may comprise an oxazoline polymer.

Abstract: Modular units having one or more bays or compartments are installed into openings of aerial vehicles that are sized and configured to accommodate the modular units. Multiple items may be loaded into the respective bays or compartments of the modular unit, which is installed into an opening of an aerial vehicle, and carried by the aerial vehicle to locations where the items are to be delivered. Hatches or coverings of the bays or compartments are selectively operated to deploy the items therefrom at the designated locations. A modular unit may be selected for use in a mission based on a number of bays or compartments therein, or any other features of the modular unit, and installed in any number of aerial vehicles having appropriately sized and configured openings.

Abstract: A laminated multilayer polymer containing film (P) comprises at least one layer comprising at least one copolyamide wherein the copolyamide is prepared by polymerizing the following components: (A) 15% to 84% by weight of at least one lactam, (B) 16% to 85% by weight of a monomer mixture (M) comprising the following components: (B1) at least one C32-C40 dimer acid and (B2) at least one C4-C12 diamine, where the percentages by weight of components (A) and (B) are each based on the sum total of the percentages by weight of components (A) and (B) and wherein the laminated multilayer polymer containing film (P) comprises at least one further layer, where the at least one further layer is selected from the group consisting of (i) at least one further polymer (FP) selected from the group consisting of polyolefins, poly(ethylene-vinyl alcohols), poly(ethylene-vinyl acetates), polyethylene terephthalates, polyvinylidene chlorides, maleic anhydride-grafted polyolefins, polyesters and ionomers and (ii) aluminum metal a

Abstract: Systems, methods, and other embodiments associated with deploying resources are described. In one embodiment, a method includes receiving a service request comprising an activity to be performed, and accessing a database to identify resources eligible to perform the activity, and a remote device associated with the plurality of resources. An electronic invitation to perform the activity is generated, and includes an option that is selectable by each of the plurality of resources to indicate acceptance of the electronic invitation to perform the activity. The electronic invitation is concurrently transmitted to the remote device associated with each of the plurality of resources identified from the data structure. An earliest acceptance of the electronic invitation is received from a first resource over the communication network, and a schedule associated with the first resource is modified to include the service request as a result of receiving the earliest acceptance.

Abstract: A process for recovery of lithium ions from a lithium-bearing brine, the process comprising: contacting the lithium-bearing brine with a lithium ion adsorbent based on orthosilicate. The lithium ion adsorbent is a de-lithiated form of: Li2X1-y-zYyZzSiO4, where y and z together=0 to 1 and X, Y and Z are each Fe, Mg, Ca, Ni, Mn, Co, Zn, Cu, Ti, V, Sr or Zr.

Abstract: An ultrasonic diagnostic imaging system has a user control by which a user positions the user's selection of a heart chamber border in relation to two myocardial boundaries identified by a deformable heart model. The user's border is positioned by a single degree of freedom control which positions the border as a function of a single user-determined value. This overcomes the vagaries of machine-drawn borders and their mixed acceptance by clinicians, who can now create repeatably-drawn borders and exchange the control value for use by others to obtain the same results.