Abstract: Compositions comprising an AhR agonist compound, such as indigo and/or an indigo derivative, such as indirubin and isatin, are described. Methods of treatment, including the treatment of ulcerative colitis, by administering the compositions are described. In an embodiment, compositions in the form of a solid amorphous dispersion of the AhR agonist are described.

Abstract: The present application provides BCMA targeting chimeric antigen receptor (CAR) comprising a BCMA binding region and an intracellular costimulatory domain derived from DAP10. Further provided are engineered immune effector cells (such as NK cells) comprising the chimeric antigen receptors. Pharmaceutical compositions, kits and methods of treating cancer are also provided.

Abstract: Disclosed herein are ceramic materials, such as bismuth substituted garnets, which can have high curie temperatures and high dielectric constants. In certain implementations, indium can be incorporated into the ceramic to improve certain properties and to avoid calcium compensation. The ceramic materials disclosed herein can be particular advantageous for below resonance applications.

Abstract: Depth maps are generated based on a sequence of posed images captured by a camera, the depth maps are fused into a truncated signed distance function (TSDF), and an initial estimate of 3-dimensional (3D) scene geometry is generated by extracting a 3D mesh via the TSDF. 3D embeddings are estimated for each vertex in the 3D mesh by mapping each vertex to a multi-view consistent plane embedding space such that vertices on a same plane map to nearly a same place in the embedding space. The vertices are clustered into 3D plane instances based on respective 3D embeddings and geometry information defined by the 3D mesh to create a planar representation of the scene. A location of a virtual element in a virtual world of an augmented reality game is determined based on the planar representation.

Abstract: The present disclosure provides compositions and methods for rapid production of chemicals in genetically engineered microorganisms in a large scale. Also provided herein is a high-throughput metabolic engineering platform enabling the rapid optimization of microbial production strains. The platform, which bridges a gap between current in vivo and in vitro bio-production approaches, relies on dynamic minimization of the active metabolic network.

Abstract: An anti-rollout assembly may comprise: a housing defining a cavity; a guide/restraint head pivotably coupled to the housing at a first end of the cavity; an overridable trigger pivotably coupled to the housing at a second end of the cavity, the second end opposite the first end; and a locking system operably coupled to the guide/restraint head and the overridable trigger, the locking system configured to bias the guide/restraint head into an upright position, the locking system configured to retract the guide/restraint head into the cavity in response to a first lateral force driving the overridable trigger. The locking system may comprise a drive link and a locking link and be configured to lock the guide/restraint head in a raised state.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating controllable videos using generative neural networks.

Abstract: A system includes a show element with a first show element body coupled to a second show element body via one or more tether assemblies. Each tether assembly of the one or more tether assemblies includes a tether and a first retainer at a first end of the tether and positioned in a first recess of the first show element body. The one or more tether assemblies enable the first show element body to move relative to the second show element body to transition the show element between an engaged configuration and a disengaged configuration.

Abstract: The present disclosure relates to a portable display system, products which can be easily carried to display booth, quickly hand assembled and disassembled without tools, and repackaged for easy transportation on the return trip. In an embodiment, the system includes one or more of a signage stand, shelving, a podium, or even a wall. Each of these items are light weight and conveniently packaged in flat carry containers, and come with parts and pieces and assembly instructions for easily assembling and disassembling the items step-by-step. In another embodiment, the system includes flat parts and pieces that can be assembled together. Each part or piece includes at least one extending tab or slot which is configured to mate with one or more corresponding slots or extending tabs in another part or piece, such that the parts or pieces, when fully assembled form a finished article, such as a signage stand, shelving, a podium, or a wall.

Abstract: A facility for transforming a subject data item sequence is described. The facility accesses a trained relationship model. For each of a plurality of subject items of the subject data item sequence, the facility: selects a first contiguous series of items of the subject data item sequence immediately before the subject data item; selects a second contiguous series of items of the subject data item sequence immediately after the subject data item; and applies the trained relationship model to the selected first and second contiguous series of data items to obtain a denoised version of the subject data item. The facility then assembles the obtained denoised subject data items into a denoised data item sequence.

