Abstract: Single-stranded oligonucleotide probes, systems, kits and methods for chromosome enumeration, gene copy enumeration, or tissue diagnostics. The probes are particularly suited for detecting gene amplification, deletion, or rearrangement in tissue samples in a single, dual, or multiplexed assay. The probes exhibit improved performance compared to industry leading dual-stranded probes; particularly in terms of the rate of hybridization.

Abstract: Managing client access token requests is provided. It is determined whether a current time interval between a last allowed access token request matches a regular access token request interval for a client. In response to determining that the current time interval does match the regular access token request interval for the client, a current access token request is allowed. An access token is generated for the client to access a protected resource hosted by a resource server based on allowing the current access token request. The access token is issued to the client via a network.

Abstract: Single-stranded oligonucleotide probes, systems, kits and methods for chromosome enumeration, gene copy enumeration, or tissue diagnostics. The probes are particularly suited for detecting gene amplification, deletion, or rearrangement in tissue samples in a single, dual, or multiplexed assay. The probes exhibit improved performance compared to industry leading dual-stranded probes; particularly in terms of the rate of hybridization.

Abstract: Systems and methods for attaching with a ski to provide improved traction while climbing snowy grades. Exemplary climbing track assemblies can include an attachment to the bottom of a ski that improves traction for hiking or climbing uphill. Assemblies can also include an under-binding bracket, which is mounted under the toe-piece binding of the ski which allows the device to be securely fastened. Assemblies may further include a shim, provided as a small plate mounted under the heel-piece binding, which operates to keep the binding level.

Abstract: A bicycle water bottle system is provided. The system includes a mount having a mounting base and a mounting plate extending substantially perpendicular to the mounting base. The mounting base may be configured to connect to a bicycle frame using two fixed pre-formed mounting screw holes. The system also includes a water bottle having a slot formed in one side of the water bottle. The mounting plate is shaped and sized to fit tightly into the slot of the water bottle and the slot is correspondingly shaped and sized to receive the mounting plate to secure the water bottle to the mounting plate.

Abstract: Disclosed herein are antibody-nanoparticle conjugates that include two or more nanoparticles (such as gold, palladium, platinum, silver, copper, nickel, cobalt, iridium, or an alloy of two or more thereof) directly linked to an antibody or fragment thereof through a metal-thiol bond. Methods of making the antibody-nanoparticle conjugates disclosed herein include reacting an arylphosphine-nanoparticle composite with a reduced antibody to produce an antibody-nanoparticle conjugate. Also disclosed herein are methods for detecting a target molecule in a sample that include using an antibody-nanoparticle conjugate (such as the antibody-nanoparticle conjugates described herein) and kits for detecting target molecules utilizing the methods disclosed herein.

Abstract: A bicycle frame is discussed having a battery fully contained within a down tube of the bicycle frame. The battery may be inserted into or removed from the down tube via a through opening through a bottom bracket housing of the bicycle frame. Weakness in the bottom bracket housing due to the through opening may be compensated for, fully or partially, by utilizing a bottom bracket bearing assembly that has a structural component, or structural component assembly, that extends completely through the bottom bracket housing and removably couples to the bottom bracket housing.

Abstract: Systems and methods for attaching with a ski to provide improved traction while climbing snowy grades. Exemplary climbing track assemblies can include an attachment to the bottom of a ski that improves traction for hiking or climbing uphill. Assemblies can also include an under-binding bracket, which is mounted under the toe-piece binding of the ski which allows the device to be securely fastened. Assemblies may further include a shim, provided as a small plate mounted under the heel-piece binding, which operates to keep the binding level.

Abstract: A bicycle frame is discussed having a battery fully contained within a down tube of the bicycle frame. The battery may be inserted into or removed from the down tube via a through opening through a bottom bracket housing of the bicycle frame. Weakness in the bottom bracket housing due to the through opening may be compensated for, fully or partially, by utilizing a bottom bracket bearing assembly that has a structural component, or structural component assembly, that extends completely through the bottom bracket housing and removably couples to the bottom bracket housing.

