Abstract: Architectures and methods of operation for a pump for pumping two-phase magnetic fluids are described. The pump is capable of such pumping and may operate with no moving parts. Instead, the pump operates by selectively activating and deactivating each of a series of electrical circuits to control the presence or absence of magnetic fields applied to the two-phase magnetic fluid. The two-phase magnetic fluid may include liquid phase and gas phase, which may be in the form of bubbles. Though a presence of bubbles in a liquid may lead to cavitation and failure in some pumps, pumps for pumping two-phase magnetic fluids can avoid such a failure mechanism, in addition to avoiding another failure mechanism of wear and tear on moving parts.

Abstract: A medical appliance for the treatment of one or more sleep disorders such as obstructive sleep apnea in a patient, the appliance comprising: a biasing member for inserting behind and exerting a force upon the patient's soft palate or tongue, wherein the biasing member is inserted in a reduced or minimized form and then expanded or firms once in place to exert the force. The appliance may be nasally inserted or be placed through the mouth. In a particular configuration, both the soft palate and tongue are biased to prevent obstruction of the flow of air in the nasopharyngeal airway.

Abstract: A boiler system and methods of operating the system in a low-gravity environment are disclosed. The boiler system, which converts a cryogenic liquid to its gas phase, may be used in various types of space vehicles for various types of missions. The system principally operates using waste heat that is invariably produced during the many functions and processes that occur during space flight. The waste heat is collected and applied to a boiler tank in the system, where the cryogenic liquid is resultantly heated to a gas, which may be subsequently used or collected in one or more accumulator tanks, for example. Because waste heat is used in this liquid-to-gas conversion process, the boiler system consumes relatively low amounts of energy produced by, or stored in, a space vehicle.

Abstract: A medical appliance for the treatment of one or more sleep disorders such as obstructive sleep apnea in a patient, the appliance comprising: a biasing member for inserting behind and exerting a force upon the patient's soft palate or tongue, wherein the biasing member is inserted in a reduced or minimized form and then expanded or firms once in place to exert the force. The appliance may be nasally inserted or be placed through the mouth. In a particular configuration, both the soft palate and tongue are biased to prevent obstruction of the flow of air in the nasopharyngeal airway.

Abstract: Techniques and systems involve a magnetically enhanced cryogenic boiler that produces, without requiring pumps, high pressure gaseous oxygen from liquid oxygen for use in a spacecraft or other applications. The boiler heats, using a heat exchanger element, a closed container of liquid oxygen to boil the liquid oxygen at constant volume and increasing the pressure in the container. When a desired target pressure is reached, the boiler may release and transfer the high pressure fluid into a gaseous oxygen accumulator for storage. Magnets may be used to draw low pressure liquid oxygen into the boiler and to keep the liquid oxygen on or near one or more heat exchanger elements in the boiler, by exploiting paramagnetism of oxygen. The magnets produce a magnetic field that maintains relatively strong thermal contact between the heat exchanger elements and the liquid oxygen, even in the absence of gravity.

Abstract: Architectures and methods of operation for a pump for pumping two-phase magnetic fluids are described. The pump is capable of such pumping and may operate with no moving parts. Instead, the pump operates by selectively activating and deactivating each of a series of electrical circuits to control the presence or absence of magnetic fields applied to the two-phase magnetic fluid. The two-phase magnetic fluid may include liquid phase and gas phase, which may be in the form of bubbles. Though a presence of bubbles in a liquid may lead to cavitation and failure in some pumps, pumps for pumping two-phase magnetic fluids can avoid such a failure mechanism, in addition to avoiding another failure mechanism of wear and tear on moving parts.

Abstract: A medical appliance for the treatment of one or more sleep disorders such as obstructive sleep apnea in a patient, the appliance comprising: a biasing member for inserting behind and exerting a force upon the patient's soft palate or tongue, wherein the biasing member is inserted in a reduced or minimized form and then expanded or firms once in place to exert the force. The appliance may be nasally inserted or be placed through the mouth. In a particular configuration, both the soft palate and tongue are biased to prevent obstruction of the flow of air in the nasopharyngeal airway.

Abstract: The present invention concerns a solid oral dosage form comprising albumin and at least one cannabinoid, wherein the oral dosage form is free of a gas generating agent (GGA) and wherein the oral dosage form is prepared using a compression force Q of below 1 ton.

Abstract: A medical appliance for the treatment of one or more sleep disorders such as obstructive sleep apnea in a patient, the appliance comprising: a biasing member for inserting behind and exerting a force upon the patient's soft palate or tongue, wherein the biasing member is inserted in a reduced or minimized form and then expanded or firms once in place to exert the force. The appliance may be nasally inserted or be placed through the mouth. In a particular configuration, both the soft palate and tongue are biased to prevent obstruction of the flow of air in the nasopharyngeal airway.

