Abstract: A vessel rinsing apparatus including a mounting base, a fluid discharge member including a plurality of nozzles, a valve member operably coupled to the fluid discharge member and configured to control water flow through the nozzles, and an escutcheon supported by the mounting base.

Abstract: An air delivery conduit includes first and second conduit portions that cooperate to form the conduit, each conduit portion including an inner layer of a film laminate that forms an interior surface of the conduit and an outer layer of a textile that forms an exterior surface of the conduit.

Abstract: A device for harvesting electrical energy from movement of a prosthetic limb. The device including a generator and a controller. The generator adapted to attach to a prosthetic limb. The generator comprising a magnetic linear motor that is configured to generate electrical energy in response to movement of a portion of the prosthetic limb. The controller is electrically connected to the generator and configured to provide electrical energy to a power supply of the prosthetic limb.

Abstract: The present disclosure describes compositions and methods for treating at least one negative symptom in a human subject who does not have a clinical diagnosis of schizophrenia.

Abstract: The present invention relates to the treatment of cardiovascular disease, more particularly to the treatment of subjects suffering from or at risk of suffering from atherosclerotic cardiovascular disease that are hypo-responsive to HIS treatment. The present inventors have found that HIS hypo-responders show remarkable improvements in their blood lipid profiles when their statin therapy is combined with treatment with the CETP inhibitor obicetrapib. In a general aspect, the present invention thus provides methods of treating subjects that are hypo-responsive to high intensity statin (HIS) therapy, said method comprising the administration of a composition comprising obicetrapib or a pharmaceutically acceptable salt, hydrate or solvate thereof.

Abstract: The present disclosure relates to an anatomically aligned prosthetic ankle with a passive assist and associated methods. The prosthetic ankle includes a talus movably coupled to a tibia section by a connector about which the talus is pivotal such so during locomotion by a user of the prosthetic ankle. The passive to assist provides a selected dorsi-flexion force to aid in the push-off or pre-swing phases of gait for the user.

Abstract: A system and message for message selection and presentation, including: receiving a request for content, wherein the request is associated with a context account of a messaging platform; identifying a set of unviewed messages associated with the context account; identifying grouping criteria for grouping content based on messages; applying, by a computer processor, the grouping criteria to the unviewed messages to generate a content group, wherein the content group is associated with a subset of the unviewed messages; and providing at least a portion of the content group in response to the request.

Abstract: A system and message for message selection and presentation, including: receiving a request for content, wherein the request is associated with a context account of a messaging platform; identifying a set of unviewed messages associated with the context account; identifying grouping criteria for grouping content based on messages; applying, by a computer processor, the grouping criteria to the unviewed messages to generate a content group, wherein the content group is associated with a subset of the unviewed messages; and providing at least a portion of the content group in response to the request.

Abstract: A system, device, and method for controlling operation of a surgical tool (214) during a surgical procedure are described. For example, the system includes a tool assembly (210) and a surgical system (100). The tool assembly includes a rotating tool (214) and a sleeve (212) for holding the rotating tool. The surgical system includes a navigation system (200) configured to track at least a portion of the rotating tool and determine position information for the rotating tool, an alignment module (222) configured to receive the position information and determine whether the rotating tool is in a proper position for drilling a hole into a target bone (240), a robotic control component (220) configured to actuate and advance the rotating tool if the rotating tool is in the proper position, and a monitor (226) configured to determine if the rotating tool is advancing into the target bone along a predetermined path.

Abstract: A secure storage device includes a physical key input device, a secure memory and a controller. The controller arbitrates access by a host to securely configure the device based on the device's mode of operation. The controller determines whether the device is in a configuration-ready mode based on information within the device. Only when the device is in the configuration-ready mode, the device may be configured by the host. When a device is in a non-configuration-ready mode, the device is prevented from being configured by the host, but the device can be set to the configuration-ready mode, for example, by nullifying configuration data (e.g., PINs), by creating new encryption key(s), and by setting the mode to the configuration-ready mode. A null PIN is unusable to unlock the device after being locked. A new encryption key is unusable to decrypt data previously stored in the device, making such data unrecoverable.

