Abstract: A reusable urinary catheter (72), comprising a catheter tube (12), a drainage member (22), the proximal end portion of the drainage member being connected to the distal end of the catheter tube, the distal end portion of the drainage member defining a drainage opening (28); a collapsible sleeve (18) surrounding the catheter tube, an introducer attached to the proximal end portion of the sleeve and the distal end portion of the sleeve being attached to the drainage member, the drainage member including channels (23) in fluid communication with the interior cavity of the sleeve, the channels allowing passage of sterilization fluid into and out of the sleeve; a holder (74) having a first port (66) and a second port (68), the introducer being releasably attached to the first port and the drainage member being releasable attached to the second port; and a sterilization fluid located within the sleeve.

Abstract: Kits are provided for storing, transporting, and sterilizing reusable urinary catheters. A reusable urinary catheter stored within a housing of the kit may be sterilized between uses using a sterilization fluid or sterilizing light. If the reusable urinary catheter is sterilized using a sterilization fluid, the housing may include a manually actuated or electromechanical pump to circulate the sterilization fluid through the housing. The reusable urinary catheter may include a funnel secured to a catheter shaft, with a plurality of lateral openings defined in the funnel, which provide fluid communication between an interior of the funnel and an external surface of the catheter shaft. By allowing fluid communication between the interior of the funnel and the external surface of the catheter shaft, the lateral openings allow for fluid sterilization of both internal and external surfaces of the catheter shaft.

Abstract: Reusable catheter products (10) are provided for storing, transporting, and sterilizing reusable urinary catheters. The products include a case (12) comprising a proximal section (30), a middle section (40), and a distal section (32). The case includes a cavity (16) configured to receive a catheter (14); the cavity includes a hydration fluid (18). The catheter comprises a distal end, a proximal end and a tubular section therebetween and includes a hydrophilic coating. When the catheter is inserted into the case, the hydration fluid sterilizes and lubricates the catheter.

Abstract: Kits are provided for storing, transporting, and sterilizing reusable urinary catheters. A reusable urinary catheter stored within a housing of the kit may be sterilized between uses using a sterilization fluid or sterilizing light. If the reusable urinary catheter is sterilized using a sterilization fluid, the housing may include a manually actuated or electro-mechanical pump to circulate the sterilization fluid through the housing. The reusable urinary catheter may include a funnel secured to a catheter shaft, with a plurality of lateral openings defined in the funnel, which provide fluid communication between an interior of the funnel and an external surface of the catheter shaft. By allowing fluid communication between the interior of the funnel and the external surface of the catheter shaft, the lateral openings allow for fluid sterilization of both internal and external surfaces of the catheter shaft.

Abstract: Hydration mediums, assemblies containing hydration mediums and methods of making the same are disclosed. The hydration mediums are intended for hydrating or wetting a medical device such as a catheter and comprise a hydration foam. Furthermore, methods and products involving hydrophilic substances are disclosed e.g. involving mucilage, deep eutectic liquids, antifreeze substances or cryoprotectants, oil or a hydration medium together with water, surfactant, polyol and stabilizer.

Abstract: A catheter (24) and catheter assembly (22) having a drainage member (46), defining a generally ring-shaped opening (48).

Abstract: A package (10, 34) having an opening tab (26, 48) that extends beyond the perimeter of the package.

Abstract: Methods of making sleeved hydrophilic urinary catheters.

Abstract: A method for producing a transgenic plant includes providing a nucleic acid molecule comprising at least two regions of nucleic acid sequence that lack sequence homology with genomic DNA of the plant cell, and at least two zinc finger nuclease recognition sites, wherein the at least two regions of nucleic acid sequence that lack sequence homology with genomic DNA of the plant cell flank the at least two zinc finger nuclease recognition sites. A plant cell or tissue having the nucleic acid molecule stably integrated into the genome of the plant cell is transformed. A plant is regenerated from the plant cell. Transgenic plants are produced by the method. Seeds are produced by the transgenic plants.

Abstract: A female urinary catheter deployment device includes a housing, an inner tip, an outer tip, a catheter, and an actuator. The outer tip is moved into the vicinity of the urethral opening of a female urethra. The outer tip is then moved from a closed condition to an open condition so as to expose a proximal end of the inner tip and position the proximal end of the inner tip within the urethra. The actuator is then moved with respect to the housing so as to proximally advance a proximal end of the catheter through and out of the proximal end of the inner tip and into the urethra. The proximal end of the catheter is further advanced through the urethra and into the bladder so as to drain urine from the bladder, through the catheter, and out of the housing.