Abstract: A razor including a head and a handle attached to the head via a pivot mechanism. An adjustable spring is used to orient the head. The head includes a top member, a bottom member, and one or more pins to retain a blade stack between the top member and the bottom member, the blade stack to comprise at least one razor blade and at least one spacer. The head also includes at least one removable fastener to enable the user to fasten the top member and the bottom member around the blade stack. The handle may be made of multiple segments with a common connection type making it reconfigurable by the user. The head may have channels to allow a fluid, gel or product from a cavity in the handle to the surface of the head. The handle may have a magnet at the end or in the last segment.

Abstract: A medical apparatus for the treatment of one or more sleep disorders such as obstructive sleep apnea in a patient is provided. The apparatus has an elongate member with a middle portion, a first fixation element and a second fixation element. The middle portion applies a force to a segment of a patient's airway.

Abstract: A medical appliance for the treatment of one or more sleep disorders such as obstructive sleep apnea in a patient, the appliance comprising: a biasing member for inserting behind and exerting a force upon the patient's soft palate or tongue, wherein the biasing member is inserted in a reduced or minimized form and then expanded or firms once in place to exert the force. The appliance may be nasally inserted or be placed through the mouth. In a particular configuration, both the soft palate and tongue are biased to prevent obstruction of the flow of air in the nasopharyngeal airway.

Abstract: Provided herein injectable implant compositions useful for acceleration of bone fracture healing, treatment of dental or oral pathologies, and controlled drug delivery.

Abstract: The present disclosure relates to methods for predicting time-to-delivery in pregnant women. The methods include predicting that a pregnant woman will deliver within a predetermined time frame if PAMG-1 is determined to be present at a level above a predetermined detection threshold in a vaginal fluid sample obtained from the pregnant woman. Also provided are methods for determining a patient's risk of preterm labor and/or spontaneous rupture of the chorioamniotic membrane.

Abstract: A drug delivery device includes a housing, a drug delivery assembly disposed within the housing along a longitudinal axis, and a cap defining a shell. At least one electronic component, a power source, and a switch assembly are at least partially disposed in and coupled to the cap. The switch assembly is movable along a plane orthogonal to the longitudinal axis of the drug delivery assembly to cause the power source to provide power to the electronic component. The device further includes an activation mechanism at least partially disposed in the cap. Upon urging the cap along the longitudinal axis in a direction away from the housing, the activation mechanism engages the switch assembly and causes the switch assembly to move, thereby causing the power source to provide power to the at least one electronic component.

Abstract: A medical appliance for the treatment of obstructive sleep apnea in a patient, the appliance comprising: a securing device configured to be removably affixed to the patient's jaw; and a biasing member which is insertable behind the soft palate and/or the base of the patient's tongue, thereby providing for the flow of air in the nasopharyngeal airway; wherein the securing device is connected to the biasing member to allow insertion and/or removal of the biasing member from the nasopharyngeal airway.

Abstract: A drug delivery device includes a housing defining a shell, a drug delivery assembly at least partially disposed within the housing, a cap defining an opening and being adapted to at least partially cover an end of the housing, at least one electronic component, a power source which powers the at least one electronic component, and a switch assembly. The drug delivery assembly comprises a guard which engages an inner surface of the housing and is movable between a first position, a second position, and a third position relative to the housing and is adapted to restrict external contact with a cannula. The switch assembly causes the power source to provide power to the at least one electronic component when the cap is removed from the housing, restrict the power source from providing power when the cap is coupled to the housing and the guard is in the first position, and cause the power source to provide power when the cap is coupled to the housing and the guard is in the third position.

Abstract: The present disclosure relates to methods for predicting time-to-delivery in pregnant women. The methods include predicting that a pregnant woman will deliver within a predetermined time frame if PAMG-1 is determined to be present at a level above a predetermined detection threshold in a vaginal fluid sample obtained from the pregnant woman. Also provided are methods for determining a patient's risk of preterm labor and/or spontaneous rupture of the chorioamniotic membrane.

Abstract: A medical device with limited computational capability includes medical hardware, a first register to store a static, substantially unique identifier of the medical device, a second register to store a static encryption key, an interface to receive and transmit data over a short-range communication link, and processing hardware. The processing hardware is configured to apply the static encryption key to the identifier of the medical device to generate an encrypted identifier, transmit the encrypted identifier of to another device via the interface, receive an encrypted identifier of the other device, decrypt the encrypted identifier of the other device using the static encryption key to determine an identifier of the other device, generate a dynamic encryption key using the identifier of the medical device and the identifier of the other device, and apply the dynamic encryption key to medical data transmitted between the medical device and the other device.

Abstract: Provided herein are compositions of injectable antibiotics for veterinary use. The compositions are characterized by forming a gel at animal physiological temperature, said gel being characterized by a stable and repeatable release profile of the antibiotic. The compositions comprise high loading of drug in poloxamer solutions with addition of a co-solvent, and preferably with an addition of a cellulose derivative at least partially soluble in organic solvents. Methods of treatment of veterinary infections are also provided.