Abstract: The present invention relates to new solid forms of a plasma kallikrein inhibitor, a pharmaceutical composition containing them and their use in therapy. Also provided are processes for preparing the solid forms of the present invention.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed to generate a workscope. An example apparatus includes a workscope mapper, workscope strategy analyzer, and workscope selector. The workscope strategy analyzer is to evaluate each of the plurality of workscopes using dynamic optimization to determine a maintenance value and benefit to an asset associated with each workscope based on a stage in a remaining life of a constraint at which the evaluation is executed and a state of the asset. The dynamic optimization is to determine a prediction of the maintenance value based on a probability of a future change in state and associated workscope value until the end of life of the constraint. The maintenance value, used to select a workscope from the plurality of workscopes, is to be determined by the dynamic optimization as a sum of the associated workscope values until the end of life of the constraint.

Abstract: Apparatus and methods are described herein for use in the transvascular delivery and deployment of a prosthetic mitral valve. In some embodiments, a method includes inverting an outer frame of a prosthetic mitral valve when the valve is in a biased expanded configuration. After inverting the outer frame, the prosthetic mitral valve is inserted into a lumen of a delivery sheath such that the mitral valve is moved to a collapsed configuration. The distal end portion of the delivery sheath is inserted into a left atrium of a heart. The prosthetic mitral valve is moved distally out of the delivery sheath such that the inverted outer frame reverts and the prosthetic mitral valve assumes its biased expanded configuration. In some embodiments, actuation wires are used to assist in the reversion of the outer frame. The prosthetic mitral valve is then positioned within a mitral annulus of the heart.

Abstract: The invention encompasses methods for reducing the proportion of sperm cells with abnormal morphology, and unviable sperm cells, in a sperm cell population.

Abstract: Aneurysms are treated by placing a scaffold across an aneurysmal sac to provide a blood flow lumen therethrough. An aneurysmal space surrounding the scaffold is filled with one or more expandable structures which are simultaneously or sequentially expanded to fill the aneurysmal space and reduce the risk of endoluminal leaks and scaffold migration. The expandable structures are typically inflatable and delivered by delivery catheter, optionally with an inflation tube or structure attached to the expandable structure.

Abstract: The present invention provides compounds of formula (I): (I) compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, A, B, U, D, E, W, X, Y and Z are as defined herein.

Abstract: The invention comprises depletive methods of sex-sorting sperm at high event rates, while simultaneously achieving high technical yields.

Abstract: A system for additive manufacturing machine energy beam alignment error compensation includes, a calibration table having x-y planar offsets to correct laser alignment errors representing energy beam positional offsets between beam-steering commanded energy beam locations and fiducial marks generated on a burn-paper, a recoater mechanism that distributes successive layers of powder, one or more sensors monitoring the powderbed surface proximal to the beam scan unit, and a processor unit configured to perform a method. The method including collecting sensor data representing height variations across at least a portion of the powderbed surface, deriving dimensional data from the collected data, analyzing the dimensional data to determine a distribution of differences between the powderbed surface and a reference plane containing the burn-paper when the fiducial marks were generated, and calculating z-axis calibration offset points for inclusion in the calibration table x-y planar offsets.

Abstract: A method of sorting cells including magnetically coupling a nozzle assembly to a flow cytometer in a predetermined orientation to form a fluid stream having a sheath fluid and a sample fluid. Particles within the sample fluid are oriented and then interrogated at an inspection zone to produces signals representative of emitted or reflected electromagnetic radiation. The electromagnetic radiation is analyzed to classify the cells and the cells are sorted according to their classification.

Abstract: A mouth guard includes a pair of spaced-apart molar receiving members with an inner wall extending therebetween. The inner wall is configured for insertion between a user's lips and teeth. An outer wall is configured to confront an exterior surface of the user's lips. A conduit extends between the inner and outer walls and includes a passage formed therethrough. The passage extends through the inner wall between the molar receiving members and extends through the outer wall whereby a user may breathe or drink through the passage.

Abstract: A restaurant service system for assessing the accuracy of estimated delivery time provided by a restaurant includes an order server, a restaurant server, a service server and an assessment server. Each of the servers includes a server software application. The order server software application collects a set of orders from a set of diner devices. The restaurant server software application retrieves an estimated delivery time for each order in the set. The service server software application determines an order actual delivery time for at least one order in the set. The assessment server software application determines an accuracy measure of estimated delivery time for the restaurant.

Abstract: A restraint apparatus for securing a mobility device in a vehicle includes a base configured to being mounted to a floor of the vehicle, a support coupled to the base and extending upward therefrom, and a backing plate adjustably coupled to the support. The backing plate defines a channel to provide vertical adjustment of the backing plate with respect to the support. An upper support is pivotally coupled to the backing plate, and a claw assembly is coupled to the upper support. The claw assembly includes a claw member and a latching member, where the latching member is pivotally coupled to the claw member to enable pivotal movement between an unlatched position and a latched position. A control system operably controls the pivotal movement of the latching member between its latched position to its unlatched positions. In the unlatched position, the claw assembly provides an opening for receiving the device.

Abstract: A computer-implemented method of generating a form definition for a user interface form is disclosed. The method involves retrieving form definition data for a requested form from a database. One or more overrides are optionally applied to the form definition data to modify properties of form elements. Form instance data for the modified form is generated and stored for reuse. The form instance data is transmitted to a rendering module at a client device for generation of a user interface form based on the form instance data.

Abstract: A controller for use in an additive manufacturing system including at least one laser device configured to generate at least one melt pool in powdered material including a processing device and a memory device. The controller is configured to generate at least one control signal to control a power output of the at least one laser device throughout at least one scan path across the layer of powdered material, the scan path generated at least partially based on a functional relationship between a plurality of points of a generating path and each point of a plurality of points of the scan path. The controller is further configured to generate a non-uniform energy intensity profile for the scan path, and transmit the control signal to the laser device to emit at least one laser beam to generate at least one melt pool.

Abstract: A system for commissioning for first responders at a site of an incident is provided. The system includes a data processing device configured to: receive personnel data; generate a unique personnel profile based on the personnel data; communicating the unique personnel profile to a tag creation device for creation of a tag corresponding to the unique personnel profile; receive scanning location information of the tag, and cause display, at a monitoring display, of alert data associated with the scanning location information. The alert data is a result of applying at least one user-defined rule to the scanning locating information.

Abstract: Some embodiments facilitate creation of an industrial asset item via a rotary additive manufacturing process. For example, a build plate may rotate about a vertical axis and move, relative to a print arm, along the vertical axis during printing. An industrial asset item definition data store may contain at least one electronic record defining the industrial asset item. A frame creation computer processor may slice the data defining the industrial asset item to create a series of two-dimensional, locally linear frames helically arranged as a spiral staircase of steps (and each step may be oriented normal to the vertical axis. Indications of the series of two-dimensional frames may then be output to be provided to a rotary three-dimensional printer.

Abstract: The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, A, B, W, X, Y and Z are as defined herein.

Abstract: Cell sorting methods that improve sorting efficiency and productivity by elevating sorting pressures and incorporate certain steps to help the cells better survive such elevated pressures. In the case of sperm, sorting the steps of standardizing sperm samples, staining sperm samples in a single step, calibrating a flow cytometer to place sperm in the leading edge of droplets, and changing a catch fluid distance may be incorporated individually, or in combination to help sperm better survive the sex sorting process.