Abstract: The field of the invention relates to systems and methods for managing healthcare information systems, and more particularly to systems and methods for coordinating the delivery of high-quality health care and medical services over an information network. In one embodiment, a processing server is configured to electronically receive a patient's health information over a data network from one or more patient systems. The processing server also includes a computer program product having a computer-usable medium including a sequence of instructions which, when executed by a processor, causes said processor to execute a process that coordinates the delivery of transferrable patient health information and provides preoperative testing recommendations based on a single acquisition of electronic patient health information.

Abstract: The method provides methods and compositions for treating metabolic disorders such as impaired glucose tolerance, elevated blood glucose, insulin resistance, dyslipidaemia, obesity, and fatty liver.

Abstract: The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine fibroblast growth factor (“FGF”) and the C-terminus includes a C-terminal portion of an FGF19 molecule. The portion of the paracrine FGF is modified to decrease binding affinity for heparin and/or heparan sulfate compared to the portion without the modification. The present invention also relates to pharmaceutical compositions including chimeric proteins according to the present invention, methods for treating a subject suffering from diabetes, obesity, or metabolic syndrome, and methods of screening for compounds with enhanced binding affinity for the ?Klotho-FGF receptor complex involving the use of chimeric proteins of the present invention.

Abstract: A computer implemented method and media performance apparatus. Content items include user owned content and advertising supported content. A determination is made as to whether a next content item for presentation is an advertising supported content item or a user-owned content item. The content item is present if the next content item for presentation is a user-owned content item, and, if not, add to a count if the next content item is an advertising supported content item. An advertisement is presented prior to performing any next advertising supported content item when the count reaches a threshold number.

Abstract: Disclosed herein are methods for enhancing one or more effects of exercise in a subject by administering a PPAR? agonist (e.g., GW1516) to the subject in combination with an exercise program. Also disclosed are gene expression profiles unique to the combination of agonist-induced PPAR? activation and exercise. Such profiles are useful, at least, in methods for identifying the use of performance-enhancing drugs in exercised subjects (such as, professional or athletes). Direct interactions between PPAR? and exercised-induced kinases (e.g., AMPK or its subunits, AMPK ?1 and/or AMPK ?2) also are disclosed. Such protein-protein interactions provide new targets for identification of useful compounds.

Abstract: A shipping container is constructed for shipping channeled fuel bundle assemblies. The shipping container includes an outer container, an inner container sized to fit within the outer container, and shock absorbing material disposed at least between the outer and inner containers. The inner container is shaped to house at least one pre-channeled fuel bundle assembly including a channel, a channel fastener, and an array of fuel rods supported by grid spacers between an upper tie plate and a lower tie plate. The inner container includes a lower tie plate restraint device shaped to receive the lower tie plate and a lower portion of the channel, and an upper tie plate restraint device shaped to receive the upper tie plate and an upper portion of the channel and channel fastener assembly. The lower and upper tie plate restraint devices are lockable within the inner shipping container.

Abstract: The method provides methods and compositions for treating metabolic disorders such as impaired glucose tolerance, elevated blood glucose, insulin resistance, dyslipidaemia, obesity, and fatty liver.

Abstract: Embodiments related to the non-uniform scrolling of a scrollable list displayed on a computing device display are disclosed. For example, one disclosed embodiment provides a method of operating a display comprising displaying a scrollable list of items that includes a first pair of list positions separated by a first spacing on the display, and a second pair of list positions separated by a second spacing that is different than the first spacing. The method further comprises detecting a movement of a manipulator from a first location to a second location, and in response, scrolling a first list item on the display between the first pair of list positions at a first scroll distance/manipulator movement distance correspondence, and scrolling a second list item between the second pair of list positions at a second scroll distance/manipulator movement distance correspondence.

Abstract: A method for creating a media stream comprising a plurality of individual media segments includes obtaining a first media segment, obtaining a first matching criterion, and automatically associating the first media segment with a second media segment to produce the media stream.

Abstract: A method for creating a compound media stream includes obtaining a first media segment, obtaining a first matching criterion, and automatically associating the first media segment with an existing media stream to produce the compound media stream.

