Abstract: Certain example embodiments relate to systems and/or methods for cloud-based event-driven integration, which in essence inverts the current point-to-point integration pattern by using an event-driven system in its place. Certain example embodiments transform and normalize integration patterns in connection with an underlying framework that helps decouple data producers from data consumers and advantageously allows additional systems to simply “plug into” the framework. Data from event sources is transformed into an event with a well-defined event type that may be picked up by an event sink, transformed into a format relevant for that event sink, and subsequently processed.

Abstract: The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.

Abstract: We have disclosed systems and methods for portable performance monitoring of an individual during a physical activity. The systems and methods may include a portable sensor component configured to be carried by the individual during the physical activity and configured to obtain movement data for the athlete individual during the physical activity. The systems and methods may also include a portable output component configured to be carried by the individual during the physical activity and configured to provide an output to the individual during the physical activity. The systems and methods may further include a portable processing component in communication with the portable sensor component and the portable output component, where the portable processing component is configured to be carried by the individual during the physical activity. The portable processing component may be configured to identify movement of the individual during the physical activity.

Abstract: A method for generating a smaller dataset from a larger dataset, each dataset holding a plurality of records, includes profiling the larger dataset to identify a plurality of patterns, each of which is descriptive of one or more records held in the larger dataset. A plurality of slots of the smaller dataset is filled with records held in the larger dataset. Multiple records held in the larger dataset are individually retrieved, and for each retrieved record it is determined whether to place the retrieved record into a slot of the smaller dataset and evict a record already occupying that slot, or not place the retrieved record into the smaller dataset. This determination is based on a pattern of the retrieved record and a representation status of the pattern in the smaller dataset.

Abstract: Methods and systems for in situ cleaning of internal cooling circuits of a turbine engine with detergent that provide cleaning a turbine engine that includes circumferentially arranged internal impingement cooling circuits that each include a baffle plate configured to air cool a respective surface or component of the turbine engine. Detergent is introduced through the outer wall and proximate to a back side of a baffle plate such that the detergent passes through at least one aperture in the baffle plate and acts at least upon the surface or component that the baffle plate is configured to cool. The detergent may also act on the front side of the baffle plate that is proximate to the surface or component.

Abstract: Various embodiments relating to providing touch input control of a computing device are disclosed. In one example, responsive to detecting a touch input on a display, a zero point of an adaptive virtual control may be established at a display location of the touch input. Responsive to a translation of the touch input on the display away from the zero point being greater than a radius of the adaptive virtual control, the zero point may be translated.

Abstract: The present disclosure provides methods and systems for in situ cleaning of hot gas flowpath components of a turbine engine that form portions of a hot gas flowpath extending through the turbine. The hot gas flowpath components may include a layer of accumulated contaminants on first portions thereof that form a respective portion of the hot gas flowpath. The first portions may include a thermal battier coating (TBC), and the layer of accumulated contaminants may overlie the TBC and at least partially infiltrate into the TBC. The accumulated contaminants may include CaO—MgO—Al2O3-SiO2 (CMAS) partial melt. The methods may include introducing an acid-including detergent into the hot gas flowpath of the turbine engine and onto the hot gas flowpath components to clean the accumulated contaminants from the first surfaces of the components.

Abstract: The present disclosure provides methods and systems for in situ cleaning of hot gas flowpath components of a turbine engine that form portions of a hot gas flowpath extending through the turbine. The hot gas flowpath components may include a layer of accumulated contaminants on first portions thereof that form a respective portion of the hot gas flowpath. The first portions may include a thermal battier coating (TBC), and the layer of accumulated contaminants may overlie the TBC and at least partially infiltrate into the TBC. The accumulated contaminants may include CaO—MgO—Al2O3-SiO2 (CMAS) partial melt. The methods may include introducing an acid-including detergent into the hot gas flowpath of the turbine engine and onto the hot gas flowpath components to clean the accumulated contaminants from the first surfaces of the components.

Abstract: An approach for creation of an electrical vault cover that is able to generate power that is stored in a battery for use by a heater to maintain the temperature above a minimum in a utility vault.

Abstract: Described herein are techniques for identifying and displaying key excerpts of a digital work and related key excerpts of other digital works. Key excerpts are identified by evaluating (a) the number of interactions by human readers within each of the key excerpts and (b) the number of reviews that reference each of the key excerpts. Related excerpts from other books can be identified by comparing the key excerpts of the other books. Excerpts can be displayed by subject, and links are provided to move from one subject to another.

Abstract: The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein ring R1, R2, R3, R4, ring B, and the subscript r are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).

Abstract: Crucible compositions and methods of using the crucible compositions to melt titanium and titanium alloys. More specifically, crucible compositions having extrinsic facecoats comprising a rare earth oxide that are effective for melting titanium and titanium alloys for use in casting titanium-containing articles. Further embodiments are titanium-containing articles made from the titanium and titanium alloys melted in the crucible compositions. Another embodiment is a crucible curing device and methods of use thereof.

Abstract: In its many embodiments, the present invention provides certain C-6 spirocarbocyclic iminothiadiazine compounds, including compounds Formula (I): or a tautomers thereof, and pharmaceutically acceptable salts of said compounds and said tautomers, wherein R1, R4, ring A, RA, m, L1, and RL are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including for the possible treatment of Alzheimer's disease, are also disclosed.

Abstract: The invention provides certain pyrazine-2-carboxamide compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein A, B, and X are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).

Abstract: We have disclosed systems and methods for portable performance monitoring of an individual during a physical activity. The systems and methods may include a portable sensor component configured to be carried by the individual during the physical activity and configured to obtain movement data for the athlete individual during the physical activity. The systems and methods may also include a portable output component configured to be carried by the individual during the physical activity and configured to provide an output to the individual during the physical activity. The systems and methods may further include a portable processing component in communication with the portable sensor component and the portable output component, where the portable processing component is configured to be carried by the individual during the physical activity. The portable processing component may be configured to identify movement of the individual during the physical activity.

Abstract: The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4, and R4 are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).

Abstract: A system and method for using a portable device to communicate with a vehicle to authorize one or more vehicle operations. The portable device may authorize the vehicle to unlock/lock doors, start the vehicle engine, or mobilize the vehicle, or a combination thereof. The vehicle may include a vehicle transmitter system with one or more transmitters disposed at various locations on the vehicle, and the portable device may be configured to monitor a communication strength between the portable device and the one or more transmitters of the transmitter system. Based on the monitored signal strength, the portable device may determine location information about itself.