Abstract: A bicycle water bottle system is provided. The system includes a mount having a mounting base and a mounting plate extending substantially perpendicular to the mounting base. The mounting base may be configured to connect to a bicycle frame using two fixed pre-formed mounting screw holes. The system also includes a water bottle having a slot formed in one side of the water bottle. The mounting plate is shaped and sized to fit tightly into the slot of the water bottle and the slot is correspondingly shaped and sized to receive the mounting plate to secure the water bottle to the mounting plate.

Abstract: A bicycle water bottle system is provided. The system includes a mount having a mounting base and a mounting plate extending substantially perpendicular to the mounting base. The mounting base may be configured to connect to a bicycle frame using two fixed pre-formed mounting screw holes. The system also includes a water bottle having a slot formed in one side of the water bottle. The mounting plate is shaped and sized to fit tightly into the slot of the water bottle and the slot is correspondingly shaped and sized to receive the mounting plate to secure the water bottle to the mounting plate.

Abstract: A first authenticator payload is obtained that includes a first authenticator random value. A first authenticator encrypted file is generated with an authenticator public key that is related to a client authenticator application. The first authenticator encrypted file is generated based on a first cryptographic algorithm. The first authenticator encrypted file includes the first authenticator payload. A first target payload is obtained that includes a first target random value. A first target encrypted file is generated with the first authenticator random value. The first target encrypted file is generated based on a second cryptographic algorithm. The first target encrypted file includes the first target payload.

Abstract: Systems and methods for attaching with a ski to provide improved traction while climbing snowy grades. Exemplary climbing track assemblies can include an attachment to the bottom of a ski that improves traction for hiking or climbing uphill. Assemblies can also include an under-binding bracket, which is mounted under the toe-piece binding of the ski which allows the device to be securely fastened. Assemblies may further include a shim, provided as a small plate mounted under the heel-piece binding, which operates to keep the binding level.

Abstract: A method and apparatus for dynamic rotation of streaming protocols are disclosed. In the method and apparatus, a first portion of content is streamed to a client device in accordance with a first content delivery protocol. Further, information indicating client device attributes, network conditions or usage conditions is received. A plurality of content delivery protocols including the first content delivery protocol are evaluated based at least in part on the received information to identify a content delivery protocol for streaming the a second portion of the content.

Abstract: Managing client access token requests is provided. It is determined whether a current time interval between a last allowed access token request matches a regular access token request interval for a client. In response to determining that the current time interval does match the regular access token request interval for the client, a current access token request is allowed. An access token is generated for the client to access a protected resource hosted by a resource server based on allowing the current access token request. The access token is issued to the client via a network.

Abstract: Embodiments of the present invention provide a system for electronic identification of attributes for performing maintenance, monitoring, and distribution of designated resource assets. In particular, the system may be configured to extract one or more legacy resources from a data repository of an entity system associated with an entity, wherein the legacy resources are in a first format, convert the one or more legacy resources from the first format to a second format, process the one or more legacy resources, via one or more machine learning models, identify one or more attributes based on processing the one or more legacy resources via the one or machine learning models, and implement one or more actions based on the one or more attributes.

Abstract: In an approach for autonomous claim requirements discovery of APIs, a processor receives an access request from a client to a server. A processor validates the access request. A processor queries claim requirements in a claim document from the server upon the validation of the access request. A processor receives the claim requirements. A processor constructs a token based on the claim requirements. A processor sends the token to the server. A processor receives a response from the server. A processor sends the response to the client.

Abstract: The present disclosure is directed to epitope-tagged antibodies, as well as methods of employing the epitope-tagged antibodies for detecting one or more targets in a biological sample, e.g. a tissue sample.

Abstract: In an approach for autonomous claim requirements discovery of APIs, a processor receives an access request from a client to a server. A processor validates the access request. A processor queries claim requirements in a claim document from the server upon the validation of the access request. A processor receives the claim requirements. A processor constructs a token based on the claim requirements. A processor sends the token to the server. A processor receives a response from the server. A processor sends the response to the client.

Abstract: The present disclosure is directed to epitope-tagged antibodies, as well as methods of employing the epitope-tagged antibodies for detecting one or more targets in a biological sample, e.g. a tissue sample.