Abstract: The example systems, methods, and/or computer-readable media described herein help with design treatment plans for orthodontic treatments. Treatment templates expressed according to treatment domain-specific protocols may be processed to provide treatment planning software, including automated or real-time treatment planning software, that accommodates treatment preferences of a practitioner and/or patient data relevant to a treatment plan. These methods and systems may be also be useful for planning, designing and producing as series of dental appliances (e.g., aligners).

Abstract: A method for removing one or more objects or materials from a body lumen includes delivering a tube and an expandable device to the body lumen to a position proximal to the one or more objects or materials. The expandable device is positioned with a lumen of the tube, and the expandable device includes a lumen extending from a distal portion to a proximal portion. The method further includes proximally retracting the tube such that the expandable device remains in the position proximal to the one or more objects or materials, distally advancing the expandable device such that the distal portion of the expandable device at least partially surrounds the one or more objects or materials, at least partially closing a distal end of the expandable device, and moving the expandable device proximally to remove the expandable device and the one or more objects or materials from the lumen.

Abstract: The present disclosure provides a tissue debridement device and describes an example treatment for ANP using the tissue debridement device. The tissue debridement device has a sheath, a distal tip, and a plurality of rotating tines coupled to the distal tip and the sheath. The distal tip can be adjusted to be closer or further from the sheath to change a diameter of the rotating tines, thereby changing a cutting diameter of the tissue debridement device.

Abstract: An improved device and system for facilitating polymerase chain reaction including a light source, detector, waveguide, and filters that occupy minimal space and facilitate detection of stationary samples, reduced sample read time, and simultaneous reading of multiple light wavelengths.

Abstract: The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression.

Abstract: A cannulation device is adapted to gain access to the patient's common bile duct. In some instances, the cannulation device includes a first guidewire lumen extending through an elongate shaft and terminating at a first oblique guidewire port, and a second guidewire lumen extending through the elongate shaft and terminating at a second oblique guidewire port. In some instances, the cannulation device includes an inflatable balloon that is inflatable from a collapsed configuration to an expanded configuration in which the inflatable balloon is adapted to occlude the patient's pancreatic duct. In some instances, the cannulation device includes an expandable element that is expandable from a collapsed configuration in which the expandable element is disposed within the guidewire lumen and an extended configuration in which a portion of the expandable element extends distally from a guidewire port.

Abstract: Provided herein is a unit cell for a phased array antenna. The unit cell can include a base plate and a shell. The shell can include a plurality of spectrum element cavities, with each spectrum element cavity comprising a post. An inner surface of each of the spectrum element cavities can be coated with a conductive material such that the spectrum element cavities form a signal ear and a ground ear of the unit cell. The base plate can be configured to provide a path to ground and include a plurality of holes. The shell can be aligned with the base plate such that the post of each signal ear of each spectrum element cavity is aligned with one of the holes of the base plate.

Abstract: Techniques for capturing and recording processor events and scheduler data in a production system on a per processing resource basis are discussed herein. In some examples, a process metric collection component may be associated with the scheduler and the processing resource such that the process metric collection component can capture real time data associated with the processes or threads both executed by the processing resource and waiting to execute on the processing resource. The captured data may be used by the system to monitor operations.

Abstract: A collision is analysed by receiving telematics data relating to a collision and determining a feature of the collision. An entity may be notified of said collision based on the determined features.

Abstract: Systems and methods are disclosed for user modification of a rule or set of textual rules in plain language the reference instructions in a domain-specific treatment language that is used to generate dental appliance data. In some cases, the user may interact with a graphical user interface to modify a practitioner-specific subset of textural rules. The graphical user interface may allow modification of the practitioner-specific subset of textural rules without prior knowledge of the domain-specific treatment programming language. Each interaction region may cause sections of the predefined treatment preferences to be modified without knowledge of the dental protocol language. The example systems, methods, and/or computer-readable media described herein help with designing treatment plans for orthodontic treatments, including treatment plans based on predefined treatment preferences expressed in a dental protocol language.

Abstract: In various implementations, computer-implemented method, such as one executed on a computer system or on instructions stored on computer-readable media may include: receiving from a user device associated with a user, a request to access one or more treatment plans for patient; identifying a treatment template for user, the treatment template representing treatment preferences of the user, the treatment template being expressed according to treatment domain-specific protocols; processing the treatment template with the treatment domain-specific protocols to convert one or more parts of the treatment template into one or more runtime elements that interactively display customized user interface elements related to the treatment plan, the customized user interface elements configured to provide one or more customized user interactions with the treatment plan in accordance with the treatment preferences of the user; and providing instructions to display the one or more runtime elements on the user device.

Abstract: Methods and apparatuses, including systems, for forming and modifying treatment plans, including modifying treatment plan in real time. In particular are methods and apparatuses for modifying and orthodontic treatment plan in real time that may include the use of an enhanced user interface including a 3D user overlay.

Abstract: The invention provides methods of dosing for the treatment of cancers. In particular, provided are methods for treating human patients having lung cancer, such as non-small cell lung cancer (NSCLC), by administering a combination of an anti-TIGIT antagonist antibody and a PD-1 axis binding antagonist.

Abstract: Performance anomalies in complex systems can be difficult to identify and diagnose. In an example, CPU-usage associated with one or more of the systems can be determined. An anomalous event can be determined based on the determined CPU-usage. In some examples, based at least in part on determining the event, the system may be controlled in a safe state and/or reconfigured to obviate the anomalous event.

Abstract: A method, computer program product, and system are disclosed. The method includes receiving a first communication at a computer system, performing a search operation, sending a second communication, receiving a third communication, and storing the at least the portion of item information in a transaction storage construct. The computer system can cause presentation of a search field in a user interface displayed by a remote computer system. The first communication is received as a result of an event in the search field. Further, a search result (a result of the performing the search operation) is communicated to the remote computer system and comprises item information corresponding to an item. The second communication can cause presentation of the search results in the user interface. The third communication represents a selection of the item in the user interface, and comprises at least a portion of the item information.

Abstract: The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (MAO against target gene expression.

Abstract: The invention provides methods of dosing for the treatment of cancers. In particular, provided are methods for treating human patients having cancer, such as a hematologic cancer, by administering a combination of an anti-TIGIT antagonist antibody and an anti-CD20 antibody or anti-CD38 antibody.

Abstract: Performance anomalies in complex systems can be difficult to identify and diagnose. In an example, CPU-usage associated with one or more of the systems can be determined. An anomalous event can be determined based on the determined CPU-usage. In some examples, based at least in part on determining the event, the system may be controlled in a safe state and/or reconfigured to obviate the anomalous event.

Abstract: The invention provides a material feed process for magnetically separating magnetic and non-magnetic particles from a material feed by means of a magnetic roller separator wherein the process is characterised therein that particle separation is independent of centrifugal force, and where the process can equally well be applied to both wet and dry particle separation. The process specifically provides feeding the particles at an incident zone above the horizontal axis centre line, and separating the magnetic and non-magnetic particles at opposite rotational sides of the roller.

Abstract: A system for mimicking a blood vessel of a patient includes a microfluidic device including a body and a microfluidic channel formed in the body, wherein the microfluidic channel includes a fluid inlet and a fluid outlet, and a coating formed on the microfluidic channel including a plurality of blood outgrowth endothelial cells (BOECs) isolated from the patient and which define an inner surface of the microfluidic channel.