Abstract: According to one embodiment of the present invention, a method is provided for receiving a wager for a secondary game at a gaming device that offers a primary game, in which the wager indicates at least one parameter corresponding to a potential outcome of the secondary game; determining an outcome of the secondary game; and providing a payout for the secondary game.

Abstract: According to one embodiment of the present invention, a method is provided for receiving a wager for a secondary game at a gaming device that offers a primary game, in which the wager indicates at least one parameter corresponding to a potential outcome of the secondary game; determining an outcome of the secondary game; and providing a payout for the secondary game.

Abstract: According to one embodiment of the present invention, a method is provided for receiving a wager for a secondary game at a gaming device that offers a primary game, in which the wager indicates at least one parameter corresponding to a potential outcome of the secondary game; determining an outcome of the secondary game; and providing a payout for the secondary game.

Abstract: One embodiment of the present invention provides for a method comprising determining sales data associated with a sales device (e.g., a vending machine) and adjusting a level of sensitivity of a currency validator based on the sales data.

Abstract: The present invention provides compositions comprising the ligand binding domain (LBD) of a farnesoid X receptor (FXR) in crystalline form. In alternative embodiments, the LBD of FXR is complexed with a ligand therefor. There are provided high resolution structures of FXR complexed with a novel high affinity agonist, fexaramine. The discovered structure of a FXR LBD provides the first three-dimensional view of the structural basis for FXR ligand binding. The present invention further provides a computer for producing a three-dimensional representation of FXR or a complex thereof, and a computer for determining at least a portion of the structure coordinates of FXR or a complex thereof. The present invention further provides methods of using this structural information to predict molecules capable of binding to FXR; to identify compounds with agonist, antagonist or partial agonist activity for FXR; and to determine whether a test compound is capable of binding to the LBD of FXR.

Abstract: The efficient regulation of cholesterol synthesis, metabolism, acquisition, and transport is an essential component of lipid homeostasis. The farnesoid X receptor (FXR) is a transcriptional sensor for bile acids, the primary product of cholesterol metabolism. Accordingly, the development of potent, selective, small molecule agonists, partial agonists, and antagonists of FXR would be an important step in further deconvoluting FXR physiology. In accordance with the present invention, the identification of novel potent FXR activators is described. Two derivatives of invention compounds, bearing stilbene or biaryl moieties, contain members that are the most potent FXR agonists reported to date in cell-based assays. These compounds are useful as chemical tools to further define the physiological role of FXR as well as therapeutic leads for the treatment of diseases linked to cholesterol, bile acids and their metabolism and homeostasis.

Abstract: In some embodiments, methods and apparatus allow for a plurality of options to be displayed to a player for playing at least one round of a game in accordance with at least one advantage and/or disadvantage. The player may accept an option. For example, a player may accept an option to play at least one future round of play in accordance with a rule that is different from a rule used in a current round of play.

Abstract: A shaft seal assembly for use with a reciprocating or rotating shaft includes a shaft seal, a lubricant-storing ring, and a retainer. The retainer and ring can be formed as a subassembly and then combined with a shaft seal. The seal includes an annular body portion, a first sealing lip portion, and a first pocket portion. The first sealing lip portion has a substantially uniform axial dimension and is adapted to sealingly engage a shaft. The first pocket portion includes a plurality of pockets, each having an opening toward the first sealing lip portion. The plurality of pockets are each adapted to collect a working fluid when the shaft axially displaces in a first direction and to dispense the working fluid when the shaft axially displaces in a second direction. The assembly provides a lubricated shaft and seal that improves the effective life of the shaft seal.

Abstract: Printed articles are disclosed, where the article includes a transparent film, the film comprising a first side coated with a pressure-sensitive acrylate adhesive; and a second side printed with an image. The printed image can be produced with a digital or flexographic printed. Also disclosed are systems and methods for producing printed articles.

