Abstract: Briefly summarized, embodiments disclosed herein are directed to apparatus and methods for removing an occlusion from an indwelling catheter. The system can include a pressurized fluid conduit for delivering pressurized fluid to an occlusion site, and ablating the occlusion. A negative pressure source in fluid communication with the catheter lumen can then aspirate the occlusion. The positive pressure source can provide a pulsed pressurized fluid to facilitate ablation. The system can also include tip tracking and tip location systems to ensure the pressurized fluid conduit does not extend beyond the catheter lumen, causing damage to the vasculature. The system can further include an ultrasound transducer, coupled with one of the catheter and the pressurized fluid conduit to provide ultrasonic wave energy to the occlusion to further facilitate ablation thereof.

Abstract: Disclosed herein are systems, devices, and methods for thrombolysis. For example, a medical device for thrombolysis can include a conduit, a supply reservoir, and a waste reservoir. The conduit can be configured to insert into a lumen of a venous access device having an intraluminal clot. The conduit can include a supply lumen configured to convey an aqueous thrombolytic composition from the supply reservoir through an opening in a distal-end portion of the conduit to the intraluminal clot. The waste reservoir can be configured to collect waste from the lumen of the venous access device including fibrin fragments, platelets, red blood cells, or spent solution of the thrombolytic composition used to break down the intraluminal clot. Administering a thrombolytic composition in accordance with the disclosed systems, devices, and methods can break down clots more quickly than at least the common 3-way stopcock method.

Abstract: A data processing system (10) for compressing gamma spectroscopy data includes a data input (18) for receiving data representing counts for each of a plurality of bins. The counts represent a set of binned gamma spectroscopy data. The data processing system (10) also includes a processor (20). The processor (20) is arranged to: read the counts in each bin; calculate a measure representative of the counts using the counts in one or more of the bins; choose, using the measure, which one of at least two compression schemes to use to compress the data representing the counts; and compress the data representing the counts according to the chosen compression scheme; and write the compressed data representing the counts to a data storage device (22).

Abstract: A bioreactor vessel includes a bottom plate, a vessel body coupled to the bottom plate, the vessel body and the bottom plate defining an interior compartment therebetween, and a plurality of recesses formed in the bottom plate, each recess of the plurality of recesses being configured to receive a corresponding alignment pin on a bed plate for aligning the bioreactor vessel on the bed plate.

Abstract: An apparatus for bioprocessing includes a housing, a drawer receivable within the housing, the drawer including a plurality of sidewalls and a bottom defining a processing chamber, and a generally open top, the drawer being movable between a closed position in which the drawer is received within the housing, and an open position in which the drawer extends from the housing enabling access to the processing chamber through the open top, and at least one bed plate positioned within the processing chamber and configured to receive a bioreactor vessel.

Abstract: In an embodiment, a tubing module for a bioprocessing system includes a first tubing holder block configured to receive at least one pump tube and hold the at least one pump tube in position for selective engagement with a peristaltic pump, a second tubing holder block configured to receive a plurality of pinch valve tubes and hold each pinch valve tube of the plurality of pinch valve tubes in position for selective engagement with a respective actuator of a pinch valve array, and wherein the first tubing holder block and the second tubing holder block are interconnected.

Abstract: A bioprocessing method for cell therapy includes the steps of genetically modifying a population of cells in a bioreactor vessel to produce a population of genetically modified cells, and expanding the population of genetically modified cells within the bioreactor vessel to generate a number of genetically modified cells sufficient for one or more doses for use in a cell therapy treatment without removing the population of genetically modified cells from the bioreactor vessel. Cells are settled on a gas permeable, liquid impermeable membrane for expansion, and are resuspended when, or after, the desired cell density is reached.

Abstract: A system for bioprocessing includes a tray having plurality of sidewalls and a bottom surface defining an interior compartment, and a generally open top, and an opening formed in the bottom surface of the tray, the opening having a perimeter. The perimeter of the opening is shaped and/or dimensioned such that a bioreactor vessel can be positioned above the opening and supported by the bottom surface of the tray while a portion of the bioreactor vessel is accessible through the opening in the bottom surface. The tray is receivable within a processing chamber such that the bed plate extends through the opening in the bottom surface of the tray to support the bioreactor vessel.

Abstract: Dynamically instrumenting code that executes based on a historic execution of a subject executable entity. Historic execution information for a subject executable entity is accessed. The historic execution information includes execution state information for at least one point in time in the historic execution the executable entity. Diagnostic code instruction(s) are identified, for instrumenting subject code instruction(s) of the executable entity. The subject code instruction(s) are virtually executed based at least on supplying the subject code instruction(s) with data from the historic execution information. While virtually executing the identified executable code instruction(s), the diagnostic code instruction(s) are also executed. The diagnostic code instruction(s) collecting diagnostic data regarding the virtual execution of the subject code instruction(s), or override at least one of a value or an execution behavior of the subject code instruction(s).

