Abstract: The present invention is directed to immune adjuvants containing IAP inhibitors, including Smac mimetics. The invention further provides pharmaceutical compositions and vaccines containing an IAP inhibitor and an antigen. Methods of enhancing an immune response by administration of an IAP inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods of potentiating cytokine or antibody production are also provided.

Abstract: The present invention is directed to immune adjuvants containing IAP inhibitors, including Smac mimetics. The invention further provides pharmaceutical compositions and vaccines containing an IAP inhibitor and an antigen. Methods of enhancing an immune response by administration of an IAP inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods of potentiating cytokine or antibody production are also provided.

Abstract: The present invention is directed to immune adjuvants containing IAP inhibitors, including Smac mimetics. The invention further provides pharmaceutical compositions and vaccines containing an IAP inhibitor and an antigen. Methods of enhancing an immune response by administration of an IAP inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods of potentiating cytokine or antibody production are also provided.

Abstract: The present invention is directed to immune adjuvants containing IAP inhibitors, including Smac mimetics. The invention further provides pharmaceutical compositions and vaccines containing an IAP inhibitor and an antigen. Methods of enhancing an immune response by administration of an IAP inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods of potentiating cytokine or antibody production are also provided.

Abstract: The present invention is directed to immune adjuvants containing IAP inhibitors, including Smac mimetics. The invention further provides pharmaceutical compositions and vaccines containing an IAP inhibitor and an antigen. Methods of enhancing an immune response by administration of an IAP inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods of potentiating cytokine or antibody production are also provided.

Abstract: A hydraulic control system for a transmission includes a source of pressurized hydraulic fluid that communicates with an electronic transmission range selection (ETRS) subsystem or manual valve and a clutch actuation subsystem.

Abstract: The present invention is directed to immune adjuvants containing IAP inhibitors, including Smac mimetics. The invention further provides pharmaceutical compositions and vaccines containing an IAP inhibitor and an antigen. Methods of enhancing an immune response by administration of an IAP inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods of potentiating cytokine or antibody production are also provided.

Abstract: A hydraulic control system for a transmission includes a source of pressurized hydraulic fluid that communicates with an electronic transmission range selection (ETRS) subsystem or manual valve and a clutch actuation subsystem.

Abstract: A hydraulic control system for a transmission includes a source of pressurized hydraulic fluid that communicates with an electronic transmission range selection (ETRS) subsystem or manual valve and a clutch actuation subsystem.

Abstract: A system for controlling a transmission of a vehicle includes an engine control module that generates a command, while the vehicle is rolling in either a forward or reverse direction, to change a transmission of the vehicle from a reverse drive gear to a forward drive gear. The transmission includes a first clutch, a second clutch, a third clutch, and a fourth clutch. A transmission control module, in response to the command, maintains a first clutch in an engaged state, releases a second clutch and a fourth clutch, with the first clutch in the engaged state and the second clutch and the fourth clutch released, applies a third clutch with a synchronizer to engage the third clutch, and, after the third clutch is engaged, reapplies the fourth clutch to engage the fourth clutch.

Abstract: A system for providing pressurized hydraulic fluid in a transmission of a motor vehicle includes a pump for providing pressurized hydraulic fluid having an inlet port and an outlet port. A bypass valve includes an inlet port in communication with the outlet port of the pump, a first outlet port in communication with the inlet port of the pump, and a second outlet port. The inlet port of the bypass valve is in communication with the second outlet port of the bypass valve when the bypass valve is in a first position and the inlet port of the bypass valve is in communication with the first outlet port of the bypass valve when the bypass valve is in a second position. A control device and accumulator are operatively associated with the bypass valve.

Abstract: A hydraulic control system for a transmission includes a source of pressurized hydraulic fluid that communicates with an electronic transmission range selection (ETRS) subsystem or manual valve and a clutch actuation subsystem.

Abstract: A hydraulic fluid circuit for a power transmission device includes a first hydraulic circuit segment fluidly decoupled from a second hydraulic circuit segment. A hydraulic pump includes a first fluidic pumping element and a second fluidic pumping element. The first fluidic pumping element fluidly communicates with the first hydraulic circuit segment. The second fluidic pumping element fluidly communicates with the second hydraulic circuit segment. The first fluidic pumping element is controllable to a first pump operating point to achieve a preferred high fluidic flow rate in the first hydraulic circuit segment. The second fluidic pumping element is controllable to a second pump operating point to achieve a preferred high fluidic pressure in the second hydraulic circuit segment.