Abstract: A urinary collection receptacle (10,50,650) with a handle seal (22,52,654) defining a handle opening is provided with one or more tear-controlling features to prevent a user from tearing through the handle seal when creating a spout to empty urine. The receptacle is be configured to require a user to create a generally linear tear (30) that extends from one edge (16) of the bag to the opposite edge (18) without passing through the handle seal. Alternatively a tear-stopping formation (62) is positioned adjacent to the handle seal to terminate a fear propagating toward the handle seal. Alternatively, a tear-starting formation (652) is positioned adjacent to the handle seal to direct a tear away from the handle seal. Such a receptacle further includes a frangible region that can be broken to dissociate a torn portion of the receptacle from the remainder of the receptacle.

Abstract: A catheter packing assembly that provides directions to the user on the proper procedure for contamination-free use of the catheter.

Abstract: A catheter (24) and catheter assembly (22) having a drainage member (46), defining a generally ring-shaped opening (48).

Abstract: An intermittent urinary catheter assembly (20) comprises a catheter tube (22) having a proximal insertion end (24) and a distal end (26) remote from the proximal insertion end and a lumen (28) which extends from at or near the proximal insertion end to the distal end for draining urine from a human bladder. The intermittent urinary catheter assembly includes a urine discharge sleeve (34) associated with the discharge opening (30) of the catheter tube, and the urine discharge sleeve has a compact stowed configuration and is extendable into a deployed configuration for directing urine flow. Alternatively, an adapter assembly (50?) comprises a fitting or nipple (52?) having a urine passageway for insertion into a funnel (40?) associated with a urine discharge end of an intermittent urinary catheter, and a discharge funnel (42?) associated with the fitting or nipple, and an extendable urine discharge sleeve (34?) within the discharge funnel.

Abstract: A catheter and package combination including a package having opposed front and rear panels that are sealed together to define a sealed interior cavity. The package also has top and bottom edges and opposed side edges. The cavity has a first height extending in a direction between the top and bottom edges. The front and rear panels are configured to tear adjacent to one of the side edges in the direction between the top and bottom edges to form an opening in communication with the cavity wherein the opening has a second height in the direction between the top and bottom edges that is smaller than the first height of the cavity. A urinary catheter in a compact configuration is disposed within the cavity.

Abstract: A flushable catheter configured to facilitate flushing of the catheter down the toilet and for disposal thereof. The flushable catheter optionally having a selected density such that the catheter has a desired buoyancy relative to water. Alternatively or in addition to having a selected density, the flushable catheter optionally includes a water capture element that is contacted by flushing water and captures the force of the flushing water to propel the catheter down the toilet and/or across a trapway/U-bend sewer pipe.

Abstract: An intermittent urinary catheter assembly (20) comprises a catheter tube (22) having a proximal insertion end (24) and a distal end (26) remote from the proximal insertion end and a lumen (28) which extends from at or near the proximal insertion end to the distal end for draining urine from a human bladder. The intermittent urinary catheter assembly includes a urine discharge sleeve (34) associated with the discharge opening (30) of the catheter tube, and the urine discharge sleeve has a compact stowed configuration and is extendable into a deployed configuration for directing urine flow. Alternatively, an adapter assembly (50?) comprises a fitting or nipple (52?) having a urine passageway for insertion into a funnel (40?) associated with a urine discharge end of an intermittent urinary catheter, and a discharge funnel (42?) associated with the fitting or nipple, and an extendable urine discharge sleeve (34?) within the discharge funnel.

Abstract: A catheter and package combination including a package having opposed front and rear panels that are sealed together to define a sealed interior cavity. The package also has top and bottom edges and opposed side edges. The cavity has a first height extending in a direction between the top and bottom edges. The front and rear panels are configured to tear adjacent to one of the side edges in the direction between the top and bottom edges to form an opening in communication with the cavity wherein the opening has a second height in the direction between the top and bottom edges that is smaller than the first height of the cavity. A urinary catheter in a compact configuration is disposed within the cavity.

Abstract: Disclosed herein are methods and compositions for targeted integration and/or targeted excision of one or more sequences into a cell, for example, for expression of one or more polypeptides of interest.

Abstract: A compact catheter assembly and methods of making such a catheter are disclosed. The catheter assembly incudes a receiver and a catheter sub-assembly. The catheter sub-assembly includes a gripping member and a catheter tube carried by the gripping member.