Abstract: A method that includes replacing a standard keyboard displayed on a display of a first mobile device with a second shopping keyboard. The second shopping keyboard includes third keys that represent purchasable items (a product and/or service). After one of the third keys, which represents a particular item, is selected, a sharing option and/or purchasing option is/are displayed. When selected, the sharing option supplies information about the particular item to a messaging application that communicates the information to a second mobile device. When selected, the purchasing option initiates purchase of the particular item. The method may also include displaying a first shopping keyboard comprising second keys representing businesses. After one of the second keys, representing a particular business, is selected, the second shopping keyboard is displayed. The purchasable items represented by the third keys are available from the particular business.

Abstract: A supplemental vehicle illumination system is mounted on a structure that is received by a trailer hitch receiver on a vehicle. The supplemental illumination system receives a signal from the vehicle. This actuates a supplemental lighting system that provides additional illumination, in addition to lights disposed on the vehicle. The supplemental lighting system can also, or instead, be activated over a wireless connection.

Abstract: The present approach improves the query performance of a database in a manner that is transparent to a user. In one aspect, this approach creates separate partition tables that are not directly accessible to a user of the database. A client-facing aspect of the database is a logical model which may correspond to a single, main table with which the user interacts. Thus, queries or operations may be generated on the client side in the context of the logical model. A database or query layer can then, transparent to the user, translate the user generated requests into query language that addresses the proper partitions to generate a result set or otherwise perform a database operation.

Abstract: A system and method for selective capture of and presentation of native image portions are provided. In a first embodiment a first image or video is captured at a first resolution, which resolution is greater than high definition and higher than a predetermined broadcast display resolution. A desired portion of the native, first image or video is then displayed at a second, lower resolution, which resolution is less than and closer to the predetermined broadcast display resolution. Accordingly, a selected portion of the captured image may be displayed at or near the predetermined broadcast display resolution. In other exemplary embodiments, video is captured at a first frame rate that is higher than a predetermined broadcast frame rate, and an extraction window extracts frames from a portion of the native, first video to provide improved broadcast quality of the portion(s) selected by the extraction window.

Abstract: The automatic identification of execution behavior(s) of software. This automatic identification is based on a historical analysis of execution records to identify a particular pattern that represents an execution behavior. In order to automatically identify an execution behavior present within particular software, an execution record (or perhaps multiple execution records) representing the execution of that particular software may be accessed. Based on finding the particular pattern within the execution record (or one, some, or all of the multiple execution records) representing the execution of that particular software, the computing system may automatically identify that the execution behavior is present within the software. This may dramatically assist in modifying that execution behavior.

Abstract: An electronic device includes a first portion, a second portion, and a joint moveably coupling the first and second portions for angular adjustment between the first and second portions. A speaker is fixed on the first portion at a first known distance from the joint, and a microphone is fixed on the second portion at a second known distance from the joint. An angle sensing machine is configured to emit a known sound from the speaker, detect the known sound at the microphone, and measure a transmission time of the known sound from speaker to microphone. Based on the transmission time, a current angle of the first portion relative to the second portion is calculated.

Abstract: The present disclosure relates to an aerosol delivery device filling system. The system includes multiple source containers each respectively including a differing aerosol precursor composition. The system further includes a mixing container configured to engage the source containers to receive and mix the aerosol precursor compositions to form a mixed aerosol precursor composition. An aerosol delivery device may engage the mixing container to receive at least a portion of the mixed aerosol precursor composition. A related method for customizing an aerosol precursor composition is also provided.

Abstract: The present systems and methods generally relate to facilitating real-time monitoring and maintenance of high-volume facilities. Using a unique combination of components, the present systems and methods can assess facility maintenance requirements and assign employees to facilities as needed, as well as predict future staffing requirements. For example, in certain embodiments, the present systems and methods leverage sensor and signal transmitting technologies to record facility activity and respond accordingly with appropriate staff assignments.

Abstract: The present approach relates to improving query performance in a database context. Examples of query improvement are described in the context of certain query patterns, one or more of which may be observed in a given query. When a given query pattern is observed, changes may be made to the query at the application or database level to improve performance of the respective query. Query improvements may be performed in a manner transparent to the user.

Abstract: A valve has a housing defining an inlet and an outlet and a cavity therebetween which receives a valve seat. The valve seat defines a slot which receives a gate. The valve seat is sealingly engaged with the housing, the gate sealingly engages the valve seat and is movable within the slot between an open and a closed position using an actuator. An opening in the housing provides access to the cavity. The valve seat may be removed from the housing through the opening by attaching the valve seat to the gate, thereby attaching the valve seat to the actuator, and withdrawing the gate from the housing using the actuator.

Abstract: A non-transitory computer readable medium includes instructions configured to adapt a controller to maintain a first target environment in a bioreactor vessel containing a population of cells for a first incubation period to produce a population of genetically modified cells from the population of cells, initiate a flow of media to the bioreactor vessel, maintain a second target environment in the bioreactor vessel for a second incubation period to produce an expanded population of genetically modified cells.