Abstract: The present disclosure provides for IL2 engrafted into the CDR sequences of an antibody having preferred therapeutic profiles over molecules known and used in the clinic. In particular, the provided antibody cytokine engrafted protein compositions increase or maintain CD8+ T effector cells while reducing the activity of Treg cells. Additionally, provided compositions convey improved half-life, stability and produceability over recombinant human IL2 formulations such as Proleukin®.

Abstract: A measuring system for measuring a mass flow rate, a density, a temperature or a flow velocity. The measuring system includes a main line, a first Coriolis measuring device arranged in the main line, a second Coriolis measuring device arranged in series with the first Coriolis measuring device in the main line, a bypass line which bypasses the second Coriolis measuring device, a first valve arranged in the bypass line, and a computing unit which is connected to the first Coriolis measuring device and to the second Coriolis measuring device. The first valve opens depending on a pressure. The first Coriolis measuring device is designed for a higher maximum flow rate than the second Coriolis measuring device.

Abstract: The present invention relates to fusion proteins comprising variant IL-15 proteins, fusion proteins comprising variant anti-PD-1 antigen binding domains, and fusion proteins comprising variant IL-15 proteins and variant anti-PD-1 antigen binding domains. The present invention also relates to nucleic acid molecules, expression vectors, host cells and methods for making such fusion proteins and the use of such fusion proteins in the treatment of cancer.

Abstract: Embodiments described herein generally relate to searching of media items associated with one or more keywords. Content search features may be generated and configured to receive search scope selections. A root level limitation may be associated with a folder within a media organization architecture. A query limitation may be associated with the content search features. In certain embodiments, means for automatically correcting the search scope selections to satisfy the query limitation are provided.

Abstract: The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through a high affinity interleukin receptor. The antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prevention of immune related disorders such as Type 1 Diabetes.

Abstract: Provided herein are novel anti-CD28×anti-B7H3 (also referred to as “?CD28×?B7H3”) heterodimeric bispecific antibodies and methods of using such antibodies for the treatment of cancers. Subject ?CD28×?B7H3 antibodies are capable of agonistically binding to CD28 costimulatory molecules on T cells and targeting to B7H3 on tumor cells. Thus, such antibodies selectively enhance anti-tumor activity at tumor sites while minimizing peripheral toxicity. The subject antibodies provided herein are particularly useful for enhancing anti-tumor activity when used in combination with other anti-cancer therapies.

Abstract: A wearable posture monitoring device is provided. The device includes a first posture sensor to measure a first bend parameter associated with shoulders of a user and a second posture sensor to measure a second bend parameter associated with vertebral column of the user. The device includes a control unit operatively coupled to the first posture sensor and the second posture sensor and is configured to compare the first bend parameter with a first predefined reference value and the second bend parameter with a second predefined reference value to detect an improper bend in one or more of the shoulders and vertebral column of the user. The control unit is further configured to display a visual indication, on a display interface associated with the posture monitoring device, to indicate the detected improper bend of one or more of the shoulders and vertebral column of the user.

Abstract: Systems and methods are provided for generating data for sensor system validation. A representative vehicle is equipped with a set of sensors positioned to provide a collective field of view defining a set of sensor locations as a set of master data and encompassing a field of view of a sensor positioned at any of the set of sensor locations. The set of sensor locations includes a sensor location at which no sensor of the set of sensors is placed. The representative vehicle is driven for a distance required for validation of a sensor system to provide master data representing the entire distance required for validation.

Abstract: A fertilizer coating that provides nutrients and/or biocatalysts, as well as added dust control and caking control. The fertilizer coating may comprise a carrier, one or more micronutrient dispersants, and one or more micronutrients. The carrier may be aqueous-based or oil based. The coating may further comprise one or more biocatalysts in an aqueous media.

Abstract: Embodiments described herein generally relate to searching of media items associated with one or more keywords. Content search features may be generated and configured to receive search scope selections. A root level limitation may be associated with a folder within a media organization architecture. A query limitation may be associated with the content search features. In certain embodiments, means for automatically correcting the search scope selections to satisfy the query limitation are provided.

Abstract: Embodiments described herein generally relate to searching of media items associated with one or more keywords. Content search features may be generated and configured to receive search scope selections. A root level limitation may be associated with a folder within a media organization architecture. A query limitation may be associated with the content search features. In certain embodiments, means for automatically correcting the search scope selections to satisfy the query limitation are provided.

Abstract: Embodiments described herein generally relate to searching of media items associated with one or more keywords. Content search features may be generated and configured to receive search scope selections. A root level limitation may be associated with a folder within a media organization architecture. A query limitation may be associated with the content search features. In certain embodiments, means for automatically correcting the search scope selections to satisfy the query limitation are provided.

Abstract: A wearable posture monitoring device is provided. The device includes a first posture sensor to measure a first bend parameter associated with shoulders of a user and a second posture sensor to measure a second bend parameter associated with vertebral column of the user. The device includes a control unit operatively coupled to the first posture sensor and the second posture sensor and is configured to compare the first bend parameter with a first predefined reference value and the second bend parameter with a second predefined reference value to detect an improper bend in one or more of the shoulders and vertebral column of the user. The control unit is further configured to display a visual indication, on a display interface associated with the posture monitoring device, to indicate the detected improper bend of one or more of the shoulders and vertebral column of the user.

Abstract: A hydraulic fracturing and gravel packing proppant composite with protectant on the surface of the proppant and the composition matters of the protectant and proppant. The surface protectant reduces the generation of dust/fines from the proppant caused by abrasion and impingement during transportation and conveyance, particularly pneumatic transfer.

Abstract: Embodiments described herein generally relate to searching of media items associated with one or more keywords. Content search features may be generated and configured to receive search scope selections. A root level limitation may be associated with a folder within a media organization architecture. A query limitation may be associated with the content search features. In certain embodiments, means for automatically correcting the search scope selections to satisfy the query limitation are provided.

Abstract: A hydraulic fracturing and gravel packing proppant composite with protectant on the surface of the proppant and the composition matters of the protectant and proppant. The surface protectant reduces the generation of dust/fines from the proppant caused by abrasion and impingement during transportation and conveyance, particularly pneumatic transfer.

Abstract: A hydraulic fracturing and gravel packing proppant composite with protectant on the surface of the proppant and the composition matters of the protectant and proppant. The surface protectant reduces the generation of dust/fines from the proppant caused by abrasion and impingement during transportation and conveyance, particularly pneumatic transfer.

Abstract: The present disclosure provides devices and methods relating to surgical breast procedures. The devices can include a holder and backing to assist in positioning a biological material adjacent to a tissue expander or implant.

Abstract: A hydraulic fracturing and gravel packing proppant composite with protectant on the surface of the proppant and the composition matters of the protectant and proppant. The surface protectant reduces the generation of dust/fines from the proppant caused by abrasion and impingement during transportation and conveyance, particularly pneumatic transfer.