Abstract: A solenoid pump and associated hydraulic circuitry are intended for use in automatic transmissions capable of engine start stop (ESS) operation. In a first embodiment, a solenoid pump provides pressurized hydraulic fluid to respective inputs of two way check valves. The other inputs are provided with controlled hydraulic fluid from a transmission valve body. The outputs of the check valves are provided to those hydraulically operated torque transmitting devices associated with first gear. The solenoid pump is activated when the transmission is in gear and the engine is stopped to maintain hydraulic pressure in those actuators associated with first gear. A second embodiment provides hydraulic fluid to actuators associated with reverse. A third embodiment includes a solenoid pump and latching solenoid valve both communicating with a hydraulic supply In a fourth embodiment, a solenoid pump provides hydraulic fluid to the exhaust backfill circuits of hydraulic operators in an automatic transmission.

Abstract: A system for controlling a transmission of a vehicle includes an engine control module that generates a command, while the vehicle is rolling in either a forward or reverse direction, to change a transmission of the vehicle from a reverse drive gear to a forward drive gear. The transmission includes a first clutch, a second clutch, a third clutch, and a fourth clutch. A transmission control module, in response to the command, maintains a first clutch in an engaged state, releases a second clutch and a fourth clutch, with the first clutch in the engaged state and the second clutch and the fourth clutch released, applies a third clutch with a synchronizer to engage the third clutch, and, after the third clutch is engaged, reapplies the fourth clutch to engage the fourth clutch.

Abstract: A hydraulic control system for a dual clutch transmission includes a source of pressurized hydraulic fluid, first and second actuator control devices in downstream fluid communication with the source of pressurized hydraulic fluid, and first and second clutch control devices in downstream fluid communication with the source of pressurized hydraulic fluid. A first valve is in downstream fluid communication with the first and second actuator control devices. A second valve is in downstream fluid communication with the first valve, the first clutch control device and the second clutch control device, and the second valve is moveable between two positions by the first and second clutch control devices. Selective activation of combinations of the control devices allows for a pressurized fluid to engage the dual clutch and an actuator in order to shift the transmission into a desired gear ratio.

Abstract: Pairs of variable feed solenoid valves provide fluid to a pair of input clutch actuators and a pair of inlet ports of a first logic valve. The position of the first logic valve spool is controlled by a solenoid valve. A first pair of outlet ports of the first logic valve provide hydraulic to a first piston which selects two speed ratio. A second pair of outlet ports of the first logic valve provide fluid to a pair of inlet ports of a second logic valve. The position of the second logic valve spool is controlled by fluid from the input clutch circuits. A first pair of outlet ports of the second logic valve provide fluid to a second piston which selects two other speed ratios and a second pair of outlet ports of the second logic valve provide fluid to a third piston which selects two additional speed ratios.

Abstract: A hydraulic control system for a transmission includes a motor, a sump for storing a hydraulic fluid, and a dual element pump connected to the motor. The dual element pump has at least one input port connected to the sump, a first outlet port, and a second outlet port. The dual element pump provides a first volume of hydraulic fluid to the first outlet port and provides a second volume of hydraulic fluid to the second outlet port. The first volume is greater than the second volume. The first outlet port is connected to a diversion valve. The second outlet port is connected to a high pressure hydraulic circuit. The diversion valve is operable to transmit the hydraulic fluid from the first outlet port to a low pressure hydraulic circuit and the high pressure hydraulic circuit.

Abstract: A solenoid pump and associated hydraulic circuitry are intended for use in automatic transmissions capable of engine start stop (ESS) operation. In a first embodiment, a solenoid pump provides pressurized hydraulic fluid to respective inputs of two way check valves. The other inputs are provided with controlled hydraulic fluid from a transmission valve body. The outputs of the check valves are provided to those hydraulically operated torque transmitting devices associated with first gear. The solenoid pump is activated when the transmission is in gear and the engine is stopped to maintain hydraulic pressure in those actuators associated with first gear in order that a first gear vehicle launch may be quickly and smoothly achieved when the engine is restarted. A second, similar embodiment provides hydraulic fluid to actuators associated with reverse gear.

Abstract: The present invention provides a control system for a dual clutch automatic transmission having a torque converter. The transmission provides seven forward speeds or gear ratios and reverse. The control system includes a hydraulic pump, a pressure regulator assembly and control valves that provide and release pressurized hydraulic fluid to the torque converter, a pair of input clutches and eight synchronizer clutches. A first pair of control valves are high flow rate valves which are capable of rapidly engaging and disengaging the input clutches. A second pair of high flow rate valves, control valves and spool valves provide a branching control circuit which controls engagement and disengagement of the synchronizer clutches. A control valve linked to the shift lever blocks hydraulic fluid flow to the first pair of high flow rate valves to inhibit input clutch activation when the shift lever is in Park or Neutral.