Abstract: Optical sensing of trigger region incursion in the context of a firearm training system may be enhanced or otherwise improved through selective use of light absorbent materials within an optical detection range of one or more optical sensors. Surfaces located within a field of view of the optical sensor(s), such as interior facing surfaces of the trigger guard, surfaces of the trigger, and other surfaces located along the optical signal path may include light absorbent materials, such as dark surface colors, matte finishes, surface textures, and/or thin-film coatings that filter and/or absorb light of a particular wavelength or wavelength range.

Abstract: Disclosed herein are antibody-nanoparticle conjugates that include two or more nanoparticles (such as gold, palladium, platinum, silver, copper, nickel, cobalt, iridium, or an alloy of two or more thereof) directly linked to an antibody or fragment thereof through a metal-thiol bond. Methods of making the antibody-nanoparticle conjugates disclosed herein include reacting an arylphosphine-nanoparticle composite with a reduced antibody to produce an antibody-nanoparticle conjugate. Also disclosed herein are methods for detecting a target molecule in a sample that include using an antibody-nanoparticle conjugate (such as the antibody-nanoparticle conjugates described herein) and kits for detecting target molecules utilizing the methods disclosed herein.

Abstract: Systems and methods are presented for enabling a user to provide rules for the placement of computing resources at a data center for an entity that employs or is associated with the user. The data center can use the placement rules to select a data center computer system to host computing resources for a user. The rules can be used to establish diversity in computing resource placement at the data center thereby reducing the number of users who lose access to computing resources when a specific data center computer suffers a failure. Further, the placement rules can be used to facilitate configuration of the computer resources for the user based, for example, on the user's employment responsibilities.

Abstract: It may be determined that a cloud desktop should be migrated from a current region. A destination region to which the cloud desktop will be migrated can be identified. A data volume of the cloud desktop may be copied from the current region to the destination region. The data volume at the current region and the data volume at the destination region may be maintained in sync during the copying. Upon completion of the copying, a current user session associated with the cloud desktop at the current region may be frozen, a current memory and processor state of the current user session may be copied to the destination region, and a second cloud desktop instance at the destination region may be started using the copied data volume and current memory and processor state. The current user session may be connected to the second cloud desktop instance.

Abstract: The present invention provides probes and probe systems for detection of nucleic acids, and in particular probes and probe systems comprising target nucleic acid probes which comprise a plurality of detection sequences and detection nucleic acid probes which hybridize to the detection sequences of the target nucleic acid probes and which further comprise a plurality of detectable moieties, such as haptens.

Abstract: Systems and methods are presented for storing and updating data. The metadata associated with a user computing device may be used to determine whether the user computing device is configured to maintain a synchronized copy of the file. Moreover, a user computing device may be authorized to modify a file through a virtual desktop instance on a PES. If a user computing device is authorized to synchronize the file, the file may be accessible locally without a network connection.

Abstract: Single-stranded oligonucleotide probes, systems, kits and methods for chromosome enumeration, gene copy enumeration, or tissue diagnostics. The probes are particularly suited for detecting gene amplification, deletion, or rearrangement in tissue samples in a single, dual, or multiplexed assay. The probes exhibit improved performance compared to industry leading dual-stranded probes; particularly in terms of the rate of hybridization.

Abstract: It may be determined that a cloud desktop should be migrated from a current region. A destination region to which the cloud desktop will be migrated can be identified. A data volume of the cloud desktop may be copied from the current region to the destination region. The data volume at the current region and the data volume at the destination region may be maintained in sync during the copying. Upon completion of the copying, a current user session associated with the cloud desktop at the current region may be frozen, a current memory and processor state of the current user session may be copied to the destination region, and a second cloud desktop instance at the destination region may be started using the copied data volume and current memory and processor state. The current user session may be connected to the second cloud desktop instance.

Abstract: Disclosed herein are methods and compositions for detecting differential expression of certain miRNAs in cancer cells or their surrounding normal tissues in the tumor microenvironment. The disclosure describes an automated, highly sensitive and specific method for detection of any cellular RNA molecule, including microRNA, messenger RNA and non-coding RNA. The technology includes probe design as well as probe use in an automated fashion for detection of RNA molecules in formalin-fixed paraffin-embedded tissue (FFPET) samples.

Abstract: Systems and methods are presented for enabling a user to provide rules for the placement of computing resources at a data center for an entity that employs or is associated with the user. The data center can use the placement rules to select a data center computer system to host computing resources for a user. The rules can be used to establish diversity in computing resource placement at the data center thereby reducing the number of users who lose access to computing resources when a specific data center computer suffers a failure. Further, the placement rules can be used to facilitate configuration of the computer resources for the user based, for example, on the user's employment responsibilities.

Abstract: A method for selecting a communication protocol for a virtual desktop instance in a service provider environment may include providing to a client computing device, access to a virtual desktop instance running on a server computer using a first communication channel associated with a first communication protocol. A request for functionality from a user of the device is detected, the requested functionality being unsupported by the first communication protocol. A second communication protocol from a plurality of available communication protocols may be selecting based on the requested functionality. The second communication protocol may support the requested functionality. A user authorization for using the second communication protocol can be verified.

