Abstract: A method is disclosed for applying thermal spray particles to a composite, wherein the method includes the steps of providing a composite that includes a thermally sensitive surface, and applying the thermal spray particles at a temperature that is high enough to cause a temperature-dependent change in the thermally sensitive surface of the composite. The temperature-dependent change improves adhesion between the thermal spay particles and the composite.

Abstract: Substituted benzimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of using substituted benzimidazole compounds, in, e.g., reducing virulence and infectivity, inhibiting biofilms and treating bacterial infections are also provided.

Abstract: Methods for using tetracycline compounds for the treatment of spinal muscular atrophy are described.

Abstract: Methods and compositions for the treatment of skin disorders (e.g., acne, rosacea) are described.

Abstract: The present invention relates, at least in part, to the use of substituted tetracycline compounds for regulation of expression of nucleic acids operably linked to a tetracycline operator system. The invention pertains to compounds used in a regulatory system which utilizes components of the Tet repressor/operator/inducer system of prokaryotes to regulate gene expression in cells. Use of certain substituted tetracycline compounds, as featured in the methods of the invention, result in improved dose-response results when compared to those for e.g., tetracycline and doxycycline. Certain methods of the invention thus allow for enhanced control of the Tet repressor/operator/inducer system in regulating gene expression in cells.

Abstract: The present invention relates to a method of making an industrial fabric comprising the following steps: -applying a radiation-curable powder onto the surface of a fabric, melting the powder such that the powder forms a layer on the fabric surface and directing radiation at said surface layer so as to cure the constituent material of said coating layer.

Abstract: The present invention relates to an automated method of transposon-mediated multiplex sequencing of DNA fragments inserted into a vector. It relates more particularity to an increased efficiency in such automated methods, where the increased efficiency is obtained by screening out before the sequencing those constructs in which the transposon inserted into the vector sequence. This prevents a waste of time and resources in performing reactions sequencing the vector instead of the DNA fragments of interest.

Abstract: A planar element is disclosed for use in a papermaking machine. The planar element includes a composite of multiple layers, with at least some of the layers including resin impregnated fabrics including basalt fibers.

Abstract: Methods and compounds for treating diseases with tetracycline compounds having a target therapeutic activity are described.

Abstract: Disclosed in this specification is a decal assembly comprising a decal support, a releasable covercoat, a heat activatable layer, and an ink layer. The ink layer forms a digital image. The heat activatable layer has a high adhesion to a ceramic substrate at high temperatures and a low adhesion to the substrate at lower temperatures. Thus the adhesive properties of the decal are activated by heat. The resulting image has excellent adhesion to the substrate and resists the effects of washing.

Abstract: Methods and compositions for treating for the synergistic treatment of fungal associated disorders are discussed.

Abstract: A planar element for use in a papermaking machine comprising a synthetic construction incorporating nanoparticles in a polymeric resin matrix.

Abstract: An industrial textile including a polymeric substrate and a resin system grafted onto the polymeric substrate by way of a primer. The resin system includes a water-borne thermoplastic, a polyhydroxyether resin and/or an analogue of a polyhydroxyether resin, and at least one co-resin.

Abstract: Methods and compositions for treating for the synergistic treatment of fungal associated disorders are discussed.

Abstract: Methods and compositions for treating fungal associated disorders in subjects are discussed.

Abstract: Methods and compositions for treating fungal associated disorders in subjects are discussed.

Abstract: This invention provides a method for treating or preventing malaria in a subject. The method includes administering to the subject an effective amount of a substituted tetracycline compound, such that malaria is treated or prevented. In one aspect, the invention relates to pharmaceutical compositions which include an effective amount of a tetracycline compound to treat malaria in a subject and a pharmaceutically acceptable carrier. The substituted tetracycline compounds of the invention can be used to in combination with one or more anti-malarial compounds or can be used to treat or prevent malaria which is resistant to one or more other anti-malarial compounds.

Abstract: A method for modulating RNA with tetracycline compounds is described.

Abstract: This invention provides a method for treating or preventing malaria in a subject. The method includes administering to the subject an effective amount of a substituted tetracycline compound, such that malaria is treated or prevented. In one aspect, the invention relates to pharmaceutical compositions which include an effective amount of a tetracycline compound to treat malaria in a subject and a pharmaceutically acceptable carrier. The substituted tetracycline compounds of the invention can be used to in combination with one or more anti-malarial compounds or can be used to treat or prevent malaria which is resistant to one or more other anti-malarial compounds.

Abstract: Methods and compounds for treating diseases with tetracycline compounds having a target therapeutic activity are described.