Abstract: Applicator devices (1), kits, systems, and methods of using such devices for treating one or more body surface conditions (e.g., warts, Molluscum contagiosum, conjunctivitis, otitis) are provided. The applicator device facilitates topical administration of a controllable amount of a pharmaceutical composition to a desired area of an affected body surface (e.g., skin, eye, ear, nose, mouth, anus, vagina). The applicator device includes an ampule (40) containing the pharmaceutical composition, the ampule being positioned within a tube (50). Squeezing the tube breaks the ampule, releasing the pharmaceutical composition. The applicator device includes a filter (30) that permits passage of fluid and inhibits passage of broken ampule shards. The applicator device includes a dispensing tip (20) through which the pharmaceutical composition passes.

Abstract: A food processor assembly includes a receptacle for receiving food therein, a lid configured to selectively cover the receptacle and having a chute for conveying food into the receptacle, and a pusher assembly configured to push food through the chute and into the receptacle. The pusher assembly includes a pusher body and a spring that biases the pusher body relative to the lid to urge movement of the pusher body within the chute toward the receptacle.

Abstract: Provided herein is an engagement and care support platform (“ECSP”) computer system including at least one processor in communication with at least one memory device for facilitating senior user engagement. The processor is programmed to: (i) register a user through an application, (ii) register a caregiver associated with the user through the application, (iii) generate a senior profile based upon user personal and scheduling data, (iv) build a daily interactive user interface that reflects the senior profile, (v) display the daily interactive user interface at a first client device associated with the user, (vi) cause the first client device to initiate a daily interaction prompt to the user, (vii) determine whether any user interaction was received in response to the daily interaction prompt, and (viii) transmit a daily update message to a second client device associated with the caregiver, including an indication of whether any user interaction was received.

Abstract: A vessel rinsing apparatus including a mounting base, a fluid discharge member including a plurality of nozzles, a valve member operably coupled to the fluid discharge member and configured to control water flow through the nozzles, and an escutcheon supported by the mounting base.

Abstract: Methods of treating one or more skin lesions using cantharidin as well as associated compositions, treatment regimens, kits, devices, and systems are provided. A method of treating a subject having one or more skin lesions may involve administering a composition comprising cantharidin to one or more skin lesions. The method may allow for the efficacious treatment of the skin lesion(s) with minimal or no adverse side effects (e.g., severe adverse side effects, permanent damage of the dermal tissue, scarring, excessive blistering of skin surrounding the lesion, elevated plasma cantharidin concentration, systemic exposure to cantharidin). The efficacy and/or safety of the treatment may be due, to certain features of the composition and/or prolonged exposure of the skin lesion(s) to cantharidin. The methods described herein may be used for a wide variety of cutaneous disorders, including skin disorders that primarily affect the epidermis of skin.

Abstract: Aspects of the present technology comprise a positioning and stabilising structure to hold a seal-forming structure in a therapeutically effective position on a head of a patient. The seal-forming structure may be constructed and arranged to form a seal with a region of the patient's face surrounding an entrance to the patient's airways for sealed delivery of a flow of air at a therapeutic pressure of at least 4 cmH2O with respect to ambient air pressure throughout the patient's respiratory cycle in use. The positioning and stabilising structure may comprise a front hoop arranged to contact, in use, at least a region of the patient's head superior to an otobasion superior of the patient's head and a rear strap.

Abstract: A patient interface is configured to deliver a flow of pressurized breathable gas to a patient's airways. The patient interface includes a central portion with an opening configured to deliver the pressurized breathable gas to the patient's nares. A first stabilizing portion extends from the central portion and is structured to engage an outer side of a respective one of the patient's nostrils. A second stabilizing portion is opposite the first stabilizing portion and extends from the central portion. In addition, the second stabilizing surface is structured to engage an outer side of a respective one of the patient's nostrils. The central portion, the first stabilizing portion and the second stabilizing portion cooperate to form a U-shape configured to cradle the patient's nose so that the tip of the patient's nose remains exposed when the patient interface is mounted on the patient's face.

Abstract: Aspects of the present technology comprise a positioning and stabilising structure to hold a seal-forming structure in a therapeutically effective position on a head of a patient. The seal-forming structure may be constructed and arranged to form a seal with a region of the patient's face surrounding an entrance to the patient's airways for sealed delivery of a flow of air at a therapeutic pressure of at least 4 cmH2O with respect to ambient air pressure throughout the patient's respiratory cycle in use. The positioning and stabilising structure may comprise at least one gas delivery tube to deliver the flow of air to the entrance of a patient's airways via the seal-forming structure. The positioning and stabilising structure may comprise an adjustment mechanism for adjustment of a length of the at least one gas delivery tube to enable the positioning and stabilising structure to fit different size heads.

Abstract: A method and apparatus are provided for thermal treatment of poultry appendages, such as chicken feet or paws. In this regard, the apparatus may include a thermal transport assembly that may be structured and dimensioned to be filled with a thermal treatment liquid (e.g., water, or the like) that is regulated at a designated target temperature. The poultry appendages may be pumped from a picker assembly to the thermal transport assembly such that the appendages are at least partially submerged in the thermal treatment liquid while being transported through the thermal transport assembly. The thermal treatment liquid may be maintained at a specified temperature, and the thermal transport assembly may be operated such that the poultry appendages are at least partially submerged in the thermal treatment liquid for a specified amount of time.