Abstract: A system for identifying and targeting individual cells within a cell population for selective extraction of cellular content. The system includes a digital microfluidic device having at least one hydrophilic site for receiving cells, an imaging system including a stage for receiving the digital microfluidic device and an imaging module for identifying at least one targeted cell among the cells at the at least one hydrophilic site and a pulsed laser source for lysing the targeted cell to produce a lysate. A control system controls the pulsed laser source, the imaging system and the digital microfluidic device and is programmed for coordinating steps of i) moving droplets on the digital microfluidic device, ii) selecting the targeted cell to be lysed located at the hydrophilic site, iii) illuminating the selected targeted cell by the pulsed laser source to lyse the selected targeted cell to produce lysate, and iv) collecting the lysate.

Abstract: Embodiments of the technology described herein identify and mitigate phishing attempts by analyzing user input received at the operating system level. Initially, a credential, such as a username or password, is registered with the threat detection system. The technology described herein intercepts user input at the operating system level, generates a hash of the input, and compares it with a hash of a credential being monitored. The technology described herein will perform a threat assessment when a secret entry is detected. The threat assessment may use the application context and the network context as inputs to the assessment. When the threat assessment results in an unknown classification or when the snapshot is otherwise requested, a snapshot is captured to supplement the threat assessment. Based on user settings, the snapshot is consumed by a snapshot phishing machine learning model. Various mitigation actions may be taken when a threat is detected.

Abstract: Semisolid oral dispersions for improving the health and/or appearance of the oral cavity. The semisolid oral dispersions include hydrophilic active agent particles in hydrophobic phase. The hydrophilic active agent particles can include bleaching agents, antimicrobial agents, anticalculus agents, and/or combinations thereof. The hydrophilic active agent particle can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water. The hydrophobic phase can be semisolid petrolatum.

Abstract: The present disclosure relates to stable aqueous compositions of alkyl sulfates, which are suitable for numerous commercial applications due to their favorable cleaning and foaming properties. More particularly, the disclosure relates to stable aqueous compositions of alkyl sulfates in combination with select hydrophobic agents, such as essential oils.

Abstract: Systems and methods are provided herein for minimizing retinal exposure to flash during image gathering for diagnosis. In an embodiment, a system captures a plurality of retinal images of different retinal regions. The system determines that a first portion of a first image does not meet a criterion while a second portion of the first image does meet the criterion, identifies a portion of the retina depicted in the first portion that does not meet the criterion, and determines whether the portion of the retina is depicted in a third portion of a second image and whether the third portion meets the criterion. Responsive to determining that the third portion meets the criterion, the system performs the diagnosis. Responsive to determining that the portion of the retina is not depicted in the second image, the system captures an additional image of the retinal region.

Abstract: Systems and methods for onboard vehicle certificate distribution are provided. A system can include a plurality of devices including a master device for authenticating processes and one or more requesting devices. The master device can include a master host security service configured to authenticate the one or more processes of the system. The master host security service can run a certificate authority to generate a root certificate and a private root key corresponding to the root certificate. A respective host security service can receive a request for a process manifest for a requesting process of a respective device from a respective orchestration service. The respective host security service can generate the process manifest for the requesting process and provide the process manifest to the requesting process. The requesting process can use the process manifest to communicate with the certificate authority to obtain an operational certificate based on the root certificate.

Abstract: A blower includes a housing including an inlet and an outlet, a bearing-housing structure provided to the housing and adapted to rotatably support a rotor, a motor provided to the bearing-housing structure and adapted to drive the rotor, and an impeller provided to the rotor. The bearing-housing structure includes a bearing shaft having a bearing surface that rotatably supports the rotor. The bearing shaft provides only a single bearing of the non-ball bearing type for the rotor.

Abstract: Provided herein are compounds of Formula A, B or C that can inhibit the replication of influenza viruses, reduce the amount of influenza viruses, and/or treat influenza.

Abstract: A lock for an information handling system includes a sensor configured to detect removal of an element from a chassis prior to verification of a user credential, and a plunger that engages the chassis at a first position. A security controller verifies the user credential, and causes the muscle wire to move the plunger from the first position to a second position in response to the verified user credential.