Abstract: The present invention is directed to immune adjuvants containing IAP inhibitors, including Smac mimetics. The invention further provides pharmaceutical compositions and vaccines containing an IAP inhibitor and an antigen. Methods of enhancing an immune response by administration of an IAP inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods of potentiating cytokine or antibody production are also provided.

Abstract: The present invention is directed to immune adjuvants containing IAP inhibitors, including Smac mimetics. The invention further provides pharmaceutical compositions and vaccines containing an IAP inhibitor and an antigen. Methods of enhancing an immune response by administration of an IAP inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods of potentiating cytokine or antibody production are also provided.

Abstract: The present invention is directed to immune adjuvants containing IAP inhibitors, including Smac mimetics. The invention further provides pharmaceutical compositions and vaccines containing an IAP inhibitor and an antigen. Methods of enhancing an immune response by administration of an IAP inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods of potentiating cytokine or antibody production are also provided.

Abstract: The present invention is directed to immune adjuvants containing IAP inhibitors, including Smac mimetics. The invention further provides pharmaceutical compositions and vaccines containing an IAP inhibitor and an antigen. Methods of enhancing an immune response by administration of an IAP inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods of potentiating cytokine or antibody production are also provided.

Abstract: The present invention is directed to immune adjuvants containing IAP inhibitors, including Smac mimetics. The invention further provides pharmaceutical compositions and vaccines containing an IAP inhibitor and an antigen. Methods of enhancing an immune response by administration of an IAP inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods of potentiating cytokine or antibody production are also provided.

Abstract: The present invention is directed to immune adjuvants containing IAP inhibitors, including Smac mimetics. The invention further provides pharmaceutical compositions and vaccines containing an IAP inhibitor and an antigen. Methods of enhancing an immune response by administration of an IAP inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods of potentiating cytokine or antibody production are also provided.

Abstract: The present invention is directed to immune adjuvants containing IAP inhibitors, including Smac mimetics. The invention further provides pharmaceutical compositions and vaccines containing an IAP inhibitor and an antigen. Methods of enhancing an immune response by administration of an IAP inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods of potentiating cytokine or antibody production are also provided.

Abstract: A dental floss device includes a handle having a head piece and a disposable holder for a length of dental floss. The holder includes a base portion and a pair of spaced-apart jaws extending from the base and which extend to embrace the head piece of the handle when the holder is in a correct alignment configuration with respect to the handle. The device has an interlock which ensures that the holder can be interengaged with the head piece only when the holder is correctly aligned with the head piece. The interlock includes a head interlock part provided by interlock grooves and a holder interlock part provided by corresponding interlock tongues. There are two interlock grooves and corresponding interlock tongues which slidably interengage when the holder is correctly aligned with the head piece If the holder is turned so that it is not correctly aligned with the head piece, the interlock tongues of the holder prevent engagement of the holder with the head piece.

Abstract: A dental floss device 1 comprises a handle 2 having a head piece 3 and a disposable holder 4 for a length of dental floss 5. The holder 4 comprises a base portion 20 and a pair of spaced-apart jaws 21 extending from the base and which extend to embrace the head piece 3 of the handle 2 when the holder 4 is in a correct alignment configuration with respect to the handle 2. The device has an interlock which ensures that the holder 4 can be interengaged with the head piece 3 only when the holder 4 is correctly aligned with the head piece 3. The interlock comprises a head interlock part provided by interlock grooves 10 and a holder interlock part provided by corresponding interlock tongues 11. There are two interlock grooves 10 and corresponding interlock tongues 11 which slidably interengage when the holder 4 is correctly aligned with the head piece 3.

Abstract: A dental floss device includes a handle having a head piece and a disposable holder for a length of dental floss. The holder includes a base portion and a pair of spaced-apart jaws extending from the base and which extend to embrace the head piece of the handle when the holder is in a correct alignment configuration with respect to the handle. The device has an interlock which ensures that the holder can be interengaged with the head piece only when the holder is correctly aligned with the head piece. The interlock includes a head interlock part provided by interlock grooves and a holder interlock part provided by corresponding interlock tongues. There are two interlock grooves and corresponding interlock tongues which slidably interengage when the holder is correctly aligned with the head piece. If the holder is turned so that it is not correctly aligned with the head piece, the interlock tongues of the holder prevent engagement of the holder with the head piece.

Abstract: A dental floss device 1 comprises a handle 2 having a head piece 3 and a disposable holder 4 for a length of dental floss 5. The holder 4 comprises a base portion 20 and a pair of spaced-apart jaws 21 extending from the base and which extend to embrace the head piece 3 of the handle 2 when the holder 4 is in a correct alignment configuration with respect to the handle 2. The device has an interlock which ensures that the holder 4 can be interengaged with the head piece 3 only when the holder 4 is correctly aligned with the head piece 3. The interlock comprises a head interlock part provided by interlock grooves 10 and a holder interlock part provided by corresponding interlock tongues 11. There are two interlock grooves 10 and corresponding interlock tongues 11 which slidably interengage when the holder 4 is correctly aligned with the head piece 3.