Abstract: A device for harvesting electrical energy from movement of a prosthetic limb. The device including a generator and a controller. The generator adapted to attach to a prosthetic limb. The generator comprising a magnetic linear motor that is configured to generate electrical energy in response to movement of a portion of the prosthetic limb. The controller is electrically connected to the generator and configured to provide electrical energy to a power supply of the prosthetic limb.

Abstract: The present disclosure describes compositions and methods for treating at least one negative symptom in a human subject who does not have a clinical diagnosis of schizophrenia.

Abstract: The present invention relates to the treatment of cardiovascular disease, more particularly to the treatment of subjects suffering from or at risk of suffering from atherosclerotic cardiovascular disease that are hypo-responsive to HIS treatment. The present inventors have found that HIS hypo-responders show remarkable improvements in their blood lipid profiles when their statin therapy is combined with treatment with the CETP inhibitor obicetrapib. In a general aspect, the present invention thus provides methods of treating subjects that are hypo-responsive to high intensity statin (HIS) therapy, said method comprising the administration of a composition comprising obicetrapib or a pharmaceutically acceptable salt, hydrate or solvate thereof.

Abstract: The present disclosure relates to an anatomically aligned prosthetic ankle with a passive assist and associated methods. The prosthetic ankle includes a talus movably coupled to a tibia section by a connector about which the talus is pivotal such so during locomotion by a user of the prosthetic ankle. The passive to assist provides a selected dorsi-flexion force to aid in the push-off or pre-swing phases of gait for the user.

Abstract: A system and message for message selection and presentation, including: receiving a request for content, wherein the request is associated with a context account of a messaging platform; identifying a set of unviewed messages associated with the context account; identifying grouping criteria for grouping content based on messages; applying, by a computer processor, the grouping criteria to the unviewed messages to generate a content group, wherein the content group is associated with a subset of the unviewed messages; and providing at least a portion of the content group in response to the request.

Abstract: A system and message for message selection and presentation, including: receiving a request for content, wherein the request is associated with a context account of a messaging platform; identifying a set of unviewed messages associated with the context account; identifying grouping criteria for grouping content based on messages; applying, by a computer processor, the grouping criteria to the unviewed messages to generate a content group, wherein the content group is associated with a subset of the unviewed messages; and providing at least a portion of the content group in response to the request.

Abstract: A system, device, and method for controlling operation of a surgical tool (214) during a surgical procedure are described. For example, the system includes a tool assembly (210) and a surgical system (100). The tool assembly includes a rotating tool (214) and a sleeve (212) for holding the rotating tool. The surgical system includes a navigation system (200) configured to track at least a portion of the rotating tool and determine position information for the rotating tool, an alignment module (222) configured to receive the position information and determine whether the rotating tool is in a proper position for drilling a hole into a target bone (240), a robotic control component (220) configured to actuate and advance the rotating tool if the rotating tool is in the proper position, and a monitor (226) configured to determine if the rotating tool is advancing into the target bone along a predetermined path.

Abstract: A secure storage device includes a physical key input device, a secure memory and a controller. The controller arbitrates access by a host to securely configure the device based on the device's mode of operation. The controller determines whether the device is in a configuration-ready mode based on information within the device. Only when the device is in the configuration-ready mode, the device may be configured by the host. When a device is in a non-configuration-ready mode, the device is prevented from being configured by the host, but the device can be set to the configuration-ready mode, for example, by nullifying configuration data (e.g., PINs), by creating new encryption key(s), and by setting the mode to the configuration-ready mode. A null PIN is unusable to unlock the device after being locked. A new encryption key is unusable to decrypt data previously stored in the device, making such data unrecoverable.

Abstract: A secure storage device includes a physical key input device, a secure memory and a controller. The controller arbitrates access by a host to securely configure the device based on the device's mode of operation. The controller determines whether the device is in a configuration-ready mode based on information within the device. Only when the device is in the configuration-ready mode, the device may be configured by the host. When a device is in a non-configuration-ready mode, the device is prevented from being configured by the host, but the device can be set to the configuration-ready mode, for example, by nullifying configuration data (e.g., PINs), by creating new encryption key(s), and by setting the mode to the configuration-ready mode. A null PIN is unusable to unlock the device after being locked. A new encryption key is unusable to decrypt data previously stored in the device, making such data unrecoverable.

Abstract: A system, device, and method for controlling operation of a surgical tool (214) during a surgical procedure are described. For example, the system includes a tool assembly (210) and a surgical system (100). The tool assembly includes a rotating tool (214) and a sleeve (212) for holding the rotating tool. The surgical system includes a navigation system (200) configured to track at least a portion of the rotating tool and determine position information for the rotating tool, an alignment module (222) configured to receive the position information and determine whether the rotating tool is in a proper position for drilling a hole into a target bone (240), a robotic control component (220) configured to actuate and advance the rotating tool if the rotating tool is in the proper position, and a monitor (226) configured to determine if the rotating tool is advancing into the target bone along a predetermined path.

Abstract: The present disclosure describes compositions and methods for treating at least one negative symptom in a human subject who does not have a clinical diagnosis of schizophrenia. The compositions and methods employ a therapeutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt, hydrate, solvate or polymorph thereof.