Abstract: This application provides methods of increasing vascularization, muscle performance, muscle rehabilitation, and/or mitochondrial activity in subjects in need thereof, by administering a therapeutically effective amount of one or more agents that increases ERR? activity to the subject. Such agents can include one or more ERR? agonists. In some examples the method does not require that the subject exercise, and as such, the subject may be sedentary (such as bedridden or in a wheelchair).

Abstract: This application relates to methods of treating and ameliorating fibrosis, such as fibrosis of the pancreas. In particular, the application relates to methods of using a vitamin D receptor agonist (such as vitamin D, vitamin D analogs, vitamin D precursors, and vitamin D receptor agonists precursors) for the treatment of pancreatic fibrosis.

Abstract: The field of the invention relates to systems and methods for managing healthcare information systems, and more particularly to systems and methods for coordinating the delivery of high-quality health care and medical services over an information network. In one embodiment, a processing server is configured to electronically receive a patient's health information over a data network from one or more patient systems. The processing server also includes a computer program product having a computer-usable medium including a sequence of instructions which, when executed by a processor, causes said processor to execute a process that coordinates the delivery of transferrable patient health information and provides preoperative testing recommendations based on a single acquisition of electronic patient health information.

Abstract: A tool to slide a channel on a nuclear reactor fuel bundle assembly, the tool includes: a plate having a slot to receive a handle of the fuel bundle and a lower surface that engages an upper edge of the channel; at least one post extends up from the plate, and an arm is attached to a pivot on the post and includes a first end to receive a downward force and a second end adapted to engage the handle of the fuel bundle to apply an upward force to the handle and push down on the channel.

Abstract: Provided herein is, inter alia, methods and compositions useful in therapeutic interrogation of complex physiologic pathways by massively parallel and permissive transcriptional screening. Thus, methods and compositions are provided herein that are useful for high-throughput functional analysis of complex, transcriptionally regulated physiological pathways. While examples are provided relating to nuclear receptors, the methods and composition can be generalized and applied to any class of transcription factor or any class of gene product that can regulate the activity of transcription. For example, in addition to nuclear receptors, the methods and compositions provided herein are generally applicable to all known transcription factors and any gene encoded product that modulates said transcription factor activity. Moreover, data obtained through the methods provided herein are directly comparable thereby facilitating high-throughput functional analysis.

Abstract: This disclosure concerns the use of agonists of AMP-activated protein kinase (AMPK) for improving exercise and modifying energy metabolism in a subject. The disclosure also relates to a combination of AMPK and peroxisome proliferator-activated receptor (PPAR) ? agonists for improving exercise performance in a subject, methods for identifying substance-enhanced exercise performance in a subject, and methods for identifying compounds that affect the interaction of PPAR? with exercise-induced kinases.

Abstract: A tool to slide a channel on a nuclear reactor fuel bundle assembly, the tool includes: a plate having a slot to receive a handle of the fuel bundle and a lower surface that engages an upper edge of the channel; at least one post extends up from the plate, and an arm is attached to a pivot on the post and includes a first end to receive a downward force and a second end adapted to engage the handle of the fuel bundle to apply an upward force to the handle and push down on the channel.

Abstract: This application relates to methods of treating, preventing, and ameliorating fibrosis, such as fibrosis of the liver. In particular, the application relates to methods of using a vitamin D receptor agonist (such as vitamin D, vitamin D analogs, vitamin D precursors, and vitamin D receptor agonists precursors) for the treatment of liver fibrosis. Also disclosed are methods for screening for agents that treat, prevent, and ameliorate fibrosis.

Abstract: A tool to slide a channel on a nuclear reactor fuel bundle assembly, the tool includes: a plate having a slot to receive a handle of the fuel bundle and a lower surface that engages an upper edge of the channel; at least one post extends up from the plate, and an arm is attached to a pivot on the post and includes a first end to receive a downward force and a second end adapted to engage the handle of the fuel bundle to apply an upward force to the handle and push down on the channel.