Abstract: Disclosed herein are antibody-nanoparticle conjugates that include two or more nanoparticles (such as gold, palladium, platinum, silver, copper, nickel, cobalt, iridium, or an alloy of two or more thereof) directly linked to an antibody or fragment thereof through a metal-thiol bond. Methods of making the antibody-nanoparticle conjugates disclosed herein include reacting an arylphosphine-nanoparticle composite with a reduced antibody to produce an antibody-nanoparticle conjugate. Also disclosed herein are methods for detecting a target molecule in a sample that include using an antibody-nanoparticle conjugate (such as the antibody-nanoparticle conjugates described herein) and kits for detecting target molecules utilizing the methods disclosed herein.

Abstract: Systems and methods are presented for enabling a user to provide rules for the placement of computing resources at a data center for an entity that employs or is associated with the user. The data center can use the placement rules to select a data center computer system to host computing resources for a user. The rules can be used to establish, diversity in computing resource placement at the data center thereby reducing the number of users who lose access to computing resources when a specific data center computer suffers a failure. Further, the placement rules can be used to facilitate configuration of the computer resources for the user based, for example, on the user's employment responsibilities.

Abstract: A system and method for providing destination recommendations to a user based on mining of a location history. The location history provides information on locations visited by users of the system over time. The system mines the location history to identify location pairs. Each location pair comprises an originating location visited by a user and a next location that was visited by the user within a defined time threshold of visiting the originating location. The system aggregates location pairs by common originating location. The system then takes into account the current location of a requesting user. The system uses the current location information to identify a corresponding originating location in a location history index. The system provides recommendations based at least in part on how frequently certain next locations were visited after visiting the originating location.

Abstract: Disclosed herein are antibody-nanoparticle conjugates that include two or more nanoparticles (such as gold, palladium, platinum, silver, copper, nickel, cobalt, iridium, or an alloy of two or more thereof) directly linked to an antibody or fragment thereof through a metal-thiol bond. Methods of making the antibody-nanoparticle conjugates disclosed herein include reacting an arylphosphine-nanoparticle composite with a reduced antibody to produce an antibody-nanoparticle conjugate. Also disclosed herein are methods for detecting a target molecule in a sample that include using an antibody-nanoparticle conjugate (such as the antibody-nanoparticle conjugates described herein) and kits for detecting target molecules utilizing the methods disclosed herein.

Abstract: A schedule may be determined. The schedule may include a shutdown time and a startup time. At the shutdown time, user data for a first virtual desktop instance for a virtual desktop may be saved and the first virtual desktop instance may be shut down. At the startup time, a second virtual desktop instance for the virtual desktop may be started up with the saved user data. The shutdown and startup of a virtual desktop instance may be based on rules or logic for an individual or an organization.

Abstract: It may be determined that a cloud desktop should be migrated from a current region. A destination region to which the cloud desktop will be migrated can be identified. A data volume of the cloud desktop may be copied from the current region to the destination region. The data volume at the current region and the data volume at the destination region may be maintained in sync during the copying. Upon completion of the copying, a current user session associated with the cloud desktop at the current region may be frozen, a current memory and processor state of the current user session may be copied to the destination region, and a second cloud desktop instance at the destination region may be started using the copied data volume and current memory and processor state. The current user session may be connected to the second cloud desktop instance.

Abstract: Systems and methods are presented for enabling a user to provide rules for the placement of computing resources at a data center for an entity that employs or is associated with the user. The data center can use the placement rules to select a data center computer system to host computing resources for a user. The rules can be used to establish diversity in computing resource placement at the data center thereby reducing the number of users who lose access to computing resources when a specific data center computer suffers a failure. Further, the placement rules can be used to facilitate configuration of the computer resources for the user based, for example, on the user's employment responsibilities.

Abstract: A proximity detection method is described that utilizes enzymatic biotinylation to detect targets in a sample, particularly formalin fixed paraffin embedded samples using automated staining platforms. One disclosed embodiment comprises contacting the sample with a first conjugate comprising a biotin ligase and a first specific binding moiety that binds proximally to the first target; contacting the sample with a second conjugate comprising a biotin ligase substrate and a second specific binding moiety that binds proximally to the second target; subjecting the sample to conditions that allow biotinylation of the biotin ligase substrate by the biotin ligase when the first target and the second target have a proximal arrangement; and detecting biotinylation of the biotin ligase substrate. The conditions that allow biotinylation of the substrate include addition of biotin and ATP. The method also may comprise contacting the sample with a streptavidin-enzyme conjugate. Signal amplification also can be used.

Abstract: Systems and methods are presented for storing and updating data. The metadata associated with a user computing device may be used to determine whether the user computing device is configured to maintain a synchronized copy of the file. Moreover, a user computing device may be authorized to modify a file through a virtual desktop instance on a PES. If a user computing device is authorized to synchronize the file, the file may be accessible locally without a network connection.