Abstract: Some embodiments of the present invention are directed to providing lottery outcomes and other types of lottery information to a player (e.g., in accordance with one or more preferences of a player). In some embodiments, lottery information may be provided over a network, via postal mail, via CD-ROM, and/or via a set-top device.

Abstract: In accordance with one embodiment of the present invention, a method provides for determining data associated with a player of a gaming device; determining whether the data meets at least one established criterion; and providing an offer to the player if the data meets the at least one established criterion, the offer including a condition and a description of a product to be provided to the player in exchange for the player agreeing to the condition.

Abstract: An embodiment of the invention includes outputting, from a vending machine, an inactive voucher which includes a voucher identifier. A request to activate the voucher and a payment are received. An amount of payment is determined based on the voucher identifier, and at least the amount of payment is received. The voucher is activated, and then a request to redeem the voucher is received. A gift that corresponds to the voucher is determined, and the gift is provided via the vending machine.

Abstract: The efficient regulation of cholesterol synthesis, metabolism, acquisition, and transport is an essential component of lipid homeostasis. The farnesoid X receptor (FXR) is a transcriptional sensor for bile acids, the primary product of cholesterol metabolism. Accordingly, the development of potent, selective, small molecule agonists, partial agonists, and antagonists of FXR would be an important step in further deconvoluting FXR physiology. In accordance with the present invention, the identification of novel potent FXR activators is described. Two derivatives of invention compounds, bearing stilbene or biaryl moieties, contain members that are the most potent FXR agonists reported to date in cell-based assays. These compounds are useful as chemical tools to further define the physiological role of FXR as well as therapeutic leads for the treatment of diseases linked to cholesterol, bile acids and their metabolism and homeostasis.

Abstract: A method according to some embodiments of the present invention provides for a game server to receive policy requirements of a user for a gambling loss insurance policy from a terminal. The game server determines a premium amount based on the policy requirements of the user and transmits information concerning the premium amount to the user.

Abstract: In various embodiments a casino has the flexibility to download games from a central controller to the gaming devices on the casino floor. The success of various games is periodically monitored. If a game is successful, as measured by its profitability or by some other success metric, then the game may be downloaded automatically to additional gaming devices. If a game is unsuccessful, then the game may be replaced on a gaming device with a new download. In this way, the types and quantities of different games present on a casino floor may be varied in real time based on their popularity.

Abstract: The present invention relates to the identification, isolation, sequencing and characterization of a new member of the histone deacetylase family, as well as its transcripts, gene products, associated sequence information, and related genes. The present invention also relates to methods for detecting and diagnosing carriers of normal and mutant alleles of these genes, methods for detecting and diagnosing diseases, methods of identifying genes and proteins related to or interacting with such genes and proteins, methods of screening for potential therapeutics for diseases, methods of treatment for diseases, and to cell lines and animal models useful in screening for and evaluating potentially useful therapies for diseases. In a particular aspect of the present invention, a novel family member, HDAC7, is described and its interaction with SMRT/N-CoR and mSin3A, its biochemical properties and subcellular localization are characterized.

Abstract: This invention discloses benzoxazinone and benzothiazinone compounds which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing disease states in mammals characterized by abnormal thrombosis.

Abstract: This invention discloses benzoxazinone and benzothiazinone compounds which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing disease states in mammals characterized by abnornal thrombosis.

Abstract: A radial shaft seal for use on a shaft, said radial shaft seal including a rigid insert generally having a L-shaped cross section. The shaft seal including a circumferential seal body molded around the insert. The shaft seal further including an exclusion lip integral with the seal body, the exclusion lip having a venting mechanism. The venting mechanism allows fluid transfer into the primary sealing lip.

Abstract: A carpet tucking device utilizing a rotatable member having a core and a removable cover for the core. The cover possesses an outer surface capable of contacting the carpet and further includes a first flange portion and second endless portion. A handle is connected to the rotatable member by a connecting element which forms an obtuse angle between the handle and the rotatable member.