Abstract: A secure storage device includes a physical key input device, a secure memory and a controller. The controller arbitrates access by a host to securely configure the device based on the device's mode of operation. The controller determines whether the device is in a configuration-ready mode based on information within the device. Only when the device is in the configuration-ready mode, the device may be configured by the host. When a device is in a non-configuration-ready mode, the device is prevented from being configured by the host, but the device can be set to the configuration-ready mode, for example, by nullifying configuration data (e.g., PINs), by creating new encryption key(s), and by setting the mode to the configuration-ready mode. A null PIN is unusable to unlock the device after being locked. A new encryption key is unusable to decrypt data previously stored in the device, making such data unrecoverable.

Abstract: A system, device, and method for controlling operation of a surgical tool (214) during a surgical procedure are described. For example, the system includes a tool assembly (210) and a surgical system (100). The tool assembly includes a rotating tool (214) and a sleeve (212) for holding the rotating tool. The surgical system includes a navigation system (200) configured to track at least a portion of the rotating tool and determine position information for the rotating tool, an alignment module (222) configured to receive the position information and determine whether the rotating tool is in a proper position for drilling a hole into a target bone (240), a robotic control component (220) configured to actuate and advance the rotating tool if the rotating tool is in the proper position, and a monitor (226) configured to determine if the rotating tool is advancing into the target bone along a predetermined path.

Abstract: The present disclosure describes compositions and methods for treating at least one negative symptom in a human subject who does not have a clinical diagnosis of schizophrenia. The compositions and methods employ a therapeutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt, hydrate, solvate or polymorph thereof.

Abstract: Method and system for ongoing monitoring for underground structure at or near a production wellpad is provided. The system includes a sparse acquisition grid and utilizes information obtained from Rayleigh waves to monitor subsurface structures.

Abstract: A system and message for message selection and presentation, including: receiving a request for content, wherein the request is associated with a context account of a messaging platform; identifying a set of unviewed messages associated with the context account; identifying grouping criteria for grouping content based on messages; applying, by a computer processor, the grouping criteria to the unviewed messages to generate a content group, wherein the content group is associated with a subset of the unviewed messages; and providing at least a portion of the content group in response to the request.

Abstract: The invention relates to a drug conjugate including a drug and a plant steroid. The drug conjugate may target the drug for intestinal cell delivery, and thus may be used to treat diseases, including intestinal diseases, or to affect intestinal metabolism. The invention therefore also relates to treating intestinal diseases and affecting intestinal metabolism with the drug conjugate.

Abstract: Connectors and a duplex clip for forming duplex connector assemblies are provided herein. The connector includes a rigid latch member for positive locking with another component, such as an adaptor. The duplex clip is configured to hold two connectors to form a duplex connector assembly.

Abstract: The invention relates to a drug conjugate including a drug and a plant steroid. The drug conjugate may target the drug for intestinal cell delivery, and thus may be used to treat diseases, including intestinal diseases, or to affect intestinal metabolism. The invention therefore also relates to treating intestinal diseases and affecting intestinal metabolism with the drug conjugate.

Abstract: Connectors and a duplex clip for forming duplex connector assemblies are provided herein. The connector includes a rigid latch member for positive locking with another component, such as an adaptor. The duplex clip is configured to hold two connectors to form a duplex connector assembly.

Abstract: A secure storage device includes a physical key input device, a secure memory and a controller. The controller arbitrates access by a host to securely configure the device based on the device's mode of operation. The controller determines whether the device is in a configuration-ready mode based on information within the device. Only when the device is in the configuration-ready mode, the device may be configured by the host. When a device is in a non-configuration-ready mode, the device is prevented from being configured by the host, but the device can be set to the configuration-ready mode, for example, by nullifying configuration data (e.g., PINs), by creating new encryption key(s), and by setting the mode to the configuration-ready mode. A null PIN is unusable to unlock the device after being locked. A new encryption key is unusable to decrypt data previously stored in the device, making such data unrecoverable.